Announcements

14 August 2023
MDPI’s 2022 Outstanding Reviewer Awards in Biology and Life Sciences—Winners Announced


In order to acknowledge our reviewers, who demonstrate diligence, professionalism, and timeliness when generously dedicating their time to reviewing manuscripts, MDPI journals regularly offer outstanding reviewer awards to scholars who participate in the peer review process.

We are proud to recognize the winners for the year 2022 in biology and life sciences for their outstanding contributions, among extensive competition, by presenting them with an Outstanding Reviewer Award.

We would like to take this opportunity to congratulate all of the winners on their achievements. MDPI will continue to provide support and recognition to the academic community.

Agronomy:

  • Ewa Ropelewska, The National Institute of Horticultural Research, Poland
  • Marek Rašovský, Slovak University of Agriculture in Nitra, Slovakia
  • Prakash Jha, Kansas State University, USA
  • Vasileios Greveniotis, Institute of Industrial and Forage Crops, Greece

Biology:

  • Alberto Collareta, University of Pisa, Italy
  • Francisco Curate, University of Coimbra, Portugal
  • Gianpiero Greco, University of Study of Bari, Italy
  • Luca Poli, University of Study of Bari, Italy
  • Shaohua Chen, South China Agricultural University, China

Brain Sciences:

  • Chong Chen, Yamaguchi University Graduate School of Medicine, Japan

Children:

  • Marco Sapienza, University of Catania, Italy
  • Sabina Barrios-Fernández, University of Extremadura, Spain

Diversity:

  • Corrado Battisti, Torre Flavia LTER (Long Term Ecological Research) Station, Italy
  • Daniel Stec, Institute of Systematics and Evolution of Animals of the Polish Academy of Sciences, Poland
  • Emilia Grzędzicka, Institute of Systematics and Evolution of Animals of the Polish Academy of Sciences, Poland
  • Igor Zelnik, University of Ljubljana, Slovenia

Endocrines:

  • Eva S. Liu, 1Harvard Medical School, USA 2Brigham and Women’s Hospital, USA

Fermentation:

  • Aleksandra Szydlowska, Warsaw University of Life Sciences (WULS), Poland
  • Mohamed Ali Abdel-Rahman, Al-Azhar University, Egypt

Fishes:

  • Andrew G. Jeffs, University of Auckland, New Zealand
  • Mohamed Samy-Kamal, Universitat d'Alacant, Spain

Foods:

  • Baskaran Stephen Inbaraj, Fu Jen Catholic University, Taiwan
  • Marzena Włodarczyk-Stasiak, University of Life Sciences in Lublin, Poland
  • Minaxi Sharma, Haute Ecole Provinciale de Hainaut-Condorcet, Belgium
  • Viviani Ruffo de Oliveira, Federal University of Rio Grande do Sul (UFRGS), Brazil

Genes:

  • Federico Manuel Giorgi, University of Bologna, Italy
  • Jan Bocianowski, Poznań University of Life Sciences, Poland
  • Magdalena Mroczek, Center for Cardiovascular Genetics and Gene Diagnostics, Switzerland

IJMS:

  • Keigi Fujiwara, University of Texas MD Anderson Cancer Center, USA
  • Tomasz W. Kaminski, University of Pittsburgh, USA
  • Takujiro Homma, Yamagata University, Japan
  • William Bryan Terzaghi, Wilkes University, United States
  • Zong-jie Cui, Beijing Normal University, China

Insects:

  • Abraão Almeida Santos, University of Florida, USA
  • Agata Kaczmarek, Polish Academy of Sciences, Poland
  • Miguel A. García-Martínez, Universidad Veracruzana, Mexico

Life:

  • Andrei S. Rodin, Diabetes and Metabolism Research Institute, USA
  • Kazuhiko Kotani, Jichi Medical University, Japan

Metabolites:

  • Jianing Mi, King Abdullah University of Science and Technology, Saudi Arabia
  • Nguyen Phuoc Long, Inje University College of Medicine, Republic of Korea
  • Xian Luo, University of Alberta, Canada

Pathogens:

  • Guillaume Fiches, Ohio State University, USA
  • Jianxuan Wu, Gilead Sciences, USA
  • Tomasz M. Karpiński, Poznań University of Medical Sciences, Poland

Plants:

  • Alicia Ayerdi Gotor, Institut Polytechnique UniLaSalle, France
  • Andrea Mastinu, University of Brescia, Italy
  • Edyta Paczos-Grzeda, University of Life Sciences in Lublin, Poland
  • Narayan Bhusal, Seoul National University, Republic of Korea
  • Mohsen Hesami, University of Guelph, Canada

Toxins:

  • Christian Müller, University of Greifswald, Germany
  • Margarita Fernández-Tejedor, IRTA, Spain

Vaccines:

  • Christian Napoli, “Sapienza” University of Rome, Italy
  • Federico Marchesi, University of Parma, Italy
  • Roger E. Thomas, University of Calgary, Canada

Veterinary Sciences:

  • Fun-In Wang, National Taiwan University, Taiwan
  • Valeria Grieco, University of Milan, Italy

About MDPI Awards:

In order to reward the academic community, especially young researchers and enhance communication among scientists, MDPI journals regularly offer various awards to researchers in specific fields. These awards, serving as a source of inspiration and recognition, help raise the influence of talented individuals who have been credited with outstanding achievements and are making a significant contribution to the advancement of their fields.

To explore more MDPI awards, please click here.

14 August 2023
MDPI’s 2022 Best PhD Thesis Awards in Biology and Life Sciences—Winners Announced


MDPI’s Best PhD Thesis Awards are presented to recognize the young scholars who are judged to have completed the most outstanding PhD thesis in their field of research and to encourage them to continue their outstanding work and further contributions to their field.

We would like to warmly congratulate the winners of the 2022 Best PhD Thesis Awards and wish them success in their future research endeavors. MDPI will continue to enhance communication among scientists.

