Enzyme Inhibitors: Design, Synthesis and Biological Evaluation—3rd Edition
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Chemical Biology".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 431
Special Issue Editors
Interests: medicinal chemistry; drug design; organic synthesis; enzyme inhibition; channel blockers; G protein-coupled receptors (GPCRs); ligands
Special Issues, Collections and Topics in MDPI journals
Interests: medicinal plants; drug discovery from plants; enzymology; alkaloids; mass spectrometry; metabolomics; ethnopharmacology; enzyme inhibitors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Enzymes are specialized proteins that increase the speed of chemical reactions, thus acting as biocatalysts. In the human body, enzymes catalyze all kinds of chemical reactions, playing vital roles in digestion and metabolism, blood coagulation, neuronal signaling, DNA repair, and replication, as well as many other functions. Under physiological conditions, an enzyme works by first binding to its substrate, forming an enzyme–substrate complex, which is then converted into the final product. The final product then dissociates from the enzyme, and a new catalytic cycle begins. Although they are crucial in maintaining life, dysfunctional, improperly regulated, over-active, or over-expressed enzymes contribute to the pathology of many diseases. Both naturally derived and synthetic molecules can bind to enzymes and alter their catalytic activity, and, in most cases, reduce enzyme activity. Many of these enzyme inhibitors are approved drugs, and enzyme inhibition continues to play a pivotal role in medicinal chemistry. A primary understanding of the action of enzyme inhibitors is fundamental in the development of new therapeutic agents. This Special Issue will focus on all aspects of enzyme inhibitors, ranging from the design and synthesis of these compounds to their pharmacological evaluation and computational modeling and structural biology studies designed to elucidate the interactions between inhibitors and enzymes. Papers that focus on innovative aspects or novel mechanisms in enzyme inhibition are also welcome. We hope that this Special Issue stimulates authors and readers and makes an important contribution to the field of medicinal chemistry.
Dr. Letizia Crocetti
Dr. Maris Cinelli
Guest Editors
Manuscript Submission Information
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Keywords
- enzyme inhibitors
- drug design
- organic synthesis
- biological evaluation
- molecular modeling studies
- kinetic experiment
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