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Telomere Length as a Marker of Biological Age and Age-Related Diseases

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 20 November 2025 | Viewed by 476

Special Issue Editor


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Guest Editor
Toxicology & Forensics Department, University of Crete, Rethymno, Greece
Interests: telomeres; molecular biology; genetics; cancer; immunobiology

Special Issue Information

Dear Colleagues,

I am pleased to announce the release of a Special Issue entitled “Telomere Length as a Marker of Biological Age and Age-Related Diseases”. The characterization of biological aging has attracted significant interest with regard to the factors contributing to the difference between a person's biological and chronological age. Identifying biological age is complicated, as this estimation must encompass all aspects of the aging process. One of the key biomarkers used to determine biological age is telomere length. Current research suggests that telomere length acts as both a diagnostic and prognostic biomarker for several age-related disorders, aiding in predicting the potential risk of developing age-related illnesses. In addition to the predictive value of telomere length, assessing individuals’ biological age through the evaluation of their telomere length dynamics can be beneficial in uncovering novel therapeutic strategies that halt the aging process. This Special Issue will provide an overview of current research on telomere length dynamics and present the latest data on age-related diseases, including cancer.

Dr. Stella Baliou
Guest Editor

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Keywords

  • telomeres
  • biological aging
  • diseases
  • mechanisms

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Published Papers (1 paper)

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Review

37 pages, 4731 KiB  
Review
The Interplay Between Obesity and Type 2 Diabetes: Common Pathophysiological Mechanisms Contributing to Telomere Shortening
by Stella Baliou, Miruna-Maria Apetroaei, Eleftheria Hatzidaki, Sergey V. Kuzmin, Manolis N. Tzatzarakis, Andreea Letiția Arsene, Aristides Tsatsakis and Petros Ioannou
Life 2025, 15(6), 873; https://doi.org/10.3390/life15060873 - 28 May 2025
Viewed by 289
Abstract
The worldwide prevalence of obesity continues to increase, representing a serious public health issue due to associated comorbidities. Obesity is associated with type 2 diabetes mellitus (T2D), which shares similar pathophysiological mechanisms. In both conditions, oxidative stress, inflammation, mitochondrial dysfunction, abnormal adipose tissue [...] Read more.
The worldwide prevalence of obesity continues to increase, representing a serious public health issue due to associated comorbidities. Obesity is associated with type 2 diabetes mellitus (T2D), which shares similar pathophysiological mechanisms. In both conditions, oxidative stress, inflammation, mitochondrial dysfunction, abnormal adipose tissue function, and senescence are observed, ultimately leading to insulin resistance. In both cases, hypertrophic adipose tissue is associated with telomere shortening. Elucidating the mechanisms underlying telomere shortening in obesity and diabetes may be crucial for deepening our understanding of these pathologies, with the ultimate aim of its translational implications. Several studies have shown that telomere shortening is present in patients with metabolic disorders, emphasizing its prognostic value for the onset and progression of these diseases. From this perspective, this article highlights the importance of telomere biology, which can aid in developing new therapeutic options for metabolic disorders. Full article
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