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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Utilizing Induced Pluripotent Stem Cells and Cardiomyocytes: From Basic Research to Disease Modeling
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 2539 | Submission Open
Keywords: induced pluripotent stem cells; cardiomyocytes; disease modeling; basic research; translational applications
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Cardiovascular Risk Factors: 2nd Edition
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 2471 | Submission Open
Keywords: atherosclerosis; cardiovascular risk; arterial stiffness; blood pressure; vitamin D; miRNA; inflammation
(This special issue belongs to the Section Molecular Biology)
Molecular Advances in Parvovirus
edited by Zahra Kadri
submission deadline 20 Sep 2025 | 1 articles | Viewed by 2461 | Submission Open
Keywords: parvovirus structure; parvovirus replication; parvovirus proteome; cell signaling pathways; transcription; translation and post-translational modification; host restriction factor; host/parvovirus interaction; recombinant virus and VLP; immune evasion and/or activation; host tropism (cell type and species); new experimental models and approaches
(This special issue belongs to the Section Molecular Microbiology)
The Roles of Mesenchymal Stem/Stromal Cells in Tumor Therapies
edited by Francesco Agostini
submission deadline 20 Sep 2025 | 1 articles | Viewed by 2459 | Submission Open
Keywords: mesenchymal stem cells; tumor; cancer patients; ex vivo cell modification; cell and gene therapy; targeted drug delivery; homing; migration; current regulatory guidelines; MSC therapeutic potential
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Current Trends in MOF (Metal–Organic Framework) and Metal X-ides Development, 2nd Edition
edited by Siwei Li
submission deadline 20 Sep 2025 | 2 articles | Viewed by 2457 | Submission Open
Keywords: MOF; metal carbide; metal sulfide; metal phosphide; catalysis; biomedicine; electromagnetic absorption; energy conversion and storage
(This special issue belongs to the Section Materials Science)
C. elegans as a Disease Model: Molecular Perspectives: 2nd Edition submission deadline 20 Sep 2025 | 2 articles | Viewed by 2440 | Submission Open
Keywords: Caenorhabditis elegans; model organism; disease model; neurodegenerative diseases; cancer model; ageing
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Smooth Muscle Cells in Vascular Disease submission deadline 20 Sep 2025 | 3 articles | Viewed by 2437 | Submission Open
Keywords: smooth muscle cells (SMCs); atherosclerosis; hypertension; aortic aneurysm; vascular ageing; extracellular matrix; endothelial cells (ECs); SMC senescence; interleukin; platelet-derived growth factor; phenotype switching; SMC plasticity; SMC-derived cells; molecular subtypes; intimal thickening; plaque stability; transcription factors; microRNAs; clonality
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advancements in Host-Directed Antiviral Therapies submission deadline 20 Sep 2025 | 1 articles | Viewed by 2416 | Submission Open
Keywords: antiviral drugs; drug discovery; host cell targets; HIV; HCV; influenza; SARS-CoV-2
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Microbiota’s Role in Respiratory Disorders and Diseases
edited by and Mauro Carone
submission deadline 20 Sep 2025 | 1 articles | Viewed by 2385 | Submission Open
Keywords: microbiota; microbiome; metabolome; transcriptome; microbiota gut/lung axis; microbiota gut/oral axis; respiratory disorders; respiratory diseases; respiratory rehabilitation
(This special issue belongs to the Section Molecular Microbiology)
Emerging Heterocycles submission deadline 20 Sep 2025 | 1 articles | Viewed by 2357 | Submission Open
Keywords: synthesis; reactions; applications; biological activity; medicinal chemistry; natural products; alkaloids; new methodology
(This special issue belongs to the Section Biochemistry)
Application of Artificial Intelligence in Molecular Sciences
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 2339 | Submission Open
Keywords: artificial intelligence; deep learning; algorithms; molecular modeling and simulation; materials discovery; analysis of biological sequence data; computational chemistry; bioinformatics; genomics; protein structure prediction; molecular dynamics simulation
(This special issue belongs to the Section Molecular Informatics)
Cellular Metabolism and Retinal Diseases: Unraveling Molecular Pathways and Therapeutic Targets submission deadline 20 Sep 2025 | 3 articles | Viewed by 2327 | Submission Open
