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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Motor Activity and Cognitive Development in Early Childhood: Clinical Implications

edited by

Michele Roccella

and

Daniela Smirni

submission deadline 25 Aug 2026 | Viewed by 69 | Submission Open

Keywords: motor activity; cognitive development; early childhood; neurodevelopmental disorders; autism spectrum disorder; attention-deficit/hyperactivity disorder; developmental coordination disorder; preterm birth

(This special issue belongs to the Section Clinical Neurology)

Etiology, Diagnosis, and Management of Upper Gastrointestinal Disorders: 2nd Edition

edited by

Hidekazu Suzuki

submission deadline 25 Aug 2026 | Viewed by 68 | Submission Open

Keywords: esophagus; stomach; duodenum; DGBI; FGIDs; helicobacter; eosinophilic esophagitis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Hand Surgery in Practice: Current Evidence and Emerging Techniques

edited by Guy Rubin

submission deadline 25 Aug 2026 | Viewed by 63 | Submission Open

Keywords: trauma; mallet; burn; nerve; tendon

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Kidney Transplantation: From Donor Selection to Recipient Outcomes

edited by Basma Merhi and Reginald Gohh

submission deadline 25 Aug 2026 | Viewed by 60 | Submission Open

Keywords: kidney transplantation; end-stage renal disease (ESRD); living-donor kidney transplantation; deceased-donor kidney transplantation; organ shortage; dialysis waiting time; transplant candidate evaluation; immunosuppression

(This special issue belongs to the Section Nephrology & Urology)

Advances in Percutaneous Coronary Intervention: Techniques, Tools and Outcomes

edited by Takashi Ashikaga

submission deadline 25 Aug 2026 | Viewed by 57 | Submission Open

Keywords: percutaneous coronary intervention; orbital atherectomy; coronary artery calcification; intravascular ultrasound (IVUS); optical coherence tomography (OCT)

(This special issue belongs to the Section Cardiovascular Medicine)

Personalized Therapy and Clinical Outcome for Vasculitis

edited by

Giulia Cassone

submission deadline 25 Aug 2026 | Viewed by 53 | Submission Open

Keywords: immune-mediated systemic vasculitis; personalized therapy; treatment; outcome; biomarkers; risk factors; management; multidisciplinary care

(This special issue belongs to the Section Immunology & Rheumatology)

Gastrointestinal Cancer: Outcomes and Therapeutic Management—2nd Edition

edited by Maximos Frountzas

submission deadline 25 Aug 2026 | Viewed by 52 | Submission Open

Keywords: surgical oncology; gastrointestinal cancer; esophageal; gastric; hepatic; biliary; pancreatic; colon; rectal; neoplasm

(This special issue belongs to the Section Oncology)

Hypertension in Adults: Current Updates on Diagnosis, Treatment and Management—Second Edition

edited by Emelina Stambolliu and Antonios A. Argyris

submission deadline 25 Aug 2026 | Viewed by 50 | Submission Open

Keywords: essential hypertension; nighttime blood pressure; blood pressure measurement; blood pressure management; blood pressure medical treatment; hypertension thresholds

(This special issue belongs to the Section Vascular Medicine)

Clinical Updates of Pediatric Craniofacial Surgery

edited by Federica Tosi

submission deadline 25 Aug 2026 | Viewed by 43 | Submission Open

Keywords: pediatric craniofacial surgery; craniosynostosis; near-infrared spectroscopy; blood transfusion; perioperative monitoring; pediatric anesthesia; hemodynamic management; tissue oxygenation

(This special issue belongs to the Section Clinical Pediatrics)

Complications of Laparoscopic Cholecystectomy: Surgical Outcomes and Clinical Challenges

edited by

Roberto Cirocchi

submission deadline 25 Aug 2026 | Viewed by 40 | Submission Open

Keywords: laparoscopic cholecystectomy; bile duct injury; management of intraoperative injuries; surgical outcomes; postoperative infections

