Zoonotic Diseases

Background: Human monkeypox is a zoonotic disease caused by the monkeypox virus (MPXV), endemic in Central and West Africa. A significant 2022 outbreak affected 104 countries, driven by increased susceptibility due to the cessation of smallpox vaccination, global travel, and interactions with infected animals. Strengthening surveillance, public health measures, and raising awareness are essential for early diagnosis, vaccination acceptance, and preventing future outbreaks. Methods: The survey was distributed to 645 nursing students of the University of Palermo between July 2022 and August 2022, and we estimated the knowledge, attitudes and behaviors through a KAP Survey. Descriptive statistics were used to summarize the data, while chi-squared, Fisher’s exact, and Student’s t-tests were employed to analyze differences between groups, with statistical significance set at p < 0.05. At least 80% of the students surveyed had already taken the microbiology exam, as microbiology is studied in the first year of the Bachelor of Science in Nursing program at the University of Palermo. Results: The survey showed a predominantly young, female nursing student population with limited knowledge of monkeypox, as only 3.88% demonstrated adequate understanding. Despite this, attitudes toward prevention were positive, with 82.64% scoring adequately and 41.09% expressing strong willingness to get vaccinated. Knowledge improved with academic progression (p = 0.005), while attitudes and behaviors remained consistent. These findings imply a critical gap in education; the limited knowledge, especially regarding transmission and severity, may lead to an underestimation of the risks associated with global infectious diseases. This underscores the need to better prepare future healthcare professionals for public health emergencies Conclusions: The study found that nursing students had limited knowledge of monkeypox, especially regarding epidemiology and disease severity. Despite positive attitudes toward vaccination, some behaviors reflected an underestimation of global infection risks. Knowledge improved with academic progression, underscoring the importance of education. Targeted educational programs are needed to enhance awareness and preparedness for future outbreaks.

Zoonotic diseases represent an important interface between socio-environmental change and public health, yet integrative assessments linking ecological and social determinants remain limited in tropical regions. This study mapped how socio-environmental drivers have shaped research patterns on zoonotic diseases in Brazil. We integrated socio-environmental data from empirical evidence with statistical modeling to evaluate temporal trends, thematic associations, and geographic distribution across six major zoonoses: leishmaniasis, Chagas disease, leptospirosis, yellow fever, Brazilian spotted fever, and hantavirus infection. Research output increased after 2010, particularly for leishmaniasis, Chagas disease, and leptospirosis, reflecting growing recognition of land-use change and socioeconomic vulnerability as key drivers of disease risk. Network analyses revealed strong thematic connections between zoonoses and land-use or socioeconomic factors, whereas climate change remained underrepresented. Spatially, research efforts were concentrated in the Amazon and Cerrado biomes, underscoring both ecological significance and persistent regional disparities in knowledge production. These findings demonstrate that Brazil’s zoonotic research landscape mirrors broader socio-environmental pressures, where deforestation, poverty, and climatic variability jointly influence disease dynamics. Strengthening geographically inclusive and environmentally informed research frameworks that integrate climate, land-use, and surveillance data will be essential to improve early-warning systems and guide sustainable, cross-sectoral public health policies.

Viral zoonoses represent a critical intersection of global health, ecology, and ethical issues. Pathogens that pass from animals to humans. This review examines the complex landscape of viral zoonoses, including their mechanisms, impact, and mitigation strategies. We begin with insights into the historical context and significance of these diseases and then explore spillover mechanisms influenced by genetic, ecological, and anthropogenic factors. This review covers the host range, transmission dynamics, and immunological barriers, including viral detection, adaptation, and immune evasion. Genomic insights have revealed the genetic determinants of host switching and adaptation, illuminating the dynamics of viral spillover events. We emphasize the anticipation and prevention of zoonotic events, highlighting surveillance, early warning systems, and the “One Health” approach. Using case studies of outbreaks such as Ebola, avian influenza, and COVID-19, this review examines the real-world consequences of zoonotic diseases. We then discuss interventions, including mitigation strategies and vaccination, and their ethical and social implications. Drawing on past outbreaks, we provide recommendations for the future, aiming to balance human health, conservation, and animal welfare. This review aims to inform professionals, academics, and policymakers by offering a multidisciplinary perspective on the complex world of viral zoonoses and strategies to protect global health.