Keywords: retina; metabolic dysfunction in retinal diseases; metabolism and retinal cell function; metabolism and oxidative stress; therapeutic targets; intracellular signaling; epigenetic modification
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
False-Positive and False-Negative Laboratory Biomarkers
edited by Michela Salvatici and Lorenzo Drago
submission deadline 20 Sep 2025 | 2 articles | Viewed by 2288 | Submission Open
Keywords: biomarkers; false positives/negatives; protein biomarkers; nucleic acid markers; multi-omics; single-cell sequencing; liquid biopsy
(This special issue belongs to the Section Biochemistry)
Physiological Functions and Pathological Effects of Microglia
edited by Hiroshi Nakanishi
submission deadline 20 Sep 2025 | 2 articles | Viewed by 2280 | Submission Open
Keywords: circadian clock; homeostasis; immune response; microglia; neurodegenerative diseases; neuroinflammation; neuropsychiatric disorders; neuromodulation; phagocytosis; synaptic pruning
(This special issue belongs to the Section Molecular Neurobiology)
The Gut-Brain Axis: Genomic and Metagenomic Involvement
edited by and Elias Odusseas Tzavellas
submission deadline 20 Sep 2025 | 1 articles | Viewed by 2279 | Submission Open
Keywords: gut– brain axis; central nervous system; gastrointestinal tract; genomic; metagenomic
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Genetics, Breeding, and Multi-Omics Approaches in Rice Research
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 2257 | Submission Open
Keywords: rice genetics and breeding; molecular breeding of rice; rice genomics and proteomics; genes related to abiotic stress tolerance in rice; molecular biology and multi-omics in rice research
(This special issue belongs to the Section Molecular Plant Sciences)
Antiphospholipid Syndrome: From Pathophysiology to Therapy
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 2244 | Submission Open
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Editorial Board Members’ Collection Series: Cancer Metabolism submission deadline 20 Sep 2025 | 1 articles | Viewed by 2239 | Submission Open
Keywords: cancer metabolism; metabolic pathway; glucose consumption and energy production; amino acid requirement
(This special issue belongs to the Section Molecular Oncology)
Novel Technologies in the Study of the Pathogenesis of Cardiac Diseases submission deadline 20 Sep 2025 | 1 articles | Viewed by 2196 | Submission Open
Keywords: artificial Intelligence; multi-omics; organoids; engineered heart tissue; advanced imaging; personalized medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Impact of Mitochondria on Human Disease and Health
edited by
submission deadline 20 Sep 2025 | 3 articles | Viewed by 2179 | Submission Open
Keywords: mitochondrial dysfunction; mitochondrial bioenergetics; mitochondrial dynamics; mitophagy; oxidative stress; mitochondrial DNA (mtDNA) mutations; neurodegenerative diseases; cardiovascular diseases; metabolic disorders; aging and mitochondria; cancer
(This special issue belongs to the Section Biochemistry)
Molecular Dimensional Design, Synthesis Modification and Application of Sustainable Polymer Materials
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 2163 | Submission Open
Keywords: sustainable polymeric materials; 3D printing; sustainability; environmental impact; molecular modifications
(This special issue belongs to the Section Materials Science)
Neuroinflammation in the Pathogenesis of Alzheimer’s Disease and Related Dementias: 2nd Edition
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 2162 | Submission Open
Keywords: Alzheimer’ s disease; neuroinflammation; drug development; microglia; astrocytes; cytokines; TREM2; risk factors; biomarkers
(This special issue belongs to the Section Molecular Immunology)
Research of Hydroxyapatite-Based Materials and Their Applications
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 2140 | Submission Open
Keywords: hydroxyapatite; nanobiocomposite; biomedical applications; coatings; environment remediation; biological properties; drug delivery; pollutant adsorption efficiency; morphology and structural features
(This special issue belongs to the Section Materials Science)
Advanced Molecular Research on the Diagnosis and Treatment of Chronic Liver Diseases
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 2135 | Submission Open
Keywords: biomarker; genomic research; epigenomic research; molecular mechanisms; viral hepatitis; alcoholic-related liver disease; non-alcoholic fatty liver disease; autoimmune liver diseases; liver cirrhosis; hepatocellular carcinoma
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research Progress of Skin and Skin Diseases: 2nd Edition
