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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Prognosis and Management of Dry Eye Disease

edited by

Hugo Pena-Verdeal

Alena Furdova

and

Jacobo Garcia-Queiruga

submission deadline 31 Jul 2025 | 2 articles | Viewed by 3624 | Submission Open

Keywords: dry eye disease; dry eye epidemiology; dry eye management; dry eye natural course; meibomian gland dysfunction; evaporative dry eye; aqueous deficiency dry eye; artificial tear substitutes; tear film lipid layer; meibomian glands

(This special issue belongs to the Section Medical Research)

Skin Cancer: From Molecular Basis to Therapy: 2nd Edition

edited by

Alvise Sernicola

submission deadline 31 Jul 2025 | 2 articles | Viewed by 2071 | Submission Open

Keywords: nonmelanoma skin cancer; melanoma; cutaneous lymphoma; Kaposi sarcoma; skin-directed therapy; carcinogenesis; UV radiation; tumor predisposition syndrome

(This special issue belongs to the Section Medical Research)

Inflammation and Natural Products: 2nd Edition

edited by

Azahara Rodríguez-Luna

Salvador González

and Irene García Domínguez

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1309 | Submission Open

Keywords: natural products; inflammation; biological activity; anti-inflammatory activity; antioxidant activity; anticancer potential; terrestrial products; marine products; phytochemistry; pharmacology

(This special issue belongs to the Section Pharmaceutical Science)

Updates on Respiratory Pathologies

edited by

Mieczyslaw Pokorski

submission deadline 31 Jul 2025 | 2 articles | Viewed by 1245 | Submission Open

Keywords: respiratory disorders; chronic obstructive pulmonary disease; respiratory tract infection; pulmonary clinical treatment

(This special issue belongs to the Section Physiology and Pathology)

Gastrointestinal Diseases: Innovations in Diagnostics, Therapeutics, and Prognosis

edited by Ľudovít Danihel

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1116 | Submission Open

Keywords: diagnostics; therapeutics; gastrointestinal diseases; artificial intelligence; clinical cases

(This special issue belongs to the Section Medical Research)

Recent Advances in Lymphomas

edited by Magdalena Witkowska

submission deadline 31 Jul 2025 | 1 articles | Viewed by 777 | Submission Open

Keywords: lymphoma; cellular therapy; epigenetics; immunotherapy; targeted therapies

(This special issue belongs to the Section Medical Research)

Structure, Activity, and Function of Protein Methyltransferases: 2nd Edition

edited by

Albert Jeltsch

and

Arunkumar Dhayalan

submission deadline 31 Jul 2025 | Viewed by 516 | Submission Open

(This special issue belongs to the Section Proteins and Proteomics)

Novel Therapies for Chronic Inflammatory Diseases and Autoimmune Diseases

edited by

Emina Karahmet Sher

submission deadline 31 Jul 2025 | 1 articles | Viewed by 494 | Submission Open

Keywords: chronic inflammatory diseases; autoimmune diseases; biomarker identification; innovative biologics; small-molecule inhibitors; gene editing technologies; cell-based therapeutics

(This special issue belongs to the Section Medical Research)

Minimally Invasive Neuroendoscopy

edited by Stefan Linsler

submission deadline 31 Jul 2025 | Viewed by 478 | Submission Open

Keywords: spinal neuroendoscopy; spine and brain surgery; endonasal endoscopic skull base surgery; intraventricular neuroendoscopy

(This special issue belongs to the Section Medical Research)

Advances in Wildlife Behavior and Biodiversity

edited by

Katarzyna Tajchman

and

Pawel Janiszewski

submission deadline 31 Jul 2025 | 1 articles | Viewed by 351 | Submission Open

Keywords: behavioral abnormalities; the ability to exhibit natural behavior; reduced genetic diversity; habitat loss; extinction of species; species rehousing; coexistence

(This special issue belongs to the Section Diversity and Ecology)

