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Host Non-Coding RNA Regulates Influenza A Virus Replication

1
Gansu Tech Innovation Center of Animal Cell, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China
2
Life Science and Engineering College, Northwest Minzu University, Lanzhou 730030, China
3
Key Laboratory of Biotechnology & Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China
*
Author to whom correspondence should be addressed.
Academic Editor: Craig McCormick
Viruses 2022, 14(1), 51; https://doi.org/10.3390/v14010051
Received: 3 December 2021 / Revised: 21 December 2021 / Accepted: 21 December 2021 / Published: 29 December 2021
(This article belongs to the Section Human Virology and Viral Diseases)
Outbreaks of influenza, caused by the influenza A virus (IAV), occur almost every year in various regions worldwide, seriously endangering human health. Studies have shown that host non-coding RNA is an important regulator of host–virus interactions in the process of IAV infection. In this paper, we comprehensively analyzed the research progress on host non-coding RNAs with regard to the regulation of IAV replication. According to the regulation mode of host non-coding RNAs, the signal pathways involved, and the specific target genes, we found that a large number of host non-coding RNAs directly targeted the PB1 and PB2 proteins of IAV. Nonstructural protein 1 and other key genes regulate the replication of IAV and indirectly participate in the regulation of the retinoic acid-induced gene I-like receptor signaling pathway, toll-like receptor signaling pathway, Janus kinase signal transducer and activator of transcription signaling pathway, and other major intracellular viral response signaling pathways to regulate the replication of IAV. Based on the above findings, we mapped the regulatory network of host non-coding RNAs in the innate immune response to the influenza virus. These findings will provide a more comprehensive understanding of the function and mechanism of host non-coding RNAs in the cellular anti-virus response as well as clues to the mechanism of cell–virus interactions and the discovery of antiviral drug targets. View Full-Text
Keywords: IAV; miRNA; lncRNA; circRNA; interferon; antiviral innate immune response IAV; miRNA; lncRNA; circRNA; interferon; antiviral innate immune response
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MDPI and ACS Style

Liao, Y.; Guo, S.; Liu, G.; Qiu, Z.; Wang, J.; Yang, D.; Tian, X.; Qiao, Z.; Ma, Z.; Liu, Z. Host Non-Coding RNA Regulates Influenza A Virus Replication. Viruses 2022, 14, 51. https://doi.org/10.3390/v14010051

AMA Style

Liao Y, Guo S, Liu G, Qiu Z, Wang J, Yang D, Tian X, Qiao Z, Ma Z, Liu Z. Host Non-Coding RNA Regulates Influenza A Virus Replication. Viruses. 2022; 14(1):51. https://doi.org/10.3390/v14010051

Chicago/Turabian Style

Liao, Yuejiao, Shouqing Guo, Geng Liu, Zhenyu Qiu, Jiamin Wang, Di Yang, Xiaojing Tian, Ziling Qiao, Zhongren Ma, and Zhenbin Liu. 2022. "Host Non-Coding RNA Regulates Influenza A Virus Replication" Viruses 14, no. 1: 51. https://doi.org/10.3390/v14010051

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