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Analytical Chemistry in Europe: Towards Sustainability and Quality of Life, 3rd Edition

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Analytical Chemistry".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 2917

Special Issue Editors

Dr. Luís Passarinha

E-Mail Website
Guest Editor
1. Associate Laboratory i4HB—Institute for Health and Bioeconomy, NOVA School of Science and Technology, Universidade NOVA de Lisboa, 2819-516 Caparica, Portugal
2. UCIBIO—Applied Molecular Biosciences Unit, Chemistry Department, NOVA School of Science and Technology, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal
3. RISE-Health, Department of Medical Sciences, Health Science Faculty, University of Beira Interior, 6201-506 Covilhã, Portugal
Interests: method development and validation; electrochemical detection; proteomics; protein biomarkers
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Eugenia Gallardo

E-Mail Website
Guest Editor
1. Health Sciences Research Centre, University of Beira Interior (CICS-UBI), 6200-506 Covilhã, Portugal
2. Pharmaco-Toxicology Laboratory, UBIMedical, University of Beira Interior, 6200-284 Covilhã, Portugal
3. Centro Académico Clínico das Beiras (CACB)—Grupo de Problemas Relacionados com Toxicofilias, 6200-284 Covilhã, Portugal
Interests: toxicology; analytical method development; recreational drugs; natural psychoactive substances; therapeutic drug monitoring; sample preparation; alternative samples; miniaturized extraction procedures
Special Issues, Collections and Topics in MDPI journals
Dr. Mário Barroso

E-Mail Website
Guest Editor
AlphaBiolabs, 14 Webster Court, Carina Park, Warrington WA5 8WD, UK
Interests: method development and validation; hair testing; alternative specimens; drug monitoring; toxicology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Due to the success of the previous Special Issues, we are pleased to announce the opening of this third edition of the Special Issue "Analytical Chemistry in Europe: Towards Sustainability and Quality of Life, 3rd Edition". This Special Issue intends to gather full scientific papers, short communications, and review articles covering novel analytical and bioanalytical methods and technologies that have a huge societal impact, as well as technologies that are sufficiently innovative, robust, and accurate compared to other methods currently available for the intended application. Developments that use interdisciplinary approaches are particularly welcome, and systems should be proven with suitably complex and analytically challenging samples.

Presenting a very broad scope, this Special Issue welcomes papers covering, but not limited to, the following technologies and emergent applications: global health; point-of-care and molecular diagnostics; biosensors and bioengineering; drug development and pharmaceutical analyses; microfluidics and nanotechnology; omics analyses (such as proteomics, metabolomics, or glycomics); environmental, veterinary, agricultural, and food science; neuroscience; biochemical, clinical, and forensic analyses; and the development of industrial processes and methods.

This Special Issue will provide an excellent collection of academic papers and will act as a reference tool for researchers, particularly those working in the fields of biotechnology, medicine, food sciences, pharmaceutical sciences, chemistry, toxicology, and biology, including health and industry professionals.

We are looking forward to receiving your contributions.

Dr. Luís Passarinha
Prof. Dr. Eugenia Gallardo
Dr. Mário Barroso
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • analytical and bioanalytical methods
  • chemistry
  • drugs
  • toxic compounds
  • biomarkers
  • sample preparation
  • life quality
  • sustainability

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Related Special Issues

Published Papers (4 papers)