Brain Sciences:

  • “CYP2D in the Brain Alters Response to Drugs and Neurotoxins”
    by Marlaina R. Stocco, University of California, USA
  • “Neural Encoding of Prior Experience in Sensorimotor Behavior”
    by Nicolas Meirhaeghe, Institut de Neurosciences de la Timone, France
  • “Perinatal Stem Cell: Epigenetic, Biological and Differentiative Characteristics”
    by Giulia Gaggi, University "G.D'Annunzio" of Chieti-Pescara, Italy

Genes:

  • “Uncovering the Genetic Variation Involved in Asthma Exacerbations through Multiple Genomic Approaches”
    by Esther Herrera Luis, Universidad de La Laguna, Spain

Veterinary Sciences:

  • “Development of Novel Tools for Monitoring Antimicrobial Resistance in Complex Microbial Communities and Their Application to Improving Our Stewardship of Antimicrobials in Livestock”
    by Ashenafi Feyisa Beyi, Iowa State University, United States

About MDPI Awards:

In order to reward the academic community, especially young researchers and enhance communication among scientists, MDPI journals regularly offer various awards to researchers in specific fields. These awards, serving as a source of inspiration and recognition, help raise the of talented individuals who have been credited with outstanding achievements and are making a significant contribution to the advancement of their fields.

To explore more MDPI awards, please click here.

14 August 2023
MDPI’s Best Paper Awards in Biology and Life Sciences—Winners Announced in 2022


The purpose of our Best Paper Awards is to promote and recognize the most impactful contributions published within MDPI journals.

The editors of each journal carefully selected reviews and research papers through a rigorous judging process based on criteria such as scientific merit, overall impact, and the quality of presentation.

We are honored to present the winners for the year 2022 in biology and life sciences, who were selected amongst extensive competition, and congratulate the authors for their outstanding scientific publications. MDPI will continue to provide support and recognition to the academic community.

Agronomy:

Biology:

Brain Sciences:

Diversity:

Genes:    

IJMS:     

Insects:  

Life:

Metabolites:          

MPs:

Pathogens:

Plants:

Toxins:

Vaccines:               

Veterinary Sciences:

About MDPI Awards:

In order to reward the academic community, especially young researchers and enhance communication among scientists, MDPI journals regularly offer various awards to researchers in specific fields. These awards, serving as a source of inspiration and recognition, help raise the influence of talented individuals who have been credited with outstanding achievements and are making a significant contribution to the advancement of their fields.

To explore more MDPI awards, please click here.

9 August 2023
MDPI World Hepatitis Day Webinar 2023, Held on 28 July 2023

To commemorate the World Hepatitis Day 2023, MDPI organized a webinar on 28 July 2023 to encourage researchers to come together, take action, and highlight how the exchange of findings facilitates efforts to raise awareness of hepatitis. The low coverage of testing and treatment is the most important gap to be addressed to achieve the global elimination goals of hepatitis B virus (HBV) by 2030.

Session 1:

Speaker/Presentation
Introduction
Prof. Dr. Chia-Yen Dai
Achieving Elimination of Hepatitis C in Taiwan
Dr. Tan Yee Joo
Understanding the Functions of Hepatitis B Viral Proteins and Targeting Them in Antiviral Drug Development
Dr. Sheikh Mohammad Fazle Akbar
Standing at the Half-Way: An Analysis of “Elimination of Hepatitis by 2030” in Developed and Developing Countries
Q&A Session

 You can watch the recorded webinar below:

Session 2:

Speaker/Presentation
Introduction
Prof. Dr. John Tavis
The International Coalition to Eliminate HBV (ICE-HBV): Promoting Global Scientific Collaboration in HBV Cure Research
Prof. Dr. Mark A. Feitelson
Microbial Metabolites that Attenuate the Pathogenesis of Cancer and Autoimmunity
Prof. Dr. Natalia Osna
Hepatitis in HIV Infection
Q&A Session

 You can watch the recorded webinar below:

 Relevant Special Issues:

Pathogens
Research on Hepatitis B Virus: Past, Present, and Future
Edited by: Hyung Joon Yim
Submission deadline: 31 August 2023 

JPM
Novel Challenges and Therapeutic Options for Liver Diseases
Edited by: Guido Gerken
Submission deadline: 30 September 2023 

Medicina
Viral Hepatitis Research: Updates and Challenges
Edited by: Endrit Shahini, Antonio Giovanni Solimando and Antonella Argentiero
Submission deadline: 15 October 2023 

Cells
Non-alcoholic Steatohepatitis (NASH) and Liver Fibrosis: Molecular and Multicellular Control of Evolving Diseased States
Edited by: Jérôme Eeckhoute
Submission deadline: 15 February 2024 

Diagnostics
Diagnosis and Management of Liver Diseases—2nd Edition
Edited by: Jeong-Ju Yoo
Submission deadline: 30 September 2023 

Vaccines
Vaccination and Treatments against Viral Hepatitis: Achievements, Challenges and Perspectives
Edited by: Bárbara Vieira Do Lago and Vinicius M. Mello
Submission deadline: 15 October 2023

3 August 2023
Viruses | Invitation to Read Selected Papers from Editor’s Choice Articles


We are excited to present the latest edition of the Editor’s Choice Articles, where we shine a spotlight on exceptional research published in Viruses (ISSN: 1999-4915). As passionate advocates of scientific excellence, our team of scientific editors has carefully curated a selection of high-quality articles covering diverse topics in the virology community.

In this edition, you will find an array of fascinating studies exploring Baculovirus, HIV, Flavivirus, Rodent-Borne Viruses, Avian Influenza Viruses, Phage, Lyssavirus, Coronaviruses, SARS-CoV, Papillomavirus, and much more. To provide you with a glimpse into the essence of each research endeavor, every article is accompanied by a graphical abstract and a succinct summary.

Our Editor's Choice Articles not only celebrate groundbreaking discoveries, but also foster engagement within the scientific community. We look forward to your insights and feedback, as they are paramount to advancing our collective understanding of virology.

Dive into the latest advancements in virology research and join us in exploring the frontiers of science.

Global Metabolic Profiling of Baculovirus Infection in Silkworm Hemolymph Shows the Importance of Amino-Acid Metabolism
by Min Feng, Shigang Fei, Junming Xia, Mengmeng Zhang, Hongyun Wu, Luc Swevers and Jingchen Sun
Viruses 2021, 13(5), 841; https://doi.org/10.3390/v13050841
Available online: https://www.mdpi.com/1999-4915/13/5/841

Message from the Editor:

In this study, global metabolic changes associated with BmNPV infection in silkworm hemolymphs were analyzed to understand the interaction between the host metabolic responses and BmNPV infection. The results revealed a unique amino acid utilization process that was implemented during BmNPV infection, in which amino acid consumption was increased at 24 hours post infection, but its abundance recovered at 72 hours post infection. Furthermore, it was found that glycolysis and glutaminolysis are not essential during BmNPV infection.


