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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Surgical Treatment and Postoperative Recovery of Heart and Lung Disease
edited by
submission deadline 20 Dec 2025 | 6 articles | Viewed by 8753 | Submission Open
Keywords: heart and lung disease; complications; frailty; rehabilitation; atrial fibrillation; infections
(This special issue belongs to the Section Cardiovascular Medicine)
Diagnosis and Treatment of Rheumatic Diseases
edited by Răzvan Gabriel Drăgoi and
submission deadline 20 Dec 2025 | 4 articles | Viewed by 7766 | Submission Open
Keywords: rheumatic diseases; patient-reported outcomes; assessment; arthritis; impairment; connective tissue diseases; biological and targeted synthetic therapies; impairment
(This special issue belongs to the Section Immunology & Rheumatology)
New Advances in Extracorporeal Membrane Oxygenation (ECMO)
edited by Camilla L'Acqua
submission deadline 20 Dec 2025 | 4 articles | Viewed by 7738 | Submission Open
Keywords: ECMO; anticoagulation; circuit; global collaboration
(This special issue belongs to the Section Emergency Medicine)
New Insights in Ophthalmic Surgery
edited by Irina S. Barequet
submission deadline 20 Dec 2025 | 8 articles | Viewed by 7438 | Submission Open
Keywords: cataract surgery; corneal surgery; refractive surgery; ocular surface reconstruction; anterior segment surgery
(This special issue belongs to the Section Ophthalmology)
Pelvic Organ Prolapse: Current Challenges and Future Perspectives
edited by Marco Soligo
submission deadline 20 Dec 2025 | 5 articles | Viewed by 6983 | Submission Open
Keywords: pelvic organ prolapse; urinary incontinence; lower urinary disorders; quality of life; patient-reported outcomes
(This special issue belongs to the Section Obstetrics & Gynecology)
Patient Reported Outcomes (PROs) in Inflammatory Bowel Disease (IBD) Around the World
edited by Irina Blumenstein
submission deadline 20 Dec 2025 | 5 articles | Viewed by 6913 | Submission Open
Keywords: inflammatory bowel disease; patient reported outcomes; symptom burden; quality of life; treatment satisfaction
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Perspectives on Congenital Heart Disease from Children to Adults
edited by
submission deadline 20 Dec 2025 | 4 articles | Viewed by 6456 | Submission Open
Keywords: congenital heart disease; pediatric cardiac surgery; pediatric cardiology; children; adult congenital heart disease
(This special issue belongs to the Section Cardiology)
Clinical Treatment and Management of Rheumatic Diseases, Autoinflammatory Diseases, and Autoimmune Disorders
edited by Merav Lidar and
submission deadline 20 Dec 2025 | 6 articles | Viewed by 6314 | Submission Open
Keywords: rheumatic diseases; autoinflammatory diseases; autoimmune disorders; rheumatoid arthritis; diagnosis
(This special issue belongs to the Section Immunology & Rheumatology)
Clinical Advances in Metabolic Dysfunction-Associated Steatotic Liver Disease
edited by Hirsh D. Trivedi
submission deadline 20 Dec 2025 | 5 articles | Viewed by 6270 | Submission Open
Keywords: metabolic dysfunction-associated steatotic liver disease; MASLD; non-alcoholic fatty liver disease; NAFLD; liver disease; liver fibrosis; metabolic syndrome
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Robotic Bariatric Surgery
edited by and Vincenzo Pilone
submission deadline 20 Dec 2025 | 2 articles | Viewed by 5795 | Submission Open
Keywords: bariatric surgery; metabolic surgery; sleeve gastrectomy; bariatrics; general surgery; gastric bypass; robotic surgery; robotics
(This special issue belongs to the Section General Surgery)
State of the Art in Hand Surgery
edited by Leszek Romanowski and
submission deadline 20 Dec 2025 | 5 articles | Viewed by 5244 | Submission Open
Keywords: hand surgery; nerve surgery; state-of-the-art; hand therapy; tendons; thumb arthritis; hand fractures
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Emergency Ultrasound: State of the Art and Perspectives submission deadline 20 Dec 2025 | 3 articles | Viewed by 4988 | Submission Open
Keywords: point-of-care ultrasound; emergency ultrasound; focus cardiac ultrasound; lung ultrasound; shock; venous thromboembolic disease; systemic venous congestion; resuscitation; polytrauma
(This special issue belongs to the Section Emergency Medicine)
Latest Advances in Orthodontics
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 4598 | Submission Open
Keywords: digital treatment planning; clear aligners; skeletal anchorage; OSAS; artificial intelligence
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Perspectives on Acute Coronary Syndrome
edited by and
submission deadline 20 Dec 2025 | 3 articles | Viewed by 4174 | Submission Open
