Stress Beyond Cardiac Mortality: The Road to the Development of Cardiac Remodeling and Heart Failure
A Special Issue of Journal of Clinical Medicine (ISSN 2077-0383) belonging to the section "Cardiology".
Deadline for manuscript submissions: 15 May 2027 | Viewed by 9
Editors
2. Albert Einstein College of Medicine, Bronx, NY, USA
Interests: early imaging biomarkers for heart diseases; novel imaging in the early diagnosis of heart failure for optimal medical management
Special Issues, Collections and Topics in MDPI journals
Interests: stressed heart morphology; ultimate phases of hypertensive disease; hemodynamic stress and microscopic remodeling
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The Special Issue, “Stress Beyond Cardiac Mortality: The Road to the Development of Cardiac Remodeling and Heart Failure,” explored differences in heart remodeling between animals and humans. Comparative studies have shown that the human adaptive phase of heart remodeling is more complex, with tissue heterogeneity contributing to “segmental remodeling”. Long-standing exposure to multiple external stressors in human beings has an extremely dynamic aspect and is associated with blood pressure variability and hemodynamic overload-mediated high mortality. Beyond classical stressors such as functional abnormalities in vascular tone or mechanical stress from aortic valve disease, the literature now includes emotional stress in new algorithms (https://www.mdpi.com/journal/jcm/special_issues/clinical_frontiers_heart_failure).
The heart is a unique source affected by a variety of stress stimuli and a unique opportunity to evaluate and detect sympathetic overdrive in the brain. In fact, vagal innervation over heart tissue is limited to the supraventricular portion of heart tissue, and this reality results not only in malignant ventricular arrhythmias playing a fundamental role as the number one killer in the population but also in extremely interesting segmental findings over ventricular tissue due to multiple stressors and high stress scores. These novel findings support the idea that caregivers globally must remember brain–heart interaction.
All researchers are invited to contribute original articles and reviews.
Prof. Dr. Mario J. Garcia
Prof. Dr. Fatih Yalcin
Guest Editors
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Keywords
- cardiac remodeling
- heart failure
- heart remodeling
- microscopic remodeling
- hemodynamic stress
- segmental re-modeling
- aortic valve disease
- arrhythmias
- brain–heart interaction
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