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Pharmaceuticals, Volume 19, Issue 4

2026 April - 4 articles

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Articles (4)

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Article

17 Pages

A Lecithin-Based Delivery Form of Quercetin Promotes Stress Resistance and Longevity in Caenorhabditis elegans

Margherita Romeo,
Maria Monica Barzago,
Claudia Fracasso,
Manuel Nettis,
Antonella Riva,
Marco Gobbi,
Serena Tongiani and
Luisa Diomede

Pharmaceuticals2026, 19(4), 525;https://doi.org/10.3390/ph19040525
(registering DOI)

24 March 2026

Background/Objectives: The flavonoid quercetin (Q) has recently been suggested as a natural anti-aging and senolytic agent. However, its low stability and poor oral bioavailability may limit its efficacy. To address this, we investigated whether a le...

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Article

20 Pages

NGR1 Ameliorates Hepatocyte Steatosis and Mitochondrial Dysfunction Associated with the Restoration of NDUFS2

Min Liu,
Dongsheng Liu,
Qian Zhang,
Rui Zhang,
Jiye Aa,
Guangji Wang and
Yuan Xie

Pharmaceuticals2026, 19(4), 524;https://doi.org/10.3390/ph19040524
(registering DOI)

24 March 2026

Background: Metabolic disorder-associated fatty liver disease (MASLD) is closely related to obesity and type 2 diabetes. Its pathogenesis involves many factors, including mitochondrial dysfunction, endoplasmic reticulum stress and intestinal flora di...

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Article

24 Pages

Lingguizhugan Decoction Ameliorates MASLD by Modulating the Gut Microbiota and Enriching Non-12-OH Bile Acids to Activate TGR5-Mediated Thermogenesis

Yun-Hong Sun,
Pei-Lun Ding,
Xue Wang,
Yi-Rong Wang,
Ming-Zhe Zhu,
Kai Wang,
Liang Dai,
Yan-Qi Dang,
Guang Ji and
Wen-Jun Zhou
+ 1 author

Pharmaceuticals2026, 19(4), 523;https://doi.org/10.3390/ph19040523
(registering DOI)

24 March 2026

Objective: Based on previous findings on the Lingguizhugan (LGZG)-mediated gut–liver axis, this study clarifies the therapeutic mechanisms of LGZG in metabolic dysfunction-associated steatotic liver disease (MASLD), with a focus on the gut micr...

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Article

16 Pages

Antioxidant Enzymes Genetic Variants Associated with Urticaria/Angioedema Induced by Cross-Reactive Hypersensitivity to Nonsteroidal Anti-Inflammatory Drugs

Isabel M. Jiménez-Sánchez,
Raquel Jurado-Escobar,
José Triano-Cornejo,
Rocío Sáenz de Santa María,
Rafael Núñez,
Imane Allali-Bouamara,
Victoria Raya-López,
Pedro Chacón,
José J. Laguna and
José A. Cornejo-García
+ 2 authors

Pharmaceuticals2026, 19(4), 522;https://doi.org/10.3390/ph19040522

24 March 2026

Background/Objectives: Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most consumed drugs worldwide and the main cause of drug hypersensitivity reactions (HSRs). The most common NSAID-HSR class is cross-hypersensitivity (CR), with patien...

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Pharmaceuticals - ISSN 1424-8247

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