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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Vascular and Endovascular Surgery: State of the Art and Emerging Insights

edited by Georgios Meimarakis and Volker Ruppert

submission deadline 10 May 2027 | 3 articles | Viewed by 1672 | Submission Open

Keywords: carotid stenosis; peripheral arterial disease; abdominal aortic aneurysm; type B aortic dissection; chronic limb-threatening ischemia; endovascular therapy; vascular surgery; drug-coated balloon; hemodialysis access; health disparities

(This special issue belongs to the Section Vascular Medicine)

Robotic Urologic Surgery: Clinical Applications and Advances

edited by Athanasios N. Kostakopoulos and

Nikolaos Kostakopoulos

submission deadline 10 May 2027 | 2 articles | Viewed by 1634 | Submission Open

Keywords: robotic surgery; robotic urology; advances in robotics; urologic surgery; minimally invasive urologic surgery; robotic partial nephrectomy; robotic radical prostatectomy

(This special issue belongs to the Section Nephrology & Urology)

Maternal–Fetal Health Monitoring, Prediction and Management of Perinatal Complications

edited by Ioakeim Sapantzoglou and Marianna Theodora

submission deadline 10 May 2027 | 1 articles | Viewed by 333 | Submission Open

Keywords: fetal medicine; prenatal assessment; fetal ultrasound; prenatal genetics; maternal medicine; fetal monitoring; high risk pregnancy

(This special issue belongs to the Section Obstetrics & Gynecology)

Innovative Approaches to the Epidemiology, Diagnosis, and Treatment of Systemic Sclerosis

edited by

Antonio-Javier Chamorro

submission deadline 10 May 2027 | Viewed by 299 | Submission Open

Keywords: systemic sclerosis; scleroderma; epidemiology; biomarkers; personalized therapy; therapeutic strategies

(This special issue belongs to the Section Clinical Neurology)

Current Treatment on Urinary Tract Infection

edited by

Biagio Barone

submission deadline 10 May 2027 | Viewed by 290 | Submission Open

Keywords: urinary tract infections (UTIs); antibiotic resistance; probiotics and alternative therapies; diagnostic advancements; urinary infection management

(This special issue belongs to the Section Nephrology & Urology)

Research and Application of Orthopedic Rehabilitation and Ultrasound-Guided Interventional Procedures

edited by Danilo Donati

submission deadline 10 May 2027 | Viewed by 65 | Submission Open

Keywords: orthopaedic rehabilitation; clinical and diagnostical evaluation; clinical physiopathogenesis of muscle; tendon and joint disease; prevention of fall risks; treatment of musculoskeletal disease; ultrasound; interventional procedures; neuropathies

(This special issue belongs to the Section Orthopedics)

Gynecologic Robotic Surgery: Evolution, Current Status and Future Directions

edited by Youn-Jee Chung

submission deadline 13 May 2027 | 3 articles | Viewed by 2062 | Submission Open

Keywords: laparoscopy; robot surgery; minimally invasive surgery; gynecology; endometriosis; myoma; adenomyosis

(This special issue belongs to the Section Obstetrics & Gynecology)

Sports Injuries: Emerging Trends in Risk Mitigation, Management and Recovery

edited by

Luis Suárez-Arrones

and Jose Asian-Clemente

submission deadline 14 May 2027 | 4 articles | Viewed by 2332 | Submission Open

Keywords: injury prevention; rehabilitation; muscle; return-to-sport; surgery; therapy; testing; regenerative medicine; ultrasound; MRI; sports medicine

(This special issue belongs to the Section Sports Medicine)

Cancers: Clinical Radiation Therapy

edited by Julianne M. Pollard-Larkin

submission deadline 14 May 2027 | 2 articles | Viewed by 1386 | Submission Open

Keywords: reirradiation; tissue tolerance; image registration; treatment planning; dose accumulation

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Clinical Perspectives in Pediatric Surgery: From Neonatal Procedures to Adolescent Care

edited by

Mirko Bertozzi

and

Giovanna Riccipetitoni

submission deadline 14 May 2027 | 2 articles | Viewed by 1220 | Submission Open

Keywords: mini invasive surgery; transitional care of rare diseases; newborn surgery; long-term follow up; congenital malformations

(This special issue belongs to the Section Clinical Pediatrics)

