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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Pathogenesis of Alcohol-Associated Hepatitis and Its Therapies

edited by

Mrigya Babuta

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2244 | Submission Open

Keywords: alcohol-associted hepatitis; acute kidney injury; hepatic encephalopathy; adaptive immune response; innate immune response; neutrophilia

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Modulating the Function of the Immune System by Thyrotropin and Thyroid Hormones

edited by Graciela Alicia Cremaschi and Claudia Gabriela Pellizas

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2235 | Submission Open

Keywords: thyrotropin (TSH); thyroid hormones (THs); immune modulation; immunology; immune; autoimmune; immunoendocrinology; hypothalamic-pituitary-thyroid axis; antitumor immune response

(This special issue belongs to the Section Molecular Immunology)

Molecular Research on Tumor Suppressor Proteins

edited by Jie Liu

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2211 | Submission Open

Keywords: DNA repair; genome stability; tumor suppressor; BRCA1; BRCA2; PALB2; RAD51C

(This special issue belongs to the Section Molecular Oncology)

Molecular Breeding and Genetic Regulation of Crops, 2nd Edition

edited by

Chiara Biselli

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2096 | Submission Open

Keywords: molecular breeding; genetic regulation; genomics; genome-editing techniques; epigenetic modifications

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research in Animal Nutrition

edited by Jie Fu

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2066 | Submission Open

Keywords: animal nutrition; animal immunity; epigenetics; m6A methylation; gut microbiota; host– microbiome interaction; metabolic reprogramming

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Impact of Cancer–Immune Cell Crosstalk on Diagnosis, Prognosis and Treatment

edited by Fabricio Figueiro

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2042 | Submission Open

Keywords: protumoral immunity; anticancer immunity; crosstalk; tumor microenvironment; purinergic signaling; immune checkpoints; immunometabolism; extracellular vesicles; RNA communication

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Oxidative Stress in Dermatology, Aesthetics and Regenerative Medicine

edited by

Eugenio Luigi Iorio

submission deadline 20 Jan 2026 | Viewed by 1960 | Submission Open

Keywords: oxidative stress; redox system; antioxidant chemical species; dermatology; aesthetics; regenerative medicine; inflammatory; degenerative skin diseases

(This special issue belongs to the Section Molecular Biology)

Latest Research in Photocatalysis

edited by

María Teresa Colomer

submission deadline 20 Jan 2026 | 2 articles | Viewed by 1958 | Submission Open

Keywords: design; simulation; synthesis; properties; functionalities; reactions; photocatalysis

(This special issue belongs to the Section Biochemistry)

Molecular Insights and Regulation Mechanisms of Tea Quality

edited by

Xujun Zhu

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1873 | Submission Open

Keywords: molecular ecology; spectroscopic techniques; tea quality; tea plant growth

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Plant Nematology Research

edited by

Sergei A. Subbotin

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1862 | Submission Open

Keywords: DNA barcoding; Molecular evolution; Genomes; Molecular systematics; Phylogenetics; Plant– nematode interactions; Transcriptomics

(This special issue belongs to the Section Molecular Plant Sciences)

Advances and Applications in Molecular Enzymology

edited by

Gustavo Molina

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1807 | Submission Open

Keywords: microbial enzymes; biosynthesis and bioengineering; drug development and targets; enzymes in the environment; engineered enzymes; enzymes in agri-food; enzymatic formulations; enzyme engineering; enzymes in biomedical sciences; green chemistry/technology; glycans; molecular evolution; nanocatalyst and nanotechnology; pharma enzymes; recombinant proteins production and purification; system and synthetic biology

(This special issue belongs to the Section Biochemistry)

Coagulation Factors and Natural Anticoagulants in Health and Disease

edited by

Zsuzsanna Bereczky

submission deadline 20 Jan 2026 | 2 articles | Viewed by 1742 | Submission Open

Keywords: coagulation factor; natural anticoagulant; hemostasis; thrombosis; molecular studies; molecular interactions; structure; functional studies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Extracellular Histones in Patho(physio)logical Hemostasis

edited by Fabrizio Semeraro and

Mauro Coluccia

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1654 | Submission Open

Keywords: extracellular histones; hemostasis; platelets; coagulation; fibrinolysis; thrombosis; inflammation; extracellular traps