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Bariatric Surgery: Clinical Advances and Future Directions

edited by

Natalia Dowgiałło-Gornowicz

and

Mateusz Wityk

submission deadline 25 Aug 2026 | Viewed by 35 | Submission Open

Keywords: metabolic surgery; bariatric surgery; reflux; laparoscopy; conversion surgery; obesity

(This special issue belongs to the Section General Surgery)

Emerging Trends and Therapeutic Innovations in Corneal and Ocular Surface Disorders

edited by

Zala Lužnik Marzidovšek

and Špela Štunf Pukl

submission deadline 25 Aug 2026 | Viewed by 31 | Submission Open

Keywords: corneal diseases; ocular surface disorders; regenerative medicine; stem cell therapy; gene therapy; nanomedicine and targeted drug delivery

(This special issue belongs to the Section Ophthalmology)

Clinical Advancements in Orthopedic Trauma Treatments

edited by

Alessandro Rava

submission deadline 25 Aug 2026 | Viewed by 30 | Submission Open

Keywords: fractures; osteoporosis; fixation; trauma; fracture healing; osteosynthesis; pain

(This special issue belongs to the Section Orthopedics)

Early Palliative Care for Patients with Advanced Cancer

edited by

Daryl Bainbridge

submission deadline 25 Aug 2026 | Viewed by 15 | Submission Open

Keywords: palliative care; early integration; cancer care transitions; communication; symptom management; end of life

(This special issue belongs to the Section Oncology)

Hidradenitis Suppurativa: Clinical Diagnosis, Treatment, and Management

edited by Piotr K. Krajewski

submission deadline 25 Aug 2026 | Viewed by 15 | Submission Open

Keywords: hidradenitis suppurativa; acne inversa; clinical diagnosis; disease severity assessment; biologic therapy; surgical management; comorbidities; quality of life; multidisciplinary care; real world evidence

(This special issue belongs to the Section Dermatology)

Recent Advances and Future Perspective of Subarachnoid Hemorrhage

edited by

Tihamer Molnar

submission deadline 26 Aug 2026 | Viewed by 42 | Submission Open

Keywords: subarachnoid bleeding; neuromonitoring; neuroimaging; delayed cerebral infarction; biomarkers; personalized medicine; AI-guided decision support; outcome

(This special issue belongs to the Section Clinical Neurology)

Clinical Updates in Heart Failure: Innovations in Diagnosis, Therapy and Management

edited by Paolo Severino

submission deadline 28 Aug 2026 | Viewed by 54 | Submission Open

Keywords: heart failure; HFrEF therapy; HFpEF phenotyping; right ventricular dysfunction; renal congestion assessment; diuretic resistance; NT-proBNP dynamics; cardiac imaging; post-discharge management

(This special issue belongs to the Section Cardiology)

Chronic Obstructive Pulmonary Disease (COPD): Treatment and Management—Second Edition

edited by

Maurizio Marvisi

and Alfredo Antonio Chetta

submission deadline 31 Aug 2026 | Viewed by 68 | Submission Open

Keywords: chronic obstructive pulmonary disease (COPD); treatable traits; precision medicine; COPD comorbidities; COPD mortality

(This special issue belongs to the Section Respiratory Medicine)

The New Perspective in Transcatheter Aortic Valve Implantation (TAVI)

edited by Salvatore Giordano, Arturo Giordano and Nicola Corcione

submission deadline 31 Aug 2026 | Viewed by 66 | Submission Open

Keywords: transcatheter aortic valve implantation (TAVI); structural heart intervention; aortic stenosis; valve technology and durability; imaging and procedural optimization

(This special issue belongs to the Section Cardiovascular Medicine)

Clinical Management of Type 1 Diabetes: 2nd Edition

edited by Carmen Quirós

submission deadline 31 Aug 2026 | Viewed by 53 | Submission Open

Keywords: type 1 diabetes; continuous glucose monitoring; hybrid closed loop; hypoglycemia; physical activity; new onset type 1 diabetes; pre-stage 3 type 1 diabetes; smart insulin pens

