Special Issues

Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Effects of Exercise Training on Muscle Function
edited by Marco Duca and
submission deadline 26 May 2025 | 7 articles | Viewed by 16768 | Submission Open
Keywords: exercise; training; muscle function; resistance training; HIIT
(This special issue belongs to the Section Physiology and Pathology)
Conservative Management of Chronic Disease
edited by
submission deadline 26 May 2025 | 5 articles | Viewed by 14826 | Submission Open
Keywords: chronic disease  ; conservative management; trial protocol; clinical research; interventions
(This special issue belongs to the Section Medical Research)
Feature Papers in Synthetic Biology and Systems Biology 2024
edited by
submission deadline 26 May 2025 | 1 articles | Viewed by 1017 | Submission Open
Keywords: design and construction of synthetic biological systems; innovations in the creation of synthetic organisms; genetic circuits; and biomolecular devices; bottom-up synthetic biology; cell-free synthetic biology; tissue engineering and organoids; bioorthogonal parts; devices; systems; microcompartmentalized systems with soft or hard interfaces; theoretical considerations about synthetic biology; synthetic biology intersection with systems chemistry and bioorganic chemistry; computational modeling and simulation of biological processes; advances in computational tools and models that enhance our understanding of biological processes and systems; metabolic engineering and synthetic pathways; development of novel approaches for the production of biofuels; pharmaceuticals; and other valuable compounds; synthetic biology for approaching evolutionary problems; artificial evolution and in vitro evolution; optogenetics and related techniques; gene editing technologies; applications; and developments; education in synthetic and systems biology; cutting-edge techniques and applications of CRISPR and other gene editing tools; systems biology approaches to understanding complex biological networks; mathematical aspects of systems biology approaches; artificial photosynthesis; applications of synthetic biology in medicine; agriculture; and industry; practical applications of synthetic and systems biology in various sectors; including healthcare; agriculture; and industrial biotechnology; ethical; legal; and social implications of synthetic and systems biology; exploration of the broader implications of advancements in synthetic and systems biology; including ethical considerations and regulatory challenges and social implications
(This special issue belongs to the Section Synthetic Biology and Systems Biology)
New Updates in Adipocytes and Adipose Tissue: 2nd Edition submission deadline 30 May 2025 | 5 articles | Viewed by 18382 | Submission Open
Keywords: adipose tissue; obesity; inflammation; thermogenesis; adipokines; insulin resistance
(This special issue belongs to the Section Physiology and Pathology)
Interdisciplinary Approach to Diabetes Mellitus: From Pathophysiology to Diagnosis and Therapeutic Challenges submission deadline 30 May 2025 | 8 articles | Viewed by 16248 | Submission Open
Keywords: cardiovascular disease; hyperlipidemia; neuropathy; nephropathy; retinopathy; skin conditions; impaired wound healing; hearing impairment; psychological effects; epigenetic imprinting; molecular profiling; biomarkers; targeted therapy; glucose control; conventional and complementary approaches; stem cell damage; vascular damage and regeneration; diabetes complications
(This special issue belongs to the Section Physiology and Pathology)
Bioactive Natural Compounds: Therapeutic Insights and Applications
edited by Vaidotas Žvikas
submission deadline 30 May 2025 | 7 articles | Viewed by 11202 | Submission Open
Keywords: medicinal plants; bioactive compounds; plant extracts; phytochemicals; analytical method validation
(This special issue belongs to the Section Pharmaceutical Science)
Fish Nutrition, Production, and Welfare
edited by Liviu-Dan Miron, , and
submission deadline 30 May 2025 | 4 articles | Viewed by 9538 | Submission Open