Biomarker Analysis for Sports Performance and Health

edited by

Domenico Martone

Johnny Padulo

and

Luca Paolo Ardigò

submission deadline 31 Jul 2025 | Viewed by 314 | Submission Open

Keywords: exercise physiology; bioenergetics; biology; human locomotion; performance analysis; sports sciences; training optimization

(This special issue belongs to the Section Physiology and Pathology)

Musculoskeletal Imaging: Innovations in Diagnostics and Interventional Therapies

edited by

Paolo Spinnato

submission deadline 31 Jul 2025 | Viewed by 225 | Submission Open

Keywords: magnetic resonance imaging; bone and bones; computed tomography; sarcoma; interventional radiology

(This special issue belongs to the Section Medical Research)

Pathological and Clinical Updates on Eye Diseases

edited by Pier Luigi Surico and

Rohan Bir Singh

submission deadline 31 Jul 2025 | Viewed by 210 | Submission Open

Keywords: ophthalmology; eye diseases; gene therapy; ocular surface; ocular immunology; cornea

(This special issue belongs to the Section Medical Research)

Organ Predilection of Certain Gastrointestinal Diseases—Pathophysiology, Diagnosis and Management

edited by

Monjur Ahmed

submission deadline 31 Jul 2025 | Viewed by 162 | Submission Open

Keywords: disease predilection in gastrointestinal tract; esophagus with certain diseases; stomach with certain diseases; duodenum with certain diseases; jejunum with certain diseases; ileum with certain diseases; colorectum with certain diseases

(This special issue belongs to the Section Physiology and Pathology)

Gynecological Cancer: Etiologic, Diagnostic, Prognostic, and Therapeutic Research

edited by

Violante Di Donato

and

Tullio Golia D’Augè

submission deadline 31 Jul 2025 | Viewed by 143 | Submission Open

Keywords: gynecological cancer; chemotherapy in gynecological cancers; radiation therapy in gynecological oncology; gynecological cancer biomarkers; cancer prevention; gynecological cancer immunotherapy

(This special issue belongs to the Section Medical Research)

Gene Editing of Large Mammals: 2nd Edition

edited by

Zhengxing Lian

Xuguang Du

and

Shou-Long Deng

submission deadline 1 Aug 2025 | Viewed by 104 | Submission Open

Keywords: gene editing; large mammals; molecular breeding; application prospect

(This special issue belongs to the Section Animal Science)

Current Trends in Obstructive Sleep Apnea

edited by Kimberly A. Hardin

submission deadline 15 Aug 2025 | Viewed by 263 | Submission Open

Keywords: obstructive sleep apnea ; diagnosis and biomarkers ; personalized treatment strategies ; clinical phenotypes ; innovative therapies

(This special issue belongs to the Section Medical Research)

Natural Bioactives: Exploring Their Therapeutic Potential—2nd Edition

edited by

Dagmara Wróbel-Biedrawa

submission deadline 20 Aug 2025 | Viewed by 145 | Submission Open

Keywords: bioactive compounds; medicinal plants; bioactive metabolites with antioxidant properties; anti-inflammatory properties; antitumor properties; cytotoxic properties; antipsychotic properties; anxiolytic properties; neuroprotective properties; hypotensive properties; vasorelaxant properties; antimicrobial properties (antiviral; antibacterial; antifungal; and antiparasitic properties)

(This special issue belongs to the Section Pharmaceutical Science)

Environmental Stress and Adaptation: Molecular Mechanisms and Ecosystems Biodiversity

edited by

Mizanur Rahman

and

Takashi Asaeda

submission deadline 21 Aug 2025 | Viewed by 263 | Submission Open

Keywords: abiotic oxidative stress; aquatic biodiversity monitoring; reactive oxygen species; riparian and mangrove vegetation management; environmental DNA (eDNA) metabarcoding

(This special issue belongs to the Section Diversity and Ecology)

New Insights Into Artificial Intelligence in Medical Imaging

edited by

Luigi La Via

Antonino Maniaci

Caterina Gagliano

and Salvatore Lavalle

submission deadline 22 Aug 2025 | 2 articles | Viewed by 6647 | Submission Open

Keywords: artificial intelligence; machine learning; deep learning; image analysis; precision medicine; image-guided interventions; decision support systems