(This special issue belongs to the Section Endocrinology & Metabolism)

Advances in Anticoagulant and Antiplatelet Therapy for Coronary Artery Disease: 2nd Edition

edited by

Giuseppe De Luca

submission deadline 31 Aug 2026 | Viewed by 48 | Submission Open

Keywords: platelet; anticoagulant therapy; antiplatelet therapy; coronary artery disease (CAD); atrial fibrillation (AF); thromboembolic events; myocardial ischemic; bleeding events; aspirin; clopidogrel; cardiovascular and cerebrovascular diseases; diagnosis and treatment; percutaneous coronary intervention; acute coronary syndrome

(This special issue belongs to the Section Cardiology)

Infectious Diseases and Host Responses: Clinical, Immunological, and Outcome-Orientated Perspectives

edited by

Nicoleta Negruț

submission deadline 31 Aug 2026 | Viewed by 23 | Submission Open

Keywords: microbiology; infection; resistance; epidemiology; microbiome; prevention; therapy

(This special issue belongs to the Section Infectious Diseases)

Optimizing the Surgical Journey: From Abdominal Operation to Recovery

edited by

Alessio Giordano

and Carlo Bergamini

submission deadline 1 Sep 2026 | Viewed by 57 | Submission Open

Keywords: surgical complications; comanagement; comorbidities; elective surgical procedure; emergency surgery procedure; multidisciplinary approach; hospitalist

(This special issue belongs to the Section General Surgery)

Cardiac Intensive Care Units: Clinical Advances and Future Challenges

edited by Luca Baldetti

submission deadline 10 Sep 2026 | Viewed by 45 | Submission Open

Keywords: cardiac intensive care; heart failure; cardiogenic shock; mechanical circulatory support; invasive hemodynamic monitoring; acute cardiac care; shock; myocardial infarction

(This special issue belongs to the Section Cardiology)

Management of Inguinal Hernia Surgery, Chronic Pain and Technological Future

edited by

Alfredo Moreno Egea

submission deadline 10 Sep 2026 | Viewed by 18 | Submission Open

Keywords: inguinal hernia; chronic pain; radical cure; technology; medical and surgery future

(This special issue belongs to the Section General Surgery)

Robotic Urologic Surgery: Clinical Applications and Advances

edited by Athanasios N. Kostakopoulos and Nikolaos Kostakopoulos

submission deadline 10 Sep 2026 | Viewed by 18 | Submission Open

Keywords: robotic surgery; robotic urology; advances in robotics; urologic surgery; minimally invasive urologic surgery; robotic partial nephrectomy; robotic radical prostatectomy

(This special issue belongs to the Section Nephrology & Urology)

Improving Short- and Long-Term Neurological Outcomes in Perioperative Anesthesia and Critical Care

edited by

Michele Salvagno

and

Marta Baggiani

submission deadline 10 Sep 2026 | Viewed by 12 | Submission Open

Keywords: perioperative brain injury; neuroprotection; multimodal neuromonitoring; delirium; neurocritical care; cerebral perfusion and oxygenation; precision anesthesia; artificial intelligence in critical care

(This special issue belongs to the Section Intensive Care)

Clinical Practice of Imaging in Coronary Interventional Therapy

edited by Nobuaki Suzuki

submission deadline 10 Sep 2026 | Viewed by 6 | Submission Open

Keywords: coronary artery disease; cardiac imaging; intravascular ultrasound; near-infrared spectroscopy; optical coherence tomography; fractional flow reserve computed tomography

(This special issue belongs to the Section Cardiology)

Photodynamic Therapy for Cancers: Clinical Advances and Prospects

edited by

Waseem Jerjes

submission deadline 10 Sep 2026 | Viewed by 4 | Submission Open

Keywords: photodynamic therapy; cancer treatment; photosensitisers; light-based therapy; PDT dosimetry; minimally invasive oncology; combination cancer therapies; translational photomedicine; clinical outcomes; precision oncology