Microglial HIV-1 Expression: Role in HIV-1 Associated Neurocognitive Disorders
by Hailong Li, Kristen A. McLaurin, Jessica M. Illenberger, Charles F. Mactutus and Rosemarie M. Booze
Viruses 2021, 13(5), 924; https://doi.org/10.3390/v13050924
Available online: https://www.mdpi.com/1999-4915/13/5/924

Message from the Editor:

In this study, two complementary studies were conducted to (1) evaluate the HIV-1 mRNA distribution pattern and major cell type expressing HIV-1 mRNA in HIV-1 transgenic (Tg) rats, and (2) validate our findings by developing and critically testing a novel biological system to model active HIV-1 infection in rats. The results showed that microglia were the predominant cell type expressing HIV-1 mRNA in the HIV-1 Tg rats. Within eight weeks of infection, EcoHIV rats exhibited neurocognitive impairments and synaptic dysfunction, which may have resulted from the activation of the NogoA-NgR3/PirB-RhoA signaling pathway and/or neuroinflammation.


An Absolutely Conserved Tryptophan in the Stem of the Envelope Protein E of Flaviviruses Is Essential for the Formation of Stable Particles
by Iris Medits, Franz X. Heinz and Karin Stiasny
Viruses 2021, 13(9), 1727; https://doi.org/10.3390/v13091727
Available online: https://www.mdpi.com/1999-4915/13/9/1727

Message from the Editor

Medits, Heinz, and Stiasny (2021) investigated the importance of tryptophan in different stages of the viral life cycle via a mutagenesis-based approach using tick-borne encephalitis virus (TBEV). The study shows that W421 does not play an important role in viral fusion-related processes, but is essential for virus assembly by establishing interactions that confer stability to infectious mature particles. As revealed by a resuscitating mutation in passaged virus mutants, these stabilizing interactions could also be provided by another large hydrophobic amino acid (leucine) at the same position.


Phylogenomic Characterization of Lopma Virus and Praja Virus, Two Novel Rodent-Borne Arteriviruses
by Bert Vanmechelen, Zafeiro Zisi, Sophie Gryseels, Joëlle Goüy de Bellocq, Bram Vrancken, Philippe Lemey, Piet Maes and Magda Bletsa
Viruses 2021, 13(9), 1842; https://doi.org/10.3390/v13091842
Available online: https://www.mdpi.com/1999-4915/13/9/1842

Message from the Editor:

The complete genome sequences of four new arterivirus variants belonging to two putative novel species were reported in this study. These new arteriviruses were discovered in African rodents and were given the names Lopma virus and Praja virus. Phylogenetic analysis shows that Lopma virus clusters in the subfamily Variarterivirinae, while Praja virus clusters near members of the subfamily Heroarterivirinae: the yet undescribed forest pouched giant rat arterivirus and hedgehog arterivirus 1.


The Pathobiology of H7N3 Low and High Pathogenicity Avian Influenza Viruses from the United States Outbreak in 2020 Differs between Turkeys and Chickens
by Miriã F. Criado, Christina M. Leyson, Sungsu Youk, Suzanne DeBlois, Tim Olivier, Mary Lea Killian, Mia L. Torchetti, Darren J. Parris, Erica Spackman, Darrell R. Kapczynski et al.
Viruses 2021, 13(9), 1851; https://doi.org/10.3390/v13091851
Available online: https://www.mdpi.com/1999-4915/13/9/1851

Message from the Editor:

In this study, Criado et al. (2021) reported clear differences in the pathobiology of avian influenza viruses (AIVs) in turkeys and chickens. Results showed that the H7N3 2020 low-pathogenicity avian influenza viruses (LPAIVs) and the high-pathogenicity avian influenza virus (HPAIV) were more infectious in turkeys than in chickens and were efficiently transmitted to contact turkeys but not chickens, corroborating the high susceptibility of turkeys to AIV infections. Other than that, the LPAIV with the NA stalk deletion was found to be more infectious in turkeys, but did not have enhanced infectivity in chickens.


Reduced Infection Efficiency of Phage NCTC 12673 on Non-Motile Campylobacter jejuni Strains Is Related to Oxidative Stress
by Jessica C. Sacher, Muhammad Afzal Javed, Clay S. Crippen, James Butcher, Annika Flint, Alain Stintzi and Christine M. Szymanski
Viruses 2021, 13(10), 1955; https://doi.org/10.3390/v13101955
Available online: https://www.mdpi.com/1999-4915/13/10/1955

Message from the Editor:

This investigation revealed a complex interplay between phage infectivity, oxidative stress, and flagellar motility in C. jejuni. The results indicated that the apparent dependence of phage NCTC 12673 on C. jejuni motility is not related to adsorption to the flagella, but instead can be explained by the phage’s reduced infection efficiency under conditions of oxidative stress. Moreover, evidence has demonstrated that the phage-encoded FlaGrab is phase-variable, and that variable expression of this protein may be linked to a mechanism by which the phage can tune its infectivity according to the oxidative-stress state of the cell.


Spillover of West Caucasian Bat Lyssavirus (WCBV) in a Domestic Cat and Westward Expansion in the Palearctic Region
by Stefania Leopardi, Ettore Barneschi, Giuseppe Manna, Barbara Zecchin, Pamela Priori, Petra Drzewnioková, Francesca Festa, Andrea Lombardo, Fabio Parca, Dino Scaravelli et al.
Viruses 2021, 13(10), 2064; https://doi.org/10.3390/v13102064
Available online: https://www.mdpi.com/1999-4915/13/10/2064

Message from the Editor:

In June 2020, a cat from Arezzo (Italy) that died from a neurological disease was diagnosed with West Caucasian Bat Lyssavirus (WCBV). People that were exposed to the cat received full post-exposure prophylaxis, while animals underwent six months of quarantine. In a tunnel located near the cat’s house, a group of bent-winged bats that had shown virus-neutralizing antibodies to WCVB across four sampling occasions was identified, but no virus was found in salivary swabs.