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Advances in Endovascular Therapies and Acute Stroke Management

edited by

Anna Podlasek

submission deadline 25 Aug 2025 | 1 articles | Viewed by 584 | Submission Open

Keywords: mechanical thrombectomy; endovascular reperfusion; stroke intervention technologies; acute ischemic stroke treatment; stroke imaging biomarkers

(This special issue belongs to the Section Medical Research)

Applications of Molecular Dynamics to Biological Systems

edited by

Ron Elber

submission deadline 26 Aug 2025 | 2 articles | Viewed by 1363 | Submission Open

Keywords: computer simulation; biophysical modeling; molecular dynamics

(This special issue belongs to the Section Biochemistry, Biophysics and Computational Biology)

Hand Soft Tissue Disorders: Mechanisms and Therapeutic Advances

edited by Ishith Seth

submission deadline 26 Aug 2025 | 1 articles | Viewed by 800 | Submission Open

Keywords: dupuytren’ s disease; hand soft tissue disorders; genomics; biomarkers; artificial intelligence

(This special issue belongs to the Section Medical Research)

Pharmacology, Diagnosis and Treatments of Psychiatric Diseases

edited by Giuseppe Marano and

Marianna Mazza

submission deadline 26 Aug 2025 | Viewed by 244 | Submission Open

Keywords: mental health disorders; clinical psychology; psychopharmacology; treatment efficacy; neuroimaging techniques; personalized medicine; diagnosis

(This special issue belongs to the Section Medical Research)

Emerging Applications of Nanobiotechnology in Medicine and Health

edited by Roshanak Khandanlou

submission deadline 28 Aug 2025 | Viewed by 152 | Submission Open

Keywords: nanobiotechnology; targeted drug-delivery; tissue engineering; cancer treatment; regenerative medicine; medical applications

(This special issue belongs to the Section Medical Research)

Cystic Fibrosis: A Disease with a New Face

edited by

Janice Wang

and Patricia A. Walker

submission deadline 29 Aug 2025 | 11 articles | Viewed by 30296 | Submission Open

Keywords: cystic fibrosis; CFTR modulator; CF newborn screening; CF nutrition; lung transplant in CF; CF family planning

(This special issue belongs to the Section Medical Research)

Applications of Dermatoscopy in Skin Diseases

edited by

Paweł Pietkiewicz

Enzo Errichetti

and

Cristian Navarrete

submission deadline 29 Aug 2025 | 5 articles | Viewed by 28537 | Submission Open

Keywords: melanoma; skin cancer; inflammoscopy; trichoscopy; ultraviolet reflectance dermatoscopy; skin of colour; basal cell carcinoma; squamous cell carcinoma; nevus; digital dermoscopy

(This special issue belongs to the Section Medical Research)

Elements Cycling and Plants’ Physiological Characteristics: A Soil–Plant–Atmosphere Continuum Perspective

edited by

Ling Zhang

and

Zhi Li

submission deadline 29 Aug 2025 | 7 articles | Viewed by 12424 | Submission Open

Keywords: element cycling; microbial communities; plant nutrition; plant physiology; plant biochemistry; atmospheric composition; climate change; soil– plant– atmosphere interaction; plant– soil feedback

(This special issue belongs to the Section Plant Science)

Back to Basics in Palaeontology

edited by Hua Stephane

submission deadline 29 Aug 2025 | 6 articles | Viewed by 11692 | Submission Open

Keywords: fundamentals; natural history; multidisciplinarity; first hand bibliography; actualism

(This special issue belongs to the Section Paleobiology)

Nutritional Supplementation, Body Composition and Performance in Athletes

edited by

Bojan Knap

submission deadline 29 Aug 2025 | 2 articles | Viewed by 8644 | Submission Open

Keywords: optimal macro and micronutrients in exercise; plant-based food in sports nutrition; beetroot as ergogenic aid; body mass composition and nutrition practice; phase angle as VO2 max predictor; RED syndrome low and high energetic availability in sports praxis

