Coagulation and Its Disorders: Physiology and Pathological Mechanisms
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 42
Special Issue Editor
Interests: coagulation; inflammation; diabetes; laboratory medicine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Coagulation is an active process initiated by regulated proteolytic activation via intrinsic and extrinsic pathways, involving a series of coagulation proteins. Any genetic alteration or functional impairment related to coagulation factors changes thrombin production, leading to bleeding or clotting.
Various infectious and inflammatory disorders, organ dysfunctions, genetic abnor-malities, and syndromes can affect coagulation processes, with outcomes varying from minor changes to serious, such as disseminated intravascular coagulation (DIC). Understanding the molecular mechanisms is pivotal to develop new tools and therapeutic approaches for the management of the proteolytic cascade. New-drug development and experimentation may help to modulate haemostatic processes and to prevent bleeding or clot formation, resulting in clinical features and prognosis enhancement when translated in animal models or in humans.
Laboratory diagnostics plays a crucial role in diagnosis and follow-up and special attention must be paid to the choice of laboratory methods, and its execution and dedicated personnel, space, and equipment are indispensable.
This Special Issue aims to collect the most recent knowledge in the field, accepting research articles and reviews related to physiology and pathological mechanisms of coagulation disorders.
Topics include, but are not limited to, the following:
- Original research articles and reviews on the physiology of coagulation
- Studies on genetic and functional defects of coagulation factors
- Infectious and inflammatory diseases impact on coagulation and molecular mechanisms
- Examination of organ failure-related coagulation disorders
- Research on the pathogenesis of severe coagulation disorders such as DIC
Dr. Anna Lisa Montemari
Guest Editor
Manuscript Submission Information
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Keywords
- coagulation
- bleeding disorders
- thrombotic mechanisms
- animal models
- molecular mechanisms
- disseminated intravascular coagulation
- fibrinolysis
- new diagnostic tools and treatment
- inflammatory response
- thrombin generation
- coagulation alterations induced by hepatic and metabolic disorders
- drug-induced coagulation alterations
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