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Molecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Isolation, Characterization, and Application of Anticancer Agents from Natural Products
edited by and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1106 | Submission Open
Keywords: medicinal plants; bioactive phytochemicals; cytotoxic activity; oxidative stress; anticancer potential; mechanism of action; cancer cells
(This special issue belongs to the Section Natural Products Chemistry)
Spectroscopic Insights into Innovative Materials
edited by Waldeci Paraguassu
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1025 | Submission Open
Keywords: spectroscopic techniques; materials science; electronic structure; chemical composition; surface analysis
(This special issue belongs to the Section Physical Chemistry)
Enzyme Inhibitors: Design, Synthesis and Biological Evaluation—3rd Edition submission deadline 31 Dec 2025 | 1 articles | Viewed by 893 | Submission Open
Keywords: enzyme inhibitors; drug design; organic synthesis; biological evaluation; molecular modeling studies; kinetic experiment
(This special issue belongs to the Section Chemical Biology)
Recent Advances in Flame Retardant Polymeric Materials, 2nd Edition
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 792 | Submission Open
Keywords: polymeric materials; flame retardants; synthesis; multifunctionality; mechanisms; nanocomposites
(This special issue belongs to the Section Materials Chemistry)
Advances in European Medicinal Chemistry submission deadline 31 Dec 2025 | 1 articles | Viewed by 779 | Submission Open
Keywords: medicinal chemistry; drug design; natural compounds; synthesis and analysis; structure-activity relationships; biological screening; chemical biology and biological chemistry; biomaterials; excipients
(This special issue belongs to the Section Medicinal Chemistry)
Research on Functional Active Ingredients of Edible Fungi
edited by Tianqiao Yong, and
submission deadline 31 Dec 2025 | 1 articles | Viewed by 767 | Submission Open
Keywords: fungi; compounds; biological activities; uric acid; metabolism; diabetes; cancer; virus
(This special issue belongs to the Section Food Chemistry)
New Insights into Electrochemical Energy Storage and Conversion: Aqueous Rechargeable Batteries
edited by and Ruizheng Zhao
submission deadline 31 Dec 2025 | 1 articles | Viewed by 747 | Submission Open
Keywords: aqueous batteries; electrochemical reactions; electrode materials; electrolyte; regulation
(This special issue belongs to the Section Electrochemistry)
Analysis of Pesticide Residues in Food and Environmental Samples
edited by and Xueke Liu
submission deadline 31 Dec 2025 | 1 articles | Viewed by 729 | Submission Open
Keywords: analytical methods; green analytical chemistry; sample pretreatment; microextraction methods; detection techniques; quantitative determination; degradation pathways; metabolite analysis; toxicity evaluation
(This special issue belongs to the Section Analytical Chemistry)
Advances in Natural Fiber Composites
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 711 | Submission Open
Keywords: natural fibers; polymer composites; natural fiber-reinforced polymers; heterogeneous structures; complex interfaces
(This special issue belongs to the Section Macromolecular Chemistry)
Magnetic Targeted Nanomaterials and Applications in Drug Delivery and Diagnostics submission deadline 31 Dec 2025 | 1 articles | Viewed by 682 | Submission Open
Keywords: magnetic targeting; theranostics; drug delivery; nanomaterials; magnetic hyperthermia
(This special issue belongs to the Section Nanochemistry)
Functional Hybrid Materials via Sol–Gel Processing: Design and Properties
edited by
submission deadline 31 Dec 2025 | Viewed by 676 | Submission Open
Keywords: sol– gel synthesis; hybrid materials; biomedicine; encapsulation of biomolecules; catalysis; magnetic behavior; structural properties; thermal behavior
(This special issue belongs to the Section Materials Chemistry)
Advances in Nanomaterials for Biomedical Applications, 2nd Edition
edited by Xueen Jia and Ce Zhang
submission deadline 31 Dec 2025 | 1 articles | Viewed by 669 | Submission Open
Keywords: 2D nanomaterials; metal– organic frameworks (MOFs); metasurfaces; biosensor; drug delivery
(This special issue belongs to the Section Nanochemistry)
Ionic Liquids and Molecular Materials: Advances in Functional Interfaces and Applications submission deadline 31 Dec 2025 | 1 articles | Viewed by 646 | Submission Open
Keywords: ionic fluids; bulk properties; surface and interfacial properties; thin films; vacuum engineering; energy harvesting and storage; functional materials
(This special issue belongs to the Section Physical Chemistry)
