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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Selected Papers from the 3rd International Online Conference on Clinical Medicine

edited by

Kent Doi

and

Francisco Guillen-Grima

submission deadline 28 Apr 2026 | 1 articles | Viewed by 1409 | Submission Open

Keywords: cardiology; cardiovascular medicine; nephrology; urology; emergency medicine; nuclear medicine & radiology; general surgery; clinical rehabilitation; respiratory medicine; anesthesiology

Current Trends in Hand Surgery

edited by

Alexandre Kaempfen

and Florian Frueh

submission deadline 28 Apr 2026 | 1 articles | Viewed by 1106 | Submission Open

Keywords: microsurgery; minimally invasive; arthroscopy; sonography; nerve surgery; joint replacement

(This special issue belongs to the Section Orthopedics)

Symptoms and Treatment of Cardiac Amyloidosis

edited by Syed Bukhari

submission deadline 28 Apr 2026 | Viewed by 266 | Submission Open

Keywords: cardiac amyloidosis; transthyretin amyloidosis; light chain amyloidosis; cardiac magnetic resonance; echocardiography; nuclear scintigraphy; endomyocardial biopsy; gene silencers; transthyretin stabilizers; immunotherapy

(This special issue belongs to the Section Cardiology)

Periodontal and Other Associated Oral Diseases: Diagnosis and Management in the Context of Systemic Pathology, 2nd Edition

edited by

Silvia Martu

Liliana-Georgeta Foia

and

Maria Alexandra Mârțu

submission deadline 30 Apr 2026 | 4 articles | Viewed by 6749 | Submission Open

Keywords: periodontitis; oral diseases; periimplantitis; biomarkers; cytokines; oxidative stress markers; PCR test; point-of-care test; CBCT; periodontal treatment; immunomodulatory therapy; local drug delivery

(This special issue belongs to the Section Otolaryngology)

Sequelae of COVID-19: Clinical to Prognostic Follow-Up

edited by

Mariana Tudoran

and

Cristina Tudoran

submission deadline 30 Apr 2026 | 5 articles | Viewed by 4543 | Submission Open

Keywords: COVID-19; post-COVID-19 syndromes; sequelae of COVID-19; pathophysiological pathways; multiorgan sequelae; long-term management of post-COVID-19 syndromes; quality of life; long-term prognosis of COVID-19

(This special issue belongs to the Section Vascular Medicine)

Interstitial Lung Diseases: New Treatments and Future Directions

edited by Justyna Fijołek

submission deadline 30 Apr 2026 | 1 articles | Viewed by 3119 | Submission Open

Keywords: Interstitial Lung Disease (ILD); pulmonary fibrosis; orphan lung disease; AAV-ILD; occupational ILD; rheumatic lung disease; treatment strategies; emerging therapies; precision medicine; future directions

(This special issue belongs to the Section Respiratory Medicine)

Advances in Gastroenterological Surgery

edited by Alan Biloslavo and Antonio La Greca

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2757 | Submission Open

Keywords: mini-invasive surgery; technology; artificial intelligence; negative pressure; indocyanine green; ultrasound; GE surgery; emergency surgery; precision surgery

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Rehabilitation Strategies for Neurological Disorders: Advances and Insights

edited by Delia Cinteză and Mihai Berteanu

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2619 | Submission Open

Keywords: neurorehabilitation; physical medicine; virtual reality; AI in rehabilitation medicine; robotic rehabilitation; telerehabilitation; advanced technologies; upper neuromotor lesions; peripheral neuropathies; wearable sensor devices; assessment; goal-setting; individual rehabilitation plan

(This special issue belongs to the Section Clinical Rehabilitation)

New Advances in the Management of Voice Disorders: 2nd Edition

edited by

Ben Barsties v. Latoszek

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1212 | Submission Open

Keywords: voice disorders; laryngology; laryngoscope; acoustic analysis; dysphonia; voice surgery; diagnosis; treatment; rehabilitation; vocal folds; voice assessment/measures

(This special issue belongs to the Section Otolaryngology)