Keywords: aquaculture; fish nutrition; fish welfare; water quality; fish disease; feed additives; rearing systems; modern feeding technologies; waste management
(This special issue belongs to the Section Animal Science)
Applications of EEG in Neural Rehabilitation: 2nd Edition submission deadline 30 May 2025 | 2 articles | Viewed by 6425 | Submission Open
Keywords: neurorehabilitation; neuroplasticity; EEG; ERPs; qEEG; EEG mediated patient-therapist interaction; BCI; exoskeleton; cognitive rehabilitation; brain rewiring
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
Pain Management and Related Complications in the Orthopedics and Neurology
edited by Danilo Donati and
submission deadline 30 May 2025 | 1 articles | Viewed by 3484 | Submission Open
Keywords: pain management of the upper and lower limb; pain management of the spine; orthopaedic rehabilitation; prevention of fall risks prevention and management infections; muscle; tendon; and joint diseases; neurological impacts on musculoskeletal health
(This special issue belongs to the Section Physiology and Pathology)
Human Infertility and Reproductive Endocrinology: 2nd Edition
edited by
submission deadline 30 May 2025 | 2 articles | Viewed by 3195 | Submission Open
Keywords: infertility; reproduction; reproductive endocrinology; male infertility; female infertility
(This special issue belongs to the Section Reproductive and Developmental Biology)
Strategies for Enchancing the Production in Plant
edited by , , Jie Huang and Xixi Liu
submission deadline 30 May 2025 | 2 articles | Viewed by 1678 | Submission Open
Keywords: genetic improvement; biostimulants; nutrient management; synthetic biology
(This special issue belongs to the Section Plant Science)
Diagnostic Imaging in Colorectal Cancer
edited by and Chiara Zanon
submission deadline 30 May 2025 | 1 articles | Viewed by 1588 | Submission Open
Keywords: colorectal cancer; artificial intelligence; texture analysis; ultrasound; magnetic resonance imaging; PET/MRI
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
Advances in Vascular Health and Metabolism
edited by Ana Blazquez-Medela
submission deadline 30 May 2025 | 2 articles | Viewed by 1055 | Submission Open
Keywords: cardiovascular; cardiometabolic disease; adipogenesis; atherosclerosis; obesity; overweight; peripheral artery disease
(This special issue belongs to the Section Medical Research)
Molecular Biomarkers in Inflammatory Disease
edited by Stelvio Tonello
submission deadline 30 May 2025 | 1 articles | Viewed by 785 | Submission Open
Keywords: cytokines; chemokines; and immune mediators as pharmacodynamic biomarkers; genomic and epigenomic contributions to drug response variability; proteomic and metabolomic profiling to guide pharmacotherapy in inflammation; biomarker-driven strategies for drug development and personalized treatment; mechanistic studies on drug– biomarker interactions and their clinical relevance; novel biomarkers for predicting adverse drug reactions in inflammatory diseases
(This special issue belongs to the Section Medical Research)
Role of Mitochondria in the Pathophysiology of Cardiovascular Diseases
edited by Yuriana Oropeza-Almazán and Héctor Chapoy-Villanueva
submission deadline 30 May 2025 | Viewed by 487 | Submission Open
Keywords: cardiovascular diseases (CVDs); mitochondria; mitochondrial dysfunction; ATP production; mitochondrial fission; mitochondrial fusion; electron transport chain; oxidative phosphorylation; mitophagy; cardiac hypertrophy; myocardial infarction; IR injury; mitochondrial ROS; ROS signaling; ion homeostasis; cardiac arrhythmias
(This special issue belongs to the Section Physiology and Pathology)
Advances in Knee Osteoarthritis and Photobiomodulation Therapy submission deadline 30 May 2025 | Viewed by 314 | Submission Open
Keywords: knee osteoarthritis; light-emitting diode therapy; low-level laser therapy; high-intensity laser therapy; photobiomodulation therapy
(This special issue belongs to the Section Medical Research)
Sustainable Agroforestry: Molecular Strategies for Integrated Pest and Disease Management
edited by Gothandapani Sellamuthu and Kanakachari Mogilicherla
submission deadline 30 May 2025 | Viewed by 211 | Submission Open