Evolution of Anti-RBD IgG Avidity following SARS-CoV-2 Infection
by Alexandra Tauzin, Gabrielle Gendron-Lepage, Manon Nayrac, Sai Priya Anand, Catherine Bourassa, Halima Medjahed, Guillaume Goyette, Mathieu Dubé, Renée Bazin, Daniel E. Kaufmann et al.
Viruses 2022, 14(3), 532; https://doi.org/10.3390/v14030532
Available online: https://www.mdpi.com/1999-4915/14/3/532

Message from the Editor:

Tauzin et al. (2022) developed a simple assay to measure the avidity of anti-receptor-binding domain (RBD) IgG elicited by SARS-CoV-2 infection. It was observed that, while the level of antibodies declined over time, the anti-RBD avidity progressively increased and correlated with the B cell class switch. Additionally, it was observed that anti-RBD avidity increased similarly after SARS-CoV-2 mRNA vaccination and after SARS-CoV-2 infection.


Depo Medroxyprogesterone (DMPA) Promotes Papillomavirus Infections but Does Not Accelerate Disease Progression in the Anogenital Tract of a Mouse Model
by Jiafen Hu, Sarah A. Brendle, Jingwei J. Li, Vonn Walter, Nancy M. Cladel, Timothy Cooper, Debra A. Shearer, Karla K. Balogh and Neil D. Christensen
Viruses 2022, 14(5), 980; https://doi.org/10.3390/v14050980
Available online: https://www.mdpi.com/1999-4915/14/5/980

Message from the Editor:

In this study, a mouse papillomavirus (MmuPV1) anogenital infection model was used to test two hypotheses: (1) contraceptives such as DMPA increase the susceptibility of the anogenital tract to viral infection and (2) long-term contraceptive administration induces more advanced disease at the anogenital tract. From the experiment’s results, DMPA promoted initial papillomavirus infections in the lower genital tract, and the chronic administration of DMPA did not promote cancer development in the infected tissues in our mouse model.


SARS CoV-2 (Delta Variant) Infection Kinetics and Immunopathogenesis in Domestic Cats
by Miruthula Tamil Selvan, Sachithra Gunasekara, Ping Xiao, Kristen Griffin, Shannon R. Cowan, Sai Narayanan, Akhilesh Ramachandran, Darren E. Hagen, Jerry W. Ritchey, Jennifer M. Rudd et al.
Viruses 2022, 14(6), 1207; https://doi.org/10.3390/v14061207
Available online: https://www.mdpi.com/1999-4915/14/6/1207

Message from the Editor:

A feline model was established to study COVID-19 disease progression, and this model was utilized to evaluate infection kinetics and immunopathology of the rapidly circulating Delta variant (B.1.617.2) of SARS-CoV-2. From the results, RNA sequencing of infected feline lung tissues identified upregulation of multiple gene pathways associated with cytokine–receptor interactions, chemokine signaling, and viral protein–cytokine interactions during acute infection with SARS-CoV-2. Weighted correlation network analysis (WGCNA) of differentially expressed genes identified several distinct clusters of dysregulated hub genes that are significantly correlated with both clinical signs and lesions during acute infection.


Origins and Evolution of Seasonal Human Coronaviruses
by James R. Otieno, Joshua L. Cherry, David J. Spiro, Martha I. Nelson and Nídia S. Trovão
Viruses 2022, 14(7), 1551; https://doi.org/10.3390/v14071551
Available online: https://www.mdpi.com/1999-4915/14/7/1551

Message from the Editor:

In this study, the evolutionary histories of seasonal human coronaviruses (sHCoVs) were found to be highly complex, owing to the frequent recombination of CoVs, including within and between sHCoVs, and uncertain, due to the under sampling of non-human viruses. The recombination rate was highest for 229E and OC43, whereas substitutions per recombination event were highest in NL63 and HKU1. Additionally, OC43 may have ungulate, canine, or rabbit CoV ancestors, while 229E may have origins in bat, camel, or unsampled intermediate hosts, depending on the gene studied.


Increased Polymerase Activity of Zoonotic H7N9 Allows Partial Escape from MxA
by Philipp P. Petric, Jacqueline King, Laura Graf, Anne Pohlmann, Martin Beer and Martin Schwemmle
Viruses 2022, 14(11), 2331; https://doi.org/10.3390/v14112331
Available online: https://www.mdpi.com/1999-4915/14/11/2331

Message from the Editor:

The objective of this study was to determine whether the H7N9 can adapt to escape MxA-mediated restriction. From the results, it showed that viral polymerase activity-enhancing mutations can partially overcome the antiviral activity of MxA against zoonotic H7N9. However, in patients and in an experimental infection model, no true MxA escape mutations were detected, suggesting that, fortunately, MxA still seems to pose a high human species barrier for H7N9.


SIV Infection Regulates Compartmentalization of Circulating Blood Plasma miRNAs within Extracellular Vesicles (EVs) and Extracellular Condensates (ECs) and Decreases EV-Associated miRNA-128
by Steven Kopcho, Marina McDew‑White, Wasifa Naushad, Mahesh Mohan and Chioma M. Okeoma
Viruses 2023, 15(3), 622; https://doi.org/10.3390/v15030622
Available online: https://www.mdpi.com/1999-4915/15/3/622

Message from the Editor:

This study aimed to (i) investigate the abundance and compartmentalization of exmiRNAs in EVs versus ECs in the healthy uninfected state and (ii) evaluate how SIV infection may affect exmiRNA abundance and compartmentalization in these particles. The data showed that SIV infection altered the profile of the miRNAome of EVs and revealed that miR-128-3p may be a potential target of HIV/SIV. The significant decrease in miR-128-3p in HIV-infected humans and in SIV-infected RMs may indicate disease progression.

