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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Glaucoma: Diagnosis and Management Insights

edited by

Stamatios Lampsas

and Efthymios Karmiris

submission deadline 29 Sep 2026 | 4 articles | Viewed by 2876 | Submission Open

Keywords: glaucoma; risk factors; progression; novel biomarkers; diagnosis; management

(This special issue belongs to the Section Ophthalmology)

New Advances in Musculoskeletal Physiotherapy: Exercise, Manual Therapy and Invasive Physiotherapy

edited by

Marcos José Navarro-Santana

and Ignacio Cancela-Cilleruelo

submission deadline 30 Sep 2026 | 6 articles | Viewed by 22870 | Submission Open

Keywords: musculoskeletal disorders; exercise therapy; manual therapy; invasive physical therapy; rehabilitation

(This special issue belongs to the Section Orthopedics)

Catheter Ablation of Cardiac Arrhythmias: Current Updates and Perspectives: 2nd Edition

edited by

Shaojie Chen

submission deadline 30 Sep 2026 | 3 articles | Viewed by 7658 | Submission Open

Keywords: ablation; arrhythmia; electrophysiology; atrial fibrillation; atrial flutter; atrial tachycardia; mapping; supraventricular tachycardia; ventricular arrhythmia

(This special issue belongs to the Section Cardiology)

Clinical Updates on Dyslipidemia

edited by

Nathan Wong

submission deadline 30 Sep 2026 | 4 articles | Viewed by 5517 | Submission Open

Keywords: dyslipidemia; cardiovascular disease; prevention; treatment; risk factors

(This special issue belongs to the Section Cardiovascular Medicine)

Artificial Intelligence in Women’s Health and Medicine: Improving Clinical Practice, Diagnosis, Treatment Management and Patient Experiences

edited by

Shivaram Poigai Arunachalam

and Nasibeh Zanjirani Farahani

submission deadline 30 Sep 2026 | 1 articles | Viewed by 4405 | Submission Open

Keywords: women’s health; artificial intelligence; machine learning; personalized medicine; reproductive health; health equity; social determinants of health; mental health; cancer; cardiovascular disease

(This special issue belongs to the Section Epidemiology & Public Health)

Updates and Advances in Aplastic Anemia and Other Bone Marrow Failures

edited by

Alicia Rovo

, Beatrice Drexler and Olaia Naveiras

submission deadline 30 Sep 2026 | Viewed by 514 | Submission Open

Keywords: aplastic anemia; severe aplastic anemia (SAA); bone marrow failures; paroxysmal nocturnal hemoglobinuria (PNH); inherited bone marrow failures

(This special issue belongs to the Section Hematology)

Acute Care Surgery: The Evolution of a Modern Specialty

edited by Mayur Narayan

submission deadline 30 Sep 2026 | Viewed by 384 | Submission Open

Keywords: acute care surgery; emergency surgery; health equity; global surgery; trauma care; surgical workforce; surgical in-novation; decision-making

(This special issue belongs to the Section Emergency Medicine)

Update and Emerging Trends in Urological Surgery

edited by Yasmin Abu-Ghanem

submission deadline 30 Sep 2026 | Viewed by 280 | Submission Open

Keywords: urology; urological surgery; precision medicine; biomarkers; minimally invasive surgery; multidisciplinary care

(This special issue belongs to the Section Nephrology & Urology)

Current Concepts in Shoulder Arthroplasty—Degenerative Pathology, Scapular Morphology, Posture and Kinematics, Realignment Procedures, Fracture Reconstruction, and Outcome Measurement

edited by

Stefan Bauer

Allan W. Wang

and

William G. Blakeney

submission deadline 1 Oct 2026 | 3 articles | Viewed by 2019 | Submission Open

Keywords: reverse total shoulder arthroplasty; cuff tear arthropathy; osteoarthritis; proximal humeral fracture sequelae; revision; long-term outcome; implant design; biomechanics

(This special issue belongs to the Section Orthopedics)

Diagnosis and Treatment of Obstetrics and Gynecology Cancers

edited by

Gaspare Cucinella

submission deadline 5 Oct 2026 | 4 articles | Viewed by 12834 | Submission Open

Keywords: gynecological cancers; endometrial cancer; ovarian cancer; cervical cancer; vulvar cancer; vaginal cancer; breast cancer; surgery; radio-therapy; systemic treatment; immunotherapy; sentinel lymph node biopsy; minimally invasive surgery; fertility preservation; gestational trophoblastic disease