Keywords: acute coronary syndrome; ischemic heart disease; multidisciplinary approach; interventional cardiology; new research lines; diagnosis and risk stratification; biomarkers; reperfusion strategies
(This special issue belongs to the Section Cardiovascular Medicine)
Advancements in Gait Rehabilitation: Innovative Approaches and Clinical Insights submission deadline 20 Dec 2025 | 4 articles | Viewed by 4042 | Submission Open
Keywords: sarcopenia; swallowing therapy; physical therapy; early mobilization; early rehabilitation; robot-assisted gait training; neurorehabilitation; wearable sensors
(This special issue belongs to the Section Clinical Rehabilitation)
Accelerating Fracture Healing: Clinical Diagnosis and Treatment
edited by Seong-Eun Byun
submission deadline 20 Dec 2025 | 4 articles | Viewed by 3895 | Submission Open
Keywords: fracture; fracture surgery; fracture healing; diagnosis; treatment
(This special issue belongs to the Section Orthopedics)
Targeted Treatment of Oral Cancer submission deadline 20 Dec 2025 | 3 articles | Viewed by 3354 | Submission Open
Keywords: precision medicine; immunotherapy; targeted drugs; combination therapy; tumor immune evasion; clinical trials
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Advancements in Femtosecond Laser Applications
edited by Luca Schwarzenbacher, Eva Stifter and Philipp Roberts
submission deadline 20 Dec 2025 | 4 articles | Viewed by 3349 | Submission Open
Keywords: femtosecond laser; cataract surgery; DSAEK; DALK; femto-CAIRS; congenital cataract
(This special issue belongs to the Section Ophthalmology)
Clinical Advances in Trauma and Orthopaedic Surgery
edited by Valerio Pace and Pierluigi Antinolfi
submission deadline 20 Dec 2025 | 3 articles | Viewed by 3344 | Submission Open
Keywords: orthopaedic surgery; hand/wrist surgery; tendon injury; ligament injury; artificial intelligence (AI); robotic surgery; orthopaedic injections; nerve injury
(This special issue belongs to the Section Orthopedics)
Anesthesia and Intensive Care in Orthopedic and Trauma Surgery
edited by Liliana Mirea, Răzvan Ene and Cristian Cobilinschi
submission deadline 20 Dec 2025 | 2 articles | Viewed by 3255 | Submission Open
Keywords: opioid sparing analgetic technique; pain management; perioperative medicine; perioperative cognitive disfunction; delirium
(This special issue belongs to the Section Intensive Care)
Clinical Management of Burns: Past, Present and Future
edited by Lior Rosenberg
submission deadline 20 Dec 2025 | 1 articles | Viewed by 3115 | Submission Open
Keywords: history of burn care; burn care infection; inflammation; burn wound care and closure; debridement; traditional Chinese burn care; traditional Indian (Ayurveda) burn care; burn mass casualty incidents (BMCIs); surge capacity; burn pain control; pruritus; burn scar treatment
(This special issue belongs to the Section General Surgery)
Maternal–Fetal Medicine: Current Status, Challenges, and Future Directions
edited by Jessian Munoz
submission deadline 20 Dec 2025 | 3 articles | Viewed by 2973 | Submission Open
Keywords: maternal– fetal medicine; preterm delivery; preterm birth management; newborn; obstetrics; high-risk pregnancy; perinatal outcome; placenta accreta; fetal surgery
(This special issue belongs to the Section Obstetrics & Gynecology)
Diagnosis, Treatment and Comorbidities in Chronic Obstructive Pulmonary Disease (COPD): 2nd Edition
edited by Juan Luis Rodriguez Hermosa, José Luis Álvarez-Sala Walther and Myriam Calle Rubio
submission deadline 20 Dec 2025 | 3 articles | Viewed by 2946 | Submission Open
Keywords: COPD; diagnosis; comorbidities; respiratory rehabilitation; inhaled therapy; biological therapies
(This special issue belongs to the Section Respiratory Medicine)
Clinical Investigations into Diagnosing and Managing Strabismus
edited by Mario Cantó Cerdán and Pilar Cacho-Martínez
submission deadline 20 Dec 2025 | 3 articles | Viewed by 2901 | Submission Open
Keywords: oculomotricity; binocular vision; strabismus; ocular motility disorders; exotropia; esotropia; video oculography; eye tracker; ocular deviation
(This special issue belongs to the Section Ophthalmology)
Colorectal Surgery: Current Practice and Future Perspectives
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 2869 | Submission Open
Keywords: colorectal surgery; minimal invasive surgery; open surgery; robot assisted surgery; colorectal cancer; stomach cancer; pancreatic cancer; diverticular disease
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Updates on the Clinical Applications of Dental Restorative Materials
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 2539 | Submission Open
Keywords: restorative dentistry; restorations; adhesive dentistry; resin composites; ceramics; aesthetics; dental materials; direct restorations; indirect restorations; conservative dentistry; prosthetic dentistry; partial restorations; total restorations
