Interplay Between Metabolism, Oxidative Stress, and Cellular Signaling in Health and Disease

Dear Colleagues,

The close relationship between metabolism, oxidative stress, and cellular signaling has been widely demonstrated in the literature. ROS produced during oxidative metabolism by the mitochondria act as secondary messengers. Based on this, the main mitochondrial fuels also act as regulators of cellular signaling through the production of ROS, as well as catabolites. From this perspective, lipids, necessarily catabolized into mitochondria, are crucial in regulating ROS production and contribute to activating downstream responses, including transcriptional factor activation (e.g., the PPAR family) and DNA damage promotion. Consequently, the cell's antioxidant resources also fall into this type of relationship, regulating intracellular ROS levels and buffering oxidative stress. This means that the signaling generated by the activation of certain pathways can be different depending on the cell type. Moreover, knowing the type of response that is determined in a given system can be of fundamental importance from the perspective of treatment, for example, in the case of tumors. Several cancer treatments induce ROS production in order to exceed the tolerance threshold and determine tumoral cell death. Therefore, in this Special Issue, the interplay between metabolism, oxidative stress, and cellular signaling will be considered from different perspectives, taking into account both health and disease conditions.

Dr. Serena Castelli
Dr. Laura Mosca
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.