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Molecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Recent Advances in Structural Characterization by Raman Spectroscopy
edited by
submission deadline 30 Dec 2025 | Viewed by 26 | Submission Open
Keywords: Raman; pharmaceuticals; materials research; life sciences; molecular vibrations
(This special issue belongs to the Section Analytical Chemistry)
Essential Oils and Their Multifaceted Studies: From Extraction to Applications submission deadline 30 Dec 2025 | Viewed by 20 | Submission Open
Keywords: in silico; in vivo; in vitro; agriculture; food science; medicinal; pharmacological
(This special issue belongs to the Section Food Chemistry)
X-Ray Spectroscopy of Gas-Phase Biomolecules
edited by Lucas Schwob, Sadia Bari and Marta Berholts
submission deadline 30 Dec 2025 | Viewed by 14 | Submission Open
Keywords: X-ray spectroscopy; gas-phase biomolecules; structure-function relationship; time-resolved spectroscopy; core-level ionization; electronic structure and dynamics; charge migration; theoretical modeling
(This special issue belongs to the Section Analytical Chemistry)
Covalent Organic Frameworks for Photocatalysis or Fluorescence Detection
edited by
submission deadline 30 Dec 2025 | Viewed by 7 | Submission Open
Keywords: covalent organic framework (COF); photocatalysis; water splitting; CO2 reduction; H2O2 production; fluorescence detection
(This special issue belongs to the Section Photochemistry)
Metal Complexes as Potential Antimicrobial and Antiproliferative Agents
edited by
submission deadline 31 Dec 2025 | 7 articles | Viewed by 20806 | Submission Open
Keywords: metal complexes; antimicrobial activity; antiproliferative activity; cytotoxicity; biofilm
(This special issue belongs to the Section Inorganic Chemistry)
Bioactive Phenolic and Polyphenolic Compounds, Volume III
edited by
submission deadline 31 Dec 2025 | 11 articles | Viewed by 19636 | Submission Open
Keywords: food chemistry; natural products; antioxidants; polyphenols; chromatography; spectroscopy; mass spectrometry; extraction; biological activity; sensors
(This special issue belongs to the Section Natural Products Chemistry)
Research on Heterogeneous Catalysis—2nd Edition
edited by and
submission deadline 31 Dec 2025 | 18 articles | Viewed by 16892 | Submission Open
Keywords: heterogeneous; catalysis; catalyst; surface; reaction
(This special issue belongs to the Section Applied Chemistry)
Exclusive Contributions by the Editorial Board Members (EBMs) of the Organic Chemistry Section of Molecules
edited by
submission deadline 31 Dec 2025 | 11 articles | Viewed by 10941 | Submission Open
Keywords: organic compounds; organic synthesis; organic reaction; click chemistry; organocatalysis
(This special issue belongs to the Section Organic Chemistry)
Functional Molecules as Novel Cosmetic Ingredients
edited by Jing Wang and Zhong Liu
submission deadline 31 Dec 2025 | 7 articles | Viewed by 10219 | Submission Open
Keywords: synthetic molecules; plant extracts; natural compounds; biotech-derived molecules; natural-derived molecules; fermentation-derived ingredients; biological activity; cosmetics; encapsulation and delivery technologies of ingredients; skin-care; hair-care
(This special issue belongs to the Section Natural Products Chemistry)
Applied Chemistry in Asia
edited by
submission deadline 31 Dec 2025 | 10 articles | Viewed by 10117 | Submission Open
Keywords: applied chemistry; new molecules and natural materials; solar energy and photo-electro-catalysis; analytical methods and techniques; electrochemistry and energy; biodegradable materials and medicines; environment and green chemistry
(This special issue belongs to the Section Applied Chemistry)
Featured Papers in Organometallic Chemistry—2nd Edition
edited by
submission deadline 31 Dec 2025 | 11 articles | Viewed by 9791 | Submission Open
Keywords: organometallic chemistry; complexes; metals; metal– carbon bonding; main group metals; transition metals; lanthanides; catalysis; ligands; metal chemistry; phosphines; N-heterocyclic carbenes; bipyridines; homogeneous catalysis; cross-coupling; bond activation; ancillary ligands; photoredox catalysis; asymmetric catalysis; crystallography; spectroscopy
(This special issue belongs to the Section Organometallic Chemistry)
Recent Trends of Functional Nanomaterials for Biomedical and Healthcare Applications (2nd Edition) submission deadline 31 Dec 2025 | 5 articles | Viewed by 9449 | Submission Open
Keywords: nanomaterials; implants and wearable devices; drug delivery and therapeutic efficacy; biosensors and bioelectronics; biocompatible and toxicity; bio-imaging and diagnostics; healthcare devices; theranostic platforms
(This special issue belongs to the Section Inorganic Chemistry)
Natural Antioxidants in Functional Food submission deadline 31 Dec 2025 | 4 articles | Viewed by 7794 | Submission Open