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Advances in Periodontitis and Other Periodontal Diseases
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 2502 | Submission Open
Keywords: periodontal diseases; gingivitis; periodontitis; systemic disease; classification
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Multiple Sclerosis: Clinical Advances in Diagnosis and Treatment
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 2441 | Submission Open
Keywords: relapse-remitting multiple sclerosis; progressive multiple sclerosis; immunomodulatory treatments; cognitive impairment; personalized medicine in multiple sclerosis
(This special issue belongs to the Section Clinical Neurology)
Genitourinary Cancers: Clinical Advances and Practice Updates
edited by David Benjamin and Arash Rezazadeh Kalebasty
submission deadline 20 Dec 2025 | 2 articles | Viewed by 2117 | Submission Open
Keywords: rare tumors; genitourinary cancers; urachal cancer; penile cancer; testicular cancer; variant histology
(This special issue belongs to the Section Nephrology & Urology)
Clinical Innovations in Dental Implant: Expanding Possibilities for Oral Rehabilitation
edited by Marco Severino
submission deadline 20 Dec 2025 | 1 articles | Viewed by 2009 | Submission Open
Keywords: dental implants; oral rehabilitation; computer-guided surgery; biocompatibility; regenerative treatments; mini-implants; minimally invasive surgery
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Management of Bladder Cancer
edited by , Antonio Cicione and
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1991 | Submission Open
Keywords: bladder cancer; minimally invasive surgery; immunotherapy; targeted therapy; biomarkers; imaging techniques; muscle invasive bladder cancer; non-muscle-invasive bladder cancer
(This special issue belongs to the Section Nephrology & Urology)
Antithrombotic Therapies for Acute Coronary Syndrome and Atrial Fibrillation submission deadline 20 Dec 2025 | 1 articles | Viewed by 1496 | Submission Open
Keywords: atrial fibrillation; acute coronary syndrome; antiplatelet agents; anticoagulants; thrombolysis; direct coagulation factor inhibitors; medical laboratory technology
(This special issue belongs to the Section Cardiology)
New Insights in Maxillofacial Surgery
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1423 | Submission Open
Keywords: maxillofacial surgery; surgical techniques; imaging technologies; biomaterials; regenerative medicine
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Advances in Diagnosis and Treatment of Urological Cancers
edited by Davide Campobasso, and
submission deadline 20 Dec 2025 | 2 articles | Viewed by 1209 | Submission Open
Keywords: prostate cancer; kidney cancer; urothelial carcinoma; testis cancer; mini-invasive surgery; precision surgery; target therapy; immunotherapy; nuclear medicine; artificial intelligence; augmented reality; biomarkers; prognostic factors and models; focal therapy; radiotherapy; imaging; genetics
(This special issue belongs to the Section Nephrology & Urology)
Current Challenges and Perspectives in Liver Transplantation
edited by Bogdan Dorobanţu, and Waldo Concepcion
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1154 | Submission Open
Keywords: liver transplantation; liver surgery; liver cirrhosis; liver disease; alcoholic and non-alcoholic steatohepatitis; cholangiocarcinoma; hepatocellular carcinoma; auxiliary liver transplantation
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Neurological Rehabilitation: Repair Mechanisms, Plasticity, and Connectomes
edited by Thomas Mokrusch and Frank Kirchhoff
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1084 | Submission Open
Keywords: neurorehabilitation; therapeutic approaches; repair mechanism; plasticity; neurology
(This special issue belongs to the Section Clinical Neurology)
Clinical Perspectives of Vascular and Endovascular Surgeries submission deadline 20 Dec 2025 | 2 articles | Viewed by 1080 | Submission Open
Keywords: vascular surgery; varicose veins; abdominal aortic aneurysms; carotid disease; peripheral arterial disease
(This special issue belongs to the Section Vascular Medicine)
Key Challenges in Heart Transplantation and Their Solutions
edited by Elizabeth J. Maynes
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1044 | Submission Open
Keywords: heart transplantation; heart failure; cardiac surgery; minimally invasive techniques; general surgery; heart diseases
(This special issue belongs to the Section Cardiology)
Current Perspectives and Innovations in Urogynecology
edited by Stavros Athanasiou
submission deadline 20 Dec 2025 | 1 articles | Viewed by 778 | Submission Open
Keywords: urogynecology; pelvic organ prolapse; urinary incontinence; overactive bladder; pelvic floor surgery; reconstructive surgery; minimally invasive surgery; pelvic floor disorders; innovative surgical techniques; quality of life
