Microfluidic Devices for High-Throughput Screening

A special issue of Micromachines (ISSN 2072-666X).

Deadline for manuscript submissions: closed (31 December 2017) | Viewed by 5224

Special Issue Editor


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Guest Editor
Department of Electrical and Computer Engineering, Iowa State University, Ames, IA 50011, USA
Interests: MEMS; lab on a chip; microfluidics; sensors; microoptics and nanophotonics

Special Issue Information

Dear Colleagues,

Microfluidic technology has provided powerful high-throughput screening platforms to simultaneously perform a large number of chemical, genetic, or pharmacological tests, thus allowing rapid identification of chemical compounds, antibodies, and genes responsible for modulation of a particular biomolecular pathway. Many microfluidic devices have shown great potential to aid drug discovery and target validation, and expedite functional genomics and phenomics studies. In particular, some devices have already started to provide researchers and even pharmaceutical industry with an increasing number of molecular targets for therapeutic intervention, thus having increasing academic, social and economic impacts. This Special Issue seeks to contribute to this emergent field by featuring research papers, communications, opinion papers, and review articles from methodological and disciplinary perspectives, focusing on microfluidic devices enabled high throughput assays for biological, chemical, and environmental conditions of single cells and multicellular organisms. Of particular interest is the focus on system automation and miniaturization towards high-throughput approaches to gaining deeper insight into the effects and functions of molecules and the correlation between genomic and phenomic variables.

Prof. Dr. Liang Dong
Guest Editor

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Keywords

  • microfluidics
  • lab on a chip
  • high throughput screening
  • single cells studies
  • multicellular organisms

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Published Papers (1 paper)

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Research

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Article
Numerical Investigation of a Novel Wiring Scheme Enabling Simple and Accurate Impedance Cytometry
by Federica Caselli, Riccardo Reale, Nicola Antonio Nodargi and Paolo Bisegna
Micromachines 2017, 8(9), 283; https://doi.org/10.3390/mi8090283 - 18 Sep 2017
Cited by 12 | Viewed by 4864
Abstract
Microfluidic impedance cytometry is a label-free approach for high-throughput analysis of particles and cells. It is based on the characterization of the dielectric properties of single particles as they flow through a microchannel with integrated electrodes. However, the measured signal depends not only [...] Read more.
Microfluidic impedance cytometry is a label-free approach for high-throughput analysis of particles and cells. It is based on the characterization of the dielectric properties of single particles as they flow through a microchannel with integrated electrodes. However, the measured signal depends not only on the intrinsic particle properties, but also on the particle trajectory through the measuring region, thus challenging the resolution and accuracy of the technique. In this work we show via simulation that this issue can be overcome without resorting to particle focusing, by means of a straightforward modification of the wiring scheme for the most typical and widely used microfluidic impedance chip. Full article
(This article belongs to the Special Issue Microfluidic Devices for High-Throughput Screening)
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