Diabetic Retinopathy Screening: Current Advances and Future Options

edited by

Alauddin Bhuiyan

and

Roland Theodore Smith

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1211 | Submission Open

Keywords: diabetic retinopathy; diabetic retinopathy screening; retinal imaging; age-related macular degeneration; artificial intelli-gence; image analysis; color fundus photography; optical coherence tomography imaging; telemedicine

(This special issue belongs to the Section Ophthalmology)

Skin Cancers: Update on Clinical Treatment and Management

edited by Nazzaro Gianluca

submission deadline 30 Apr 2026 | Viewed by 195 | Submission Open

Keywords: basal cell carcinoma; squamous cell carcinoma; melanoma; skin cancers; dermoscopy; ultrasonography; immunotherapy; biomarker; prevention; diagnosis; treatment; innovative treatments; prognosis

(This special issue belongs to the Section Dermatology)

New Clinical Advances in Depressive Disorders and Treatment-Resistant Depression

edited by Giacomo d'Andrea and Miriam Olivola

submission deadline 30 Apr 2026 | Viewed by 114 | Submission Open

Keywords: treatment-resistant depression; MDD; ketamine; esketamine; rTMS; psylocibin; bipolar depression; clinical pheno-typing; precision psychiatry; biomarkers

(This special issue belongs to the Section Mental Health)

New Clinical Advances in Psoriasis and Psoriatic Arthritis: 2nd Edition

edited by

Diego Orsini

and Alessandra Narcisi

submission deadline 30 Apr 2026 | Viewed by 111 | Submission Open

Keywords: psoriasis; psoriatic arthritis; inflammatory skin disease; inflammatory autoimmune disease; immunotherapy; autoimmunity; comorbidities; therapeutic; diagnosis; treatment; management; biologics

(This special issue belongs to the Section Dermatology)

Advances in Clinical Craniofacial Reconstructive Surgery

edited by Rami S. Kantar

submission deadline 30 Apr 2026 | Viewed by 102 | Submission Open

Keywords: craniofacial; craniofacial conditions; craniofacial surgery; cleft; cleft lip; cleft palate; reconstructive surgery; craniofacial anomalies

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Orthopedic Approaches to Acute Trauma: Insights and Strategies in Trauma Care

edited by

Gianfilippo Caggiari

submission deadline 30 Apr 2026 | Viewed by 96 | Submission Open

Keywords: acute trauma; orthopedic surgery; fractures and dislocations; ligament injuries; cartilage lesions; post-traumatic degeneration; emergency trauma care; surgical and non-surgical management; rehabilitation strategies; musculo-skeletal injury outcomes

(This special issue belongs to the Section Orthopedics)

Clinical Updates and New Perspectives of Chronic Pain

edited by Yohannes W. Woldeamanuel

submission deadline 30 Apr 2026 | Viewed by 74 | Submission Open

Keywords: circadian rhythms; chronic pain; clock genes; neuroinflammation; chronotherapy; migraine; cancer survivors; sex differences; racial disparities; personalized medicine

(This special issue belongs to the Section Clinical Neurology)

Clinical Challenges and Innovations in Cochlear Implantation and Hearing Rehabilitation

edited by

Meredith Holcomb

submission deadline 30 Apr 2026 | Viewed by 73 | Submission Open

Keywords: cochlear implant outcomes; clinical efficiency; barriers to care; cochlear implant surgery; cochlear implant referral; cochlear implant evaluation; cochlear implant candidacy; rehabilitation; rehabilitation strategies; quality of life

(This special issue belongs to the Section Otolaryngology)

Insight into Infectious Disease Epidemiology and Public Health

edited by

Francesco Rosiello

and Filomena Pietrantonio

submission deadline 30 Apr 2026 | Viewed by 72 | Submission Open

Keywords: gender medicine; health management; public health; infectious disease; sindemics

(This special issue belongs to the Section Infectious Diseases)

Surgical Insights into Foot and Ankle Diseases

edited by Konstantinos Tsikopoulos

submission deadline 30 Apr 2026 | Viewed by 71 | Submission Open

Keywords: lower limb surgery; infection research; foot and ankle

(This special issue belongs to the Section Orthopedics)