(This special issue belongs to the Section Obstetrics & Gynecology)
New Perspectives in Maternal–Fetal Medicine
edited by Catalina de Paco-Matallana
submission deadline 20 Dec 2025 | 1 articles | Viewed by 699 | Submission Open
Keywords: maternal– fetal medicine; prenatal diagnostics; fetal therapy; precision medicine; neonatal outcomes; maternal health
(This special issue belongs to the Section Obstetrics & Gynecology)
Cardiovascular Imaging: Diagnosis and Therapeutic Guidance in Clinical Practice
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 602 | Submission Open
Keywords: cardiovascular magnetic resonance; cardiac imaging; T1 and T2 mapping; myocardial tissue characterization; late gadolinium enhancement; ischemic heart disease; cardiomyopathies; valvular heart disease; therapeutic guidance; precision medicine; mitral valve prolapse
(This special issue belongs to the Section Cardiology)
Novel Diagnostic and Therapeutic Strategies in Vitreoretinal Disease
edited by Jerzy Mackiewicz and
submission deadline 20 Dec 2025 | Viewed by 354 | Submission Open
Keywords: retinal detachment; vitreoretinal diseases; PPV; vitrectomy; macular edema; uveitis; AMD; retinal imaging; retinal pathology; diabetic retinopathy; optical coherent tomography; OCT
(This special issue belongs to the Section Ophthalmology)
Innovative Treatment and Management Strategies for Inflammatory Bowel Disease
edited by Syed Adeel Hassan and
submission deadline 20 Dec 2025 | Viewed by 316 | Submission Open
Keywords: Crohn’ s disease; ulcerative colitis; efficacy; safety; nutrition; surgery; biomarkers
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Transformative Research in Hydrocephalus: Clinical Advances
edited by Afroditi D. Lalou, Zofia Helena Czosnyka and Marek Czosnyka
submission deadline 20 Dec 2025 | Viewed by 276 | Submission Open
Keywords: cerebrospinal fluid dynamics; CSF shunt; intracranial pressure monitoring; telemetric ICP; hydrocephalus pathophysiology; neuroimaging; paediatric hydrocephalus; adult hydrocephalus; translational neuroscience
(This special issue belongs to the Section Clinical Neurology)
Risk Factors in Neonatal Intensive Care submission deadline 20 Dec 2025 | Viewed by 259 | Submission Open
Keywords: neonatal intensive care; infant birth; preterm; neonatal resuscitation; neonatal outcome; growth restriction; prenatal diagnosis; severe maternal pathology and its effects on a newborn; therapeutical hypothermia; parenteral nutrition; neonatal infection; retinopathy of prematurity
(This special issue belongs to the Section Clinical Pediatrics)
Parkinson's Disease: Recent Advances in Diagnosis and Treatment submission deadline 20 Dec 2025 | Viewed by 240 | Submission Open
Keywords: Parkinson’ s disease; disease-modifying therapies; artificial intelligence; microbiome; alpha-synuclein; neuroimaging
(This special issue belongs to the Section Clinical Neurology)
New Clinical Advances in Breast Reconstruction
edited by
submission deadline 20 Dec 2025 | Viewed by 220 | Submission Open
Keywords: breast reconstruction; autologous (flap) reconstruction; implant-based reconstruction; microsurgery and perforator flaps; robotic surgery/endoscopic surgery; fat grafting (lipofilling); patient-reported outcomes; reconstructive surgical innovation
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Applications of Artificial Intelligence in Cardiology: New Tools to Transform Care submission deadline 20 Dec 2025 | Viewed by 202 | Submission Open
Keywords: artificial intelligence in cardiology; machine learning; deep learning; AI-driven ECG analysis; cardiovas-cular imaging and AI; predictive analytics in cardiology; mHealth and wearables; clinical decision support systems; ethics and AI in healthcare; digital health and remote monitoring
(This special issue belongs to the Section Cardiology)
Recent Developments in Urinary Incontinence
edited by
submission deadline 20 Dec 2025 | Viewed by 168 | Submission Open
Keywords: urinary incontinence; overactive bladder; stress urinary incontinence; pelvic floor dysfunction; urodynamics; minimally invasive treatment; neuromodulation; regenerative medicine; conservative management; digital health in urology
(This special issue belongs to the Section Nephrology & Urology)
Hospital-Acquired Infections: Insights, Prevention, and Control Strategies
edited by
submission deadline 20 Dec 2025 | Viewed by 164 | Submission Open
Keywords: healthcare-acquired infections; bloodstream infections; hospital‐acquired pneumonia; intestinal infections; clostridium difficile; surgical site infections; urinary tract infections; emergency department
(This special issue belongs to the Section Epidemiology & Public Health)
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