Cardiac Arrest: Appropriate Prognostication and Therapeutic Options

edited by

Jae Hoon Lee

and Jin-hong Min

submission deadline 14 May 2027 | 1 articles | Viewed by 872 | Submission Open

Keywords: cardiac arrest; prognosis; hypothermia, induced; resuscitation; magnetic resonance imaging; electroencephalog-raphy; blood pressure; hypoxia-ischemia, brain; extracorporeal membrane oxygenation

(This special issue belongs to the Section Cardiovascular Medicine)

Cardiac Imaging in the Clinical Management of Heart Failure

edited by Maria Concetta Pastore

submission deadline 14 May 2027 | Viewed by 327 | Submission Open

Keywords: heart failure; cardiac imaging; echocardiography; cardiac magnetic resonance; computed tomography; nuclear imaging

(This special issue belongs to the Section Cardiology)

Innovations in Clinical Orthodontics

edited by

Natalia Zamora-Martínez

and

Beatriz Tarazona-Álvarez

submission deadline 14 May 2027 | Viewed by 47 | Submission Open

Keywords: 3D facial analysis; 3D cephalometry; accelerated orthodontics; mini-screws; digital planning; clear aligners; artificial intelligence; craniofacial imaging

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Thyroid Disease: Updates from Diagnosis to Treatment: 2nd Edition

edited by

Luca Giovanella

and

Petra Petranović Ovčariček

submission deadline 15 May 2027 | 8 articles | Viewed by 10335 | Submission Open

Keywords: autoimmune thyroid diseases; thyroiditis; thyroid cancers; PET/CT; hyperthyroidism

(This special issue belongs to the Section Endocrinology & Metabolism)

Clinical Management and Challenges of Sepsis and Septic Shock

edited by

Matteo Guarino

and

Michele Domenico Spampinato

submission deadline 15 May 2027 | 5 articles | Viewed by 2625 | Submission Open

Keywords: sepsis; septic shock; hemodynamic management; biomarkers; cardiovascular dysfunction; point-of-care ultrasound; precision medicine; emergency medicine; critical care

(This special issue belongs to the Section Intensive Care)

Advances in Pancreatic Cancer: Diagnosis and Therapy

edited by Eleonora Lai,

Nicola Silvestris

and

Mario Scartozzi

submission deadline 15 May 2027 | 1 articles | Viewed by 1690 | Submission Open

Keywords: pancreatic cancer diagnosis; endoscopic ultrasound; neoadjuvant chemotherapy; surgical resection; targeted therapy; immunotherapy

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Recent Progress and Future Perspectives in Orthodontics

edited by

Vanessa Paredes-Gallardo

and

Sara Camañes-Gonzalvo

submission deadline 15 May 2027 | 3 articles | Viewed by 1680 | Submission Open

Keywords: skeletal anchorage; temporary anchorage devices; multidisciplinary orthodontic treatment; digital orthodontics; clear aligner therapy; 3D imaging and virtual treatment planning; airway-focused orthodontics

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Targeted Management of Orofacial Pain: From Pharmacology to Temporomandibular Joint Surgery

edited by

Matteo Val

Luca Guarda-Nardini

and Giulia Ottaviani

submission deadline 15 May 2027 | 2 articles | Viewed by 1522 | Submission Open

Keywords: orofacial pain; chronic orofacial pain; neuropathic pain; pharmacological management; temporomandibular joint disorders; degenerative TMJ disease; conservative treatment; surgical management

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Advances in Cardiac Resynchronization Treatment: 2nd Edition

edited by

George Leventopoulos

, Konstantinos A. Gatzoulis, Konstantinos Aronis and

Dimitris L. Tsiachris

submission deadline 15 May 2027 | 1 articles | Viewed by 1050 | Submission Open

Keywords: conduction system; risk stratification; resynchronization; cardiac pacing; sudden cardiac death

(This special issue belongs to the Section Cardiology)

Clinical Advances in the Use of Ultrasound in Critical Care

edited by

Luigi Vetrugno

submission deadline 15 May 2027 | 1 articles | Viewed by 821 | Submission Open

Keywords: ultrasound; intensive care medicine; shock; hemodymanic monitoring; ARDS

(This special issue belongs to the Section Intensive Care)

Artificial Intelligence and Machine Learning in Cardiovascular Disease: Diagnosis, Risk Stratification, and Prognosis

edited by

Osama Soliman

and Aonghus Lawlor

submission deadline 15 May 2027 | 1 articles | Viewed by 508 | Submission Open

Keywords: artificial intelligence; machine learning; cardiovascular disease; diagnosis; risk prediction; prognosis; tripod+ai; external validation; clinical decision support; predictive modeling