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Research

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14 pages, 1692 KB  
Article
A New Approach to the Determination of Biogenic Amines in Wine
by Anna Salimova, Alexandra Vasilieva, Evgeniy Belyaev, Konstantin Sakharov and Sergey Andreev
Molecules 2026, 31(1), 71; https://doi.org/10.3390/molecules31010071 - 24 Dec 2025
Viewed by 332
Abstract
Biogenic amines (BAs) can be found in various foods, such as cheese, wine, and chocolate. The consumption of a sufficient quantity of BA can lead to symptoms including headaches, hypertonia, and diarrhea. For this reason, the amount of BA in food is regulated [...] Read more.
Biogenic amines (BAs) can be found in various foods, such as cheese, wine, and chocolate. The consumption of a sufficient quantity of BA can lead to symptoms including headaches, hypertonia, and diarrhea. For this reason, the amount of BA in food is regulated in many countries. A new method for the determination of biogenic amines in wine has been proposed, which involves derivatizing BA with p-toluene sulfonyl chloride (TsCl) and using K2S2O8 to reduce the matrix effect. The derivatives of putrescine, cadaverine, histamine, and tyramine with TsCl were synthesized and characterized by 1H NMR spectroscopy. Separation of BA derivatives was performed using a reversed-phase high-performance liquid chromatography (RP-HPLC). The chromatographic system was equipped with a reversed-phase C8 column and a diode array detector. This method was validated to analyze the above-mentioned biogenic amines simultaneously in red and white wine samples. The detection limits for putrescine, cadaverine, histamine, and tyramine in wine samples were 0.0248 mg·L−1, 0.0645 mg·L−1, 0.346 mg·L−1 and 0.00866 mg·L−1, respectively. The calibration curves showed good linearity (r > 0.999), and biogenic amines recovery varied from 83.0 to 110%. The proposed method demonstrates high sensitivity, straightforward sample preparation, and rapid analysis time. Full article
(This article belongs to the Special Issue Analytical Chemistry in Europe: Towards Sustainability and Quality of Life, 3rd Edition)
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12 pages, 1829 KB  
Article
Molecular and Thermodynamic Insights into the Enthalpy-Entropy Shift Governing HILIC Retention of Labelled Dextrans
by Matjaž Grčman, Črtomir Podlipnik, Matevž Pompe and Drago Kočar
Molecules 2025, 30(24), 4711; https://doi.org/10.3390/molecules30244711 - 9 Dec 2025
Viewed by 350
Abstract
Hydrophilic interaction liquid chromatography (HILIC) is widely used for the analysis of glycans and oligosaccharides, yet the molecular basis of retention remains incompletely understood. In this study, we investigated dextran ladders labelled with 2-aminobenzamide (2-AB) and Rapifluor-MS™ (Waters, Milford, MA, USA) across a [...] Read more.
Hydrophilic interaction liquid chromatography (HILIC) is widely used for the analysis of glycans and oligosaccharides, yet the molecular basis of retention remains incompletely understood. In this study, we investigated dextran ladders labelled with 2-aminobenzamide (2-AB) and Rapifluor-MS™ (Waters, Milford, MA, USA) across a wide range of degrees of polymerization (DP 2–15), temperature conditions (10 °C to 70 °C), and gradient programs using a Acquity™ Premier Glycan BEH Amide column (Bridged Ethylene Hybrid, Waters, Milford, MA, USA). Van’t Hoff analysis revealed distinct enthalpic and entropic contributions to retention, allowing identification of a mechanistic transition from enthalpy-dominated docking interactions at low DP to entropy-driven dynamic adsorption at higher DP. This transition occurred reproducibly between DP 4–6, depending on the fluorescent label, while gradient steepness primarily influenced the location of the minimum enthalpy. Molecular dynamics simulations provided additional evidence, showing increased conformational flexibility and end-to-end distance variability for longer oligomers. This finding is consistent with entropy-dominated adsorption accompanied by displacement of structured interfacial water. Together, these results establish a molecular-level framework linking retention thermodynamics, conformational behavior, and solvation effects, thereby advancing our mechanistic understanding of glycan separation in HILIC. Full article
(This article belongs to the Special Issue Analytical Chemistry in Europe: Towards Sustainability and Quality of Life, 3rd Edition)
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17 pages, 1285 KB  
Article
Irrigation Regime Effects on Phenolic Composition of Portuguese Grape Varieties
by Daniela Fonseca, Rosario Sánchez-Gómez, M. Rosario Salinas, Maria João Cabrita, Nuno Martins, Raquel Garcia and Cristina Cebrián-Tarancón
Molecules 2025, 30(16), 3408; https://doi.org/10.3390/molecules30163408 - 18 Aug 2025
Cited by 1 | Viewed by 1043
Abstract
Climate change has led to increased extreme weather events, such as severe droughts and intense rainfall, with regions in Portugal, like Alentejo and Algarve, being particularly affected. Understanding the influence of water availability in the concentration of phenolic compounds in autochthonous varieties could [...] Read more.
Climate change has led to increased extreme weather events, such as severe droughts and intense rainfall, with regions in Portugal, like Alentejo and Algarve, being particularly affected. Understanding the influence of water availability in the concentration of phenolic compounds in autochthonous varieties could be an important tool to know how these varieties adapt to water scarcity. This work has been carried out with the aim to analyze the profile of phenolic compounds by HPLC-DAD in four Portuguese grape varieties (Tinta Gorda, Tinta Miúda, Tinta Caiada, and Moreto), cultivated under three irrigation regimes (water comfort, moderate water deficit, and rainfed). The results reveal that Tinta Gorda, Tinta Miúda, and Tinta Caiada varieties exhibit the higher concentrations of phenolic compounds under rainfed conditions. Among these, Tinta Miúda and Tinta Caiada stand out as the most promising varieties in terms of adaptability to water scarcity. Full article
(This article belongs to the Special Issue Analytical Chemistry in Europe: Towards Sustainability and Quality of Life, 3rd Edition)
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Review

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26 pages, 1067 KB  
Review
Dried Matrix Spots for the Determination of Opiates and Opioids: Methodological Advances and Applications
by Luana M. Rosendo, Rita Gonçalves, Rodrigo Martins, Vitória Castro, Tiago Rosado, Mário Barroso and Eugenia Gallardo
Molecules 2025, 30(18), 3695; https://doi.org/10.3390/molecules30183695 - 11 Sep 2025
Viewed by 948
Abstract
Dried matrix spot (DMS) techniques have gained increasing attention in bioanalytical and forensic toxicology for the detection of opiates and opioids, offering minimally invasive sampling, enhanced sample stability, and simplified storage and transport. This review provides a critical overview of recent methodological advances [...] Read more.
Dried matrix spot (DMS) techniques have gained increasing attention in bioanalytical and forensic toxicology for the detection of opiates and opioids, offering minimally invasive sampling, enhanced sample stability, and simplified storage and transport. This review provides a critical overview of recent methodological advances and applications of DMS across multiple biological matrices, including blood, plasma, urine, and oral fluid. Particular focus is given to sample preparation protocols, extraction strategies, analytical instrumentation, and method performance. Dried blood spots (DBS) remain the most established format; however, alternative matrices such as dried plasma, urine, and saliva spots (DPS, DUS, DSS) are expanding the scope of DMS, particularly in decentralised and point-of-care contexts. Despite clear advantages, such as reduced biohazard risk and compatibility with high-throughput workflows, several limitations persist, including low sample volumes, matrix-specific recovery issues, and lack of standardised procedures. Future efforts should aim to optimise paper substrates, improve solvent–matrix compatibility, and integrate DMS workflows with automated or miniaturised mass spectrometry platforms. Overall, DMS techniques represent a versatile and evolving analytical platform with strong potential for reliable opioid monitoring in both clinical and forensic settings. Full article
(This article belongs to the Special Issue Analytical Chemistry in Europe: Towards Sustainability and Quality of Life, 3rd Edition)
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