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Applied Innovative Insights in Selective Organic Hetero-Synthesis

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: 28 February 2026 | Viewed by 305

Special Issue Editors


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Guest Editor
Department of Chemistry, Faculty of Chemistry and Chemical Engineering, University Babes-Bolyai Cluj-Napoca, 11 Aranyi Janos str., 400028 Cluj-Napoca, Romania
Interests: organic chemistry synthesis; heterocyclic chemistry; medicinal and pharmaceutical chemistry; nuclear magnetic resonance; natural product chemistry; organometallics; dendritic chemistry; stereochemistry
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Special Issue Information

Dear Colleagues,

The recent positive impact of our Special Issue “Advances in the Synthesis of Heterocyclic Compounds and their Applications” prompted us to continue in a somewhat more challenging way, addressing the title formulation to those interested in providing the scientific community with one or more contributions to it.

We expect to gather them in the form of research articles and (updated, critical) reviews that move our standard “yesterday approaches”, namely, hetero-ring synthesis and substituent modification (including their combination), through a perspective/visionary update of their meaning in the milieu of the perpetually valid notion of selectivity. Indeed, despite its explicit prefixes chemo-, regio-, diastereo- and enantio-, it still governs, equally, covalent and non-covalent syntheses. For the research articles, experimental research manuscripts should comprise consistent Materials and Methods and Supplementary Materials (additional file) subsections. The correspondence between the contents of the latter two concerning analytical and spectral data must be complete.     

Besides the below proposed eight sub-topics, additional innovative approaches and concepts are also welcome:

  • Selective multicomponent, domino and cascade reactions;
  • Selectivity in smart hetero-molecule elaboration;
  • (Chemo)selectivity in supramolecular hetero-syntheses;
  • Organo-catalytic (hetero)systems inducing stereoselectivity;
  • Current selectivity insights in total synthesis;
  • Selective functional (trans)formations of (bio)organic heterosystems;
  • DFT calculations predicting/explaining selectivity in classic/novel organic hetero-syntheses;
  • Unconventional methods, organic (nano)materials and techniques ensuring highly selective processes.

We hope to be able to provide an overview of the latest groundbreaking advancements in organic hetero-synthesis consisting of (conceptual) strategies, methodologies, reaction mechanisms, reagents, catalysts, chemical, instrumental auxiliaries, etc. The alluring chemical diversity of heterocyclic compounds, which continuously inspires forward-thinking applications to human life and the environment, we see as a summa summarum of contemporary efforts in accessing them.

Prof. Dr. Mircea Darabantu
Prof. Dr. Ionel Mangalagiu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hetarenes
  • hetero-alycycles
  • regioisomerism
  • diastereomerism
  • enantiomerism
  • biomimetics and new chemical entities (NCEs)
  • “intelligent” molecules

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Published Papers

This special issue is now open for submission.
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