(This special issue belongs to the Section Oncology)

Current Challenges in Clinical Dentistry: 3rd Edition

edited by

Eiji Tanaka

and

Susumu Abe

submission deadline 15 Sep 2026 | Viewed by 103 | Submission Open

Keywords: artificial intelligence; clinical dentistry; cutting-edge device and technology; dental material; challenging hypothesis; preventive dentistry; sleep medicine; digital dentistry; smart dentistry; stomatognathic function

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

State-of-the-Art of Lung Surgery: Modern Horizons in Lung Cancer Treatment

edited by

Alessio Mariolo

and Edouard Sage

submission deadline 15 Sep 2026 | Viewed by 36 | Submission Open

Keywords: lung-cancer-surgery; thoracic oncology; RATS; VATS; induction therapy; neoadjuvant-immunotherapy; non-intubated thoracic surgery; NITS; segmentectomy; lung-sparing surgery; 3D-reconstruction

(This special issue belongs to the Section General Surgery)

Advances in Cardiac Resynchronization Treatment: 2nd Edition

edited by

George Leventopoulos

, Konstantinos A. Gatzoulis and Konstantinos Aronis

submission deadline 15 Sep 2026 | Viewed by 14 | Submission Open

Keywords: conduction system; risk stratification; resynchronization; cardiac pacing; sudden cardiac death

(This special issue belongs to the Section Cardiology)

Clinical Advances in Endodontics

edited by Vincenzo Tosco

submission deadline 15 Sep 2026 | Viewed by 10 | Submission Open

Keywords: endodontics; vital pulp therapy; minimally invasive endodontics; clinical endodontic techniques; bioactive sealers

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Application of Physiotherapy in Clinical Rehabilitation

edited by

Kyeongbong Lee

submission deadline 17 Sep 2026 | Viewed by 14 | Submission Open

Keywords: therapeutic exercise; neurological rehabilitation; musculoskeletal physiotherapy; cardiopulmonary rehabilitation; intensive care unit (ICU) rehabilitation; gait and balance; pediatric and geriatric physical therapy; sports physical therapy; rehabilitation technology

(This special issue belongs to the Section Clinical Rehabilitation)

Current Challenges and Approaches to Post-Traumatic Stress Disorder (PTSD)

edited by

Aron Tendler

submission deadline 20 Sep 2026 | Viewed by 105 | Submission Open

Keywords: PTSD treatment; implementation; prevention; prevalence; risk factors

(This special issue belongs to the Section Mental Health)

Treatment and Clinical Management of Necrotizing Pancreatitis

edited by

Apostolos Gaitanidis

submission deadline 20 Sep 2026 | Viewed by 89 | Submission Open

Keywords: necrotizing pancreatitis; infected necrosis; step-up approach; necrosectomy; minimally invasive surgery; artificial intelligence; lumen-apposing metal stent; pancreatic necrosis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Management in Dry Eye Disease: Current Strategies and Emerging Protocols

edited by Sunil Shah and Raquel Gil-Cazorla

submission deadline 20 Sep 2026 | Viewed by 78 | Submission Open

Keywords: dry eye disease; ocular surface; diagnostics; inflammation; biomarkers; emerging therapies

(This special issue belongs to the Section Ophthalmology)

Perinatal and Postnatal Mental Health: State of the Art

edited by Adriana Mihai

submission deadline 20 Sep 2026 | Viewed by 71 | Submission Open

Keywords: peripartum depression; post-partum depression; parental– infant well-being; early detection; perinatal mental health; postnatal mental health; psychotherapy interventions

(This special issue belongs to the Section Mental Health)

Personalized Treatments for Patients with Acute Lung Injury

edited by

Gary F. Nieman

submission deadline 20 Sep 2026 | Viewed by 21 | Submission Open

Keywords: personalized; acute lung injury; acute respiratory distress syndrome (ARDS); ventilator-induced lung injury (VILI); pharmacotherapy; fluid resuscitation; phenotypes; mesenchymal stem cells; nano-systems; exosomes; biomarkers; computational models