Keywords: sustainable agroforestry; integrated pest management; genomics; transcriptomics; CRISPR technology; RNAi; plant– microbe interactions; biopesticides
(This special issue belongs to the Section Plant Science)
Cancer Genomics and Transcriptomics: Uncovering New Frontiers in Tumor Biology
edited by and Panagiotis Tsiakanikas
submission deadline 30 May 2025 | Viewed by 187 | Submission Open
Keywords: transcriptomic profiling; tumor heterogeneity; integrative omics; non-coding RNAs; oncogenes
(This special issue belongs to the Section Genetics and Genomics)
Vision Science and Optometry submission deadline 31 May 2025 | 15 articles | Viewed by 13966 | Submission Open
Keywords: clinical optometry; eye movements and binocular vision; aberrometry; accommodation; color vision; anterior and posterior poles; circadian light
(This special issue belongs to the Section Medical Research)
Pediatric Ophthalmic Pathology—Integrating Clinical and Basic Research
edited by and Brenda L. Bohnsack
submission deadline 31 May 2025 | 2 articles | Viewed by 1339 | Submission Open
Keywords: congenital eye anomalies; anterior segment disorders; genetic eye disorders; pediatric eye conditions; pediatric ophthalmology
(This special issue belongs to the Section Physiology and Pathology)
Atherosclerosis: Pathogenesis, Clinical Advances and Future Perspectives submission deadline 31 May 2025 | 1 articles | Viewed by 1206 | Submission Open
Keywords: atherosclerosis; cardiovascular risk; hypercholesterolemia; hypertension; inflammation; cardiovascular prevention
(This special issue belongs to the Section Medical Research)
Exploring Enteric Glia: Implications for Gastrointestinal and Systemic Disorders
edited by Vladimir Grubišić
submission deadline 31 May 2025 | Viewed by 925 | Submission Open
Keywords: gut– brain axis; gut– liver axis; gut– pancreas axis; intestinal epithelial barrier function; intestinal vascular barrier function; myenteric plexus barrier; neuro– glia– immune interactions; metabolic disorders; neurodegenerative diseases; neurodevelopmental disorders
(This special issue belongs to the Section Physiology and Pathology)
Advances in Emergency and Critical Care Medicine
edited by
submission deadline 31 May 2025 | Viewed by 547 | Submission Open
Keywords: emergency medicine; critical care; trauma; infectious diseases; elderly
(This special issue belongs to the Section Medical Research)
Topographic and Functional Anatomy of Musculoskeletal System: 2nd Edition submission deadline 31 May 2025 | Viewed by 286 | Submission Open
Keywords: muscle; bone; joint; peripheral nerve; motor innervation; proprioception; anatomical variant; radiologic imaging; development; comparative anatomy
(This special issue belongs to the Section Medical Research)
Advances in Novel Biomarkers and Emerging Immune/Targeted Therapies in Solid Tumors
edited by and Liang Lu
submission deadline 31 May 2025 | Viewed by 260 | Submission Open
Keywords: solid tumor; biomarker; molecular targets; tyrosine kinase inhibitors (TKIs); immune checkpoint inhibitors (ICIs); oncogenic driver mutation; acquired resistance; precision oncology; cancer; next-generation sequence
(This special issue belongs to the Section Medical Research)
Global Developments in Musculoskeletal Health Research and Practice
edited by Stefanie Krauth, and John A. Hammond
submission deadline 31 May 2025 | Viewed by 166 | Submission Open
Keywords: musculoskeletal diseases; therapeutics; epidemiological studies
(This special issue belongs to the Section Epidemiology)
Cell Asymmetry and Polarity: Guiding Cellular Behavior and Development: Second Edition
edited by
submission deadline 31 May 2025 | Viewed by 165 | Submission Open
Keywords: cell asymmetry; cell polarity; tissue morphogenesis; planar cell polarity (PCP) pathway; Wnt pathway; therapeutic implications
(This special issue belongs to the Section Cell Biology and Tissue Engineering)
Therapeutic Approaches of Marine Natural Products in Health and Disease
edited by Thilina U. Jayawardena and D. P. Nagahawatta
submission deadline 31 May 2025 | Viewed by 143 | Submission Open
Keywords: marine natural products; bioactive compounds; drug discovery; therapeutic applications
