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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Orthopedic Oncology Updates and Controversial Issues
edited by Yehuda Kollender and Ron Batash
submission deadline 20 Feb 2027 | Viewed by 763 | Submission Open
Keywords: soft tissue sarcoma; bone sarcoma; oligometastatic; atypical behavior tumor; cryosurgery; rare diseases; surgery; radiation therapy; immunotherapy; chemotherapy
(This special issue belongs to the Section Orthopedics)
Robotic-Assisted Hepato-Pancreato-Biliary (HPB) Surgery: Advances and Clinical Perspectives
edited by and Riccardo Memeo
submission deadline 20 Feb 2027 | 1 articles | Viewed by 748 | Submission Open
Keywords: liver surgery; pancreatic surgery; HPB surgery; robotic surgery; robotic systems; advances in HPB surgery
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Diet and Nutritional Aspects in Cardiovascular-Kidney-Metabolic Diseases (CKM)
edited by Krishnaswami Vijayaraghavan
submission deadline 20 Feb 2027 | 1 articles | Viewed by 714 | Submission Open
Keywords: cardiovascular-kidney-metabolic diseases (CKM); obesity; diabetes and metabolic syndrome; dietary factors; nutritional aspects; food policy and food security; chronic kidney disease; heart disease; technology
(This special issue belongs to the Section Clinical Nutrition & Dietetics)
Advances in the Field of Cariology submission deadline 20 Feb 2027 | 1 articles | Viewed by 690 | Submission Open
Keywords: dental caries; caries diagnosis; caries risk assessment; minimally invasive dentistry; preventive strategies
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Pediatric Surgery—Current Hurdles and Future Perspectives—2nd Edition
edited by
submission deadline 20 Feb 2027 | 1 articles | Viewed by 639 | Submission Open
Keywords: congenital anomalies; esophageal atresia; anorectal malformations; pediatric trauma; necrotizing enterocolitis; pediatric oncology; biliary atresia
(This special issue belongs to the Section Clinical Pediatrics)
Clinical Research and Management of Infectious Diseases
edited by
submission deadline 20 Feb 2027 | 1 articles | Viewed by 444 | Submission Open
Keywords: antimicrobial resistance (AMR); novel antibiotics; multidrug-resistant (MDR) pathogens; drug discovery and development; bacteriophage therapy; antimicrobial peptides; ESKAPE pathogens; antimicrobial stewardship
(This special issue belongs to the Section Infectious Diseases)
New Concepts in the Diagnosis and Treatment of Orthopedic Diseases in Children—2nd Edition submission deadline 20 Feb 2027 | Viewed by 424 | Submission Open
Keywords: pediatric orthopedics; flatfoot; genu valgum; genu varum; hip dysplasia; clubfoot; early onset scoliosis; Scheuermann disease; perthes; epiphysiolysis; scoliosis; pediatric trauma
(This special issue belongs to the Section Clinical Pediatrics)
Clinical Advances in Orthopedic Infections: 2nd Edition
edited by
submission deadline 20 Feb 2027 | Viewed by 373 | Submission Open
Keywords: orthopedic surgery; orthopedic infections; periprosthetic joint infection; surgical site infection; infection management
(This special issue belongs to the Section Orthopedics)
Advances in Pulmonary Embolism Therapeutics
edited by
submission deadline 20 Feb 2027 | Viewed by 344 | Submission Open
Keywords: acute pulmonary embolism; chronic pulmonary embolism; chronic thromboembolic disease; chronic thromboem-bolic pulmonary hypertension; catheter-directed therapy; pulmonary endarterectomy; balloon pulmonary angio-plasty
(This special issue belongs to the Section Vascular Medicine)
Current and Emerging Management Strategies in Gynecologic Oncology
edited by Grzegorz Szewczyk
submission deadline 20 Feb 2027 | Viewed by 327 | Submission Open
Keywords: gynecologic oncology; surgical approach; molecular diagnostics; novel therapies; rare gynecological cancers; risk factors
(This special issue belongs to the Section Obstetrics & Gynecology)
Hematoinflammatory Diseases: Bridging Autoimmunity and Autoinflammation
edited by Andrés González García and
submission deadline 20 Feb 2027 | Viewed by 320 | Submission Open