(This special issue belongs to the Section Physiology and Pathology)

The Emerging Role of Microbiota in Health and Diseases

edited by Edyta Juszczuk-Kubiak and Katarzyna Góralska

submission deadline 29 Aug 2025 | 2 articles | Viewed by 5413 | Submission Open

Keywords: microbiota; eubiosis; dysbiosis; microbiota– host interaction; microbiota– gut– brain axis; microbiome; bacteria– fungi interactions; microbiota modification; holobiont; cross-feeding; microbiota related diseases; microbiota functions

(This special issue belongs to the Section Microbiology)

Current Progress in Medical Image Segmentation

edited by

Krishna Chaitanya

submission deadline 29 Aug 2025 | 4 articles | Viewed by 5401 | Submission Open

Keywords: medical image segmentation; deep learning; generative models; algorithm; clinical integration; biological variability; transformer architectures; interactive segmentation; interdisciplinary collaboration

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Clinical and Laboratory Advancements and Challenges in Medically Assisted Reproduction

edited by

Alessandra Alteri

and Valeria Stella Vanni

submission deadline 29 Aug 2025 | 2 articles | Viewed by 4143 | Submission Open

Keywords: medically assisted reproduction; assisted reproduction technologies; clinical embryology; genetic testing; ovarian stimulation; male factor; endometriosis; endometrial receptivity; implantation

(This special issue belongs to the Section Reproductive and Developmental Biology)

Diagnosis and Management of Microbial Infections

edited by

Iulia-Cristina Bagiu

submission deadline 29 Aug 2025 | 3 articles | Viewed by 3237 | Submission Open

Keywords: microbiology; infection; germs; antimicrobial agents; antimicrobial therapy

(This special issue belongs to the Section Microbiology)

Personalized Medicine in Ophthalmic Diseases: Updated Challenges and Opportunities

edited by

Camelia Margareta Bogdanici

submission deadline 29 Aug 2025 | 3 articles | Viewed by 3207 | Submission Open

Keywords: vision-related quality of life; personalized medicine; artificial intelligence; ophthalmology and nutrition; optical coherence tomography; ocular surface diseases; retinal vascular diseases

(This special issue belongs to the Section Medical Research)

Bone Cancer: From Molecular Mechanism to Treatment

edited by

Chih-Yang Lin

and Syuan-Ling Lin

submission deadline 29 Aug 2025 | 2 articles | Viewed by 2483 | Submission Open

Keywords: bone cancer; metastasis; angiogenesis; targeted drugs; biomarkers

(This special issue belongs to the Section Medical Research)

Precision Medicine in Cardiovascular Diseases

edited by Brian Xiangzhi Wang

submission deadline 29 Aug 2025 | 1 articles | Viewed by 2101 | Submission Open

Keywords: genomic; cardiovascular disease; congenital; multi-omics studies; precision medicine; personalized medicine; biomarker

(This special issue belongs to the Section Genetics and Genomics)

Gynecological Endocrinology: From Physiological Mechanisms to Clinical Practice

edited by Ralitsa Robeva

submission deadline 29 Aug 2025 | 2 articles | Viewed by 1971 | Submission Open

Keywords: PCOS; hypothalamic amenorrhea; congenital adrenal hyperplasia; hypogonadotropic hypogonadism; premature ovarian insufficiency (POI)

(This special issue belongs to the Section Physiology and Pathology)

Current Research on Dermatology: Pathology, Clinical Manifestation, Investigation and Therapy—Third Edition

edited by

Alin Laurentiu Tatu

submission deadline 29 Aug 2025 | 1 articles | Viewed by 919 | Submission Open

Keywords: Demodex; endosymbionts; cutaneous microbiome; integrative medicine; optical coherence tomography; dermoscopy; confocal microscopy; cutaneous comorbidities keyword; inflammatory diseases; hair; skin cancer; comorbidities; skin surgery

(This special issue belongs to the Section Physiology and Pathology)