(This special issue belongs to the Section Pharmaceutical Science)
Gut Microbes Associating with the Host
edited by and
submission deadline 10 Jun 2025 | 1 articles | Viewed by 915 | Submission Open
Keywords: gut microbes; microbiome; animals; nutrition
(This special issue belongs to the Section Microbiology)
Antibiotic Resistance in Biofilm: 2nd Edition
edited by
submission deadline 16 Jun 2025 | 4 articles | Viewed by 7628 | Submission Open
Keywords: biofilm; food industry; antimicrobial resistance; antibiotic resistance gene transfer; antibiofilm activity; control strategies
(This special issue belongs to the Section Microbiology)
Advances in the Treatment of Pulmonary Hypertension and Pulmonary Embolism submission deadline 16 Jun 2025 | 2 articles | Viewed by 2793 | Submission Open
Keywords: pulmonary hypertension; pulmonary embolism; therapy; cardiac imaging; artificial intelligence
(This special issue belongs to the Section Medical Research)
New Restorative Technologies in the Management and Characterization Techniques of the Hard and Soft Tissues of Oral Cavity
edited by , Silvia Pizzi and Careri Maria
submission deadline 20 Jun 2025 | 3 articles | Viewed by 1477 | Submission Open
Keywords: microscopy analysis imaging; jaw bone; oral mucosa; autofluorescence; adhesive dentistry; oral surgery; regenerative medicine; lasers
(This special issue belongs to the Section Medical Research)
Nutrition, Exercise and Stress
edited by Maleah Holland-Winkler
submission deadline 25 Jun 2025 | Viewed by 227 | Submission Open
Keywords: nutrition; exercise; stress
(This special issue belongs to the Section Physiology and Pathology)
Innovative Strategies in Insecticide Resistance and Sustainable Pest Management
edited by Chengwang Sheng, and
submission deadline 27 Jun 2025 | 1 articles | Viewed by 1578 | Submission Open
Keywords: insecticide resistance; sustainable pest management; integrated pest management; bioinsecticides; physical pest control; gene editing; insect sterilization; transgenic technology; molecular targets for pesticides
(This special issue belongs to the Section Animal Science)
From Stem Cells to Embryos, Congenital Anomalies and Epidemiology
edited by , Soultana Meditskou and
submission deadline 30 Jun 2025 | 8 articles | Viewed by 18905 | Submission Open
Keywords: stem cell research; human embryonic development; birth defects epidemiology; birth defects prevalence; maternal and fetal medicine; congenital anomalies prevention; ultrasound evaluation; pre-birth assessment; prenatal screening; healthcare
(This special issue belongs to the Section Epidemiology)
Retinal Diseases: From Molecular Mechanisms to Therapeutics
edited by
submission deadline 30 Jun 2025 | 7 articles | Viewed by 15324 | Submission Open
Keywords: retinal disease; inflammatory disease; genetic diseases; ocular drug development
(This special issue belongs to the Section Physiology and Pathology)
New Horizons of Adipose Tissue Disorders: From Hormonal Issues to Loose Connective Disease submission deadline 30 Jun 2025 | 4 articles | Viewed by 14006 | Submission Open
Keywords: adipose tissue; lipedema; lymphedema; obesity; matrix; vascular and lymphatic disorder; connective tissue diseases; dysbiosis; inflammation; pain
(This special issue belongs to the Section Physiology and Pathology)
New Insights into Allergic Eye Diseases submission deadline 30 Jun 2025 | 2 articles | Viewed by 12408 | Submission Open
Keywords: allergy; IgE; IL-4; IL-5; IL-13; TNF-alpha; mast cells; eosinophils; Th1 cells; Th2 cells; therapeutics; immunopathogenesis; immunopathology; conjunctivitis; keratoconjunctivitis
(This special issue belongs to the Section Medical Research)
Nutritional Supplements and Cardiovascular Function in Athletes and Sedentary People submission deadline 30 Jun 2025 | 4 articles | Viewed by 6503 | Submission Open
Keywords: athletes; sedentary; eating habits; nutrition; endothelium; microcirculation; vascular function; nutritional supplements; oxidative stress; antioxidants; NRF2-signaling pathway; functional food; cardiovascular function; prevention; physical activity
