Synthesis of Bioactive Compounds from the Chiral Pool

Dear Colleagues,

Chiral pool synthesis is a well-known and widespread approach for the design and preparation of chiral compounds of biological and pharmacological interest. This particularly important and versatile strategy employs, as starting materials, simple and complex enantiopure compounds readily available from the arsenal of natural sources. The most common components of the chiral pool are monosaccharides and amino acids. The use of these cheap starting materials is of great importance and helpful if the synthetic target compounds display strong similarities to the structure of the enantiopure natural precursors. Moreover, the use of the chiral pool is especially noticeable and fruitful when meandering multistep approaches to enantiopure bioactive compounds may be required. The strategy based on natural sources of chiral compounds is also of great aid in all cases of synthetic procedures characterized by considerable losses in total yields, and when suitable enantiopure scaffolds may be difficult to achieve. The aim of this Special Issue is to gather an inspiring anthology for the dissemination of the most recent acquisitions in the field of design, preparation, and characterization of enantiopure compounds starting from the chiral pool. Reviews, feature articles, and original research papers that focus on new divergent and convergent total syntheses of bioactive natural compounds and their analogues starting from the chiral pool are all welcomed.

Prof. Dr. Carlo Siciliano
Dr. Constantinos M. Athanassopoulos
Guest Editors

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