Keywords: natural antioxidants; bioactive compounds; functional foods; novel foods; exotic foods; health and nutrition claims
(This special issue belongs to the Section Food Chemistry)
Porous Organic Materials: Design and Applications: Volume II
edited by and Qi Chen
submission deadline 31 Dec 2025 | 6 articles | Viewed by 6878 | Submission Open
Keywords: topology design; synthesis; structure— function correlation; adsorption and separation; catalysis; energy storage and conversion; mass transportation; biological application
(This special issue belongs to the Section Materials Chemistry)
The 30th Anniversary of Molecules—Recent Advances in Chemical Biology submission deadline 31 Dec 2025 | 6 articles | Viewed by 5230 | Submission Open
Keywords: bioorthogonal chemistry; peptides; nucleic acids; proteins; analytical methods; chemical inhibitors; chemical probe; ubiquitination; structure-activity relationship
(This special issue belongs to the Section Chemical Biology)
Functional Nanomaterials for Energy and Environmental Sustainability
edited by Dezhi Chen, Junfei Liang and
submission deadline 31 Dec 2025 | 5 articles | Viewed by 4940 | Submission Open
Keywords: functional nanomaterials; resource recovery; secondary batteries; supercapacitors; water purification; carbon capture; VOC elimination
(This special issue belongs to the Section Applied Chemistry)
Cutting-Edge Progress in Natural Product-Derived Antimicrobial Drugs submission deadline 31 Dec 2025 | 3 articles | Viewed by 4567 | Submission Open
Keywords: natural products; structural elucidation; bio-activity guided isolation; pathogen; antimicrobial
(This special issue belongs to the Section Natural Products Chemistry)
Phytochemical Profiling, Bioactivity, Biotechnology Studies and Practical Applications of Medicinal and Cosmetic Plants submission deadline 31 Dec 2025 | 5 articles | Viewed by 4321 | Submission Open
Keywords: plant metabolites; plant biotechnology; bioactive natural compounds; natural products metabolomics; pharmacological activity of natural compounds; cosmetic applications of natural compounds; isolation of natural compounds; essential oils; biological activity of natural compounds; in vitro approach; in vivo approach; clinical investigations; ethnopharmacological indications; ethnobotanical indications; technology of cosmetic formulations; skin permeability; irritating potential; agricultural practices
(This special issue belongs to the Section Natural Products Chemistry)
New Sights in Nanomaterials for Photoelectrochemistry
edited by Yibo Yan
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4236 | Submission Open
Keywords: photoelectrochemical catalysis; photoelectrochemical cells; photoelectrochemical sensors; photoelectrochemical characterizations; photoelectrochemical conversion; photoelectrochemical transformations; optoelectronic devices; photoelectrochemical CO2 reduction
(This special issue belongs to the Section Nanochemistry)
Chemical Profiling of Plant Extracts with Antioxidant Activity: Identification of Bioactive Compounds submission deadline 31 Dec 2025 | 2 articles | Viewed by 4145 | Submission Open
Keywords: flavonoids; phenolic acids; terpenoids; anthocyanins; antioxidant activity; chemical profiling
(This special issue belongs to the Section Natural Products Chemistry)
Phytochemicals as Valuable Tools for Fighting Metabolic Disorders
edited by Anna Ramunno and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 3669 | Submission Open
Keywords: phytochemicals; metabolic disorders; obesity; diabetes; antioxidants; therapeutic applications
(This special issue belongs to the Section Natural Products Chemistry)
Biomass Materials in Materials Chemistry: Preparation and Characterization, 2nd Edition
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 3232 | Submission Open
Keywords: biomass material (including chitosan; chitin; starch; and biomass waste); catalyst; food packing; coating and film; adsorption
(This special issue belongs to the Section Materials Chemistry)
Innovative Technologies for Functional Foods Development submission deadline 31 Dec 2025 | 3 articles | Viewed by 3188 | Submission Open
Keywords: nutraceuticals; functional foods; plant ingredients; phytochemicals; health claims; in vitro and in vivo studies
(This special issue belongs to the Section Food Chemistry)
The 30th Anniversary of Molecules—Recent Advances in Natural Products Chemistry submission deadline 31 Dec 2025 | 4 articles | Viewed by 3107 | Submission Open
Keywords: natural compounds; bioactive molecules; drug discovery; pharmacological activity; formulations; drug delivery systems; food applications and additives; cosmetic applications; synthesis
(This special issue belongs to the Section Natural Products Chemistry)
New Strategies for Drug Development
edited by and Ariel Marchlewicz
submission deadline 31 Dec 2025 | 3 articles | Viewed by 3094 | Submission Open
Keywords: drugs; biosynthesis; biotransformation; natural products; biological activity; bioactive compounds; structure– activity relationship; drug development
