Signaling Pathways' Interplay and Crosstalk with Metabolism in Human Disease
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Cell Metabolism".
Deadline for manuscript submissions: 15 June 2026 | Viewed by 64
Special Issue Editors
Interests: cancer; breast cancer; signaling; metabolism; bioinformatics; machine learning
2. Department of Molecular Biology and Genetics, Boğaziçi University, North Campus, Kuzey Park Building, 310, Bebek, Istanbul 34342, Türkiye
Interests: cancer; mass spectrometry imaging (DESI-MSI); spatial multi-omics; patient-derived organoid models; precision medicine
Special Issue Information
Dear Colleagues,
The central role of cellular metabolism in the regulation of human physiology and disease has long been recognized. Despite this, our understanding of how metabolic rewiring evolves during the development and progression of human diseases is still incomplete. This metabolic rewiring lies under the strong influence of diverse signaling pathways that are often driven by the emergence of unique disease-related events and heterogeneity. For example, the mutation of specific oncogenes or tumor suppressor genes is strongly associated with metabolic alterations in human cancers. Vice versa, metabolites themselves can influence the activation of multiple signaling pathways and downstream transcriptional programs. Principal examples of this are diabetes and obesity, where metabolic alterations lead to the activation of pathogenic cellular signaling. These observations in aggregate suggest that there is a continuous interplay between cellular signaling and metabolism across tissues and disease stages. Accordingly, more studies are urgently needed to uncover the relationship between these two important and interconnected cellular processes using integrative and systems-level approaches. A better understanding of the signaling–metabolism interplay will undoubtedly lead to the development of new therapies to treat human diseases and improve precision medicine strategies.
This Special Issue is devoted to the reciprocal regulation of signaling and metabolic pathways that underlie human diseases, including but not limited to diabetes, obesity and cancer at a bulk, single-cell, and spatial resolution. Studies using artificial intelligence systems or bioinformatic approaches for multi-omics integration to reveal the crosstalk between signaling and metabolism are particularly relevant to this Special Issue.
Dr. Theodoros Karalis
Dr. Emine Kazanc
Prof. Dr. Karsten Hiller
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- human disease
- obesity
- diabetes
- cancer
- signaling
- metabolism
- metabolic rewiring
- omics
- precision medicine
- bioinformatics
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