(This special issue belongs to the Section Obstetrics & Gynecology)

New Insights into Pediatric Otolaryngology: From Diagnosis to Minimally Invasive Therapies

edited by

Mariaconsiglia Santantonio

and

Luisa Bellussi

submission deadline 5 Oct 2026 | 3 articles | Viewed by 2751 | Submission Open

Keywords: pediatric otolaryngology; minimally invasive; early diagnosis; olfactory disorders; pediatric rhinology; pediatric airway; pediatric ENT; pediatric sleep disorders; pediatric diagnosis

(This special issue belongs to the Section Clinical Pediatrics)

Thoracic Radiochemoimmunotherapy for Non-Small Cell Lung Cancer (NSCLC): Evolving Techniques and Clinical Applications

edited by

Franz Zehentmayr

submission deadline 5 Oct 2026 | 1 articles | Viewed by 1383 | Submission Open

Keywords: radiotherapy; radiology; oncology; non-small cell lung cancer; real-world data; immunotherapy; radiation dose escalation

(This special issue belongs to the Section Oncology)

Current Progress and Future Directions in Orthodontics and Periodontology

edited by

Ligia Vaida

and

Ionut Luchian

submission deadline 5 Oct 2026 | 1 articles | Viewed by 636 | Submission Open

Keywords: orthodontics; periodontology; interdisciplinary treatment; orthodontic tooth movement; periodontal phenotype; digital dentistry; regenerative therapy; clinical outcomes; treatment planning; future perspectives of interdisciplinarity

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Neuropathic Pain: From Prevention to Diagnosis and Management

edited by Enrico Martin

submission deadline 10 Oct 2026 | 2 articles | Viewed by 5970 | Submission Open

Keywords: neuropathic pain; clinical research; TMR; RPNI; preclinical studies; QoL; PROMS; translational medicine; pain mechanisms

(This special issue belongs to the Section Clinical Neurology)

New Insights into Clinical Application of Embolization Techniques

edited by

Bedros Taslakian

and Yan Epelboym

submission deadline 10 Oct 2026 | 3 articles | Viewed by 4380 | Submission Open

Keywords: embolization; interventional radiology; musculoskeletal embolization; uterine artery embolization; prostate artery embolization; vascular malformations; catheter-directed therapy

(This special issue belongs to the Section Vascular Medicine)

Current Trends and Future Challenges in Coronary Artery Disease

edited by Federica Agnello

submission deadline 10 Oct 2026 | 2 articles | Viewed by 1831 | Submission Open

Keywords: coronary artery disease; cardiovascular prevention; coronary computed tomography angiography (CCTA); CT-derived fractional flow reserve (FFR-CT); intracoronary imaging; residual risk; functional assessment; artificial intelligence in cardiology; percutaneous coronary intervention

(This special issue belongs to the Section Cardiology)

Treatment Strategies in Congenital Heart Disease: Current Practices and Future Directions

edited by Anastasia Schleiger, Julia Moosmann and

Antonia Schulz

submission deadline 10 Oct 2026 | 2 articles | Viewed by 1771 | Submission Open

Keywords: congenital heart disease; transcatheter management of congenital heart defects; surgical strategies for congenital heart defects; medical heart failure treatment; mechanical circulatory support; hybrid procedures; pulmonary hypertension; heart teams; multidisciplinary management; quality of life

(This special issue belongs to the Section Cardiology)

Clinical Advances and Insights in Cardiovascular Imaging

edited by Maurizio Cusmà Piccione

submission deadline 10 Oct 2026 | 2 articles | Viewed by 1180 | Submission Open

Keywords: cardiovascular imaging; multimodality imaging; cardiac magnetic resonance; cardiac computed tomography; advanced echocardiography

(This special issue belongs to the Section Cardiovascular Medicine)

Biomarkers in Peripheral Artery Disease

edited by Ben Li

submission deadline 10 Oct 2026 | 1 articles | Viewed by 794 | Submission Open

Keywords: vascular diseases; biomarkers; diagnosis; prognosis; risk stratification; vascular inflammation; endothelial dysfunction; aneurysmal degeneration; imaging biomarkers; precision medicine

(This special issue belongs to the Section Vascular Medicine)

The Evolution of Knee Surgery: The Role of Robotics and Personalization

edited by

Joong Il Kim

submission deadline 10 Oct 2026 | 1 articles | Viewed by 718 | Submission Open

Keywords: robotic knee surgery; robot-assisted knee arthroplasty; personalized knee replacement; personalized alignment; total knee arthroplasty