29 July 2023
Viruses | Top Cited Papers in 2021–2022 Related to SARS-CoV-2 Host Cell Interactions

“TMPRSS11D and TMPRSS13 Activate the SARS-CoV-2 Spike Protein”
by Mai Kishimoto, Kentaro Uemura, Takao Sanaki, Akihiko Sato, William W. Hall, Hiroaki Kariwa, Yasuko Orba, Hirofumi Sawa and Michihito Sasaki
Viruses 2021, 13(3), 384; https://doi.org/10.3390/v13030384
Available online: https://www.mdpi.com/1999-4915/13/3/384

“Quinine Inhibits Infection of Human Cell Lines with SARS-CoV-2”
by Maximilian Große, Natalia Ruetalo, Mirjam Layer, Dan Hu, Ramona Businger, Sascha Rheber, Christian Setz, Pia Rauch, Janina Auth, Maria Fröba et al.
Viruses 2021, 13(4), 647; https://doi.org/10.3390/v13040647
Available online: https://www.mdpi.com/1999-4915/13/4/647

“mRNA-lncRNA Co-Expression Network Analysis Reveals the Role of lncRNAs in Immune Dysfunction during Severe SARS-CoV-2 Infection”
by Sumit Mukherjee, Bodhisattwa Banerjee, David Karasik and Milana Frenkel-Morgenstern
Viruses 2021, 13(3), 402; https://doi.org/10.3390/v13030402
Available online: https://www.mdpi.com/1999-4915/13/3/402

“The Pro-Inflammatory Chemokines CXCL9, CXCL10 and CXCL11 Are Upregulated Following SARS-CoV-2 Infection in an AKT-Dependent Manner”
by Victoria Callahan, Seth Hawks, Matthew A. Crawford, Caitlin W. Lehman, Holly A. Morrison, Hannah M. Ivester, Ivan Akhrymuk, Niloufar Boghdeh, Rafaela Flor, Carla V. Finkielstein et al.
Viruses 2021, 13(6), 1062; https://doi.org/10.3390/v13061062
Available online: https://www.mdpi.com/1999-4915/13/6/1062

“Modeling within-Host SARS-CoV-2 Infection Dynamics and Potential Treatments”
by Mehrshad Sadria and Anita T. Layton
Viruses 2021, 13(6), 1141; https://doi.org/10.3390/v13061141
Available online: https://www.mdpi.com/1999-4915/13/6/1141

“Resveratrol and Pterostilbene Inhibit SARS-CoV-2 Replication in Air–Liquid Interface Cultured Human Primary Bronchial Epithelial Cells”
by Bram M. ter Ellen, Nilima Dinesh Kumar, Ellen M. Bouma, Berit Troost, Denise P. I. van de Pol, Heidi H. van der Ende-Metselaar, Leonie Apperloo, Djoke van Gosliga, Maarten van den Berge, Martijn C. Nawijn et al.
Viruses 2021, 13(7), 1335; https://doi.org/10.3390/v13071335
Available online: https://www.mdpi.com/1999-4915/13/7/1335

“SARS-CoV-2 N Protein Targets TRIM25-Mediated RIG-I Activation to Suppress Innate Immunity”
by Gianni Gori Savellini, Gabriele Anichini, Claudia Gandolfo and Maria Grazia Cusi
Viruses 2021, 13(8), 1439; https://doi.org/10.3390/v13081439
Available online: https://www.mdpi.com/1999-4915/13/8/1439

“Robust Neutralizing Antibody Levels Detected after Either SARS-CoV-2 Vaccination or One Year after Infection”
by Stefan Glöckner, Franziska Hornung, Michael Baier, Sebastian Weis, Mathias W. Pletz, Stefanie Deinhardt-Emmer, Bettina Löffler and the CoNAN Study Group
Viruses 2021, 13(10), 2003; https://doi.org/10.3390/v13102003
Available online: https://www.mdpi.com/1999-4915/13/10/2003

“Macrophages and Monocytes: “Trojan Horses” in COVID-19”
by Elena Percivalle, Josè Camilla Sammartino, Irene Cassaniti, Eloisa Arbustini, Mario Urtis, Alexandra Smirnova, Monica Concardi, Cristina Belgiovine, Alessandro Ferrari, Daniele Lilleri et al.
Viruses 2021, 13(11), 2178; https://doi.org/10.3390/v13112178
Available online: https://www.mdpi.com/1999-4915/13/11/2178

“SARS-CoV-2 Infects Human ACE2-Negative Endothelial Cells through an αvβ3 Integrin-Mediated Endocytosis Even in the Presence of Vaccine-Elicited Neutralizing Antibodies”
by Antonella Bugatti, Federica Filippini, Marta Bardelli, Alberto Zani, Paola Chiodelli, Serena Messali, Arnaldo Caruso and Francesca Caccuri
Viruses 2022, 14(4), 705; https://doi.org/10.3390/v14040705
Available online: https://www.mdpi.com/1999-4915/14/4/705

27 July 2023
MDPI Insights: The CEO's Letter #2 - Open Peer-Review and IJERPH

Welcome to the MDPI Insights: The CEO's Letter.

In these monthly letters, I will showcase two key aspects of our work at MDPI: our commitment to empowering researchers and our determination to facilitating open scientific exchange.


Opening Thoughts

Open Peer Review Reports

Continuing the topic of openness from my inaugural monthly CEO letter, in these Opening Thoughts, I highlight the growth and importance of open peer-review reports at MDPI. Open peer reports align with the principles of open science, making the publishing process more transparent and facilitating rigorous peer review.

MDPI journals operate an open peer-review option by default, allowing authors to publish review reports and author responses (often referred to as open reports) together with the published paper. Publishing the reviewer reports and author responses together with the article provides greater transparency and trust for readers, as this allows them to track the editorial decision-making process. Open peer-review also encourages reviewers and editors to provide high-quality comments, as these will be made public if the article is accepted for publication.

Start and Growth of Open Peer Review at MDPI

The MDPI journal Life was a pioneer in offering this opportunity to its authors in 2014. The first MDPI article with peer-review reports openly published was a review by the Nobel Laureate Werner Arber, in which the review reports were published as supplementary material. By 2018, open peer-review was available across all MDPI journals. As such, MDPI authors have embraced the open peer-review model, providing a steady increase in the number of MDPI articles. As of 2023, approximately one-third (34.0%) of MDPI articles were published with open review reports.

As at July 2023, the percentage of MDPI articles published with open peer review has increased to 36.2% of the total papers published in 2023 so far, indicating ongoing growth in adoption.

Open peer review continues to play a critical role in the assessment of the peer-review process in Life. For further insights, please see the recent editorial by Dr. Pabulo Henrique Rampelotto, the former Editor-in-Chief of Life, who spearheaded the implementation of the open peer-review process.