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 2128 | Submission Open
Keywords: atopic dermatitis; psoriasis; alopecia; vitiligo; acne; skin cancer; JAK-STAT; inflammatory skin disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Tumor Microenvironment and Cancer Progression: Molecular Insights for Targeted Therapy
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 2089 | Submission Open
Keywords: tumor microenvironment; immune response modulation; signaling pathways; extracellular matrix components; tumor evolution
(This special issue belongs to the Section Molecular Oncology)
The Role of SARS-CoV-2 in Immunomodulation—Post-Pandemic Reflection on the Role of Viruses in Human Immunology submission deadline 20 Sep 2025 | 3 articles | Viewed by 2086 | Submission Open
Keywords: SARS-CoV-2; COVID-19; immunomodulation; T cells; B cells; dendritic cells; monocytes; cytokines
(This special issue belongs to the Section Molecular Immunology)
Fungal Pathogen-Host Interactions
edited by Patricia Albuquerque
submission deadline 20 Sep 2025 | 1 articles | Viewed by 2076 | Submission Open
Keywords: medical mycology; host– microbe interactions; macrophages; dendritic cells; neutrophils
(This special issue belongs to the Section Molecular Microbiology)
New Insights into Osteoclasts
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 2047 | Submission Open
Keywords: osteoclast; bone remodeling; osteoporosis; inflammatory arthritis; bone tumor
(This special issue belongs to the Section Molecular Biology)
Molecular Advances in Olive and Its Derivatives
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1993 | Submission Open
Keywords: olive; structural and functional genomics; genomic variation; breeding; biotechnologies; next-generation sequencing
(This special issue belongs to the Section Molecular Plant Sciences)
Recent Developments in Metabolism of Algal Toxins in Animals submission deadline 20 Sep 2025 | 1 articles | Viewed by 1986 | Submission Open
Keywords: marine toxins; bioacumulation; chemical conversion; detoxification mechanisms; toxin gene clusters
(This special issue belongs to the Section Molecular Toxicology)
Cellular Oxygen Homeostasis—3rd Edition
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1951 | Submission Open
Keywords: cellular oxygen homeostasis; redox signaling; cellular oxygen sensing; hypoxia; hyperoxia
(This special issue belongs to the Section Molecular Biology)
Bilirubin: Health Challenges and Opportunities
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 1946 | Submission Open
Keywords: bilirubin; biomedical science; neurobiology; Parkinson’ s disease; brain neuroprotection
(This special issue belongs to the Section Molecular Biology)
Molecular Insights into Role of Anthranilic Acid in Neuropsychiatric Diseases submission deadline 20 Sep 2025 | 1 articles | Viewed by 1936 | Submission Open
Keywords: anthranilic acid; Alzheimer’ s disease; autism; schizophrenia; bipolar disorder; major depressive disorder; post-partum depression; COVID-19; interferons; attention deficit disorder; cognitive impairment; G-protein-coupled receptor 109A; microbiome; gut– brain axis
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Mechanisms and Treatment of Chronic Kidney Disease
edited by Xinming Chen
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1920 | Submission Open
Keywords: diabetes; cardiovascular diseases; nephrology; diabetic nephropathy
(This special issue belongs to the Section Molecular Biology)
Molecular Insights into Flower Gene Regulation
edited by Wen‑Chieh Tsai
submission deadline 20 Sep 2025 | 2 articles | Viewed by 1912 | Submission Open
Keywords: floral gene regulation; flowers; homeotic genes; MADSBox; pollination
(This special issue belongs to the Section Molecular Plant Sciences)
Blueprints of Enzymatic Function and Structure in Biocatalysis submission deadline 20 Sep 2025 | 1 articles | Viewed by 1898 | Submission Open
Keywords: enzyme; biocatalysis; enzyme structure; enzyme kinetics and thermodynamics; enzyme engineering; synthetic biology applications; sustainable biocatalyst design
(This special issue belongs to the Section Biochemistry)
Recent Advances and Challenges in Colorectal Cancer: From Molecular Research to Treatment submission deadline 20 Sep 2025 | 1 articles | Viewed by 1895 | Submission Open
Keywords: tumor biology; tumor heterogeneity; molecular mechanism involved in cancer initiation; progression; and metastasis; compensatory pathways; cancer screening; cancer biomarkers discovery; tumor molecular profiling methods; early cancer diagnosis; novel therapeutic strategies; targeted therapies; drug resistance