Keywords: hematoinflammatory diseases; clonal hematopoiesis; vexas syndrome; castleman disease; Igg4-related disease; cytokine storm; autoinflammatory syndromes; immunopathogenesis; targeted therapies; biomarkers
(This special issue belongs to the Section Immunology & Rheumatology)
Towards a Better Understanding of Neuroinflammation in Mental Health
edited by Jesus Cobo
submission deadline 20 Feb 2027 | Viewed by 295 | Submission Open
Keywords: neuroinflammation; biomarkers; peripheral biomarkers; outcomes; bipolar disorders; major depression; mental health; schizophrenia; blood-based inflammatory index; lymphocyte subpopulation
(This special issue belongs to the Section Mental Health)
Current Practices and Future Challenges in Organ Transplantation
edited by and Mackenzie Morris
submission deadline 20 Feb 2027 | Viewed by 291 | Submission Open
Keywords: liver transplantation; kidney transplantation; pancreas transplantation; xenotransplantation; immunosuppression; robotic surgery; disparities; machine perfusion; organ preservation; organ allocation
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Regenerative and Biologic Therapies for Musculoskeletal Disorders submission deadline 20 Feb 2027 | Viewed by 173 | Submission Open
Keywords: regenerative medicine; musculoskeletal disorders; cell-based therapy; platelet-rich plasma; extracellular vesicles; tissue engineering; osteoarthritis; tendon; cartilage; bone; skeletal muscle; translational research; preclinical research; clinical research
(This special issue belongs to the Section Clinical Rehabilitation)
Alcohol Use Disorder: New Clinical Insights and Management Strategies
edited by Daniel König
submission deadline 20 Feb 2027 | Viewed by 146 | Submission Open
Keywords: alcohol use disorder; emerging treatments; comorbidities; outcomes; epidemiology; dual-diagnosis; interventions
(This special issue belongs to the Section Mental Health)
New Perspectives on Musculoskeletal Injuries and Disorders: Advancing Diagnosis, Treatment, and Recovery
edited by Shinnosuke Hada
submission deadline 20 Feb 2027 | Viewed by 109 | Submission Open
Keywords: musculoskeletal injuries; musculoskeletal disorders; clinical diagnosis; treatment strategies; clinical outcomes; orthobiologics; platelet-rich plasma; sports medicine; osteoarthritis; ultrasound-guided intervention; rehabilitation; return to activity; functional recovery
(This special issue belongs to the Section Orthopedics)
Optimizing Cardiovascular Intervention: From Technology Innovation to Clinical Practice
edited by
submission deadline 20 Feb 2027 | Viewed by 20 | Submission Open
Keywords: cardiovascular intervention; interventional cardiology; coronary artery disease; structural heart disease; PCI
(This special issue belongs to the Section Cardiovascular Medicine)
Oral Surgery: Recent Advances and Future Perspectives submission deadline 22 Feb 2027 | 3 articles | Viewed by 8752 | Submission Open
Keywords: oral surgery; implant dentistry; atrophic jaws; bone regeneration; digital dentistry
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Advances and New Perspectives in the Diagnosis and Treatment of Schizophrenia
edited by Pierre S. Chue and Oloruntoba J. Oluboka
submission deadline 22 Feb 2027 | 2 articles | Viewed by 1175 | Submission Open
Keywords: psychopharmacology; schizophrenia; long-acting injectable therapy; recovery; team approach to care; integrated care; clozapine; habilitation; rehabilitation; early intervention
(This special issue belongs to the Section Mental Health)
Clinical Aspects of Cardiac Arrhythmias and Arrhythmogenic Disorders
edited by and Jakub Baran
submission deadline 25 Feb 2027 | 7 articles | Viewed by 8969 | Submission Open
Keywords: non-invasive arrhythmia assessment; electrocardiography; invasive arrhythmia assessment; invasive electrophysiology; catheter ablation; implantable devices; rare diseases and arrhythmias; arrhythmia risk stratification; genetics aspects of arrhythmogenesis; channelopathy
(This special issue belongs to the Section Cardiology)
Current Advances and Future Perspectives of Ischemic Stroke
edited by
submission deadline 25 Feb 2027 | 4 articles | Viewed by 6639 | Submission Open