Benefits of Open Peer Review

The benefits of open peer review include increased transparency, trust and constructive feedback. To promote open communication further and increase the robustness of the peer-review process, we encourage reviewers to sign their reports so that their name appears on the review report (this process is referred to as open identity). The default option is for reviewers to remain anonymous; however, by signing the reports, reviewers receive direct credit for their contribution to the peer-review process and show their commitment towards open science.

As the leading open access publisher, MDPI remains committed to promoting open peer-review and encourages authors to choose this approach. Our goal is to provide a rigorous and transparent peer-review process that benefits the scientific community, and we believe that open peer-review is a vital step in fostering openness and collaboration in scientific communication.

Impactful Research

MDPI Papers Cited in the News – IJERPH edition

Every month, our corporate marketing team compiles data from Altmetrics to create a list of MDPI papers that have been cited in the news. This list continues to grow as renowned news outlets regularly reference research published by MDPI in their articles.

During 2022, a total of 111,965 MDPI research papers were mentioned in prominent news outlets such as National Geographic, The Washington Post, Forbes, The Guardian, the BBC, CNN, Time, and Harvard Business Review.

Highly Cited Journal Publications

IJERPH, known for publishing impactful research, received the most news mentions among all MDPI journals in 2022, based on Altmetrics data:

  • International Journal of Environmental Research and Public Health: 3509 mentions
  • Nutrients: 2698 mentions
  • International Journal of Molecular Sciences: 1701 mentions
  • Journal of Clinical Medicine: 1131 mentions
  • Viruses: 1111 mentions

These numbers show the recognition and impact of the articles published in IJERPH. For a more detailed view of the journal’s most cited and viewed papers, you can visit here. In total, IJERPH has garnered over 28,000 mentions in prominent news outlets, and as at July 2023, an impressive count of over 17,000 papers cited 10 times or more. These figures highlight the impactful contribution of IJERPH publications to the scientific community.

Example of Recent Mentions

During May and June 2023, a noteworthy selection of articles from IJERPH was cited in news articles, including:

The Washington Post: “Bringing nature inside can improve your health. Here’s how to do it.”
IJERPH paper:Physiological Benefits of Viewing Nature: A Systematic Review of Indoor Experiments

Harvard Business Review: “How to Take Better Breaks at Work, According to Research
IJERPH paper:Canine-Assisted Therapy Improves Well-Being in Nurses

National Geographic: “Lyme disease is spreading fast—but a vaccine may be on the way
IJERPH paper:Range Expansion of Tick Disease Vectors in North America: Implications for Spread of Tick-Borne Disease

Inside MDPI

MDPI Develops an Artificial Intelligence Tool to Enhance the Peer-Review Process

At MDPI, we believe that rigorous peer-review is the corner-stone of high-quality academic publishing. We are grateful to the scholars who generously dedicate their time to peer-review articles submitted to MDPI journals. Their contributions are invaluable to the advancement of science.

Peer-review is a critical part of the publication process, ensuring that MDPI upholds the highest quality standards for the papers we publish. Every manuscript submitted to our journals undergoes a comprehensive peer-review process conducted by subject-matter experts.

To further enhance our peer-review process, our Data Analytics team has developed an Artificial Intelligence (AI) tool designed to support the selection of reviewers. This proprietary tool utilizes Natural Language Processing (NLP), a specially designed AI language model, to extract information from the title and abstract of submitted papers. It then searches our database for similar manuscripts and suggests potential reviewers based on this analysis. Integrated with MDPI's submission system (SuSy), the AI tool cross-references the suggested candidates with our reviewer database to verify their invitation status and availability.

The goal of this tool is to provide better targeted peer-review invitations, reducing the number of emails sent for each paper and increasing the efficiency of our editorial staff.

In the near future, our Data Analytics team plans to deploy similar AI projects to improve other critical aspects of our services, offering an enhanced experience to our authors and readers.

Click here to learn about MDPI’s review process, including procedures, responsibilities, and benefits.

Read more:

Coming Together for Science

The Future of IJERPH

On 5 July 2023, Prof. Dr. Paul B. Tchounwou, the founding Editor-in-Chief of IJERPH, along with five Section Editors in Chief (Prof. Dr. Germán Vicente-Rodríguez, Prof. Dr. Karl Goodkin, Prof. Dr. William A. Toscano, Prof. Dr. Jimmy T. Efird, and Prof. Dr. William Douglas Evans), gathered in Basel to discuss the future of the journal. The meeting provided an opportunity to address the recent decision by The Web of Science to delist IJERPH due to the journal failing the Content Relevance criterion, and propose best strategies that will ensure high scientific rigor as well as a clear scope and aim of IJERPH, going forward.

While the delisting is disappointing for IJERPH, as well as for our authors, academic editors, and the entire scientific community supporting our journal, we see it as an opportunity to reflect and prepare for the future direction of the journal.

Since its launch in 2004, IJERPH’s vision and mission have evolved to be more complete and comprehensive in engaging scientific communities. In light of this, we will refresh the journal’s aims and scope, ensuring they align with the organic expansion of IJERPH. Additionally, we will restructure the journal sections into broader categories, encouraging collaborative research and transdisciplinary approaches for authors. This is designed to foster collaboration and knowledge exchange among diverse fields, contributing to a holistic understanding of health promotion and disease prevention. We are confident that these next steps will enhance the scientific strength and societal impact of our journal.

Journal Achievements

In addition to the productive discussions, we took the time to celebrate some of the remarkable achievements of IJERPH, which I highlight below:

  • Founded by Prof. Dr. Paul B. Tchounwou in 2004
  • Indexed in PubMed in 2008
  • Received its first Impact Factor in 2012
  • Published its 5000th paper in 2017
  • Over 60,000 papers published as at June 30, 2023
  • 131,628,173 paper views in 2018–2022
  • Over 28,000 mentions in prominent news outlets
  • 17,000 papers cited 10 times or more as at June 30, 2023
  • No.1 journal in the 2022 Google Scholar Metrics in the category of Public Health
  • Awarded several editions of Young Investigator Awards, Travel Awards, and Outstanding Reviewer Awards since 2018.

These achievements showcase the journal’s significant contributions to the field and its impact on global health. We are proud of the exceptional work accomplished by the IJERPH team and look forward to building upon this success in the years to come.