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Clinical Medicine)

Clinical Advances in Endodontics

edited by

Vincenzo Tosco

submission deadline 15 May 2027 | Viewed by 420 | Submission Open

Keywords: endodontics; vital pulp therapy; minimally invasive endodontics; clinical endodontic techniques; bioactive sealers

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Advances in Pulmonary Arterial Hypertension: Emerging Therapies and Clinical Outcomes

edited by Namita Sood

submission deadline 15 May 2027 | Viewed by 404 | Submission Open

Keywords: pulmonary arterial hypertension (PAH); PAH therapy; emerging treatments; sotatercept; inhaled therapy; targeted pharmacotherapy; combination therapy; therapeutic efficacy; pulmonary vascular imaging

(This special issue belongs to the Section Respiratory Medicine)

Clinical Intervention in Inflammatory Skin Diseases

edited by Anna Deda,

Dominika Wcisło-Dziadecka

and

Sławomir Wilczyński

submission deadline 15 May 2027 | Viewed by 133 | Submission Open

Keywords: inflammatory skin diseases; rosacea; psoriasis; atopic dermatitis; acne; non invasive skin imaging; clinical intervention; laser therapy in dermatology; device-based dermatologic interventions

(This special issue belongs to the Section Dermatology)

Stress Beyond Cardiac Mortality: The Road to the Development of Cardiac Remodeling and Heart Failure

edited by Mario J. Garcia and

Fatih Yalcin

submission deadline 15 May 2027 | Viewed by 37 | Submission Open

Keywords: cardiac remodeling; heart failure; heart remodeling; microscopic remodeling; hemodynamic stress; segmental re-modeling; aortic valve disease; arrhythmias; brain–heart interaction

(This special issue belongs to the Section Cardiology)

Systemic Lupus Erythematosus: Unmet Needs, Emerging Tools and New Therapeutic Perspectives

edited by Francesca Wanda Rossi and

Ilaria Mormile

submission deadline 15 May 2027 | Viewed by 35 | Submission Open

Keywords: systemic lupus erythematosus; unmet needs; biomarkers; precision medicine; artificial intelligence; difficult-to-treat lupus; real-world evidence; comorbidities

(This special issue belongs to the Section Immunology & Rheumatology)

Recent Progress and Emerging Clinical Perspectives in Flap Reconstruction

edited by Gabriele Delia and

Emanuele Cigna

submission deadline 15 May 2027 | Submission Open

Keywords: flap reconstruction; reconstructive surgery; regenerative reconstruction; adipofascial flaps; microsurgery; supermicrosurgery; perforator flaps; adipose tissue; fascia; regenerative surgery; adipose-derived stromal cells; tissue engineering; extracellular vesicles; biomaterials; tissue regeneration

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

The Importance of Advances in Urological Surgery: From Open Surgery to Minimally Invasive Surgery

edited by

Miguel Ángel Arrabal-Polo

submission deadline 17 May 2027 | 3 articles | Viewed by 2445 | Submission Open

Keywords: artificial intelligence; minimally invasive surgery; reconstructive surgical procedures; robotic surgical procedures; surgical oncology; telesurgery; virtual reality; results in urological surgery; laser in urology

(This special issue belongs to the Section Nephrology & Urology)

Application of Physiotherapy in Clinical Rehabilitation

edited by

Kyeongbong Lee

submission deadline 18 May 2027 | 4 articles | Viewed by 2372 | Submission Open

Keywords: therapeutic exercise; neurological rehabilitation; musculoskeletal physiotherapy; cardiopulmonary rehabilitation; intensive care unit (ICU) rehabilitation; gait and balance; pediatric and geriatric physical therapy; sports physical therapy; rehabilitation technology

(This special issue belongs to the Section Clinical Rehabilitation)

Clinical Management in Hand Trauma: Diagnosis, Repair and Rehabilitation

edited by

Camillo Fulchignoni

and

Tommaso Greco

submission deadline 19 May 2027 | Viewed by 96 | Submission Open

Keywords: trauma prevention; fractures; nerve injuries; tendon surgery; hand rehabilitation

(This special issue belongs to the Section Orthopedics)

