Development of Micro/Nano-Systems for Cell Manipulation/Analyses

A Special Issue of Micromachines (ISSN 2072-666X) belonging to the section "B:Biology and Biomedicine".

Deadline for manuscript submissions: 31 December 2026 | Viewed by 996

Editor


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Guest Editor
Department of Mechanical Engineering, Setsunan University, Osaka 572-8508, Japan
Interests: MEMS; nano/micro devices; microrobots; cyborgs; medical-engineering collaboration

Special Issue Information

Dear Colleagues,

Research focused on cell manipulation and analysis is gaining attention. Establishing nano- and micro-scale processing technologies is essential for manipulating micro-scale objects. Furthermore, the construction of high-resolution mechatronics-based systems is also necessary. We invite you to contribute to our Special Issue, entitled “Development of Micro/Nano-Systems for Cell Manipulation/Analyses”. This Special Issue solicits cutting-edge mechatronics research that will contribute to biochemical applications. We also welcome research results that analyze cells using small devices. In this Special Issue, original research articles and reviews are welcome. Research areas may include (but not limited to) the following:

(1) Research on mechatronics-based cell manipulation and micromanipulation: robotic arms, microfluidic devices, and support systems for their operation;

(2) Microfluidic devices: Design and structural optimization, simulation-based design theory, cell traps, particle separation;

(3) Cell analysis: Observation of the culture process, quantitative analysis, single-cell analysis;

(4) Other applications: Bio-MEMS, cell characterization, microfabrication of biocompatible materials.

We look forward to receiving your contributions.

Dr. Mitsuhiro Horade
Guest Editor

Manuscript Submission Information

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Keywords

  • microfluidic devices
  • microrobots
  • micromanipulation
  • cell manipulation
  • cell sorting
  • cell analysis
  • cell stress testing
  • single-cell analysis
  • bio-MEMS
  • micro-TAS

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Published Papers (1 paper)

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Research

20 pages, 12167 KB  
Article
Red Blood Cell Deformability in Microfluidic Constrictions Under Flow and Wall Contact
by Keigo Nonomura, Mitsuhiro Horade, Yuta Shirasaka, Shuichi Murakami, Hiroaki Ito and Kenichiro Yoshitomi
Micromachines 2026, 17(6), 670; https://doi.org/10.3390/mi17060670 - 28 May 2026
Viewed by 694
Abstract
Microfluidic devices are widely used for cell manipulation, but the effects of physical contact between cells and microchannel walls are not well understood. This study examines how such contact influences the behaviour of red blood cells (RBCs) during controlled manipulation. RBCs were driven [...] Read more.
Microfluidic devices are widely used for cell manipulation, but the effects of physical contact between cells and microchannel walls are not well understood. This study examines how such contact influences the behaviour of red blood cells (RBCs) during controlled manipulation. RBCs were driven through a narrow microchannel constriction (3.6 × 3.0 µm in cross-section and 2500 µm in length), enabling precise application of mechanical load. A pump system allowed accurate control of flow conditions, ranging from complete immobilisation to defined shear stress by adjusting flow rates. Under immobilised conditions, the recovery time constant of RBCs increased with longer loading durations, consistent with previous studies. However, when shear stress was introduced, recovery dynamics changed significantly. Notably, a 30-fold difference in recovery time constant was observed between a 5 s immobilisation and a 5 s load applied at a flow speed of 0.5 mm/s. Furthermore, the rapid elastic recovery typically occurring within approximately 0.1 s after unloading was suppressed under flow conditions. These results demonstrate that viscous interactions between channel walls and surrounding fluid play a critical role in determining cellular responses during microfluidic manipulation. Full article
(This article belongs to the Special Issue Development of Micro/Nano-Systems for Cell Manipulation/Analyses)
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