(This special issue belongs to the Section Orthopedics)

Application of Artificial Intelligence in Cardiology

edited by

Matthias Unterhuber

submission deadline 13 Oct 2026 | 9 articles | Viewed by 16002 | Submission Open

Keywords: artificial intelligence; cardiology; clinical practice; valvular heart disease; arrhythmias; device therapy; machine learning

(This special issue belongs to the Section Cardiology)

Innovations in Parkinson’s Disease

edited by

Sneha Mantri

submission deadline 15 Oct 2026 | 5 articles | Viewed by 8826 | Submission Open

Keywords: Parkinson’s disease; parkinsonism; patient-reported outcomes; wearable technology; disease-modifying therapies; non-pharmacological therapies; care delivery; models of care

(This special issue belongs to the Section Clinical Neurology)

Clinical Diagnostics and Therapeutic Advances in Pregnancy Complications

edited by

Theresa Reischer

and

Gülen Yerlikaya-Schatten

submission deadline 15 Oct 2026 | 5 articles | Viewed by 8052 | Submission Open

Keywords: prenatal diagnosis; pre-eclampsia; gestational diabetes; pregnancy complications; preterm labor; congenital mal-formations; prenatal genetic testing

(This special issue belongs to the Section Obstetrics & Gynecology)

Pharmacotherapy and Patient Care in Rheumatoid Arthritis

edited by

Ryu Watanabe

submission deadline 15 Oct 2026 | 2 articles | Viewed by 7063 | Submission Open

Keywords: rheumatoid arthritis; pharmacotherapy; patient care; biomarkers; treatment outcomes

(This special issue belongs to the Section Immunology & Rheumatology)

Retinal Dystrophies—Structure and Function Relationship

edited by

Katarzyna Nowomiejska

submission deadline 15 Oct 2026 | 3 articles | Viewed by 4343 | Submission Open

Keywords: retinal dystrophies; structural changes; functional impairment; in retinal degenerative diseases; retinitis pigmentosa

(This special issue belongs to the Section Ophthalmology)

Orthopedic Surgery: Latest Advances and Future Prospects—2nd Edition

edited by Andrea Marinozzi and

Biagio Zampogna

submission deadline 15 Oct 2026 | 4 articles | Viewed by 4030 | Submission Open

Keywords: custom-made; regenerative; prosthetic; noninvasive surgery; robotic surgery; percutaneous surgery; minimally invasive surgery

(This special issue belongs to the Section Orthopedics)

Prenatal Diagnosis and Intervention: Shaping the Future of Maternal–Fetal Medicine

edited by

Misgav Rottenstreich

submission deadline 15 Oct 2026 | 4 articles | Viewed by 3735 | Submission Open

Keywords: diabetes in pregnancy; hypertension in pregnancy; cholestasis in pregnancy; endocrine disorder in pregnancy; sepsis in pregnancy

(This special issue belongs to the Section Obstetrics & Gynecology)

Transjugular Intrahepatic Portosystemic Shunt: Challenges and Perspectives—2nd Edition

edited by

Lorenzo Ridola

, Stefania Gioia and

Silvia Nardelli

submission deadline 15 Oct 2026 | 2 articles | Viewed by 2387 | Submission Open

Keywords: hepatic encephalopathy; spontaneous portal-systemic shunts; transjugular intrahepatic portosystemic shunt; cirrhosis; portal hypertension; sarcopenia; myosteatosis; gastrointestinal bleeding; ascites; non cirrhotic portal hypertension

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Advances in Liver Transplantation and Organ Perfusion

edited by Franziska A. Meister

submission deadline 15 Oct 2026 | 4 articles | Viewed by 2236 | Submission Open

Keywords: liver transplantation; extended criteria donors; ischemia–reperfusion injury; graft dysfunction; organ preservation; machine perfusion; normothermic perfusion; hypothermic perfusion; transplant outcomes

(This special issue belongs to the Section General Surgery)

Clinical Challenges in Endocrine Oncology

edited by

Francesco Dondi

submission deadline 15 Oct 2026 | 3 articles | Viewed by 1725 | Submission Open

Keywords: neuroendocrine tumors; thyroid cancer; adrenocortical carcinoma; pituitary adenoma; multiple endocrine neoplasia (MEN); hormone-secreting tumors

(This special issue belongs to the Section Endocrinology & Metabolism)

