Novel Therapeutic Strategies for Targeting Glioblastoma Stem Cells
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 435
Special Issue Editors
Interests: glioblastoma; drug resistance; neurosteroids; Sp1
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Glioblastoma (GBM), derived from glial and astrocytes, is the most aggressive and lethal primary brain tumor in adults, classified as WHO grade 4. The standard treatment for glioblastoma is temozolomide (TMZ)-mediated chemotherapy conjugated with radiotherapy (CCRT) and surgery. Unfortunately, there is currently no effective treatment, and all patients experience recurrence after therapy. Due to its heterogeneity, the brain–blood barrier (BBB), and the immunosuppress ive tumor microenvironment, the average survival time from diagnosis is about 12–15 months. Glioblastoma stem cells (GSCs) are capable of self-renewal and tumor initiation upon repeated transplantation, contributing to tumor heterogeneity. Standard treatments often fail to fully eliminate GSCs, leading to disease recurrence. GSC research has emerged, offering new insights into GBM resistance and treatment. GSCs self-renew, drive tumor growth, and play a key role in tumor cell heterogeneity and the induction of systemic immunosuppression. Therefore, there is an urgent need for further research to understand the key mechanisms underlying glioblastoma's acquisition of chemotherapeutic resistance and identify novel biomarkers for more effective treatment strategies.
Dr. Tsung-I Hsu
Dr. Chih Jie Shen
Guest Editors
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Keywords
- glioblastoma
- chemotherapeutic resistance
- glioblastoma stem cells
- immunosuppression
- brain–blood barrier
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