Functional Materials for Small Molecule Electrocatalysis
edited by , Linlin Li and Qingxue Lai
submission deadline 31 Dec 2025 | 1 articles | Viewed by 606 | Submission Open
Keywords: electrocatalysis; nanomaterials; electrochemical conversion of H2O; CO2 and N2
(This special issue belongs to the Section Nanochemistry)
Synthesis and Characterization of Peripherally Functionalized Porphyrazines and Phthalocyanines submission deadline 31 Dec 2025 | 1 articles | Viewed by 600 | Submission Open
Keywords: porphyrazine; phthalocyanine; organic synthesis; photodynamic therapy; photodynamic inactivation; photocatalysis; photodegradation; electrocatalysis
(This special issue belongs to the Section Organic Chemistry)
Degradation of Aromatic Compounds in the Environment submission deadline 31 Dec 2025 | 1 articles | Viewed by 578 | Submission Open
Keywords: aromatic compounds; microorganisms; biodegradation; biotransformation; advanced oxidation processes
(This special issue belongs to the Section Organic Chemistry)
Epoxy Resin Synthesis, Performance and Application Research: Second Edition
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 510 | Submission Open
Keywords: synthesis; modification; and characterization; curing kinetics and mechanism; epoxy-based nanocomposites; interface characteristics; advanced hardeners; modifiers; and accelerators; thermal; mechanical; and dielectric properties; applications; quantum chemical calculations; molecular design
(This special issue belongs to the Section Macromolecular Chemistry)
Silymarin and Derivatives: From Biosynthesis to Health Benefits 2.0
edited by
submission deadline 31 Dec 2025 | Viewed by 507 | Submission Open
Keywords: silymarin: sources and biosynthesis; secondary metabolites and silymarin derivatives; silymarin bioavailability; silymarin and cardiovascular diseases; silymarin and metabolic syndrome; silymarin and cancer; silymarin and inflammation and immune diseases; silymarin and degenerative age-related diseases
(This special issue belongs to the Section Natural Products Chemistry)
Nanomaterials in Photochemical Devices: Advances and Applications submission deadline 31 Dec 2025 | 1 articles | Viewed by 507 | Submission Open
Keywords: nanomaterials; photochemistry; photocatalysis; nanoparticles; energy conversion; environmental remediation; biomedical applications; photoacoustic imaging
(This special issue belongs to the Section Photochemistry)
Recent Advances in Antibacterial Nanomaterials
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 474 | Submission Open
Keywords: nanoparticles; biochemistry; antibacterial; bacteriostatic; cell membrane
(This special issue belongs to the Section Nanochemistry)
Peptide Chemistry: Recent Trends and Advancements
edited by Fa-Jie Chen and
submission deadline 31 Dec 2025 | Viewed by 425 | Submission Open
Keywords: peptide synthesis; cyclic peptide; peptide ligation; peptide stapling; peptide library; peptide therapy; structure and activity
(This special issue belongs to the Section Medicinal Chemistry)
Microwave-Assisted Rapid Preparation and Processing of Nanostructured Materials and Their Applications
edited by and Hanping Yu
submission deadline 31 Dec 2025 | Viewed by 403 | Submission Open
Keywords: microwave; synthesis; preparation; processing; nanostructured materials; nanomaterials; nanostructures; application
(This special issue belongs to the Section Microwave Chemistry)
Multifunctional Electrocatalysts for Overall Water Splitting
edited by Haeseong Jang
submission deadline 31 Dec 2025 | Viewed by 403 | Submission Open
Keywords: electrocatalysts; water splitting; oxygen evolution reaction; hydrogen evolution reaction; nanostructure
(This special issue belongs to the Section Electrochemistry)
Heavy Metal Pollutants in Water, Wastewater and Sediments: From Occurrence and Determination to Removal and Recovery submission deadline 31 Dec 2025 | 1 articles | Viewed by 376 | Submission Open
Keywords: heavy metals; analytical methods; wastewater; sludge; recycling; green chemistry; circular economy; sustainable development
(This special issue belongs to the Section Green Chemistry)
Computational Chemistry Approach for Materials Design
edited by and Lei Zhang
submission deadline 31 Dec 2025 | Viewed by 352 | Submission Open
Keywords: computational materials; catalysts; DFT calculation; machine learning; energy conversion and storage materials
(This special issue belongs to the Section Computational and Theoretical Chemistry)
NMR Spectroscopy in Structural Biology and Drug Discovery Research submission deadline 31 Dec 2025 | Viewed by 347 | Submission Open
