Extracellular Vesicles: From Molecular Mechanisms to Therapeutic Applications: 2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 31 October 2026 | Viewed by 106
Special Issue Editor
Interests: virus infection; extracellular vesicles; virus-host interactions; immune responses; immune sensors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Extracellular vesicles (EVs) are increasingly recognized as integral mediators of intercellular communication, enabling the transfer of proteins, lipids, nucleic acids, and metabolites between neighboring and distant cells. Released by both eukaryotic and prokaryotic cells under physiological and pathological conditions, they consist of a diverse group of membrane-enclosed particles with different biogenesis pathways, molecular contents, and functions. Accumulating evidence demonstrates that EVs contribute to fundamental biological processes, including immune regulation, maintenance of tissue homeostasis, cellular adaptation to stress, and tissue repair. EVs are also deeply implicated in the pathogenesis of cancer, neurodegenerative disorders, cardiovascular disease, autoimmune conditions, and infectious diseases.
Recent advances in EV research have advanced the field from descriptive observation to mechanistic and translational investigation. Studies of EV biogenesis, cargo selection, trafficking, and cellular uptake have provided important insight into how these vesicles shape local and systemic signaling networks. Furthermore, EVs are being actively explored as minimally invasive biomarkers, therapeutic targets, and engineered delivery vehicles, highlighting their potential to refine diagnostic approaches and expand therapeutic strategies across a wide range of medical disciplines.
This Special Issue invites high-quality contributions that advance the current understanding of extracellular vesicles in physiological and pathological contexts. We particularly encourage submissions that address EV biogenesis and heterogeneity, cargo sorting and functional transfer, methodological advances in isolation and characterization, disease-associated signaling, and the development of EV-based biomarkers and therapeutics.
We welcome original research articles and comprehensive reviews offering mechanistic insight, technological innovation, and clear translational relevance. The goal of this collection is to reflect the current scope of EV research and stimulate dialogue across basic, translational, and clinical disciplines.
Dr. Jung-Hyun Lee
Guest Editor
Manuscript Submission Information
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Keywords
- extracellular vesicles
- intercellular communications
- biomarkers
- drug delivery systems
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