Advances in Cardiovascular Computed Tomography (CT)

edited by

David C. Rotzinger

submission deadline 30 Apr 2026 | Viewed by 70 | Submission Open

Keywords: computed tomography angiography; cardiovascular imaging; contrast media; spectral computed tomography; quantitative imaging; coronary artery disease; aortic disease; pulmonary embolism; structural heart disease

(This special issue belongs to the Section Cardiovascular Medicine)

Head and Neck Cancer: Clinical Diagnostics and Treatments

edited by Matti Anniko

submission deadline 30 Apr 2026 | Viewed by 61 | Submission Open

Keywords: head and neck cancer; treatment; surgery; chemotherapy; immunotherapy; diagnostics

(This special issue belongs to the Section Otolaryngology)

Antithrombotic Therapy in Special and Overlooked Populations with Cardiovascular Diseases

edited by

Leonardo De Luca

submission deadline 30 Apr 2026 | Viewed by 51 | Submission Open

Keywords: antithrombotic therapy; high-risk patients; PCI; bleeding risk; atrial fibrillation; individualized treatment; real-world evidence; complex cardiovascular disease

(This special issue belongs to the Section Cardiovascular Medicine)

Congenital Heart Disease in Adults (ACHD): Diagnosis, Therapy, and Clinical Management

edited by Mirosław Kowalski

submission deadline 30 Apr 2026 | Viewed by 15 | Submission Open

Keywords: congenital cardiac defect in adults; right ventricular failure; strain echocardiography; ventricular mechanics; cardiac resynchronizing therapy (CRT); Fontan operation; protein-losing enteropathy (PLE)

(This special issue belongs to the Section Cardiology)

Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) and Concomitant Illnesses: Diagnostic and Therapeutic Implications

edited by Kamran Qureshi and Lewis Frey

submission deadline 30 Apr 2026 | Viewed by 6 | Submission Open

Keywords: metabolic dysfunction-associated steatotic liver disease (MASLD); metabolic dysfunction-associated steatohepatitis (MASH); chronic liver diseases; metabolic syndrome; viral hepatitis; autoimmune liver diseases

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

The Role of Cardiac Rehabilitation After Myocardial Infarction, Coronary Artery Bypass Surgery, and in Other Cardiac Diseases

edited by

Aneta Aleksova

submission deadline 1 May 2026 | 3 articles | Viewed by 4836 | Submission Open

Keywords: cardiac rehabilitation; coronary artery disease; myocardial infarction; coronary artery bypass surgery; heart failure; ventricular assist device; heart transplantation; cardiomyopathies; cardiac remodeling; illness perception; treatment adherence; gender difference; biomarkers; endothelial function

(This special issue belongs to the Section Cardiology)

Recent Advancements in Periodontal and Peri-Implant Disease Management

edited by

João Martins de Mello-Neto

and Leticia Helena Theodoro

submission deadline 5 May 2026 | Viewed by 221 | Submission Open

Keywords: periodontal disease; peri-implantitis; periodontal medicine; complications and management

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Advancements and Challenges in Reconstructive Urology and Urethral Surgery

edited by

Francesco Chierigo

submission deadline 10 May 2026 | 3 articles | Viewed by 2828 | Submission Open

Keywords: reconstructive urology; urethral surgery; urethroplasty; minimally invasive surgery; robotic-assisted surgery; urinary tract reconstruction; surgical innovation; patient-reported outcomes

(This special issue belongs to the Section Nephrology & Urology)

Advances in Chronic Pain and Related Management

edited by

Sabine Sator

submission deadline 10 May 2026 | Viewed by 100 | Submission Open

Keywords: chronic pain; musculoskeletal pain; neuropathic pain; fibromyalgia syndrome; somatoform disorder; post-COVID syndrome; small fiber disease; invasive pain therapy; vagus stimulation

(This special issue belongs to the Section Anesthesiology)

Quality of Life in Patients with Gynecological Cancers

edited by

Katarzyna Plagens-Rotman

Piotr Merks

and Monika Englert-Golon

submission deadline 10 May 2026 | Viewed by 75 | Submission Open

Keywords: quality of life; gynecology oncology; ovarian cancer; breast cancer; cervical cancer; endometrial cancer; women; gynecological diseases; oncological diseases