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Studies on Oral Disease and Treatment

edited by

Daniela Adamo

submission deadline 20 Jan 2026 | 2 articles | Viewed by 1642 | Submission Open

Keywords: oral cancer; oral mucosal lesions; chronic pain; temporomandibular joint disorders; periodontal diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Fibrotic Disease: From Pathophysiology to Treatment

edited by Galina S. Bogatkevich

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1629 | Submission Open

Keywords: lung; liver; heart; kidney; fibrosis; systemic sclerosis; mechanisms; pathophysiology; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Protein Design and Engineering in Biochemistry

edited by Om Prakash Narayan

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1598 | Submission Open

Keywords: protein engineering; molecular biology; biochemical tools; computational protein design; directed evolution; CRISPR/Cas9; synthetic biology; biomaterials; protein therapeutics; regenerative medicine

(This special issue belongs to the Section Molecular Biology)

Advances in Mass Spectrometry-Based Proteomics: From Biomarker Discovery to Translational Applications

edited by

Yanlong Ji

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1563 | Submission Open

Keywords: mass spectrometry; LC-MS method development; phosphoproteomics; glycoproteomics; biomarker discovery; multi-omics data integration

(This special issue belongs to the Section Biochemistry)

Research Progress and Therapeutic Targets of Chronic Kidney Disease

edited by

Stefanos Roumeliotis

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1545 | Submission Open

Keywords: blood pressure; cardiovascular disease; chronic kidney disease; diabetes; hypertension; inflammation; oxidative stress; sodium glucose transporter-2; vascular calcification

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Studying Multi-Target Drug Approaches and Posttranslational Modification (PTM) Therapies

edited by

Guo-Ping Zhou

submission deadline 20 Jan 2026 | 2 articles | Viewed by 1545 | Submission Open

Keywords: multi-target therapy; network analysis tools; multi-label proteins; web-server predictor; posttranslational modifications (PTMs); 3D structures; rational drug design

(This special issue belongs to the Section Molecular Informatics)

Research Progress on Oocyte Development

edited by

Ken-ichi Sato

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1529 | Submission Open

Keywords: oocyte maturation; germ cell development; folliculogenesis; oocyte quality; egg cell development; oocyte activation; meiotic progression; fertility

(This special issue belongs to the Section Molecular Biology)

Progress in Adipokines Research in Cardiovascular Health and Diseases

edited by

Morris Karmazyn

submission deadline 20 Jan 2026 | 2 articles | Viewed by 1525 | Submission Open

Keywords: adipokine receptors and cell signalling; adipokines and heart failure and hypertrophy; adipokines and myocardial ischemia; adipokines and hypertension; adipokines and thrombosis/atherosclerosis; adipokines and vascular/endothelial function; structure; and integrity; adipokines and cardiovascular inflammation; adipokines; adiposity; and cardiovascular disease in obesity

(This special issue belongs to the Section Molecular Biology)

Radiolabeled Compounds for Theranostic Applications in Oncology

edited by

Cyril Fersing

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1489 | Submission Open

Keywords: radiopharmaceuticals; theranostic; cancer therapy; targeted radionuclide therapy; molecular imaging; positron emission tomography; single-photon emission tomography; radiolabeling

(This special issue belongs to the Section Molecular Oncology)

Tuberculosis: Host Immunity, Diagnosis and Treatment

edited by

Veronica Edith Garcia

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1480 | Submission Open

Keywords: tuberculosis; immune response; diagnosis; treatment; antibiotics; resistance

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nanoscience in Plants: Omics Approaches to Elucidate the Role of Nanoparticles

edited by

Setsuko Komatsu

and Zahed Hossain

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1469 | Submission Open

Keywords: nanoparticles; plant; omics-based techniques; bioinformatics; systems biology; nanotoxicology

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular and Immune Mechanisms in Pathogenic Mycobacteria Infections

edited by Fabiana Bigi and Federico Carlos Blanco

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1438 | Submission Open

Keywords: Mycobacterium tuberculosis; virulence; pathogens

(This special issue belongs to the Section Molecular Microbiology)