(This special issue belongs to the Section Medicinal Chemistry)
Advances in Photocatalytic Degradation of Organic Pollutants
edited by Qianqian Liu, Quan Zhang and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 3074 | Submission Open
Keywords: photocatalysis; photocatalytic degradation of organic pollutants; functional materials; semiconductor photocatalysts; DFT
(This special issue belongs to the Section Green Chemistry)
Porous Polymers Design, Synthesis and Applications in the Field of Catalysis, Separation and Energy
edited by and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 3006 | Submission Open
Keywords: polymers design and synthesis; pore structure; morphology; surface modification; physical characteristics; mechanical properties; catalysis; thermal stability; transport; separation; advanced techniques
(This special issue belongs to the Section Materials Chemistry)
Characterization and Instrumental Analysis of Aroma-Active Compounds in Fermented Food and Beverage, the Second Edition
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 2973 | Submission Open
Keywords: fermentation; fermented food production; fermented food flavor; aroma characterization; gas chromatography– mass spectrometry/olfactory (GC-MS/O); Sensorial properties; HS-SPME; stir bar and thin-film sorptive extraction
(This special issue belongs to the Section Flavours and Fragrances)
Synthesized and Functionalized Nanoparticles in Natural Compounds
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 2780 | Submission Open
Keywords: nanoparticles; green synthesis; two step-based mechanism growth for nanostructures; template synthetic approach; essential oil (EO); functionalized nanoparticles; shape factor (SF); antibacterial features; cytotoxicity properties; cultural heritage reparation; drug delivery and discovery; nano-carrier in biotechnologies
(This special issue belongs to the Section Materials Chemistry)
Photochemistry in Asia
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 2607 | Submission Open
Keywords: photochemistry; photophysics; photocatalysts; synthetic photochemistry; photoelectrochemistry; computational photochemistry; luminescent molecular sensors; nanomaterials; electron transfer; energy transfer
(This special issue belongs to the Section Photochemistry)
(Mass Spectrometric) Non Target Screening–Techniques and Strategies: Volume II
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2604 | Submission Open
Keywords: mass spectrometric non-target screening; NTS workflows; NTS strategies; NTS techniques (separation; ionization; detection); HPLC; SFC; GC; CE; HRMS; MS/MS; NTS software solutions; NTS open access software; NTS data evaluation; NTS and quality management
(This special issue belongs to the Section Analytical Chemistry)
Analytical Chemistry in Asia, 2nd Edition
edited by
submission deadline 31 Dec 2025 | 4 articles | Viewed by 2561 | Submission Open
Keywords: analytical chemistry; Asia; HPLC; sample preparation; bioanalysis; mass spectrometry
(This special issue belongs to the Section Analytical Chemistry)
Exclusive Feature Papers in Inorganic Chemistry, 3rd Edition submission deadline 31 Dec 2025 | 4 articles | Viewed by 2516 | Submission Open
Keywords: coordination chemistry; metal complexes; metal-based assemblies; inorganic anions; inorganic materials; coordination polymers; functional materials; chemosensors
(This special issue belongs to the Section Inorganic Chemistry)
Cross-Coupling and Related Reactions: Past and New Reactions for the Future
edited by and Satenik Mkrtchyan
submission deadline 31 Dec 2025 | 1 articles | Viewed by 2456 | Submission Open
Keywords: C-C- cross coupling reactions; C-C bond formation by transition metal catalysis; C-C bond formation by organocatalysis; C-C bond formation by photoredox catalysis; C-C bond formation by enzymatic catalysis; sustainability; green chemistry; new trends in C-C bond formation
(This special issue belongs to the Section Organic Chemistry)
Design, Synthesis, and Catalytic Applications of Metal Complexes
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2248 | Submission Open
Keywords: metal complex; metal-based material; catalysis: electrocatalysis; photocatalysis; thermocatalysis
(This special issue belongs to the Section Applied Chemistry)
Synthesis, Modification and Application of Heterocyclic Compounds
edited by and Yongjia Shang
submission deadline 31 Dec 2025 | 3 articles | Viewed by 2140 | Submission Open
Keywords: heterocyclic compounds; synthesis; modification; asymmetric catalysis; cyclization; natural products
(This special issue belongs to the Section Organic Chemistry)
Nanostructured Materials: Synthesis, Functionalization and Applications in Biomedicine—2nd Edition
edited by , and Hanping Yu
submission deadline 31 Dec 2025 | 3 articles | Viewed by 2131 | Submission Open
