Ion Channels and Transporters: Regulation and Roles in Human Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 31 October 2026 | Viewed by 141
Special Issue Editor
Interests: molecular pharmacological study of ion channel related diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Ion channels and transporters play important roles in cellular functions in various organ systems such as nervous, cardiovascular, immune and endocrine systems and are potential therapeutic targets for treatment of their dysfunction. Ion channels and transporters modulate diverse intracellular signaling pathways involved in neuronal activity, muscle contraction, cell proliferation, differentiation, apoptosis and transcription. In addition, their regulatory proteins alter electrophysiological characteristics, cellular localization/membrane trafficking and drug sensitivity of ion channels and contribute to the functional diversity and cell-specific responses. Organellar ion channels and transporters are also focused on new therapeutic targets in cellular function and dysfunction.
In this Special Issue, original studies on all aspects of ion channels and transporters are welcome and in particular, molecular analyses of ion channels and transporters in multiple body systems are favorable. It will also cover the reports providing new insights into molecular mechanisms, including the transcriptional, epigenetic and post-translational regulation of ion channels and transporters and the impact of novel screening technologies on drug discovery.
Prof. Dr. Susumu Ohya
Guest Editor
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Keywords
- Ca2+/K+/Na+/Cl- channels/transporters
- organelle ion channels/transporters
- Mg2+/ Zn2+/Mn2+ transporters
- disease microenvironment
- membrane trafficking
- transcriptional regulation
- post-translational regulation
- epigenetic modification
- protein degradation
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