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18 Results Found

  • Article
  • Open Access
950 Views
14 Pages

Background: Amphetamine-type stimulants (ATS) in water pose significant public health and ecological risks, necessitating reliable and efficient detection methods. Current approaches often involve time-consuming pH adjustments and post-processing ste...

  • Review
  • Open Access
29 Citations
7,144 Views
17 Pages

Intra- and extracellular pH regulation is a pivotal function of all cells and tissues. Net outward transport of H+ is a prerequisite for normal physiological function, since a number of intracellular processes, such as metabolism and energy supply, p...

  • Article
  • Open Access
20 Citations
10,718 Views
15 Pages

Environmental Control in Flow Bioreactors

  • Serena Giusti,
  • Daniele Mazzei,
  • Ludovica Cacopardo,
  • Giorgio Mattei,
  • Claudio Domenici and
  • Arti Ahluwalia

7 April 2017

The realization of physiologically-relevant advanced in vitro models is not just related to the reproduction of a three-dimensional multicellular architecture, but also to the maintenance of a cell culture environment in which parameters, such as tem...

  • Article
  • Open Access
8 Citations
4,517 Views
18 Pages

Regulatory Aspects of the Vacuolar CAT2 Arginine Transporter of S. lycopersicum: Role of Osmotic Pressure and Cations

  • Jessica Cosco,
  • Teresa M. R. Regina,
  • Mariafrancesca Scalise,
  • Michele Galluccio and
  • Cesare Indiveri

19 February 2019

Many proteins are localized at the vacuolar membrane, but most of them are still poorly described, due to the inaccessibility of this membrane from the extracellular environment. This work focused on the characterization of the CAT2 transporter from...

  • Article
  • Open Access
4 Citations
2,303 Views
12 Pages

26 April 2023

Octagon (HMX) is a typical organic pollutant of explosives in the surrounding environments of military factories, and it is widely regarded as a carcinogen which may enter the human body through wastewater and atmospheric exposure, resulting in poten...

  • Proceeding Paper
  • Open Access
1,993 Views
7 Pages

One of the technological developments supporting irrigation modernization is the installation of telemetry monitoring systems that are built based on three main elements of sensors, internet connections, and data centers. The Dadahup Swamp Irrigation...

  • Article
  • Open Access
6 Citations
3,199 Views
16 Pages

Efficiency of Manchega Sheep Milk Intended for Cheesemaking and Determination of Factors Causing Inefficiency

  • Ana Garzón,
  • José M. Perea,
  • Ramón Arias,
  • Elena Angón and
  • Javier Caballero-Villalobos

11 January 2023

Understanding the factors that determine and regulate cheese yield would allow, through deterministic parametric efficiency models, the determination of the most appropriate milk characteristics for the industry, and the estimation of a technological...

  • Article
  • Open Access
6 Citations
2,832 Views
17 Pages

Molecular Basis for Mambalgin-2 Interaction with Heterotrimeric α-ENaC/ASIC1a/γ-ENaC Channels in Cancer Cells

  • Ekaterina N. Lyukmanova,
  • Maxim M. Zaigraev,
  • Dmitrii S. Kulbatskii,
  • Aizek B. Isaev,
  • Ilya D. Kukushkin,
  • Maxim L. Bychkov,
  • Mikhail A. Shulepko,
  • Anton O. Chugunov and
  • Mikhail P. Kirpichnikov

13 October 2023

Cancer progression is characterized by microenvironmental acidification. Tumor cells adapt to low environmental pH by activating acid-sensing trimeric ion channels of the DEG/ENaC family. The α-ENaC/ASIC1a/γ-ENaC heterotrimeric channel is...

  • Article
  • Open Access
3 Citations
2,648 Views
15 Pages

31 May 2022

Functionalized small-molecule assemblies can exhibit nano-delivery properties that significantly improve the bioavailability of bioactive molecules. This study explored the self-assembly of short-chain fatty acids (FA, Cn < 8) to form novel biomim...

  • Article
  • Open Access
9 Citations
3,083 Views
10 Pages

Detection of Interleukin-6 Protein Using Graphene Field-Effect Transistor

  • Manoharan Arun Kumar,
  • Ramasamy Jayavel,
  • Shanmugam Mahalingam,
  • Junghwan Kim and
  • Raji Atchudan

22 August 2023

Universal platforms to analyze biomolecules using sensor devices can address critical diagnostic challenges. Sensor devices like electrical-based field-effect transistors play an essential role in sensing biomolecules by charge probing. Graphene-base...