Keywords: nanostructured materials; biomaterials; dental materials; biomedicine; biomedical applications; drug delivery; bone defect repair; orthopedic surgery; skin wound healing; anti-tumor; biosensing; bioimaging; diagnosis; therapy
(This special issue belongs to the Section Nanochemistry)
Synthesis of Bioactive Compounds, 3rd Edition
edited by
submission deadline 31 Dec 2025 | 4 articles | Viewed by 2096 | Submission Open
Keywords: biological activity; nature-derived molecules; heterocyclic moieties; aromatic species; structural diversity; alkaloids; organic synthesis
(This special issue belongs to the Section Organic Chemistry)
Synthesis and Applications of Nanoparticles and Multifunctional Nanocomposites
edited by , and Iulia Ioana Lungu
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2092 | Submission Open
Keywords: nanoparticles; nanocomposites; synthesis; multifunctional platforms
(This special issue belongs to the Section Nanochemistry)
Innovations in Metal–Organic Frameworks: Their Synthesis, Properties and Multifaceted Applications submission deadline 31 Dec 2025 | 2 articles | Viewed by 2062 | Submission Open
Keywords: MOFs; heterogeneous catalysis; storage; adsorption; photocatalysis; fluorescent sensors; electronic devices
(This special issue belongs to the Section Materials Chemistry)
Insight into Electrochemical and Photocatalysis/Photoelectrochemical Hydrogen Evolution
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2017 | Submission Open
Keywords: hydrogen evolution reactions (HER); hydrogen production; electrocatalysts (electrocatalysis); photocatalysts (photocatalysis); photoelectrochemical (PEC); energy conversion; (nano)materials
(This special issue belongs to the Section Materials Chemistry)
Determination, Adsorption and Degradation Mechanisms of Environmental Pollutants
edited by Alina Catrinel Ion
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1983 | Submission Open
Keywords: environmental pollutants; adsorption mechanisms; degradation pathways; analytical techniques; nanomaterials; heavy metals; organic contaminants
(This special issue belongs to the Section Green Chemistry)
Discovery of Microbial Natural Products
edited by and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1971 | Submission Open
Keywords: microbial natural products; determination of structure; microorganism; drug candidate; bioactive secondary metabolites; microbial biotechnology
(This special issue belongs to the Section Natural Products Chemistry)
Anticancer Computational Drug Discovery: New Approaches, New Targets, and New Treatments
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1921 | Submission Open
Keywords: anticancer; structure-based drug design; de novo drug design; artificial intelligence (AI); big data machine learning and virtual screening
(This special issue belongs to the Section Medicinal Chemistry)
Feature Papers in Photochemistry and Photocatalysis—2nd Edition
edited by
submission deadline 31 Dec 2025 | 4 articles | Viewed by 1799 | Submission Open
Keywords: photocatalytic processes; quantum yield; solar light; upconversion; heterojunctions
(This special issue belongs to the Section Photochemistry)
Bioactive Molecules in Foods: From Sources to Functional Applications submission deadline 31 Dec 2025 | 1 articles | Viewed by 1734 | Submission Open
Keywords: food compounds; biological activity; nutrition; health; food products; diet supplementary
(This special issue belongs to the Section Food Chemistry)
Exclusive Contributions by the Editorial Board Members (EBMs) of the Inorganic Chemistry Section of Molecules 2025 submission deadline 31 Dec 2025 | 3 articles | Viewed by 1721 | Submission Open
Keywords: inorganic chemistry; coordination chemistry; main-group chemistry; bioinorganic chemistry; solid-state chemistry; organometallic compounds; inorganic cluster chemistry; metal-based assemblies; inorganic anions; inorganic materials; theoretical inorganic chemistry
(This special issue belongs to the Section Inorganic Chemistry)
Exclusive Feature Papers in Synthetic Medicinal Chemistry submission deadline 31 Dec 2025 | 4 articles | Viewed by 1586 | Submission Open
Keywords: antitumor activity; antibacterial activity; natural and synthetic compounds
(This special issue belongs to the Section Organic Chemistry)
Exploring the Therapeutic Potential of Natural Antioxidants
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1543 | Submission Open
Keywords: oxidant stress; antioxidants; age; age-related disease; natural plants; polyphenol; fermentation
(This special issue belongs to the Section Natural Products Chemistry)
Development and Application of Environmentally Friendly Surfactants
edited by Christina Vakh
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1541 | Submission Open
Keywords: surfactants; green analysis; synthesis of sustainable surfactants; application of sustainable surfactants
(This special issue belongs to the Section Green Chemistry)
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