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The Gut-Brain Axis: Genomic and Metagenomic Involvement

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 20 September 2025 | Viewed by 1950

Special Issue Editors


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Co-Guest Editor
First Department of Psychiatry, “Aiginition” Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece
Interests: psychiatry

Special Issue Information

Dear Colleagues,

The gut–brain axis is the two-way biochemical signaling that occurs among the gastrointestinal tract (GI tract) and the central nervous system (CNS). Several data from functional pathway analyses suggest that genetic factors may influence a wide range of biological pathways including the gut-brain axis and different mechanisms in the etiopathology of IBS, and neuropsychiatric disorders, indicating as genetic architecture between GI and CNS diseases. We should also notice that the microbiota-gut-brain axis represents also a sophisticated communication network between the brain and the gut and evidence shows that alterations in gut microbiota composition, significantly impact GI (ie IBS, Crohn’s disease, Ulcerative colitis, GI-cancers, etc), and CNS disorders (ie anxiety, depression, schizophrenia, autism, alcoholism, Parkinson's disease, Alzheimer's disease, etc). Thus, more in-depth studies are necessary to fully understand and harness the therapeutic potential of the genomic and metagenomic implication on the gut-brain axis signaling in health and disease.

Prof. Dr. Maria Gazouli
Dr. Elias Odusseas Tzavellas
Guest Editors

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Keywords

  • gut–brain axis
  • central nervous system
  • gastrointestinal tract
  • genomic
  • metagenomic

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Published Papers (1 paper)

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Research

17 pages, 4704 KiB  
Article
Brain Tumors and Beyond: Multi-Compartment Microbiome and Mycobiome Analysis
by László Sipos, Péter Banczerowski, János Juhász, Imre Fedorcsák, György Berényi, Nóra Makra, Zsuzsanna A. Dunai, Dóra Szabó and Loránd Erőss
Int. J. Mol. Sci. 2025, 26(3), 991; https://doi.org/10.3390/ijms26030991 - 24 Jan 2025
Viewed by 1313
Abstract
Brain tumors are frequently diagnosed diseases in which etiology and progression largely depend on mutations and genetic factors. Additionally, recent reports document that the microbiome may influence tumor growth, tumor microenvironment, and response to therapy. Our goal was to examine the extent to [...] Read more.
Brain tumors are frequently diagnosed diseases in which etiology and progression largely depend on mutations and genetic factors. Additionally, recent reports document that the microbiome may influence tumor growth, tumor microenvironment, and response to therapy. Our goal was to examine the extent to which the bacterial composition—microbiota—and fungal composition—mycobiota—characteristic of the tumor and its microenvironment correlate with the composition of the gut and blood microbiota and mycobiota in five randomly selected brain tumor patients. The bacterial composition of the tumor, tumor-adjacent tissue (TAT), blood, and gut samples of the five patients were analyzed by 16S rRNA and ITS-based sequencing in order to determine the bacterial and fungal composition. The gut microbiome and mycobiome composition showed individual and tissue-specific signatures in each patient. The microbiome composition of the blood, TAT, and tumor tissue was very similar in each patient, dominated by Klebsiella, Enterococcus, Blautia, and Lactobacillus spp. In contrast, the mycobiome composition of the blood, TAT, and tumor showed a diverse, individual picture. The most common fungal species in the blood and TAT were Tomentella, Didymosphaeria, Alternaria, Penicillium, Mycosphaerella, and Discosia. The blood and TAT mycobiome were similar to each other but unique and characteristic of the patients. In contrast, in the tumor tissues, Alternaria, Malassezia, Schizophyllum, and Tomentella genus were the most common fungi genus. Our results showed that the presence of fungi in tumors shows a unique pattern that is independent of the pattern observed in the gut, blood, and tumor environment and that the effects of the mycobiome are distinct and cannot be associated with those of the microbiome. Elucidating the role of fungi in tumors and exploring the relationship between fungi and brain tumor types may open up further therapeutic options. Full article
(This article belongs to the Special Issue The Gut-Brain Axis: Genomic and Metagenomic Involvement)
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