Special Issue "Natural Pharmacons: Biologically Active Plant Based Pharmaceuticals"

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Natural Products".

Deadline for manuscript submissions: 10 February 2021.

Special Issue Editors

Dr. Dejan Stojković

Guest Editor
Mycological laboratory, Department of Plant Physiology, Institute for Biological Research "Siniša Stanković"—National Institute of Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11000 Belgrade, Serbia
Special Issues and Collections in MDPI journals
Dr. Marina Sokovic
Guest Editor
Institute for Biological Research “Siniša Stanković”, University of Belgrade, Belgrade, Serbia
Interests: Microfungi, macrofungi, antimcirobial activity, natural products
Special Issues and Collections in MDPI journals

Special Issue Information

Medicinal plants present a valuable source of chemicals with potential therapeutic properties. They are widely used in traditional medicine as supportive therapeutics for various conditions and diseases. In recent years, there have been extensive studies in the area of medicinal plant research dealing with their various pharmacological effects. Novel research on this subject is necessary, since this is a hot topic field. Many in vitro studies describe the beneficial effects of plants for human health, highlighting promising pharmacological effects.

This thematic issue will cover the biological activity of medicinal plants and isolated compounds. Screening natural preparations for their biological activities is of prime importance, since natural raw material presents an excellent source of pharmaceuticals with a wide variety of different biologically active chemical structures.

The scope of the thematic issue will cover but is not limited to:

  • Chemical characterization of natural preparations;
  • Therapeutic potential of natural matrices in cardiovascular diseases, diabetes, cancer, and neurodegenerative diseases;
  • Antimicrobial activity;
  • Antioxidant activity;
  • Anti-enzymatic activity;
  • Anti-inflammatory activity;
  • Mechanism of pharmacological actions;
  • Structure–activity studies.

Dr. Dejan Stojković
Dr. Marina Sokovic
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Open AccessArticle
Additive Effect of a Combination of Artocarpus lakoocha and Glycyrrhiza glabra Extracts on Tyrosinase Inhibition in Melanoma B16 Cells
Pharmaceuticals 2020, 13(10), 310; https://doi.org/10.3390/ph13100310 - 14 Oct 2020
Artocarpus lakoocha (Al) and Glycyrrhiza glabra (Gg) extracts have been reported to show tyrosinase inhibitory activity and melanin pigment reduction. This is the first study to assess the combination of Al and Gg extracts in enhancing inhibition of tyrosinase and reduction of melanin [...] Read more.
Artocarpus lakoocha (Al) and Glycyrrhiza glabra (Gg) extracts have been reported to show tyrosinase inhibitory activity and melanin pigment reduction. This is the first study to assess the combination of Al and Gg extracts in enhancing inhibition of tyrosinase and reduction of melanin pigments. Al and Gg extracted by maceration in 70% and 95% ethanol were analyzed for oxyresveratrol and glabridin using Ultra High Performance Liquid Chromatography. Extracts of Al and Gg singly and combinations of Al95 and Gg95 were tested for cytotoxicity, tyrosinase inhibitory activity, and reduction of melanin pigments in melanoma B16 cells. Al95 had higher antioxidant, tyrosinase inhibitory activity and reduced more melanin pigments in B16 cells compared to Al70, and exhibited higher levels of oxyresveratrol. Gg95 inhibited oxidative stress and mushroom tyrosinase better than Gg70, and exhibited higher levels of glabridin. Combinations of Al95 and Gg95 at various ratios (concentration of 0.1 mg/mL) were not cytotoxic to B16 cells. Interestingly, Al95 and Gg95 combined at a ratio 9:1 reduced melanin pigment up to 53% in B16 cells. This combination of Al95 and Gg95 extracts exhibited the additive effect of reducing melanin pigments by suppressing the expression of microphthalmia-associated transcription factor (MITF), tyrosinase (TYR) and tyrosinase-related protein-2 (TRP-2) in B16 cells. The combination of Al and Gg extracts could be developed as skin care products for hyperpigmentation treatment. Full article
(This article belongs to the Special Issue Natural Pharmacons: Biologically Active Plant Based Pharmaceuticals)
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