Thrombosis and Blood Disorders: Mechanisms and Management

Dear Colleagues,

Blood cells mediate a myriad of functions that determine the maintenance of homeostasis across all body systems and organs. The importance of blood cells is made apparent when considering how tightly regulated their numbers are in circulation. Indeed, through feedback mechanisms, the bone marrow constantly surveys the circulatory microenvironment to determine if production of a particular cell type is needed. However, dysregulation of these mechanisms either through disease or as a response to inhibitors can result in a worsening clinical picture. For example, platelets mediate hemostasis and represent first responders during infections through their capacity as members of the innate immune response, which is why thrombocytopenia can result from disease (infection) or be indicative of an impaired response that fails to fully address the need due to increased consumption. Low platelet counts and dysfunctional platelets can often lead to hemorrhage, while hyperactive platelets can have the opposite effect and result in thrombosis or embolization. On the other hand, anemia can be the result of hemorrhage or of erythrocyte hypoproduction. Likewise, dysregulated production of blood cells can be indicative of pathology, such as in myeloproliferative disorders, specifically those in which either erythrocytes or platelets are affected, such as polycythemia vera and essential thrombocythemia, among others. It is with this in mind that this Special Issue seeks to showcase reports describing the important functions carried out by blood cells and disorders resulting from defects in their production, function, and/or development. Original research describing in vitro and in vivo models of platelet, erythrocyte, lymphocyte, and neutrophil functions are welcome. Similarly, mechanistic reports looking at specific blood disorders are encouraged. Studies of pathologic mediators, receptors, signaling pathways affecting specific cell types, or targeted therapies are also invited. Lastly, major comprehensive reviews showcasing important topics within the scope of this Special Issue can be submitted. While we do not encourage the submission of case reports, we will welcome them if they represent a thorough review of the area covered by the case.

Prof. Dr. Robert Maitta
Dr. Miriam Andrea Duque
Guest Editors

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