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Article

Comparison of Phytochemicals, Antioxidant, and In Vitro Anti-Alzheimer Properties of Twenty-Seven Morus spp. Cultivated in Thailand

1
Institute of Nutrition, Mahidol University, Salaya, Phuttamonthon, Nakhon Pathom 73170, Thailand
2
Department of Food Science and Technology, Faculty of Agro-Industry, Kasetsart University, Chatuchak, Bangkok 10900, Thailand
3
Office of Sericulture Conservation and Standard Conformity Assessment, The Queen Sirikit Department of Sericulture, Ministry of Agriculture and Cooperatives, Bangkok 10900, Thailand
4
The Queen Sirikit Department of Sericulture Center (Kanchanaburi), Nong Ya, Mueang Kanchanaburi District, Kanchanaburi 71000, Thailand
5
Plant Varieties Protection Office, Department of Agriculture, Ministry of Agriculture and Cooperatives, Bangkok 10900, Thailand
6
Institute of Food Research and Product Development, Kasetsart University, Chatuchak, Bangkok 10900, Thailand
*
Author to whom correspondence should be addressed.
Academic Editors: Jianbo Xiao, Yanbo Zhang and Hui Ni
Molecules 2020, 25(11), 2600; https://doi.org/10.3390/molecules25112600
Received: 6 May 2020 / Revised: 31 May 2020 / Accepted: 1 June 2020 / Published: 3 June 2020
(This article belongs to the Special Issue Phytochemicals in Medicine and Food)
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. To fight the disease, natural products, including mulberry, with antioxidant activities and inhibitory activities against key enzymes (acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and beta-secretase 1 (BACE-1)) are of interest. However, even in the same cultivars, mulberry trees grown in different populated locations might possess disparate amounts of phytochemical profiles, leading to dissimilar health properties, which cause problems when comparing different cultivars of mulberry. Therefore, this study aimed to comparatively investigate the phytochemicals, antioxidant activities, and inhibitory activities against AChE, BChE, and BACE-1, of twenty-seven Morus spp. cultivated in the same planting area in Thailand. The results suggested that Morus fruit samples were rich in phenolics, especially cyanidin, kuromanin, and keracyanin. Besides, the aqueous Morus fruit extracts exhibited antioxidant activities, both in single electron transfer (SET) and hydrogen atom transfer (HAT) mechanisms, while strong inhibitory activities against AD key enzymes were observed. Interestingly, among the twenty-seven Morus spp., Morus sp. code SKSM 810191 with high phytochemicals, antioxidant activities and in vitro anti-AD properties is a promising cultivar for further developed as a potential mulberry resource with health benefits against AD. View Full-Text
Keywords: Morus species; anthocyanins; anthocyanidins; beta-secretase 1; antioxidant; anti-Alzheimer properties Morus species; anthocyanins; anthocyanidins; beta-secretase 1; antioxidant; anti-Alzheimer properties
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MDPI and ACS Style

Temviriyanukul, P.; Sritalahareuthai, V.; Jom, K.N.; Jongruaysup, B.; Tabtimsri, S.; Pruesapan, K.; Thangsiri, S.; Inthachat, W.; Siriwan, D.; Charoenkiatkul, S.; Suttisansanee, U. Comparison of Phytochemicals, Antioxidant, and In Vitro Anti-Alzheimer Properties of Twenty-Seven Morus spp. Cultivated in Thailand. Molecules 2020, 25, 2600. https://doi.org/10.3390/molecules25112600

AMA Style

Temviriyanukul P, Sritalahareuthai V, Jom KN, Jongruaysup B, Tabtimsri S, Pruesapan K, Thangsiri S, Inthachat W, Siriwan D, Charoenkiatkul S, Suttisansanee U. Comparison of Phytochemicals, Antioxidant, and In Vitro Anti-Alzheimer Properties of Twenty-Seven Morus spp. Cultivated in Thailand. Molecules. 2020; 25(11):2600. https://doi.org/10.3390/molecules25112600

Chicago/Turabian Style

Temviriyanukul, Piya, Varittha Sritalahareuthai, Kriskamol N. Jom, Butsara Jongruaysup, Somying Tabtimsri, Kanchana Pruesapan, Sirinapa Thangsiri, Woorawee Inthachat, Dalad Siriwan, Somsri Charoenkiatkul, and Uthaiwan Suttisansanee. 2020. "Comparison of Phytochemicals, Antioxidant, and In Vitro Anti-Alzheimer Properties of Twenty-Seven Morus spp. Cultivated in Thailand" Molecules 25, no. 11: 2600. https://doi.org/10.3390/molecules25112600

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