Channel Proteins and Transporters in Human Health and Disease

edited by

Giorgia Scarpellino

Giorgia Chinigò

and

Roberta De Zio

submission deadline 29 Aug 2025 | Viewed by 894 | Submission Open

Keywords: channel proteins; transporters; ion channel

(This special issue belongs to the Section Proteins and Proteomics)

Kidney Transplantation: What’s Hot and What’s New—2nd Edition

edited by

Giuseppe Ietto

and Caterina Di Bella

submission deadline 29 Aug 2025 | 1 articles | Viewed by 873 | Submission Open

Keywords: kidney transplantation; immunosuppression; graft quality; machine perfusion (MP); living-donor kidney transplantation

(This special issue belongs to the Section Medical Research)

Microbiota Metabolism and Gut Health in Swine

edited by

Yu Pi

submission deadline 29 Aug 2025 | Viewed by 167 | Submission Open

Keywords: gut microbiota; swine health; microbial metabolites; nutrient absorption; immune response; metagenomics; antibiotic alternatives; swine production

(This special issue belongs to the Section Microbiology)

Image Analysis and Postprocessing in Medical Imaging

edited by

Federico Bruno

submission deadline 29 Aug 2025 | Viewed by 162 | Submission Open

Keywords: quantitative imaging biomarkers; image segmentation; artificial intelligence in radiology; image postprocessing

(This special issue belongs to the Section Medical Research)

Disparities in Cancer Treatment

edited by Adam Barsouk

submission deadline 29 Aug 2025 | Viewed by 104 | Submission Open

Keywords: disparities; mortality; survival; race; sex; age; developing nations; public health; prevention

(This special issue belongs to the Section Epidemiology)

Hansen's Disease—Epidemiology, Diagnosis, Treatment and Complications

edited by Karen Olshtain-Pops

submission deadline 30 Aug 2025 | 1 articles | Viewed by 2614 | Submission Open

Keywords: hansen's disease; leprosy; Mycobacterium leprae

(This special issue belongs to the Section Epidemiology)

Animal Nutritional Physiology: Effects of Feed Additives on Livestock Products

edited by

Anna Arczewska-Włosek

and Katarzyna Poltowicz

submission deadline 30 Aug 2025 | Viewed by 708 | Submission Open

Keywords: feed additives; animal health; animal performance; animal-derived products; animal nutritional physiology

(This special issue belongs to the Section Physiology and Pathology)

Latest Updates on Clinical Microbiology and Antimicrobial Resistant Infection

edited by Jun Sung Hong

submission deadline 30 Aug 2025 | 1 articles | Viewed by 697 | Submission Open

Keywords: enterobacteriaceae; antimicrobial resistance; infection; health

(This special issue belongs to the Section Microbiology)

Microorganisms Engineering and Gene-Editing Methods

edited by

Jichao Wang

Guang Zhao

and Xia Zhao

submission deadline 30 Aug 2025 | Viewed by 245 | Submission Open

Keywords: microorganisms engineering; metabolic engineering; strain optimization; gene editing; CRISPR; recombination

(This special issue belongs to the Section Genetics and Genomics)

Feature Papers in Medical Research: 3rd Edition

edited by

Christian Lehmann

submission deadline 31 Aug 2025 | 13 articles | Viewed by 14598 | Submission Open

Keywords: dermatological research; cancer research; cardiovascular research; general medicine; gastroenterological research; hematological research; immunological research; infectious diseases research; metabolism and endocrinology; nervous system research; nursing; pediatrics; pulmonary research; psychiatric research; rehabilitation; renal and urinary research; reproductive research and women's health; rheumatological research; skeletal and muscular research; vision research

(This special issue belongs to the Section Medical Research)

Recent Advances in Crop Genetics and Breeding

edited by

Tianxiao Chen

Xiangjin Wei

Baohua Feng

and Long Chen

submission deadline 31 Aug 2025 | 3 articles | Viewed by 3330 | Submission Open

Keywords: crop; high-throughput genotyping; genetic resources; favorable haplotype; marker-assisted selection; genome editing; CRISPR-Cas9; genomic selection

(This special issue belongs to the Section Plant Science)

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