(This special issue belongs to the Section Obstetrics & Gynecology)

Innovations, Biomarkers, and Challenges in Cancer Immunotherapy

edited by

Mohammad Mousaei Ghasroldasht

and Mahzad Akbarpour

submission deadline 10 May 2026 | Viewed by 50 | Submission Open

Keywords: next-generation cellular therapies; CAR-NK cell therapy; CAR-T cell therapy; combination strategies; exosomes; T-cell engagers; oncolytic viruses; cancer immunotherapy; biomarkers for therapy response; translational immunotherapy; tumor microenvironment modulation; immune evasion mechanisms

(This special issue belongs to the Section Oncology)

Prevention and Management of Sexual Dysfunction

edited by Grażyna Jarząbek-Bielecka and Katarzyna Plagens-Rotman

submission deadline 10 May 2026 | Viewed by 49 | Submission Open

Keywords: sexual health; sexual dysfunction; reproductive health; general sexuology; sexological care

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Challenging ICU Dogma: Where Routine Practice and Evidence Collide

edited by

Yujiro Matsuishi

and Nobutake Shimojo

submission deadline 10 May 2026 | Viewed by 32 | Submission Open

Keywords: critical care; intensive care unit (ICU); clinical dogma; de-implementation; medical reversal; routine practices; clinical decision-making

(This special issue belongs to the Section Intensive Care)

Advances in the Management of Chronic Lymphocytic Leukemia

edited by

Alberto Fresa

and

Luca Laurenti

submission deadline 12 May 2026 | Viewed by 41 | Submission Open

Keywords: chronic lymphocytic leukemia; lymphoproliferative disorders; prognostic factors; targeted therapy; CAR T cell; elderly patients; comorbidities

(This special issue belongs to the Section Hematology)

Thyroid Disorders: New Clinical Diagnosis and Management

edited by

Ioannis P. Iakovou

Rodis D. Paparodis

and

Nicholaos G. Angelopoulos

submission deadline 15 May 2026 | Viewed by 963 | Submission Open

Keywords: thyroid disorders; clinical diagnosis; ultrasound; elastography; thyroid cancer; thyroiditis; hyperthyroidism; hypothyroidism; advanced imaging

(This special issue belongs to the Section Endocrinology & Metabolism)

Clinical Management of Attention Deficit Hyperactivity Disorder (ADHD)

edited by

Alessandro Pallucchini

submission deadline 15 May 2026 | Viewed by 143 | Submission Open

Keywords: ADHD; addiction; neurodevelopmental disorders; levomethadone

(This special issue belongs to the Section Mental Health)

Clinical Updates on Pediatric Surgery

edited by Carlos Theodore Huerta and Eduardo Alfonso Perez

submission deadline 15 May 2026 | Viewed by 131 | Submission Open

Keywords: pediatric surgery; robotic-assisted surgery; artificial intelligence; enhanced recovery after surgery; minimally inva-sive surgery; augmented reality

(This special issue belongs to the Section Clinical Pediatrics)

Clinical Updates on Maternal Fetal Medicine: 2nd Edition

edited by

Roberta Granese

and

Gabriele Tonni

submission deadline 15 May 2026 | Viewed by 104 | Submission Open

Keywords: diabetes in pregnancy; hypertension in pregnancy; cholestasis in pregnancy; endocrine disorder in pregnancy; sepsis in pregnancy

(This special issue belongs to the Section Obstetrics & Gynecology)

Pediatric Pulmonology: Current Hurdles and Future Perspectives

edited by Isabel Delgado-Pecellín and Anselmo Andrés-Martín

submission deadline 15 May 2026 | Viewed by 102 | Submission Open

Keywords: interstitial lung diseases; neonatal screening; complex chronic patients; home mechanical ventilation; severe asthma; telemonitoring; lung development; cystic fibrosis; genetics

(This special issue belongs to the Section Clinical Pediatrics)

