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Life
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Nutrition and NAFLD
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Nutrition and NAFLD

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: closed (22 February 2022) | Viewed by 3861

Special Issue Editors

Dr. Yu-Jin Kwon

E-Mail Website
Guest Editor
Yongin Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
Interests: Nutrition, NAFLD; metabolism
Dr. Jun-Hyuk Lee

E-Mail Website
Guest Editor
Nowon Eulji Medical Center, Eulji University School of Medicine, Seoul, Republic of Korea
Interests: clinical nutrition; fatty liver; metabolism

Special Issue Information

Dear Colleagues,

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease closely related to metabolic dysfunction such as insulin resistance, obesity, and metabolic syndrome. Managing NAFLD has focused on lifestyle modifications, such as maintaining a healthy diet. Nutrition is an important and modifiable risk factor that plays a crucial role in the prevention or delaying of the onset of non-alcoholic fatty liver disease. Reducing total calorie consumption and modification of macronutrients composition can help prevent and treat NAFLD. However, the roles of macronutrition and micronutrition on the prevention and development of NAFLD are still unclear. Additionally, numerous functional food products are known to be helpful to liver function.

The present Special Issue aims to gather the latest findings on (1) the role of macronutrients, (2) the role of micronutrients, (3) dietary pattern, and (4) functional food with regard to the health status and/or the risk of NAFLD.

Authors are invited to submit relevant original contributions, review articles, or systematic reviews for consideration for inclusion in this Special Issue.

Dr. Yu-Jin Kwon
Dr. Jun-Hyuk Lee
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • non-alcoholic fatty liver disease
  • non-alcoholic steatohepatitis
  • macronutrients
  • micronutrients

Published Papers (1 paper)

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Research

13 pages, 1805 KiB  
Article
Taurine Ameliorates Tunicamycin-Induced Liver Injury by Disrupting the Vicious Cycle between Oxidative Stress and Endoplasmic Reticulum Stress
by Sou Hyun Kim, Hyeji Seo, Doyoung Kwon, Dong Yeon Yuk and Young-Suk Jung
Life 2022, 12(3), 354; https://doi.org/10.3390/life12030354 - 28 Feb 2022
Cited by 13 | Viewed by 3517
Abstract
Non-alcoholic fatty liver disease (NAFLD) is a chronic liver dysfunction characterized by excess lipid accumulation; non-alcoholic steatohepatitis can transform into more severe conditions, such as cirrhosis and hepatocellular carcinoma. Although several pharmacologic approaches have been evaluated in clinical trials, there are no approved [...] Read more.
Non-alcoholic fatty liver disease (NAFLD) is a chronic liver dysfunction characterized by excess lipid accumulation; non-alcoholic steatohepatitis can transform into more severe conditions, such as cirrhosis and hepatocellular carcinoma. Although several pharmacologic approaches have been evaluated in clinical trials, there are no approved therapies for NAFLD. Previous studies have suggested that taurine supplementation alleviates fatty liver; however, the underlying mechanism remains obscure. In this study, we investigated the beneficial effects of taurine on fatty liver injury in vivo induced by tunicamycin, a chemical endoplasmic reticulum (ER) stressor. The mice were administered 2% taurine for 2 weeks prior to intraperitoneal tunicamycin injection; after 72 h of treatment, the mice were euthanized. Tunicamycin treatment significantly increased the levels of serum ALT and AST and hepatic triglycerides. Notably, these changes were alleviated by taurine supplementation. Taurine normalized the protein and/or mRNA levels involved in ER stress signaling (IRE1a, p-IRE1a, ATF6, XBP1, BiP, and CHOP) and lipid metabolism (CD36, MTTP, and ApoB), which were dysregulated by tunicamycin treatment. The stimulation of hepatic lipid export by taurine was evidenced by the recovery of blood VLDL levels. Furthermore, taurine supplementation prevented tunicamycin-induced lipid peroxidation and decreased glutathione (GSH) levels by correcting abnormal cysteine catabolism involved in the production of both taurine and GSH. Therefore, taurine supplementation can prevent tunicamycin-induced liver injury by counteracting oxidative and ER stress. Full article
(This article belongs to the Special Issue Nutrition and NAFLD)
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