The Multiple Roles of RNA and RNases

Dear Colleagues,

This Special Issue aims to bridge the realms of nucleic acids and proteins and promote discoveries at an interdisciplinary level. The birth of biochemistry at the beginning of the 20th century is closely related to the field of RNases, ranging from the first 3D structures to the first catalytic mechanism. Now, in the 21st century, we are witnessing the emergence of RNA protagonism, wherein a myriad of novel types of non-coding RNAs populate an expanding new world. To explore this newly discovered RNA landscape, we cannot disregard the presence of RNases and the specific generation of novel functional RNA products.

This Special Issue will focus on the RNase–RNA encounters that rule cell biology, covering topics from basic science to therapeutics. As a taster, here are some open questions for discussion: (i) What are the structural bases for RNA recognition by RNases? (ii) How do post-transcriptional modifications govern RNA processing? (iii) How do RNAs work as intercellular communicators? (iv) Which novel small RNAs can be used as diagnosis marker candidates? and (v) How can we engineer novel RNase-based drugs?

Prof. Dr. Ester Boix
Guest Editor

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