Advances in Biomarker Discovery for Rare Diseases

edited by

Bridget E. Bax

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1427 | Submission Open

Keywords: biomarker; rare diseases; pathological processes; cystic fibrosis; Duchenne muscular dystrophy; Ehlers-Danlos syndrome; haemophilia; sickle cell disease; primary biliary cholangitis; fabry disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights into Chronic Inflammatory Demyelinating Polyneuropathy and Neuroimmunological Diseases

edited by

Fumitaka Shimizu

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1415 | Submission Open

Keywords: chronic inflammatory demyelinating polyneuropathy (CIDP); multiple sclerosis (MS); neuromyelitis optica spectrum disorder (NMOSD); myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD); autoimmune encephalitis; paraneoplastic neurological syndrome; Guillain-Barre syndrome (GBS); myositis; blood-brain barrier; blood-nerve barrier

(This special issue belongs to the Section Molecular Neurobiology)

Computational Genomics and Bioinformatics in Microbiology

edited by

Andreas Martin Lisewski

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1366 | Submission Open

Keywords: computational microbial genomics; comparative genomics; structural genomics; functional genomics; genomic data bioinformatics

(This special issue belongs to the Section Molecular Informatics)

Unraveling the Enigma of Colorectal Cancer: From Mechanisms to Therapeutic Advances

edited by Valentina Belli and

Vincenza Ciaramella

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1354 | Submission Open

Keywords: Colorectal cancer; tumour microenvironment; epigenetics; diagnostic molecules; immune evasion; biomarkers; drug resistance; precision medicine; targeted

(This special issue belongs to the Section Molecular Oncology)

Hormonal and Metabolic Markers in Health and Disease

edited by

Rafał Podgórski

and

Kornelia Łach

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1348 | Submission Open

Keywords: hormonal biomarkers; molecular mechanism of endocrine disorders; steroidogenesis; hormonal dysregulation; endocrine disruptors; metabolomics; metabolic regulation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances in the Molecular Diagnosis and Treatment of Neurodegenerative Diseases

edited by

Bruno Manadas

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1311 | Submission Open

Keywords: neurodegenerative disorders; biomarkers; treatment; omics; systems biology

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Paradigm Iconoclasm

edited by

Vance G. Nielsen

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1274 | Submission Open

Keywords: paradigm shift; biochemistry; cell signaling; coagulation; toxinology

(This special issue belongs to the Section Biochemistry)

Hearing Loss: Molecular Biological Insights, 2nd Edition

edited by María Beatriz Durán-Alonso

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1266 | Submission Open

Keywords: genetics; microRNA; epigenetics; CRISPR; multi-omics; presbycusis; ototoxicity; development

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in the Physiopathology of Neurodevelopmental Disorders

edited by Antonio Falace

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1220 | Submission Open

Keywords: neuronal development; synaptogenesis; developmental and epileptic encephalopathy; epilepsy; biomarkers; neuroimmunology; translational research; cortical malformation; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Biotic and Abiotic Stress Responses of Vegetable Crops

edited by Yongqiang Tian

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1194 | Submission Open

Keywords: vegetable crops; biotic stress; abiotic stress; physiological responses; molecular mechanisms; genetic mechanisms; resistance breeding; resistance biotechnology; management strategies

(This special issue belongs to the Section Molecular Plant Sciences)

Drug Delivery Systems and Treatment of Human Diseases: Prospects and Challenges

edited by

Aruna Sharma

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1142 | Submission Open

Keywords: nanodrug delivery; blood– brain barrier; antibodies therapy; molecular mechanism; neuroprotection

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms of Sarcoma Initiation and Metastasis

edited by

Shinji Miwa

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1123 | Submission Open

Keywords: sarcoma; molecular target; metastasis; apoptosis; angiogenesis; microenvironment

(This special issue belongs to the Section Molecular Oncology)

Microbial Omics: Decoding Microbial Life

edited by

Nicole Hansmeier

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1093 | Submission Open

Keywords: omics technologies; omics methodologies; microorganisms; proteomics; genomics; transcriptomics; bioinformatics; artificial intelligence for omics; microbial physiology; microbial adaptation to environmental challenges; interspecies and host-microbe interactions; environmental monitoring

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanisms and Therapies of Gastrointestinal Cancer

edited by

Donatella Delle Cave

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1078 | Submission Open

Keywords: tumor microenvironment; therapy resistance; genetic mutations; oncogenes; molecular diagnostics