Closing Thoughts

MDPI’s Impact in Spain

During the past month, I had the opportunity to visit our new office building in Barcelona, where I met with our local colleagues to discuss the ways we serve the scholarly community, particularly in Spain. The multi-functional office plays a vital role in supporting various business needs, including editorial, design, conference management, data analytics, journal relationship management, publishing partnerships, and collaborations with societies.

Spain holds a significant position in MDPI’s global market, ranking as the fourth-largest contributor to the total number of papers published by MDPI as at July 2023, ranking next to Italy, the USA, and China, with Germany completing the top five.

The Numbers

Out of the 1,680,000 total MDPI articles published as at 25 July, almost 80,000 articles are contributed by Spanish authors, representing nearly 40,000 unique authors affiliated with Spanish institutions. Remarkably, over 6,300 of these authors hold editorial board member (EBM) positions within MDPI journals, with 30 of them serving as Editors-in-Chief (EiCs).

Our commitment to working with institutions is very evident in Spain, where we have successfully established over 40 Institutional Open Access Programs (IOAP) with esteemed institutions such as the University of Barcelona, the Autonomous University of Barcelona, Pompeu Fabra University, the University of Navarre, and Complutense University of Madrid.

Over the past five years, we have successfully organized eight in-person conferences in Barcelona, attracting over 1,150 registrations, with two forthcoming events scheduled for 2024. Barcelona's excellent connectivity to international airports makes it easily accessible to participants from around the world. Its welcoming atmosphere provides us with the perfect environment for knowledge-sharing, networking, and contributing to the local economy.

Our growth and presence in Spain are a true testament to the incredible service we provide to the scholarly community and the relationships we foster through responsive and collaborative communication. We look forward to continuing to support Spanish scholars, providing them a valuable and trusted experience with MDPI, the leader in open access publishing.

Testimonials

I close this letter as I did in the first edition, by sharing testimonials from our stakeholders. Here are a few IJERPH testimonials from a Spanish guest editor and an author:

Guest Editor
“I want to thank the kindness, attention and professionalism of the MDPI team throughout the editorial process of the Special Issue. I believe that it is a very professional and quality editorial process.”
- Professor Víctor Arufe-Giráldez, University of A Coruña
Special Issue in International Journal of Environmental Research and Public Health: Physical Activity in Childhood and Adolescence
Special Issue in International Journal of Environmental Research and Public Health: Physical Education: Present and Future
__
Author
“I want to thank the rigor of the revisions made to the manuscripts to improve their quality, the support to the authors for the editor assignment system they have and the follow-up they carry out, for the speed in answering and in carrying out the entire process of the revision, and for doing all this at an affordable price.”
- Dr. María Paz García-Caro, University of Granada
Article in International Journal of Environmental Research and Public Health: Factors Associated with Suicide Attempts and Suicides in the General Population of Andalusia (Spain)

Stefan Tochev
Chief Executive Officer
MDPI AG

19 July 2023
Meet Us at the 12th International Congress of Plant Pathology, 20–25 August 2023, Lyon, France


MDPI will attend the 12th International Congress of Plant Pathology. This event will be held from 20 to 25 August 2023 in Lyon, France, and is hosted by the International Society for Plant Pathology.

Plant pathologists and plant health researchers from around the world will meet to discuss their latest research as well as the current and future issues facing plant health experts. The host, the French Phytopathological Society, has set an exciting and challenging theme for the congress: “One Health for all plants, crops and trees”. This topic promises to provide a broad platform for talks, posters, and discussions that consider the integral nature of plant health with human, animal, and environmental health. In addition to an excellent program of keynote talks, concurrent sessions, poster presentations, and networking opportunities, there will be a number of satellite events before the meeting dates to provide opportunities for deeper discussions on a number of topics.

The following MDPI journals will be represented:

If you plan on attending this conference, please feel free to stop by our booth and start a conversation with us. Our delegates look forward to meeting you in person and answering any questions that you may have. For more information about the conference, please visit https://www.icpp2023.org/.

18 July 2023
Viruses | Top Cited Papers in 2021 Related to Phage Therapy


“Phage Therapy Related Microbial Succession Associated with Successful Clinical Outcome for a Recurrent Urinary Tract Infection”
by Austen Terwilliger, Justin Clark, Maile Karris, Haroldo Hernandez-Santos, Sabrina Green, Saima Aslam and Anthony Maresso
Viruses 2021, 13(10), 2049; https://doi.org/10.3390/v13102049
Available online: https://www.mdpi.com/1999-4915/13/10/2049

“Bacteriophage Rescue Therapy of a Vancomycin-Resistant Enterococcus faecium Infection in a One-Year-Old Child following a Third Liver Transplantation”
by Kevin Paul, Maya Merabishvili, Ronen Hazan, Martin Christner, Uta Herden, Daniel Gelman, Leron Khalifa, Ortal Yerushalmy, Shunit Coppenhagen-Glazer, Theresa Harbauer et al.
Viruses 2021, 13(9), 1785; https://doi.org/10.3390/v13091785
Available online: https://www.mdpi.com/1999-4915/13/9/1785

“The Safety and Toxicity of Phage Therapy: A Review of Animal and Clinical Studies”
by Dan Liu, Jonas D. Van Belleghem, Christiaan R. de Vries, Elizabeth Burgener, Qingquan Chen, Robert Manasherob, Jenny R. Aronson, Derek F. Amanatullah, Pranita D. Tamma and Gina A. Suh
Viruses 2021, 13(7), 1268; https://doi.org/10.3390/v13071268
Available online: https://www.mdpi.com/1999-4915/13/7/1268

“A Case of Phage Therapy against Pandrug-Resistant Achromobacter xylosoxidans in a 12-Year-Old Lung-Transplanted Cystic Fibrosis Patient”
by David Lebeaux, Maia Merabishvili, Eric Caudron, Damien Lannoy, Leen Van Simaey, Hans Duyvejonck, Romain Guillemain, Caroline Thumerelle, Isabelle Podglajen, Fabrice Compain et al.
Viruses 2021, 13(1), 60; https://doi.org/10.3390/v13010060
Available online: https://www.mdpi.com/1999-4915/13/1/60

“A Design of Experiment Approach to Optimize Spray-Dried Powders Containing Pseudomonas aeruginosaPodoviridae and Myoviridae Bacteriophages”
by Emilie Tabare, Tea Glonti, Christel Cochez, Cyrille Ngassam, Jean-Paul Pirnay, Karim Amighi and Jonathan Goole
Viruses 2021, 13(10), 1926; https://doi.org/10.3390/v13101926
Available online: https://www.mdpi.com/1999-4915/13/10/1926