Comprehensive Approaches in Gastrointestinal Oncology: Focus on Colorectal, Gastric, and Pancreatic Cancer Treatment

edited by

Stefano Rausei

and

Georgios D. Lianos

submission deadline 15 Oct 2026 | 2 articles | Viewed by 1518 | Submission Open

Keywords: colorectal cancer; gastric cancer; pancreatic cancer; biological staging; clinical staging; early tumors; locally advanced tumors; oligometastatic tumor; neoadjuvant approach; chemotherapy; radiotherapy; immunotherapy; radical surgery; conservative treatment; targeted therapy

(This special issue belongs to the Section Oncology)

Cardiac Surgery: Current Clinical Challenges and New Perspectives

edited by Sadeq Ali-Hasan-Al-Saegh and

Alexander Weymann

submission deadline 15 Oct 2026 | 3 articles | Viewed by 1375 | Submission Open

Keywords: cardiac surgery; surgical challenges; innovations in cardiology; minimally invasive techniques; robotic-assisted surgery; artificial intelligence in cardiac surgery; postoperative management; quality improvement in cardiac surgery

(This special issue belongs to the Section Cardiology)

Contemporary Challenges and Advances in Pulmonary Embolism

edited by Roy Beigel, Shlomi Matetzky and Fernando Chernomordik

submission deadline 15 Oct 2026 | 2 articles | Viewed by 1261 | Submission Open

Keywords: pulmonary embolism; treatment; coagulation; venous thrombosis; thrombolysis; anticoagulation; risk stratification; PERT; CTEPH

(This special issue belongs to the Section Respiratory Medicine)

Clinical and Surgical Treatment for Orthopedic Trauma

edited by Mihnea Ioan Gabriel Popa

submission deadline 15 Oct 2026 | Viewed by 354 | Submission Open

Keywords: orthopedic surgery; orthopedic trauma; trauma surgery; musculoskeletal oncology; musculoskeletal biomaterials; infection management; complication management

(This special issue belongs to the Section Orthopedics)

Urologic Disorders: Advances in Diagnosis and Therapy

edited by Carmen Gonzalez-Enguita and

Alberto Budía-Alba

submission deadline 15 Oct 2026 | Viewed by 305 | Submission Open

Keywords: prostatic hyperplasia; urinary incontinence; urothelial carcinoma; minimally invasive surgery; kidney stone; urinary tract infection

(This special issue belongs to the Section Nephrology & Urology)

Advances in Coronary Heart Disease: From Diagnosis to Long-Term Care

edited by

Marco Cirillo

and Cristian Leva

submission deadline 15 Oct 2026 | Viewed by 271 | Submission Open

Keywords: coronary heart disease; myocardial ischemia; percutaneous coronary intervention; coronary artery bypass surgery; left ventricular reconstruction; coronary diagnostic; coronary microvascular dysfunction; personalized medicine

(This special issue belongs to the Section Cardiology)

Clinical Management of Pemphigus

edited by

Cezary Kowalewski

submission deadline 15 Oct 2026 | Viewed by 250 | Submission Open

Keywords: pemphigus; pemphigus IgA; paraneoplastic pemphigus; cell–cell contact proteins and diagnostic procedures; novel therapies

(This special issue belongs to the Section Dermatology)

Otolaryngologic Clinical Findings and Management Across the Spectrum of Idiopathic Intracranial Hypertension

edited by Bülent Mamikoǧlu

submission deadline 15 Oct 2026 | Viewed by 238 | Submission Open

Keywords: idiopathic intracranial hypertension; intracranial pressure dysregulation; pulsatile tinnitus; venous sinus stenosis; CSF–inner ear coupling; vestibular migraine; dizziness and vertigo; aural fullness; glymphatic system; Chiari malformation; otologic manifestations of IIH; endovascular treatment; acetazolamide therapy

(This special issue belongs to the Section Otolaryngology)

Current Challenges and Innovations in Spine Deformity: Biomechanics, Imaging and AI-Driven Analysis

edited by Dong-Ho Kang

submission deadline 16 Oct 2026 | 4 articles | Viewed by 4709 | Submission Open

Keywords: spinal deformity; cervical deformity; biomechanics; postural alignment; sagittal imbalance; medical imaging; radiographic analysis; artificial intelligence; machine learning; deep learning; phenotyping; computer-assisted diagnosis; predictive modeling; surgical planning

(This special issue belongs to the Section Orthopedics)

Haemodialysis and Peritoneal Dialysis: Current Clinical Practices and Innovations

edited by

Susanne Angermann

submission deadline 16 Oct 2026 | 1 articles | Viewed by 1102 | Submission Open

Keywords: haemodialysis; peritoneal dialysis; end-stage kidney disease; chronic kidney disease; nephrology