Keywords: acute ischemic stroke care; neuroimaging in ischemic stroke; alteplase and tenecteplase; endovascular treatments; recanalization and reperfusion; prognostication in stroke patients; blood–brain barrier in ischemic stroke; bi-omarkers in ischemic stroke; omics in stroke
(This special issue belongs to the Section Clinical Neurology)
Advances and Updates in Migraine
edited by and Carl H. Göbel
submission deadline 25 Feb 2027 | 6 articles | Viewed by 5388 | Submission Open
Keywords: migraine; chronic migraine; headache disorders; CGRP antibodies; gepants; ditans; triptans; precision medicine; neuromodulation; comorbidities; disability burden; pediatric migraine; ICHD-3 classification; neurotransmitters; preventive therapy; translational headache research
(This special issue belongs to the Section Clinical Neurology)
Headache Disorders: New Advances in Management and Treatment Strategies: 2nd Edition submission deadline 25 Feb 2027 | 3 articles | Viewed by 5183 | Submission Open
Keywords: headache; migraine; cluster headache; tension-type headache; post-traumatic headache; calcitonin gene-related peptide; monoclonal antibodies; preventive therapy; acute treatment; pathophysiology; neuromodulation; pain management; drug development; gepants; ditan
(This special issue belongs to the Section Clinical Neurology)
Innovative Aspects in Dental Implantology and Related Clinical Research (Second Edition) submission deadline 25 Feb 2027 | 3 articles | Viewed by 4585 | Submission Open
Keywords: dental implants; implantology; bone regeneration; implant-supported prosthesis; zygomatic implants; reconstructive surgery; pre-implant surgery; short implants
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Advanced Hepato-Pancreato-Biliary Surgery: Clinical Innovations and Improved Outcomes
edited by Ahmad Mahamid and Riad Haddad
submission deadline 25 Feb 2027 | 3 articles | Viewed by 4355 | Submission Open
Keywords: liver surgery; pancreas surgery; biliary surgery; robotic HPB surgery; single incision surgery; prognostic biomarkers; perioperative clinical care; postoperative complications
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Updates in Cardiovascular Computed Tomography (CT)
edited by
submission deadline 25 Feb 2027 | 2 articles | Viewed by 3833 | Submission Open
Keywords: cardiovascular CT; coronary CTA; plaque imaging; artificial intelligence; low-dose imaging; structural heart disease; cardiac imaging; high-risk plaque; atherosclerosis; coronary artery disease; valve calcification; thrombus detection
(This special issue belongs to the Section Cardiovascular Medicine)
Advances in Cardiovascular Rehabilitation: The Central Role of Exercise in Prevention and Care
edited by Massimo Pistono
submission deadline 25 Feb 2027 | 4 articles | Viewed by 3731 | Submission Open
Keywords: cardiac rehabilitation; secondary prevention; physical exercise; cardiovascular health; aerobic exercise; cardio-oncology rehabilitation
(This special issue belongs to the Section Cardiovascular Medicine)
Geriatric Cardiology: Clinical Advances and Comprehensive Management
edited by
submission deadline 25 Feb 2027 | 2 articles | Viewed by 2807 | Submission Open
Keywords: geriatric assessment; management of cardiovascular disease; cardiovascular health; geriatric cardiology; frailty evaluation and management
(This special issue belongs to the Section Geriatric Medicine)
Endoscopic Therapy in Gastroesophageal Reflux Disease (GERD): Current Evidence, Techniques, and Future Perspectives
edited by Pier Alberto Testoni
submission deadline 25 Feb 2027 | 1 articles | Viewed by 2565 | Submission Open
Keywords: gastroenterology; gastroesophageal reflux disease; GERD; esophageal diseases; endoscopic therapy
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Cardiometabolic Disease and Atherosclerosis: Epidemiology, Prevention, Diagnosis, and Clinical Treatment—2nd Edition
edited by and Konstantinos Mourouzis
submission deadline 25 Feb 2027 | 2 articles | Viewed by 1913 | Submission Open
Keywords: atherosclerosis; obesity; cardiometabolic disease; prevention; diabetes mellitus; endothelium; arteriosclerosis; coronary artery disease
