Natural Products and Phytomedicines: From Chemical Profiling and Pharmacological Properties to Therapeutic Applications

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Natural Products".

Deadline for manuscript submissions: 25 April 2026 | Viewed by 121

Special Issue Editors


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Guest Editor
ICBAS, School of Medicine and Biomedical Sciences, University of Porto, 4050-313 Porto, Portugal
Interests: biomedical sciences; global and integrative health; complementary therapy development; extracellular superconductor transmission; supplementary nutrition and natural diet; physical and respiratory movements; clinical trials; medicine advances on artificial and biological intelligence integration; biomineralization of biosynthetic membranes; calcification physiology mechanisms in mollusks
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
1. Insight: Piaget Research Center for Ecological Human Development, Instituto Piaget—ISEIT, Estrada do Alto Gaio, 3515-776 Lordosa Viseu, Portugal
2. Instituto Universitario de Investigación en Olivar y Aceites de Oliva, Universidad de Jaén, GEOLIT Parque Científico y Tecnológico, 23620 Mengíbar, Spain
Interests: olive tree; olive fruit; oleic technology; physicochemical and sensory characteristics of olive oils

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Guest Editor
H-TOXRUN—One Health Toxicology Research Unit, University Institute of Health Sciences-CESPU, 4585-116 Gandra, Portugal
Interests: global and integrative health; complementary therapy development; supplementary nutrition and natural diet; clinical trials; human genetics; platelet activation; thrombosis and hemostasis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Phytomedicine and natural product chemistry are subjects that are quickly evolving thanks to constant advancements in molecular composition and their translation into therapeutic innovative value. These represent a conscious shift in pharmaceuticals and clinical care from curative interventions to preventive strategies. 

With the elderly population growing globally, the World Health Organization is prioritizing healthy ageing and investing in health systems, taking a step-by-step detour from the longstanding use of single chemosynthetic drugs toward a more modern construct of a multitarget therapy bearing upon the research of natural resources. The systematization of novel strategies requires standardization of phytopreparates, employing high-tech methodology to screen, identify, isolate, and characterize extracts and their components, as well as controlled testing for pharmacokinetics and therapeutic efficacy. Recent scientific findings justify the revitalized pursuit of natural products as drug component parts, particularly addressing immunomodulation and antimicrobial resistance, and cardiovascular, metabolic, neuroinflammatory, carcinogenic, and other multi-etiological conditions such as depression. Still, nature's biodiversity illustrates challenges that might open up windows of opportunity for creating sustainable added-value products. 

With this Special Issue, entitled “Natural Products and Phytomedicines: From Chemical Profiling and Pharmacological Properties to Therapeutic Applications”, we aim to publish rigorously peer-reviewed original research and recent review articles regarding natural products' compositional, biochemical, pharmacological, and therapeutic properties. Furthermore, works focusing on improved/new sustainable extraction, analytical screening, and molecular purification strategies are welcome to be submitted. Besides in vitro and in vivo studies, clinical trials focused on bioavailability, toxicity, secondary interaction, and synergetic properties are welcomed. Furthermore, manuscripts focused on the differential efficacy between preparations from leaf powder, decoction, infusions, or pills are also invited. Finally, the purpose of this Special Issue is to deliver the most recent scientific breakthroughs and technological developments disclosing the pivotal status held by evidence-based phytopharma and natural derivates.

 P.S. The Editors of this Special Issue extend their sincere gratitude to Dr. Natália M. De Oliveira for her invaluable contributions. Her assistance in meticulous management and dedicated efforts in promoting this Special Issue have significantly enhanced its visibility and impact within the field. 

Dr. Jorge P. Machado
Dr. Maria Helena Chéu
Dr. Maria Begoña Criado
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products and derivatives
  • (nano)phytomedicine
  • plant extracts and phytopreparates
  • biochemical profiling
  • active principles
  • phytopharmacological mechanisms
  • signaling pathways
  • network pharmacology
  • molecular docking
  • pharmacokinetics and toxicity assays
  • clinical studies
  • therapeutic novelty
  • sustainable development

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Published Papers

This special issue is now open for submission.
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