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Research on Functional Active Ingredients of Edible Fungi

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Food Chemistry".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 239

Special Issue Editors


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Guest Editor
National Health Commission Science and Technology Innovation Platform for Nutrition and Safety of Microbial Food, Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China
Interests: secondary metabolite of edible and medicinal fungi; innovative drug development; biosynthesis
State Key Laboratory of Food Nutrition and Safety, College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China
Interests: fungi; functional compounds; structural analysis
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Guest Editor
School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China
Interests: natural products; antioxidation; functional food; human health
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear colleagues,

Plant-relevant higher fungi occupy a key ecological niche worldwide, decomposing forest, animal, and insect residues and heavily affecting agricultural systems. Understanding the functional active ingredients of edible fungi has attracted significant attention. Importantly, their functional active ingredients involve various genes in their genomes for their biosynthesis, functioning for vast activities and presenting a large volume of space for therapeutics and agriculture. Importantly, the annual production of edible mushrooms in China exceeds 40 million tons, with an annual GDP of over CNY 347.563 billion, accounting for more than 75% of the world's total. It has become the fifth largest agricultural product in China, and its position in human diet continues to rise. Thus, it is posited to have an important role in future foods and industries. Present special issue focus on the Extraction, preparation, functions, and mechanisms of action of different functional components from Edible Fungi, e.g., proteins, peptides, polysaccharides, oils and lipids; polyphenols, brass, saponins, etc.

We are pleased to invite you submit your research papers on functional active ingredients of edible fungi. Research articles and review articles, as well as short communications, are welcome for elucidating various components, such as small molecules, polysaccharides, RNAs, DNAs, proteins, and lipids, and kinds of biological activities of regulating uric acid metabolism, glucose and lipid metabolism, cancers, and viruses. 

We look forward to receiving your contributions.

Dr. Tianqiao Yong
Dr. Jia Song
Prof. Dr. Zhaojun Wei
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fungi
  • compounds
  • biological activities
  • uric acid
  • metabolism
  • diabetes
  • cancer
  • virus

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Published Papers (1 paper)

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Research

19 pages, 1298 KiB  
Article
In Vivo Regenerative Potential of Coprinus comatus in Pancreatic Tissue After Acute Stress with Chronic Consequences
by Nebojša Stilinović, Ana Tomas, Saša Vukmirović, Nebojša Kladar, Miloš Čanković, Maja Đanić, Michał Seweryn Karbownik, Aleksandar Rašković and Ivan Čapo
Molecules 2025, 30(11), 2261; https://doi.org/10.3390/molecules30112261 - 22 May 2025
Viewed by 119
Abstract
The edible mushroom Coprinus comatus has a long history of use in metabolic diseases, which is increasingly documented by modern research. Due to its favorable nutritional composition, it was assumed that this mushroom could accelerate tissue recovery after acutely induced damage with subsequent [...] Read more.
The edible mushroom Coprinus comatus has a long history of use in metabolic diseases, which is increasingly documented by modern research. Due to its favorable nutritional composition, it was assumed that this mushroom could accelerate tissue recovery after acutely induced damage with subsequent disturbance of primarily carbohydrate metabolism. To test this hypothesis, the alloxan diabetes model was used, where experimental animals’ change in body weight and biochemical and histological indicators of recovery were monitored. Before performing the in vivo part, HPLC analysis of the C. comatus extract was carried out with subsequent in silico and in vitro tests. Comparing the animals treated with the mushroom in three different doses, no significant change in body weight was observed. Still, the change was also noticed in the lipid status and glycemia, with a dose-dependent beneficial effect. Morphometric analysis of pancreatic tissue stained by immuno-histochemical methods showed that long-term treatment with C. comatus leads to increased numerical density, nuclear volume, and absolute number of beta cells of the islets of Langerhans, which suffered severe damage after alloxan administration. Overall, C. comatus may contribute to faster tissue recovery after acute diabetic-relevant damage with chronic consequences. Full article
(This article belongs to the Special Issue Research on Functional Active Ingredients of Edible Fungi)
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