(This special issue belongs to the Section Nephrology & Urology)

Contemporary Treatment of Complement-Mediated Diseases

edited by

Daniel Turudić

and Danko Milošević

submission deadline 16 Oct 2026 | Viewed by 287 | Submission Open

Keywords: complement-mediated diseases; complement activation; atypical hemolytic uremic syndrome; C3 glomerulopathy; thrombotic microangiopathy; complement inhibitors; kidney transplantation; antibody-mediated rejection; complement dysregulation; genetic testing; kidney failure; dialysis; kidney transplantation; kidney allograft rejection

(This special issue belongs to the Section Nephrology & Urology)

Advances and Clinical Updates in the Gastrointestinal and Abdominal Diseases

edited by Elissavet Anestiadou, Savvas Symeonidis and Ioannis Mantzoros

submission deadline 19 Oct 2026 | 3 articles | Viewed by 1240 | Submission Open

Keywords: gastrointestinal surgery; minimally invasive surgery; enhanced recovery; digestive oncology; inflammatory bowel disease; abdominal wall reconstruction; biomaterials; perioperative management

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Acute Ischemic Stroke Management Strategies

edited by

Marta Iacobucci

submission deadline 20 Oct 2026 | 9 articles | Viewed by 17627 | Submission Open

Keywords: mechanical thrombectomy; leptomeningeal collateral circulation; neuroprotection; reperfusion injury; ischemic penumbra

(This special issue belongs to the Section Clinical Neurology)

Clinical Management of Pediatric Heart Diseases

edited by

Michele Lioncino

submission deadline 20 Oct 2026 | 11 articles | Viewed by 13066 | Submission Open

Keywords: pediatric heart diseases; children; pediatric cardiology; congenital heart disease; clinical management; congenital heart surgery; outcome

(This special issue belongs to the Section Clinical Pediatrics)

Chronic Disease Management and Rehabilitation in Older Adults

edited by

Justyna Mazurek

submission deadline 20 Oct 2026 | 7 articles | Viewed by 12352 | Submission Open

Keywords: chronic disease; older adults; geriatric rehabilitation; holistic physiotherapy; physical activity; health outcomes; elderly people; geriatric care; health promotion

(This special issue belongs to the Section Geriatric Medicine)

Clinical Challenges and Innovations in Cochlear Implantation and Hearing Rehabilitation

edited by

Meredith Holcomb

submission deadline 20 Oct 2026 | 10 articles | Viewed by 11489 | Submission Open

Keywords: cochlear implant outcomes; clinical efficiency; barriers to care; cochlear implant surgery; cochlear implant referral; cochlear implant evaluation; cochlear implant candidacy; rehabilitation; rehabilitation strategies; quality of life

(This special issue belongs to the Section Otolaryngology)

Acute Myeloid Leukemia: Latest Advances in Diagnostics, Therapeutic Strategies and Clinical Management: 2nd Edition

edited by Michael D. Diamantidis

submission deadline 20 Oct 2026 | 5 articles | Viewed by 11116 | Submission Open

Keywords: ELN; ICC and WHO 2022 AML classifications; molecular AML diagnostics; AML biology; measurable residual disease (MRD); novel targeted AML therapies; AML immunotherapies; hematopoietic stem cell transplantation (HSCT)

(This special issue belongs to the Section Hematology)

Clinical Management of Patients with Heart Failure: 3rd Edition

edited by

Cristina Tudoran

submission deadline 20 Oct 2026 | 11 articles | Viewed by 10641 | Submission Open

Keywords: acute heart failure; chronic heart failure; treatment options; management of heart failure; lifestyle changes; diagnosis of heart failure

(This special issue belongs to the Section Cardiovascular Medicine)

Clinical Update on Thoracic Trauma

edited by

Duilio Divisi

submission deadline 20 Oct 2026 | 6 articles | Viewed by 9396 | Submission Open

Keywords: flail chest; isolated sternal fractures; manubrio-sternal dislocation; pneumothorax; hemothorax; thoracic aortic injury; heart and pulmonary vessels lesion; intercostal artery injury; diaphragm rupture; thoracoabdominal hernia; chylothorax; esophageal perforation

(This special issue belongs to the Section Respiratory Medicine)

Application of Echocardiography in the Diagnosis and Management of Cardiac Diseases

edited by

Calin Pop

and