Interplay Between Metabolism, Oxidative Stress, and Cellular Signaling in Health and Disease
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Lipid Metabolism".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 23
Special Issue Editors
Interests: biochemistry; tumor metabolism; lipid metabolism
Interests: S-adenosylmethionine; cancer; epigenetics; miRNA
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The close relationship between metabolism, oxidative stress, and cellular signaling has been widely demonstrated in the literature. ROS produced during oxidative metabolism by the mitochondria act as secondary messengers. Based on this, the main mitochondrial fuels also act as regulators of cellular signaling through the production of ROS, as well as catabolites. From this perspective, lipids, necessarily catabolized into mitochondria, are crucial in regulating ROS production and contribute to activating downstream responses, including transcriptional factor activation (e.g., the PPAR family) and DNA damage promotion. Consequently, the cell's antioxidant resources also fall into this type of relationship, regulating intracellular ROS levels and buffering oxidative stress. This means that the signaling generated by the activation of certain pathways can be different depending on the cell type. Moreover, knowing the type of response that is determined in a given system can be of fundamental importance from the perspective of treatment, for example, in the case of tumors. Several cancer treatments induce ROS production in order to exceed the tolerance threshold and determine tumoral cell death. Therefore, in this Special Issue, the interplay between metabolism, oxidative stress, and cellular signaling will be considered from different perspectives, taking into account both health and disease conditions.
Dr. Serena Castelli
Dr. Laura Mosca
Guest Editors
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Keywords
- oxidative stress
- metabolism
- cellular signaling
- lipid metabolism
- ROS
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