Keywords: solution-NMR; in cell-NMR; solid state-NMR; NMR screening (small molecules and peptides); fragment-based drug discovery; SAR by NMR; ligand-based approaches; target-based approaches; protein-ligand interactions; peptides as drugs; epitope mapping; 19F  NMR; chemical shift mapping
(This special issue belongs to the Section Bioorganic Chemistry)
Chemical Conversion and Utilization of CO2
edited by Gang Li
submission deadline 31 Dec 2025 | Viewed by 277 | Submission Open
Keywords: CO2 utilization for green synthesis; photocatalytic CO2 utilization; C-H carboxylation with CO2; green synthetic methodology development; functional materials design for CO2 utilization
(This special issue belongs to the Section Organic Chemistry)
Functional Foods: Chemical Challenges and Opportunities
edited by Yan Zhang and Haixia Wu
submission deadline 31 Dec 2025 | Viewed by 274 | Submission Open
Keywords: functional foods; chemical stability; advanced extraction methods; chemical modification; chemical bioavailability; food safety
(This special issue belongs to the Section Food Chemistry)
Analytical Chemistry in Europe: Towards Sustainability and Quality of Life, 3rd Edition submission deadline 31 Dec 2025 | 1 articles | Viewed by 266 | Submission Open
Keywords: analytical and bioanalytical methods; chemistry; drugs; toxic compounds; biomarkers; sample preparation; life quality; sustainability
(This special issue belongs to the Section Analytical Chemistry)
Advances in Extraction, Biological Activity of Natural Products and Their Derivatives
edited by Ernesto Santoro and
submission deadline 31 Dec 2025 | Viewed by 265 | Submission Open
Keywords: novel extraction; absolute configuration; supercritical fluid; microwave-assisted extraction; natural products
(This special issue belongs to the Section Natural Products Chemistry)
Small-Molecule Drug Design and Discovery
edited by Qiuqin He
submission deadline 31 Dec 2025 | 1 articles | Viewed by 235 | Submission Open
Keywords: small-molecule drug design; structure-based drug design; fragment-based drug discovery; PROTAC technology; artificial intelligence technology; biological evaluation
(This special issue belongs to the Section Medicinal Chemistry)
Applications of Solid-Phase Microextraction and Related Techniques, the Second Edition
edited by
submission deadline 31 Dec 2025 | Viewed by 231 | Submission Open
Keywords: solid-phase microextraction; micriextraction techniques; extraction sorbents; pharmaceutical analysis; forensic analysis; bioanalysis; environmental analysis; food analysis
(This special issue belongs to the Section Analytical Chemistry)
Exploring Schiff Base Ligands and Their Metal Complexes
edited by
submission deadline 31 Dec 2025 | Viewed by 206 | Submission Open
Keywords: schiff base ligands; complexes; X-ray structure; antimicrobial; antitumor; antiviral activity; catalysts
(This special issue belongs to the Section Inorganic Chemistry)
Biodegradable Functional Copolymers, Second Edition
edited by
submission deadline 31 Dec 2025 | Viewed by 204 | Submission Open
Keywords: biodegradable (co)polymers; chemical functionalization; macromolecular synthesis; macromolecular bioconjugates; environmental and biomedical applications; targeted drug delivery; tissue engineering
(This special issue belongs to the Section Macromolecular Chemistry)
Molecular Approaches to Drug Design: From Target Identification to Delivery
edited by
submission deadline 31 Dec 2025 | Viewed by 204 | Submission Open
Keywords: drug design; target identification; drug delivery; protein-based therapeutics; targeted therapy
(This special issue belongs to the Section Medicinal Chemistry)
Pharmaceuticals in the Environment: Micropollutants and Degradation Dynamics
edited by Agnieszka Nowak and
submission deadline 31 Dec 2025 | Viewed by 199 | Submission Open
Keywords: pharmaceuticals; microorganisms; toxicity; micropollutants; biodegradation; biotransformation; advanced oxidation processes; analysis; intermediate identification; chromatography
(This special issue belongs to the Section Green Chemistry)
Corrosion Electrochemistry: A Themed Issue in Honor of the Many Contributions of Prof. Dr. Changjian Lin
edited by Jiming Hu and Guozhe Meng
submission deadline 31 Dec 2025 | Viewed by 196 | Submission Open
Keywords: corrosion electrochemistry; corrosion and protection; anti-corrosion coatings; electrochemical test
(This special issue belongs to the Section Electrochemistry)
30th Anniversary of Molecules—Recent Advances in Food Chemistry
edited by and Marta Coelho
submission deadline 31 Dec 2025 | 1 articles | Viewed by 193 | Submission Open
Keywords: functional foods; nutraceuticals; bioactive compounds; analytical techniques; by-products; food chemistry
(This special issue belongs to the Section Food Chemistry)
Analytical Techniques in Environmental Chemistry, 2nd Edition