Current Challenges and New Perspectives in Liver Transplantation

edited by

Anna Mrzljak

and

Quirino Lai

submission deadline 20 May 2027 | 11 articles | Viewed by 11791 | Submission Open

Keywords: liver transplantation; graft survival; immunosuppression; organ allocation; hepatocellular carcinoma; MASLD; donor shortage; transplant outcomes; innovation

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Cognitive Impairment, Dementia and Depression in Older Adults

edited by Seong Jae Kim and Ilhan Choo

submission deadline 20 May 2027 | 3 articles | Viewed by 7951 | Submission Open

Keywords: cognitive impairment; dementia; depression; Parkinson’s disease; artificial intelligence (AI); predictive modeling

(This special issue belongs to the Section Geriatric Medicine)

Personalized Treatments for Patients with Acute Lung Injury

edited by

Gary F. Nieman

submission deadline 20 May 2027 | 3 articles | Viewed by 4008 | Submission Open

Keywords: personalized; acute lung injury; acute respiratory distress syndrome (ARDS); ventilator-induced lung injury (VILI); pharmacotherapy; fluid resuscitation; phenotypes; mesenchymal stem cells; nano-systems; exosomes; biomarkers; computational models

(This special issue belongs to the Section Respiratory Medicine)

Polycystic Ovary Syndrome (PCOS): From Diagnosis to Personalized and Integrated Treatment

edited by Satu Kuokkanen

submission deadline 20 May 2027 | 3 articles | Viewed by 3953 | Submission Open

Keywords: PCOS; integrated treatment model; metabolic abnormalities; mental health; adverse obstetric outcomes

(This special issue belongs to the Section Obstetrics & Gynecology)

Residual Risk in High-Risk Patients Undergoing Percutaneous Coronary Intervention

edited by

Giampiero Vizzari

and

Antonio Micari

submission deadline 20 May 2027 | 1 articles | Viewed by 3886 | Submission Open

Keywords: cardiology; precision medicine; residual risk; acute coronary syndrome; percutaneous coronary intervention; PCI

(This special issue belongs to the Section Cardiology)

Clinical Research and Application of Artificial Intelligence and Deep Learning in Dentistry and Oral and Maxillofacial Surgery

edited by

Babak Saravi

Julian Lommen

and Lara Katharina Franziska Schorn

submission deadline 20 May 2027 | 6 articles | Viewed by 3751 | Submission Open

Keywords: artificial intelligence; deep learning; machine learning; oral and maxillofacial surgery; dentistry; medical imaging; clinical decision support

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Alopecia, Atopic Dermatitis and Other Chronic Inflammatory Skin Diseases: Pathogenesis, Comorbidities, and Precision Management

edited by

Trinidad Montero-Vilchez

and

Salvador Arias-Santiago

submission deadline 20 May 2027 | 6 articles | Viewed by 3095 | Submission Open

Keywords: alopecia; atopic dermatitis; chronic urticaria; prurigo nodularis; chronic pruritus; inflammatory skin diseases; biomarkers; biologics; JAK inhibitors; quality of life; precision medicine

(This special issue belongs to the Section Dermatology)

Current Clinical Research in Oral Maxillofacial Surgery

edited by

Krzysztof Dowgierd

, Marcin Kozakiewicz, Łukasz J. Krakowczyk and Tadeusz Morawiec

submission deadline 20 May 2027 | 5 articles | Viewed by 2598 | Submission Open

Keywords: oral and maxillofacial surgery; craniofacial surgery; orthognathic surgery; maxillofacial trauma; head and neck oncology; microsurgical reconstruction; temporomandibular joint (TMJ); virtual surgical planning (VSP); patient-specific implants (PSI); complications and outcomes

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Digestive Disorders: Updates on Disease Monitoring, Prediction Models and Management

edited by

Georgiana-Emmanuela Gîlcă-Blanariu

and

Catalina Mihai

submission deadline 20 May 2027 | 3 articles | Viewed by 2425 | Submission Open

Keywords: inflammatory bowel disease; metabolic dysfunction-associated fatty liver disease; liver disease; alcohol related liver disease; infection; Clostridioides difficile infection

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Advances in Managing High-Risk Pregnancies: Innovations in Diagnosis, Prevention and Clinical Care

edited by

Dominique A. Badr

, Vivien Dütemeyer and Jacques Jani

submission deadline 20 May 2027 | 3 articles | Viewed by 1923 | Submission Open

Keywords: high-risk pregnancy; maternal–fetal medicine; prenatal diagnosis; fetal growth restriction; preeclampsia; preterm birth; biomarkers; maternal comorbidities; clinical imaging; precision obstetrics

