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Pharmaceuticals
Volume 15
Issue 4
10.3390/ph15040387
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Article

Daphne jejudoensis Attenuates LPS-Induced Inflammation by Inhibiting TNF-α, IL-1β, IL-6, iNOS, and COX-2 Expression in Periodontal Ligament Cells

by
Ji-Yeong Bae
1,2,
Dong-Seol Lee
3,
You Kyoung Cho
3,
Ji-Yeon Lee
2,
Joo-Hwang Park
3 and
Sang Ho Lee
1,*
1
College of Pharmacy and Jeju Research Institute of Pharmaceutical Sciences, Jeju National University, Jeju 38655, Korea
2
Interdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University, Jeju 63243, Korea
3
R&D Center, Regenerative Dental Medicine Institute, HysensBio Co., Ltd., Gwacheon 13814, Korea
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2022, 15(4), 387; https://doi.org/10.3390/ph15040387
Submission received: 27 February 2022 / Revised: 19 March 2022 / Accepted: 19 March 2022 / Published: 22 March 2022
(This article belongs to the Special Issue Natural Pharmacons: Biologically Active Plant Based Pharmaceuticals)
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Abstract

Periodontitis is a common disease involving inflammation and tissue destruction in the periodontal region. Although uncontrolled long-term inflammation in the gingiva may lead to loss of the periodontal ligament, treatments or preventive solutions for periodontitis are scarce. The aim of this study is to find anti-inflammatory material from a natural source that can be used to treat or protect against periodontitis. Daphne species (Thymelaeaceae) are important and popular components of traditional Chinese medicine and are used as anti-inflammatory agents. Daphne jejudoensis is an endemic plant that grows on Jeju Island and was identified as a new species in 2013. In this study, for the first time, we investigated the anti-inflammatory effect of D. jejudoensis leaf extract (DJLE) on human periodontal ligament cells. The gene expression levels of pro-inflammatory cytokines (interleukin-1β and 6 and tumor necrosis factor-α) and inflammation-inducible enzymes (inducible nitric oxide synthase and cyclooxygenase-2) were reduced after DJLE treatment with/without lipopolysaccharide stimulation. The findings of this study indicate that D. jejudoensis possesses anti-inflammatory activities, suggesting that DJLE may be a potential preventive and therapeutic agent for periodontitis.
Keywords: Daphne jejudoensis; anti-inflammatory activity; Thymelaeaceae; periodontitis; lipopolysaccharide Daphne jejudoensis; anti-inflammatory activity; Thymelaeaceae; periodontitis; lipopolysaccharide
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MDPI and ACS Style

Bae, J.-Y.; Lee, D.-S.; Cho, Y.K.; Lee, J.-Y.; Park, J.-H.; Lee, S.H. Daphne jejudoensis Attenuates LPS-Induced Inflammation by Inhibiting TNF-α, IL-1β, IL-6, iNOS, and COX-2 Expression in Periodontal Ligament Cells. Pharmaceuticals 2022, 15, 387. https://doi.org/10.3390/ph15040387

AMA Style

Bae J-Y, Lee D-S, Cho YK, Lee J-Y, Park J-H, Lee SH. Daphne jejudoensis Attenuates LPS-Induced Inflammation by Inhibiting TNF-α, IL-1β, IL-6, iNOS, and COX-2 Expression in Periodontal Ligament Cells. Pharmaceuticals. 2022; 15(4):387. https://doi.org/10.3390/ph15040387

Chicago/Turabian Style

Bae, Ji-Yeong, Dong-Seol Lee, You Kyoung Cho, Ji-Yeon Lee, Joo-Hwang Park, and Sang Ho Lee. 2022. "Daphne jejudoensis Attenuates LPS-Induced Inflammation by Inhibiting TNF-α, IL-1β, IL-6, iNOS, and COX-2 Expression in Periodontal Ligament Cells" Pharmaceuticals 15, no. 4: 387. https://doi.org/10.3390/ph15040387

APA Style

Bae, J.-Y., Lee, D.-S., Cho, Y. K., Lee, J.-Y., Park, J.-H., & Lee, S. H. (2022). Daphne jejudoensis Attenuates LPS-Induced Inflammation by Inhibiting TNF-α, IL-1β, IL-6, iNOS, and COX-2 Expression in Periodontal Ligament Cells. Pharmaceuticals, 15(4), 387. https://doi.org/10.3390/ph15040387

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