“Characterization of Anti-Bacterial Effect of the Two New Phages against Uropathogenic Escherichia coli
by Lívia Slobodníková, Barbora Markusková, Michal Kajsík, Michal Andrezál, Marek Straka, Adriána Liptáková and Hana Drahovská
Viruses 2021, 13(7), 1348; https://doi.org/10.3390/v13071348
Available online: https://www.mdpi.com/1999-4915/13/7/1348

“Past and Future of Phage Therapy and Phage-Derived Proteins in Patients with Bone and Joint Infection”
by Tristan Ferry, Camille Kolenda, Thomas Briot, Aubin Souche, Sébastien Lustig, Jérôme Josse, Cécile Batailler, Fabrice Pirot, Mathieu Medina, Gilles Leboucher et al.
Viruses 2021, 13(12), 2414; https://doi.org/10.3390/v13122414
Available online: https://www.mdpi.com/1999-4915/13/12/2414

“Phage Therapy Experience at the Eliava Phage Therapy Center: Three Cases of Bacterial Persistence”
by Elisabed Zaldastanishvili, Lika Leshkasheli, Mariam Dadiani, Lia Nadareishvili, Lia Askilashvili, Nino Kvatadze, Marina Goderdzishvili, Mzia Kutateladze and Nana Balarjishvili
Viruses 2021, 13(10), 1901; https://doi.org/10.3390/v13101901
Available online: https://www.mdpi.com/1999-4915/13/10/1901

“A Case of In Situ Phage Therapy against Staphylococcus aureus in a Bone Allograft Polymicrobial Biofilm Infection: Outcomes and Phage-Antibiotic Interactions”
by Brieuc Van Nieuwenhuyse, Christine Galant, Bénédicte Brichard, Pierre-Louis Docquier, Sarah Djebara, Jean-Paul Pirnay, Dimitri Van der Linden, Maya Merabishvili and Olga Chatzis
Viruses 2021, 13(10), 1898; https://doi.org/10.3390/v13101898
Available online: https://www.mdpi.com/1999-4915/13/10/1898

“Bacteriophage Therapy for Difficult-to-Treat Infections: The Implementation of a Multidisciplinary Phage Task Force (The PHAGEFORCE Study Protocol)”
by Jolien Onsea, Saartje Uyttebroek, Baixing Chen, Jeroen Wagemans, Cédric Lood, Laura Van Gerven, Isabel Spriet, David Devolder, Yves Debaveye, Melissa Depypere et al.
Viruses 2021, 13(8), 1543; https://doi.org/10.3390/v13081543
Available online: https://www.mdpi.com/1999-4915/13/8/1543

18 July 2023
Meet Us at the MDPI World Hepatitis Day Webinar 2023, 28 July 2023

The low coverage of testing and treatment is the most important gap to be addressed to achieve the global elimination goals of hepatitis B virus (HBV) by 2030. 

To commemorate the World Hepatitis Day 2023, MDPI is launching a special webinar to encourage researchers to come together, take action, and highlight how the exchange of findings facilitates efforts to raise awareness of hepatitis.

We are looking forward to seeing you at the MDPI World Hepatitis Day Webinar 2023. 

Conference secretariat: Ms. Shun Li
Date and time: 28 July 2023, 7:00 a.m. and 3:00 p.m., CEST

This is a free webinar. After registering, you will receive a confirmation email containing information on how to join the webinar. Registrations with academic institutional email addresses will be prioritized. 

Unable to attend? Register anyway and we will let you know when the recording is available to watch. 

Session 1:

Speaker/Presentation Time in CEST
Introduction 7:00 a.m.–7:10 a.m.
Prof. Dr. Chia-Yen Dai
Achieving Elimination of Hepatitis C in Taiwan
7:10 a.m.–7:40 a.m.
Dr. Tan Yee Joo
Understanding the Functions of Hepatitis B Viral Proteins and Targeting Them in Antiviral Drug Development
7:40 a.m.–8:10 a.m.
Dr. Sheikh Mohammad Fazle Akbar
Standing at the Half-Way: An Analysis of “Elimination of Hepatitis by 2030” in Developed and Developing Countries
8:10 a.m.–8:40 a.m.
Q&A Session 8:40 a.m.–9:00 a.m.

Register for Session 1 for free!

Session 2:

Speaker/Presentation Time in CEST
Introduction 3:00 p.m.–3:10 p.m.
Prof. Dr. John Tavis
The International Coalition to Eliminate HBV (ICE-HBV): Promoting Global Scientific Collaboration in HBV Cure Research
3.10 p.m.–3:40 p.m.
Prof. Dr. Mark A. Feitelson
Microbial Metabolites that Attenuate the Pathogenesis of Cancer and Autoimmunity
3:40 p.m.–4:10 p.m.
Prof. Dr. Natalia Osna
Hepatitis in HIV Infection
4:10 p.m.–4:40 p.m.
Q&A Session 4:40 p.m.–5:00 p.m.

Register for Session 2 for free! 

Relevant Special Issues:
Pathogens
"Research on Hepatitis B Virus: Past, Present, and Future"
Edited by: Hyung Joon Yim
Submission deadline: 31 August 2023 

JPM
"Novel Challenges and Therapeutic Options for Liver Diseases"
Edited by: Guido Gerken
Submission deadline: 30 September 2023 

Medicina
"Viral Hepatitis Research: Updates and Challenges"
Edited by: Endrit Shahini, Antonio Giovanni Solimando and Antonella Argentiero
Submission deadline: 15 October 2023 

Cells
"Non-alcoholic Steatohepatitis (NASH) and Liver Fibrosis: Molecular and Multicellular Control of Evolving Diseased States"
Edited by: Jérôme Eeckhoute
Submission deadline: 15 February 2024 

Diagnostics
"Diagnosis and Management of Liver Diseases—2nd Edition"
Edited by: Jeong-Ju Yoo
Submission deadline: 30 September 2023 

Vaccines
"Vaccination and Treatments against Viral Hepatitis: Achievements, Challenges and Perspectives"
Edited by: Bárbara Vieira Do Lago and Vinicius M. Mello
Submission deadline: 15 October 2023

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