edited by
submission deadline 31 Dec 2025 | Viewed by 193 | Submission Open
Keywords: environmental analytical chemistry; contaminants; environmental impact assessment; analytical techniques; environmental pollution
(This special issue belongs to the Section Analytical Chemistry)
Advances in Ammonia Synthesis
edited by Wenbo Gao
submission deadline 31 Dec 2025 | Viewed by 173 | Submission Open
Keywords: ammonia synthesis; heterogeneous catalysis; nitrogen activation; ammonia energy; reaction mechanism; photo/electrochemical ammonia synthesis
(This special issue belongs to the Section Applied Chemistry)
Anti-Aging and Skin Rejuvenation Ingredients: Design and Research
edited by , and Daniela Lucia Muntean
submission deadline 31 Dec 2025 | Viewed by 164 | Submission Open
Keywords: anti-aging ingredients; skin rejuvenation; nutricosmetics and cosmeceuticals; bioactive compounds; formulation and delivery systems; extracellular matrix and skin biology; in silico; in vitro and in vivo assessment
(This special issue belongs to the Section Applied Chemistry)
Artificial Intelligence Driving Transformative Advances in Food Science and Technology submission deadline 31 Dec 2025 | Viewed by 163 | Submission Open
Keywords: food sustainability; artificial intelligence; food processes optimization; functional foods; food safety; individualized nutrition
(This special issue belongs to the Section Food Chemistry)
Propolis in Human and Bee Health—2nd Edition submission deadline 31 Dec 2025 | Viewed by 163 | Submission Open
Keywords: propolis; plant sources; biological activity; bee health; bioactive compounds; pharmacological properties; analytical methods; applications
(This special issue belongs to the Section Natural Products Chemistry)
Innovative Nanostructures for Energy and Environmental Applications submission deadline 31 Dec 2025 | Viewed by 162 | Submission Open
Keywords: nanostructures; energy conversion; environmental applications; quantum dots; nanowires; graphene; MXenes; metal nitrides; 2D materials; 3D materials; sustainable energy; pollutant removal; synthesis techniques; adsorbents; water purification; sustainable materials; green energy technologies; advanced nanomaterials; multifunctional materials; hydrogen production; catalysis
(This special issue belongs to the Section Materials Chemistry)
Synthesis, Characterization and Anticancer Activities of Metal Complexes
edited by
submission deadline 31 Dec 2025 | Viewed by 161 | Submission Open
Keywords: in vitro activity; in vivo activity; metal complex; biological studies; anticancer activity; bimetallic complexes; mechanistic studies
(This special issue belongs to the Section Inorganic Chemistry)
The Synthesis and Application of Rare-Earth-Doped Luminescent Materials
edited by and Rui Wang
submission deadline 31 Dec 2025 | Viewed by 161 | Submission Open
Keywords: luminescent materials; molecular design; luminescent mechanisms and processes; display; lighting; detection
(This special issue belongs to the Section Materials Chemistry)
Advances in Electrochemical Sensors
edited by
submission deadline 31 Dec 2025 | Viewed by 160 | Submission Open
Keywords: electrochemical sensor; modified electrodes; photoelectrochemical sensor; wearable sensor; environmental monitoring; food safety analysis
(This special issue belongs to the Section Electrochemistry)
Plant-Derived Compounds: Biological Functions and Therapeutic Potential
edited by
submission deadline 31 Dec 2025 | Viewed by 153 | Submission Open
Keywords: plant-derived bioactive compounds; natural products; phytochemicals; biological activities; extraction and isolation; molecular mechanisms; phytotherapic products; ethnopharmacology
Recent Advances in the Organic Synthesis of Bioactive Natural Compounds and Their Analogs submission deadline 31 Dec 2025 | Viewed by 152 | Submission Open
Keywords: bioactive natural compounds; organic synthesis; natural products; synthetic methodologies; medicinal chemistry; drug discovery; total synthesis
(This special issue belongs to the Section Natural Products Chemistry)
Determination of Trace Heavy Metals and Metalloids in Environmental and Food Samples, 3rd Edition submission deadline 31 Dec 2025 | Viewed by 151 | Submission Open
Keywords: environmental analytical chemistry; food analytical methods; trace heavy metals and metalloids; chemical speciation; instrumental analysis; new analytical methods and techniques; sample pre-treatment; extreme environments; reviews; emerging environmental issues; emerging food issues; food and “ novel foods” ; insects; climate change and biogeochemical cycles of trace heavy metal(loid)s
(This special issue belongs to the Section Analytical Chemistry)
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