  • Article
  • Open Access
878 Views
16 Pages

Soil Quality and Trace Element Risk in Urban and Rural Kitchen Gardens: A Comparative Analysis

  • Diego Arán,
  • Osvaldo Santos,
  • Rodrigo Feteira-Santos,
  • Yacine Benhalima and
  • Erika S. Santos

20 August 2025

The development and use of urban spaces for food production is increasing in response to the search for healthier foods and contact with nature. These spaces can be created or built on materials of various types, which might contain potentially toxic...

  • Article
  • Open Access
24 Citations
7,184 Views
20 Pages

5 June 2014

Wampee (Clausena lansium) fruits (CLS), whose pulp can be used to prepare fruit cups, desserts, jam, or jelly, can be eaten along with the peel. In this study, a PC12 cell model was built to observe the protective effect of CLS against H2O2-induced o...

  • Review
  • Open Access
10 Citations
4,868 Views
19 Pages

Pseudogene Transcripts in Head and Neck Cancer: Literature Review and In Silico Analysis

  • Juliana Carron,
  • Rafael Della Coletta and
  • Gustavo Jacob Lourenço

17 August 2021

Once considered nonfunctional, pseudogene transcripts are now known to provide valuable information for cancer susceptibility, including head and neck cancer (HNC), a serious health problem worldwide, with about 50% unimproved overall survival over t...

  • Article
  • Open Access
14 Citations
4,195 Views
24 Pages

Seminal Plasma Modulates miRNA Expression by Sow Genital Tract Lining Explants

  • Isabel Barranco,
  • Lorena Padilla,
  • Cristina A. Martinez,
  • Manuel Alvarez-Rodriguez,
  • Inmaculada Parrilla,
  • Xiomara Lucas,
  • Graça Ferreira-Dias,
  • Marc Yeste,
  • Heriberto Rodriguez-Martinez and
  • Jordi Roca

19 June 2020

The seminal plasma (SP) modulates the female reproductive immune environment after mating, and microRNAs (miRNAs) could participate in the process. Considering that the boar ejaculate is built by fractions differing in SP-composition, this study eval...

  • Article
  • Open Access
6 Citations
2,942 Views
20 Pages

Exploring the Underlying Mechanisms of Qingxing Granules Treating H1N1 Influenza Based on Network Pharmacology and Experimental Validation

  • Hujun Du,
  • Lianying Zhang,
  • Haoxiang Sun,
  • Shaoqin Zheng,
  • Hongying Zhang,
  • Shijia Yuan,
  • Jiuyao Zhou,
  • Zihao Fang,
  • Jianping Song and
  • Changsheng Deng
  • + 1 author

Background: H1N1 is one of the major subtypes of influenza A virus (IAV) that causes seasonal influenza, posing a serious threat to human health. A traditional Chinese medicine combination called Qingxing granules (QX) is utilized clinically to treat...

  • Article
  • Open Access
165 Citations
15,282 Views
18 Pages

Antrodan Alleviates High-Fat and High-Fructose Diet-Induced Fatty Liver Disease in C57BL/6 Mice Model via AMPK/Sirt1/SREBP-1c/PPARγ Pathway

  • Charng-Cherng Chyau,
  • Hsueh-Fang Wang,
  • Wen-Juan Zhang,
  • Chin-Chu Chen,
  • Shiau-Huei Huang,
  • Chun-Chao Chang and
  • Robert Y. Peng

Non-alcoholic fatty liver disease (NAFLD) and -steatohepatitis (NASH) imply a state of excessive fat built-up in livers with/or without inflammation and have led to serious medical concerns in recent years. Antrodan (Ant), a purified β-glucan fr...

  • Article
  • Open Access
1 Citations
1,128 Views
34 Pages

Investigation of the Expression, Localization, and Acidosis-Associated Conformational Changes in Connexin 43 in Traumatic Brain Injury with the Development of a Neural Network Model for Assessing Systemic Inflammation

  • Chizaram Nwosu,
  • Evgeniya Kirichenko,
  • Stanislav Bachurin,
  • Mikhail Petrushan,
  • Alexey Ermakov,
  • Rozaliia Nabiullina,
  • Marya Kaplya,
  • Alexander Logvinov and
  • Stanislav Rodkin

11 September 2025

Traumatic brain injury (TBI) is one of the most common forms of neurotrauma, accompanied by significant disruptions in neuronal homeostasis and intercellular communication. A key protein involved in these processes is connexin 43 (Cx43), which facili...

  • Article
  • Open Access
1,659 Views
23 Pages

3 October 2024

The vitreous humor (VH) is a transparent gelatin-like substance that occupies two-thirds of the eyeball and undergoes the most significant changes during eye elongation. Quantitative proteomics on the normal growth period in the VH could provide new...