(This special issue belongs to the Section Molecular Oncology)

Chitosan: Structural and Chemical Modification, Properties and Application, 2nd Edition

edited by

Joanna Kluczka

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1072 | Submission Open

Keywords: chitosan modification; adsorption removal; membrane separation; food preservation; environmental remediation; wastewater treatment; disease treatment; agricultural production; tissue engineering

(This special issue belongs to the Section Macromolecules)

Protein Structure and Its Interactions

edited by

Dong Hae Shin

submission deadline 20 Jan 2026 | 2 articles | Viewed by 1036 | Submission Open

Keywords: protein– protein interactions (PPIs); protein– ligand binding; molecular recognition; binding affinity and specificity; molecular interface analysis

(This special issue belongs to the Section Molecular Biology)

The Brain’s Regeneration Potential: The Role of Neural Progenitor Cells in Neuropsychiatric Therapy

edited by

Beatriz Caballero

and

Yaiza Potes

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1022 | Submission Open

Keywords: neural stem cells; neural progenitor cells; neuropsychiatric disorders; neurodegeneration; neurogenesis; neuroplasticity; melatonin; psychoactive drugs

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Research on Skeletal Muscle Metabolism and Diseases

edited by Shen-Liang Chen

submission deadline 20 Jan 2026 | 1 articles | Viewed by 982 | Submission Open

Keywords: muscle; metabolism; mitochondria; peroxisome; stem cell; cahcexia

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Chemical Tools for Microbial Functionalization: Bridging Organic Chemistry and Biotechnology

edited by Stefania Cicco and

Danilo Vona

submission deadline 20 Jan 2026 | Viewed by 964 | Submission Open

Keywords: organometallic biochemistry; green chemistry; bioorthogonal; living polymers; living functionalization; hybrid materials

(This special issue belongs to the Section Molecular Microbiology)

Molecular Issues in Optic Neuropathy

edited by

Nitza Goldenberg-Cohen

submission deadline 20 Jan 2026 | 1 articles | Viewed by 889 | Submission Open

Keywords: optic neuropathy; neuroprotection; glaucoma induced neuropathy; molecular pathways; novel therapeutics strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural Compounds in Neurological Diseases

edited by

Ivan Cruz-Chamorro

submission deadline 20 Jan 2026 | 1 articles | Viewed by 835 | Submission Open

Keywords: natural compounds; neuroprotection; neuroinflammation; oxidative stress; mitochondrial dysfunction; autophagy; bioactive molecules (polyphenols; flavonoids; melatonin; etc.); nutraceuticals (bioactive peptides; hydrolysates; etc.); neurodegenerative diseases

(This special issue belongs to the Section Molecular Neurobiology)

Lipid Droplet–Mitochondria Interactions in Health and Disease

edited by Anton Petcherski

submission deadline 20 Jan 2026 | Viewed by 825 | Submission Open

Keywords: mitochondria; lipid droplets; metabolism; lipotoxicity; metabolically active tissue; triacylglycerides; fatty acid oxidation

(This special issue belongs to the Section Biochemistry)

Pathogenesis and Therapy of Oral Carcinogenesis, 3rd Edition

edited by

Marko Tarle

and

Ivica Lukšić

submission deadline 20 Jan 2026 | Viewed by 777 | Submission Open

Keywords: oral cancer; oral premalignant disorders; tumor microenvironment; molecular biomarkers; targeted therapy; oral tumorigenesis

(This special issue belongs to the Section Molecular Oncology)

Ion Transporter-Based Biomarkers for Sperm Quality

edited by

Elisabeth Pinart

submission deadline 20 Jan 2026 | Viewed by 744 | Submission Open

Keywords: ion transporters; sperm quality; cryotolerance

(This special issue belongs to the Section Molecular Biology)

Rational Design and Synthesis of Bioactive Molecules, 2nd Edition

edited by

Irena Kostova

submission deadline 20 Jan 2026 | Viewed by 733 | Submission Open

Keywords: synthesis; structure; bonding; reactivity; chemical properties; physical properties; pharmacological activity; structure– activity relationship; applications

(This special issue belongs to the Section Molecular Biology)

Displaying special issue 401-450 on page 9 of 65.

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