Drug Toxicity and Its Impact on Disease Therapies

Dear Colleagues,

Adverse drug effects are an inevitable part of disease treatment. The basic approach in drug therapy is that the benefit of using drugs is greater than the risk that the drug poses to the patient. Therefore, knowledge of adverse drug reactions, their mechanisms of occurrence and potential consequences for the treatment itself are crucial for the success of drug treatment. With the emergence of biotechnological drugs, the challenge of determining the benefit-to-risk ratio of their use becomes even more difficult due to the lack of suitable test models for determining toxicity.

In this Special Issue, we aim to highlight current research trends and current knowledge in the field of drug toxicity for treatment success, from drug development to their use in the treatment of disease. We welcome full papers, short communications and review articles addressing areas including (but not limited to) the following:

• Using computational methods and machine learning to improve toxicity prediction
• Impact of genophenotypic factors and pharmacogenomics on adverse drug reactions
• Non-clinical experimental models for predicting drug toxicity
• The molecular and cellular mechanisms underlying drug toxicity
• Toxicity associated with monoclonal antibodies and advanced therapy medicinal products (cell-based therapy, gene therapy, tissue engineering)
• Organ toxicity (i.e., hepatotoxicity, nephrotoxicity, neurotoxicity)
• Treatment-related adverse reactions in polypharmacy
• Drug-induced toxicity in chronic therapies

Prof. Dr. Metoda Lipnik-Štangelj
Guest Editor

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