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Pharmaceuticals
Special Issues
Pharmaceutical and Biomaterial Approaches for Preventive and Restorative Dentistry
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Pharmaceutical and Biomaterial Approaches for Preventive and Restorative Dentistry

A Special Issue of Pharmaceuticals (ISSN 1424-8247) belonging to the section "Pharmacology".

Deadline for manuscript submissions: closed (25 April 2026) | Viewed by 1625

Editors

Dr. Jan Kiryk

E-Mail Website
Guest Editor
Dental Surgery Department, Wroclaw Medical University, Krakowska 26, 50-425 Wroclaw, Poland
Interests: dental surgery; dentistry under general anesthesia; disabled people; pediatric dentistry
Dr. Maciej Dobrzyński

E-Mail Website
Guest Editor
Department of Pediatric Dentistry and Preclinical Dentistry, Wroclaw Medical University, Krakowska 26, 50-425 Wroclaw, Poland
Interests: nanomaterials; titanium alloys; composites; nanohydroxyapatite applications; scaffolds; dental CAD/CAM materials; bone regeneration; dental bioengineering; biomaterial’s surface modification; lasers in medicine; environmental dentistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The growing burden of oral disease highlights the urgent need for innovative strategies integrating pharmaceutical and biomaterial approaches to improve preventive and restorative dentistry. This Special Issue explores advances in drug delivery systems, antimicrobial agents, bioactive compounds, and novel biomaterials for oral health and tissue regeneration. Articles focus on the design of nanostructured carriers, polymers, and surface modifications that promote remineralization, reduce biofilm formation, and modulate host–microbe interactions. Particular emphasis is placed on the development of smart materials capable of responding to the dynamic oral environment, as well as translational research that bridges laboratory findings to clinical practice. By combining preventive pharmacological strategies with innovations in restorative biomaterials, this issue offers a comprehensive overview of emerging solutions aimed at preserving natural dentition, improving patient outcomes, and reducing the global impact of dental diseases. Collectively, the articles demonstrate the potential of interdisciplinary approaches to shape the future of dentistry.

Dr. Jan Kiryk
Dr. Maciej Dobrzyński
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dental prophylaxis
  • restorative dentistry
  • pharmaceuticals
  • biomaterials
  • dental innovations
  • dentistry of the future

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Published Papers (1 paper)

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Research

16 pages, 4612 KB  
Article
From Extraction to Cryobanking: Which Critical Process Parameters Genuinely Improve DPSC Production?
by Tomasz Gedrange, Benita Wiatrak, Tomasz Gębarowski, Ewa Barg, Łucja Cwynar-Zając, Katarzyna Gębczak, Helena Moreira, Aneta Cieśla-Niechwiadowicz, Jakub Hadzik, Amelie Lupp, Sophie Gedrange and Marzena Dominiak
Pharmaceuticals 2026, 19(3), 429; https://doi.org/10.3390/ph19030429 - 7 Mar 2026
Cited by 3 | Viewed by 1124
Abstract
Background: Advanced therapy medicinal products (ATMPs) require strict control of critical process parameters (CPPs) to ensure manufacturing efficiency. The relative impact of donor systemic factors, such as vitamin D status, versus technical process parameters on dental pulp-derived stem cell (DPSC) production remains [...] Read more.
Background: Advanced therapy medicinal products (ATMPs) require strict control of critical process parameters (CPPs) to ensure manufacturing efficiency. The relative impact of donor systemic factors, such as vitamin D status, versus technical process parameters on dental pulp-derived stem cell (DPSC) production remains unclear. Methods: In this prospective observational study, 250 adults undergoing extraction of impacted mandibular third molars were included. Dental pulp was processed under a standardized SOP using different preparation methods and enzyme conditions. Primary endpoints were serum 25(OH)D concentration and cell yield; secondary endpoints included number of passages and cryovials. Results: Mean 25(OH)D concentration was 30.1 ± 14.5 ng/mL and was higher in supplemented individuals (38.2 ± 14.0 vs. 25.6 ± 12.7 ng/mL; p < 0.0001) but was not associated with cell yield (ρ = 0.14, p = 0.168) or passages (ρ = 0.07, p = 0.406). In contrast, process parameters showed strong effects: scissor preparation resulted in a substantially higher yield than mechanical methods (median 5.00 vs. 1.00 million cells; p = 3.6 × 10−13), and type II collagenase was independently associated with a higher yield (+2.04 million cells; p = 0.026). The number of passages was the strongest predictor of yield (β = 2.28 million per passage; p < 10−26). Post-thaw viability remained high (mean 90.1% and range 81–98%). Conclusions: Manufacturing efficiency of DPSCs is primarily determined by critical process parameters, particularly preparation method, enzyme selection, and passage control, whereas donor vitamin D status did not significantly influence outcomes under the studied SOP. These findings highlight process standardization as the key driver of reproducible ATMP manufacturing. Full article
(This article belongs to the Special Issue Pharmaceutical and Biomaterial Approaches for Preventive and Restorative Dentistry)
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