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Article

The Effect of Tartary Buckwheat Flavonoids in Inhibiting the Proliferation of MGC80-3 Cells during Seed Germination

by
Xiao-Li Zhou
,
Zhi-Dong Chen
,
Yi-Ming Zhou
*,
Rong-Hua Shi
and
Zong-Jie Li
School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai 201418, China
*
Author to whom correspondence should be addressed.
Molecules 2019, 24(17), 3092; https://doi.org/10.3390/molecules24173092
Submission received: 10 July 2019 / Revised: 19 August 2019 / Accepted: 19 August 2019 / Published: 26 August 2019
(This article belongs to the Special Issue Phytochemicals in Medicine and Food)
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Abstract

Tartary buckwheat (Fagopyrum tataricum (L.) Gaertn) is rich in functional compounds such as rutin, quercetin, d-chiro-inositol, dietary fiber, and essential amino acids. Electric field (EF) treatment before sprout germination results in physiological and chemical changes, and some alterations might lead to positive applications in plant seeds. MTT assay showed that the effect of total flavonoids on human gastric cancer cell line MGC80-3 was significantly changed after EF treatment for different germination days (3–7 days). Among them, the total flavonoids of tartary buckwheat (BWTF) on the third day had the most obvious inhibitory effect on MGC80-3 (p < 0.01). In addition, flow cytometry evidenced that different ratios of quercetin and rutin had effects on the proliferation of MGC80-3. The same content of quercetin and rutin had the best effect, reaching 6.18 ± 0.82%. The anti-cancer mechanism was mainly promoted by promoting the expression of apoptotic proteins. The expression of Bax/Bcl-2 and caspase-8 in MGC80-3 cells was mediated by BWTFs. This study has good research value for improving the biological and economic value of tartary buckwheat.
Keywords: tartary buckwheat; flavonoids; MGC80-3; flow cytometry; western blot tartary buckwheat; flavonoids; MGC80-3; flow cytometry; western blot

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MDPI and ACS Style

Zhou, X.-L.; Chen, Z.-D.; Zhou, Y.-M.; Shi, R.-H.; Li, Z.-J. The Effect of Tartary Buckwheat Flavonoids in Inhibiting the Proliferation of MGC80-3 Cells during Seed Germination. Molecules 2019, 24, 3092. https://doi.org/10.3390/molecules24173092

AMA Style

Zhou X-L, Chen Z-D, Zhou Y-M, Shi R-H, Li Z-J. The Effect of Tartary Buckwheat Flavonoids in Inhibiting the Proliferation of MGC80-3 Cells during Seed Germination. Molecules. 2019; 24(17):3092. https://doi.org/10.3390/molecules24173092

Chicago/Turabian Style

Zhou, Xiao-Li, Zhi-Dong Chen, Yi-Ming Zhou, Rong-Hua Shi, and Zong-Jie Li. 2019. "The Effect of Tartary Buckwheat Flavonoids in Inhibiting the Proliferation of MGC80-3 Cells during Seed Germination" Molecules 24, no. 17: 3092. https://doi.org/10.3390/molecules24173092

APA Style

Zhou, X.-L., Chen, Z.-D., Zhou, Y.-M., Shi, R.-H., & Li, Z.-J. (2019). The Effect of Tartary Buckwheat Flavonoids in Inhibiting the Proliferation of MGC80-3 Cells during Seed Germination. Molecules, 24(17), 3092. https://doi.org/10.3390/molecules24173092

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