(This special issue belongs to the Section Medical Research)
Recent Advances in Shockwave Therapy for Musculoskeletal and Soft-Tissue Disorders
edited by , , Maria Chiara Vulpiani, Maria Cristina D'Agostino, Larisa Ryskalin and Federica Fulceri
submission deadline 30 Jun 2025 | 3 articles | Viewed by 4761 | Submission Open
Keywords: shockwave; tissue regeneration; pain; functional recovery and healing; physical medicine and rehabilitation; clinical applications; imaging
(This special issue belongs to the Section Medical Research)
Advances in Endoscopic, Surgical, and Interventional Radiological Management of Gastrointestinal Diseases
edited by
submission deadline 30 Jun 2025 | 3 articles | Viewed by 4687 | Submission Open
Keywords: gastrointestinal disease; endoscopic cystogastrostomy; endoscopic biliary prosthesis; endoscopic pancreatic prosthesis; endoscopic necrosectomy; esophagectomy; gastrectomy; bowel resection; colectomy; pancreatectomy; hepatectomy; liver transplantation; gastroenterology; surgery; interventional radiology
(This special issue belongs to the Section Medical Research)
Innovative Applications of Extracellular Vesicles: From Diagnostics to Drug Delivery
edited by Alessandra Lo Cicero
submission deadline 30 Jun 2025 | 2 articles | Viewed by 4143 | Submission Open
Keywords: extracellular vesicles; exosomes; cancer; cardiovascular diseases; neurodegenerative diseases; biomarkers; diagnostics; cell-cell communication; drug delivery; therapeutics
(This special issue belongs to the Section Physiology and Pathology)
Eye Diseases: Diagnosis and Treatment, 3rd Edition
edited by and Laura De Diego-García
submission deadline 30 Jun 2025 | 4 articles | Viewed by 3934 | Submission Open
Keywords: ocular treatment; ocular diseases; retina; anterior eye; posterior eye; ocular biomarkers
(This special issue belongs to the Section Medical Research)
Musculoskeletal Pain and Disorders: Diagnosis, Treatment and Management submission deadline 30 Jun 2025 | 2 articles | Viewed by 3601 | Submission Open
Keywords: pain; connective tissue; musculoskeletal disorders; fascia; muscles; tendons; ligaments
(This special issue belongs to the Section Physiology and Pathology)
Epidemiology Studies of Cardiovascular Diseases in Older Adults
edited by Nadya Kagansky
submission deadline 30 Jun 2025 | 2 articles | Viewed by 3539 | Submission Open
Keywords: cardiovascular diseases in older adults; gerontology; hypertension; hyperlipidemia; diabetes; obesity
(This special issue belongs to the Section Epidemiology)
Revolutionizing Neuroregeneration
edited by
submission deadline 30 Jun 2025 | 3 articles | Viewed by 3486 | Submission Open
Keywords: Alzheimer’ s disease; Parkinson’ s disease; neuroregeneration; stroke; regenerative therapy
(This special issue belongs to the Section Cell Biology and Tissue Engineering)
Bone Remodeling
edited by
submission deadline 30 Jun 2025 | 3 articles | Viewed by 3349 | Submission Open
Keywords: bone remodeling; osteoblast; osteoclast; osteocyte; osteoporosis
(This special issue belongs to the Section Cell Biology and Tissue Engineering)
Physiological Responses of Plants Under Abiotic Stresses
edited by Dawei Shi
submission deadline 30 Jun 2025 | 2 articles | Viewed by 3071 | Submission Open
Keywords: crops; woody plants; horticultural plants; physiological responses; abiotic stresses; photosynthesis
(This special issue belongs to the Section Plant Science)
Current Advances in Lung Cancer Diagnosis and Treatment
edited by , Daesik Yang and
submission deadline 30 Jun 2025 | 2 articles | Viewed by 2539 | Submission Open
Keywords: lung cancer; underlying lung disease; radiotherapy; systemic therapy; survival outcomes; complication; biomarkers
(This special issue belongs to the Section Medical Research)
Neuroinflammation in Huntington’s Disease: Detrimental Crosstalk submission deadline 30 Jun 2025 | 2 articles | Viewed by 2280 | Submission Open
Keywords: Huntington’ s disease; mutant huntingtin (mHtt) protein; central nervous system; mutated protein; glial cells
(This special issue belongs to the Section Physiology and Pathology)
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