(This special issue belongs to the Section Cardiology)
Recent Clinical Advances in Cardiac Rehabilitation: 2nd Edition
edited by
submission deadline 25 Feb 2027 | 2 articles | Viewed by 1895 | Submission Open
Keywords: cardiac rehabilitation; kinesiotherapy; psychological support; lifestyle modifications; myocardial infarction; heart failure
(This special issue belongs to the Section Cardiology)
Optimizing Radiotherapy in Clinical Practice: Innovation and Outcomes
edited by , and Joseph Moore
submission deadline 25 Feb 2027 | 2 articles | Viewed by 1393 | Submission Open
Keywords: AI-assisted automated contouring and planning; AI-assisted quality assurance; AI-assisted safety and quality improvement; radiotherapy automation; radiomics; radiotherapy error detection; personalized radiopharmaceutical therapy; theranostics; online adaptive radiotherapy; real-time treatment adaptation; image-guided radiotherapy (IGRT); AI-assisted online adaptation; personalized radiotherapy; cone-beam CT adaptation
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Clinical Updates and Current Challenges in Obstetrical Anesthesia
edited by Michael Froelich
submission deadline 25 Feb 2027 | 1 articles | Viewed by 1268 | Submission Open
Keywords: obstetrical anesthesia; clinical innovation; practice guidelines; neuraxial techniques; enhanced recovery; risk stratification; maternal safety; multimodal analgesia; health systems innovation; global and low-resource care
(This special issue belongs to the Section Obstetrics & Gynecology)
Emerging Trends and Therapeutic Innovations in Corneal and Ocular Surface Disorders
edited by and Špela Štunf Pukl
submission deadline 25 Feb 2027 | 2 articles | Viewed by 1162 | Submission Open
Keywords: corneal diseases; ocular surface disorders; regenerative medicine; stem cell therapy; gene therapy; nanomedicine and targeted drug delivery
(This special issue belongs to the Section Ophthalmology)
Advances in Clinical Practice and Personalized Approaches in Cardiovascular Disease—2nd Edition
edited by Joseph B. Selvanayagam and
submission deadline 25 Feb 2027 | 2 articles | Viewed by 1086 | Submission Open
Keywords: personalized medicine; cardiovascular innovations; cardiac imaging; risk assessment; multimodal imaging; therapeutic strategies; data-driven decision making; clinical outcomes; translational research
(This special issue belongs to the Section Cardiovascular Medicine)
Pediatric Sleep Health: From Pathophysiology to Quality of Life submission deadline 25 Feb 2027 | 1 articles | Viewed by 846 | Submission Open
Keywords: pediatric sleep; sleep disorders; child development; cognition; quality of life; neurodevelopment; pathophysiology; sleep health interventions; academic; sleep-disordered breathing; MRI; neuroscience
(This special issue belongs to the Section Clinical Pediatrics)
Clinical Advancements in Laparoscopic Surgery for Gastrointestinal Diseases
edited by
submission deadline 25 Feb 2027 | 1 articles | Viewed by 534 | Submission Open
Keywords: laparoscopic surgery; minimally invasive surgery; gastrointestinal diseases; colorectal cancer; gastric cancer; robotic surgery; fluorescence imaging; endoscopic-laparoscopic hybrid surgery; surgical oncology; future perspectives
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
The Interplay of Trauma Symptoms and Cognitive Functioning: Clinical Implications
edited by and
submission deadline 25 Feb 2027 | Viewed by 388 | Submission Open
Keywords: trauma; stress; cognitive dysfunction; clinical syndromes; clinical implications
(This special issue belongs to the Section Mental Health)
Surgical Innovations in Pediatric Orthopedics
edited by
submission deadline 25 Feb 2027 | Viewed by 370 | Submission Open
Keywords: pediatric orthopedics; surgical innovation; growth modulation; absorbable implant; 3D printing
(This special issue belongs to the Section Orthopedics)
Advances in Minimally Invasive and Endoscopic Neurosurgery
edited by Shunsuke Shibao
submission deadline 25 Feb 2027 | Viewed by 353 | Submission Open