(This special issue belongs to the Section Obstetrics & Gynecology)

Diabetes and Its Complications: New Perspectives and Clinical Updates

edited by Prashanth Vas and

Erika Vainieri

submission deadline 20 May 2027 | 4 articles | Viewed by 1804 | Submission Open

Keywords: diabetes mellitus; diabetic retinopathy; cardiovascular disease; chronic kidney disease; diabetic foot; cardiorenal metabolic syndrome; integrated diabetes care

(This special issue belongs to the Section Endocrinology & Metabolism)

Clinical Advances in General and Regional Anesthesia

edited by Luciano Frassanito

submission deadline 20 May 2027 | 2 articles | Viewed by 1578 | Submission Open

Keywords: oncoanesthesia; perinatal anesthesia; ventilatory support; hemodynamic monitoring; regional anesthesia

(This special issue belongs to the Section Anesthesiology)

Management in Dry Eye Disease: Current Strategies and Emerging Protocols

edited by Sunil Shah and Raquel Gil-Cazorla

submission deadline 20 May 2027 | 3 articles | Viewed by 1506 | Submission Open

Keywords: dry eye disease; ocular surface; diagnostics; inflammation; biomarkers; emerging therapies

(This special issue belongs to the Section Ophthalmology)

Current Advances in Dysphagia Assessment and Management

edited by

Rumi Ueha

submission deadline 20 May 2027 | 3 articles | Viewed by 1505 | Submission Open

Keywords: dysphagia; pathophysiology; swallowing; assessment; swallowing surgery; clinical outcomes

(This special issue belongs to the Section Otolaryngology)

Beyond Efficacy and Trials: Real-World Value and Effectiveness in Autoimmune Rheumatic Joint Diseases

edited by

Carlos Alves

submission deadline 20 May 2027 | 2 articles | Viewed by 1417 | Submission Open

Keywords: effectiveness; efficacy; autoimmune rheumatic joint diseases; patient-reported outcomes; quality of life

(This special issue belongs to the Section Immunology & Rheumatology)

Emerging Trends in Atrial Fibrillation Management

edited by Guy Rozen

submission deadline 20 May 2027 | 1 articles | Viewed by 1336 | Submission Open

Keywords: cardiology; atrial fibrillation; left atrial appendage occlusion; echocardiography; pulse field ablation

(This special issue belongs to the Section Cardiology)

Innovations and Clinical Advances in CMR and Echocardiography

edited by Raluca Tomoaia and

Sebastian Onciul

submission deadline 20 May 2027 | 1 articles | Viewed by 1235 | Submission Open

Keywords: cardiac magnetic resonance; echocardiography; cardiomyopathy; ischaemic heart disease; valvular heart disease; risk stratification; clinical outcomes

(This special issue belongs to the Section Cardiology)

Diagnosis, Treatment and Comorbidities in Chronic Obstructive Pulmonary Disease (COPD): 3rd Edition

edited by Juan Luis Rodriguez Hermosa, José Luis Álvarez-Sala Walther and Myriam Calle Rubio

submission deadline 20 May 2027 | 2 articles | Viewed by 1230 | Submission Open

Keywords: COPD; diagnosis; comorbidities; respiratory rehabilitation; inhaled therapy; biological therapies

(This special issue belongs to the Section Respiratory Medicine)

Knee Surgery: Clinical Treatment and Management

edited by Nikolai Ramadanov

submission deadline 20 May 2027 | 2 articles | Viewed by 1194 | Submission Open

Keywords: knee surgery; sports knee injuries; ligament reconstruction; meniscal surgery; cartilage repair; knee osteotomy; knee arthroplasty; clinical outcomes; surgical techniques

(This special issue belongs to the Section Orthopedics)

Contemporary Advances in Abdominal Surgery: Precision Care, Digital Innovation, and Future Perspectives

edited by Calin Molnar

submission deadline 20 May 2027 | 3 articles | Viewed by 1044 | Submission Open

Keywords: abdominal surgery; precision surgery; digital surgery; artificial intelligence; minimally invasive surgery; surgical oncology; perioperative care

(This special issue belongs to the Section General Surgery)

Displaying special issue 1201-1250 on page 25 of 30.

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