Damage Control Surgery: New Insights into Resuscitation, Operative Strategies and Complications

edited by

Bruno de La Villéon

submission deadline 15 May 2026 | Viewed by 84 | Submission Open

Keywords: damage control surgery; damage control resuscitation; polytrauma management; massive transfusion protocol; hemorrhagic shock; trauma laparotomy; staged laparotomy; temporary abdominal closure; multidisciplinary trauma care

(This special issue belongs to the Section General Surgery)

Root Canal Treatment and Healing Outcomes: Clinical Application of Endodontic Biomaterials and Postoperative Management

edited by

Fausto Zamparini

Carlo Prati

and

Andrea Spinelli

submission deadline 15 May 2026 | Viewed by 62 | Submission Open

Keywords: root canal treatment; healing outcomes; endodontic biomaterials; bioceramic sealers; postoperative management; clinical evidence; periapical healing; post operative pain; dentistry

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Heart Failure: Challenges and Future Options

edited by Pedro Caravaca-Pérez and Marta Farrero-Torres

submission deadline 15 May 2026 | Viewed by 47 | Submission Open

Keywords: heart failure; cardiorenal syndrome; heart transplantation; ventricular assist devices; biomarkers; precision medicine; advanced therapies; diuretic resistance; risk stratification; multidisciplinary care

(This special issue belongs to the Section Cardiovascular Medicine)

Hypertrophic Cardiomyopathy: Lights and Shadows of Structural Pharmacological Treatment

edited by Daniel Dalos

submission deadline 15 May 2026 | Viewed by 36 | Submission Open

Keywords: hypertrophic cardiomyopathy; treatment; myosin inhibition; ventricular arrhythmia; atrial fibrillation

(This special issue belongs to the Section Cardiology)

Head and Neck Cancer: Clinical Diagnosis and Treatment

edited by Enrique Sanz-Garcia, Nicole Chau and Neus Baste

submission deadline 15 May 2026 | Viewed by 34 | Submission Open

Keywords: head and neck; multidisciplinary approaches; biomarkers; early detection; therapies

(This special issue belongs to the Section Otolaryngology)

Comprehensive Hernia Surgery: From Clinical Diagnosis to Postoperative Care

edited by Luca Regusci

submission deadline 15 May 2026 | Viewed by 4 | Submission Open

Keywords: ventral hernia; complexe hernias; botox treatment; laparoscopic surgery; robotic surgery

(This special issue belongs to the Section General Surgery)

Novel Insights into the Prevention and Treatment of Contact Dermatitis

edited by

Cara Bieck

, Christoph Skudlik, Swen Malte John and

Albert Nienhaus

submission deadline 20 May 2026 | 3 articles | Viewed by 5505 | Submission Open

Keywords: allergic; allergy; contact dermatitis; irritant; occupation; prevention; sensitization; skin; therapy; treatment

(This special issue belongs to the Section Dermatology)

Cardiac Imaging in Cardiovascular Disorders

edited by Leif-Christopher Engel

submission deadline 20 May 2026 | Viewed by 540 | Submission Open

Keywords: coronary CT angiography; cardiac magnetic resonance imaging; molecular imaging; echocardiography; stress echocardiography; myocardial perfusion imaging

(This special issue belongs to the Section Cardiology)

Acute Ischemic Stroke: Current Status and Future Challenges—2nd Edition

edited by

Lucio D'Anna

submission deadline 20 May 2026 | 1 articles | Viewed by 334 | Submission Open

Keywords: acute ischemic stroke; atrial fibrillation; endovascular thrombectomy; intravenous thrombolysis; direct oral anticoagulants

(This special issue belongs to the Section Clinical Neurology)

Surgical Management of Complex Spinal Pathologies: Challenges and Innovations

edited by

Spyridon Komaitis

submission deadline 20 May 2026 | 1 articles | Viewed by 293 | Submission Open

Keywords: complex spinal surgery; adult spinal deformity; complex degenerative pathologies; revision spine surgery; spinal oncology; robotics; navigation; surgical outcomes

(This special issue belongs to the Section Orthopedics)

Clinical Updates of Physical Therapy in Rehabilitation

edited by