Keywords: minimally invasive; endoscopic; keyhole; endonasal; transorbital; skull base; complications; surgical outcomes; technical innovations; robotic neurosurgery
(This special issue belongs to the Section Clinical Neurology)
Exercise, Rehabilitation, and Women’s Health: Clinical Perspectives in Sports Medicine
edited by and
submission deadline 25 Feb 2027 | Viewed by 277 | Submission Open
Keywords: women’s health; exercise intervention; rehabilitation; exercise physiology; musculoskeletal health; healthy aging; resistance training; nutrition
(This special issue belongs to the Section Clinical Rehabilitation)
Cancer Prevention and Early Detection: Epidemiological Approaches and Public Health Strategies submission deadline 25 Feb 2027 | Viewed by 273 | Submission Open
Keywords: cancer prevention; cancer screening; risk factors; cancer treatment; health information systems; cancer registry; cancer inequalities
(This special issue belongs to the Section Epidemiology & Public Health)
Pelvic Floor Disorders: Emerging Perspectives on Therapeutic Approaches submission deadline 25 Feb 2027 | Viewed by 134 | Submission Open
Keywords: pelvic floor surgery; laparoscopic approach; quality of life; pelvic organ prolapse surgery; urinary and fecal incontinence; pelvic floor disorders
(This special issue belongs to the Section Obstetrics & Gynecology)
Colorectal Surgery: New Clinical Advances, Challenges and Future Directions
edited by
submission deadline 25 Feb 2027 | Viewed by 76 | Submission Open
Keywords: colon surgery; colorectal surgery; colorectal cancer; IBD surgery; proctology; diverticular disease; diverticulitis; surgical outcomes
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advances in Immunohematology: From Pathophysiology to Tailored Treatments submission deadline 28 Feb 2027 | 1 articles | Viewed by 4341 | Submission Open
Keywords: autoimmune cytopenia; hemophagocytic lymphohistiocytosis; inborn errors of immunity; lymphoproliferative diseases; malignancy; monoclonal antibodies; secondary immunodeficiency; vaccination
(This special issue belongs to the Section Immunology & Rheumatology)
Clinical Rehabilitation Strategies and Exercise for Stroke Recovery submission deadline 28 Feb 2027 | 3 articles | Viewed by 2277 | Submission Open
Keywords: stroke; stroke rehabilitation; exercise; biomarkers; rehabilitation outcomes
(This special issue belongs to the Section Clinical Rehabilitation)
Ergonomics and Low Back Pain: Integrative Approaches to Prevention, Assessment and Management submission deadline 28 Feb 2027 | 1 articles | Viewed by 1900 | Submission Open
Keywords: advanced in diagnostic methods; therapeutic innovations; multidisciplinary and personalized care models; prevention and rehabilitation; non-pharmacological strategies; ergonomics; biomechanics
(This special issue belongs to the Section Orthopedics)
Clinical and Epidemiological Aspects of Frailty in Acute Kidney Injury: A Spotlight on Risk Factors, Prevention and Management submission deadline 28 Feb 2027 | 1 articles | Viewed by 102 | Submission Open
Keywords: sarcopenia; AKI; frailty; amyloidosis; nutrition; epidemiology
(This special issue belongs to the Section Nephrology & Urology)
Modern Challenges in Pediatric Endocrinology: From Growth Disorders to Metabolic Dysregulation
edited by Katarzyna A. Majewska and Piotr Fichna
submission deadline 2 Mar 2027 | 2 articles | Viewed by 2214 | Submission Open
Keywords: growth hormone deficiency; growth hormone therapy; short stature; obesity; obesity complications; obesity treatment; insulin resistance; prediabetes; type 1 diabetes; type 2 diabetes; hypothyroidism; hyperthyroidism; autoimmune thyroiditis; puberty disorders
(This special issue belongs to the Section Clinical Pediatrics)
Cerebrovascular Disease: Symptoms, Diagnosis and Current Treatment—Second Edition
edited by Alba Scerrati and Giorgio Mantovani
submission deadline 5 Mar 2027 | 3 articles | Viewed by 3439 | Submission Open
Keywords: ischemic stroke; cerebral aneurysms; cerebral vascular malformation; cerebral venous disease; cerebral venous thrombosis
(This special issue belongs to the Section Clinical Neurology)
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