(This special issue belongs to the Section Molecular Oncology)
Molecular Research on Oxidative Stress in Health and Disease submission deadline 20 Sep 2025 | 1 articles | Viewed by 1859 | Submission Open
Keywords: oxidative stress; antioxidants; cancer; redox signalling; reactive oxygen and nitrogen species
(This special issue belongs to the Section Molecular Biology)
New Anti-cancer Agents: Design, Synthesis and Applications
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 1822 | Submission Open
Keywords: anti-cancer drugs; cancer drug development; cancer therapy; rational drug design; structure– activity relationship; cancer therapeutics; cytotoxicity; apoptosis; anti-tumor activity
(This special issue belongs to the Section Molecular Pharmacology)
Blood Cells in Human Health and Disease
edited by Leonid Livshits
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1814 | Submission Open
Keywords: red blood cell; RBC membrane; RBC biophysical properties; RBC rheology; RBC mechanical properties; RBC membrane vesiculation; RBC clearance; RBC in diabetes; hemoglobinopathies; RBC storage TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in English   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com
(This special issue belongs to the Section Biochemistry)
Protein Stability Research: 2nd Edition
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1789 | Submission Open
Keywords: protein stability; protein degradation; conformational stability and flexibility; thermodynamic stability of proteins; mutation-induced changes in protein stability; stability of oligomeric proteins; stability of protein complexes; thermal adaptation of protein structures; protein aggregation; molten globules; heat shock proteins; chaperones
(This special issue belongs to the Section Molecular Biophysics)
Recent Research on Cardiac Troponins submission deadline 20 Sep 2025 | 2 articles | Viewed by 1789 | Submission Open
Keywords: cardiac troponin; gene mutations; post-translational modifications; therapy; high-sensitivity (hs) immunoassays; mechanisms of release; biomarkers; cardiovascular disease
(This special issue belongs to the Section Molecular Biology)
Antimicrobial Resistology: A New Approach in the Fight Against Antimicrobial Resistance
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1751 | Submission Open
Keywords: antimicrobial resistance; resistology; ESBL; AmpC; carbapenem resistance; one health
(This special issue belongs to the Section Molecular Pharmacology)
Advanced Molecular Research on Retinopathy and Protection
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1743 | Submission Open
Keywords: retinopathy; neuroprotection; antioxidants; innovative therapy; emerging technology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
DNA Damage Response from Molecular Mechanisms to Cancer Therapy
edited by Luigi Alfano and
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1728 | Submission Open
Keywords: DNA damage response; synthetic lethality; homologous recombination; cancer therapy
(This special issue belongs to the Section Molecular Oncology)
Explore Marine Biodiversity: Discover Insights from Genomics and Transcriptomics
edited by and Ambrosino Luca
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1705 | Submission Open
Keywords: comparative genomics; functional genomics; transcriptomics; gene expression; adaptation; population genomics; marine biodiversity; evolution
(This special issue belongs to the Section Molecular Genetics and Genomics)
Characterization and Biological Function of Plant Extracts submission deadline 20 Sep 2025 | 2 articles | Viewed by 1666 | Submission Open
Keywords: plant extracts; phytochemical characterization; bioactive compounds; biological activity; molecular mechanisms; gene expression; pharmacognosy
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Electrochemistry: Molecular Advances and Challenges
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1649 | Submission Open
Keywords: fundamental electrochemistry; electroanalytical techniques; sensors and biosensors; nano-electrochemistry; electrochemical energy production and storage; environmental electrochemistry
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Peptide Self-Assembly
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 1637 | Submission Open
Keywords: peptide assembly; aromatic short peptides; bioinspired supramolecular architectures; functional materials; peptide microfabrication; anticancer therapy; supercapacitor; biosensing
(This special issue belongs to the Section Macromolecules)
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