Etiology, Diagnosis, and Treatment of Coeliac Diseases
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 48
Special Issue Editor
Special Issue Information
Dear Colleagues,
Coeliac disease, which involves gluten sensitivity, is a common condition affecting 1-2% of the population, including 10 million individuals in North America, 8 million individuals in Europe, and 670,000 individuals in the UK, including children. It is known to be an inherited disease that is associated with both the HLA-DQ2 and DQ8 haplotypes.
This condition can be screened for using blood tests, including tests for IgG and IgA anti-endomysium and tissue transglutaminase levels, which are raised in the condition, although the levels of immunoglobulins should also be checked, as some people exhibit IgA deficiency. In adults, diagnosis is carried out by taking small intestinal biopsies and observing whether they exhibit villous atrophy and a reduction in enterocyte cell height. In children, a diagnosis can be made when coeliac serological tests show results more than ten times the normal value; it has been suggested that this may also be applicable to adults, but this is not generally accepted. It has been shown that there is an increased level of malignancy if the condition remains untreated. Cereals involved in the exacerbation of the condition include wheat, rye, barley, and, in the majority of cases, oats. It has been suggested that there could be improvements in dietary treatments for this condition.
We welcome manuscript suggestions on these topics and encourage authors to contact the Guest Editor for a discussion regarding their submission before preparing their manuscript.
Prof. Dr. Paul J Ciclitira
Guest Editor
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Keywords
- coeliac disease
- blood tests
- dietary treatment
- etiology
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