(This special issue belongs to the Section Respiratory Medicine)

The Diagnosis and Treatment of Endometriosis

edited by

Radoslaw Maksym

submission deadline 20 Sep 2026 | Viewed by 17 | Submission Open

Keywords: endometriosis; infertility; pregnancy; hysterosalpingography; deep lesions; medical imaging; diagnostic techniques; ultrasonography; magnetic resonance imaging (MRI); laparoscopy; pelvic imaging; fertility assessment; imaging modalities; gynecological imaging; radiological approaches; reproductive medicine; immunotherapy; inflammation; antioxidants

(This special issue belongs to the Section Obstetrics & Gynecology)

Current Advances in Artificial Intelligence in Oral Cancer Research, Early Diagnosis, and Personalized Therapy

edited by Aminollah Khormali

submission deadline 20 Sep 2026 | Viewed by 17 | Submission Open

Keywords: artificial intelligence; precision oncology; digital pathology; deep learning; early cancer detection; predic-tive modeling; oral cancer diagnostics

(This special issue belongs to the Section Oncology)

Management and Treatment Strategies for Diabetic Kidney Disease

edited by Luca Visconti

submission deadline 20 Sep 2026 | Viewed by 16 | Submission Open

Keywords: diabetic kidney disease; hemodialysis; cardiovascular; dialysis; diabetic nephropathy; diabetes

(This special issue belongs to the Section Nephrology & Urology)

PET/CT Imaging in Oncology: Clinical Applications and Updates

edited by

Nikolaos Papathanasiou

submission deadline 20 Sep 2026 | Viewed by 11 | Submission Open

Keywords: Positron Emission Tomography/Computed Tomography (PET/CT); molecular imaging; oncology; Fluoro-Deoxy-Glucose (FDG); novel tracers (PSMA; FAPI; radiolabeled peptides); quantitative PET

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Cardiac Intensive Care: Clinical Insights and Advances

edited by

Jacopo D’Andria Ursoleo

Elena G. Bignami

and Valentina Bellini

submission deadline 20 Sep 2026 | Viewed by 9 | Submission Open

Keywords: acute heart failure; artificial intelligence; cardiac intensive care; cardiogenic shock; cardiac surgery; extracorporeal life support; hemodynamic monitoring; machine learning; mechanical circulatory support; outcomes and prognostication; palliative care; postcardiotomy care; precision medicine; resuscitation science; shock management; ventricular assist devices

(This special issue belongs to the Section Intensive Care)

Beyond Efficacy and Trials: Real-World Value and Effectiveness in Autoimmune Rheumatic Joint Diseases

edited by

Carlos Alves

submission deadline 20 Sep 2026 | Viewed by 7 | Submission Open

Keywords: effectiveness; efficacy; autoimmune rheumatic joint diseases; patient-reported outcomes; quality of life

(This special issue belongs to the Section Immunology & Rheumatology)

Obsessive–Compulsive Disorder (OCD): Understanding, Treatment, and New Directions in Psychotherapy

edited by Franziska Sophia Miegel

submission deadline 20 Sep 2026 | Viewed by 6 | Submission Open

Keywords: obsessive– compulsive disorder; clinical psychopathology; mechanisms of change; psychotherapeutic interventions; treatment delivery; accessibility of care; innovative treatment approaches; technology-supported interventions

(This special issue belongs to the Section Mental Health)

Clinical Strategies in Structural Heart and Cardiothoracic Interventions

edited by

Adam Rdzanek

submission deadline 20 Sep 2026 | Viewed by 4 | Submission Open

Keywords: structural heart disease; heart team; valvular heart disease; cardiac surgery; transcatheter interventions; patient selection; real-world outcomes

(This special issue belongs to the Section Cardiology)

Advances in Imaging and Therapeutic Strategies for Cardiomyopathy Care

edited by Fabio Vagnarelli and