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Editorial Board Members’ Collection Series: Cancer Metabolism

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 20 January 2025 | Viewed by 1168

Special Issue Editors


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Guest Editor
Andrology and Kidney Transplantation Unit, Department of Emergency and Organ Transplantation—Urology, University of Bari “Aldo Moro”, 70124 Bari, Italy
Interests: kidney cancer; prostate cancer; kidney transplantation; metabolomics
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Research Institute on Terrestrial Ecosystems (IRET)-CNR, Porano, Italy
Interests: cell metabolism; cell-materials interaction; drug delivery systems; natural biomolecules

Special Issue Information

Dear Colleagues,

Cancer metabolism is a venerable area of cancer research. A century ago, Nobel Laureate Otto Warburg studied the oxygen needs of cancer cells, leading to the determination that cancer cells acquire special properties that promote distinct growth and metastatic advantages over normal cells. There is now a growing research framework for understanding how cancer cells work, leading to major advances in targeted cancer therapies. We hope that this Special Issue will increase this understanding to advance metabolic-based cancer treatment and prevention strategies.

Areas of interest for this Special issue include abnormal glucose consumption and energy production in cancer cells of all types, amino acid requirements, inflammatory mechanisms, messaging and cross-talk between malignant and normal cells, mechanisms of effective dietary changes in cancer treatment and prevention, metabolic drivers behind carcinogenesis, and, at the other end of the spectrum, reasons for the devastating syndrome of cancer cachexia. Papers addressing other areas of metabolism, innovative research ideas, and suggestions for clinical trials are also welcome. Our goal is to foster a better understanding of cancer metabolism and the application of this understanding in the development of effective targeted therapies. We welcome your help.

Please note that this Special Issue is focused on molecular research, so pure clinical studies will not be accepted. However, clinical submissions utilizing biomolecular experiments are welcomed.

Prof. Dr. Giuseppe Lucarelli
Dr. Daniel W. Nixon
Prof. Dr. Gianfranco Peluso
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer metabolism
  • metabolic pathway
  • glucose consumption and energy production
  • amino acid requirement

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Published Papers (1 paper)

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Research

17 pages, 3578 KiB  
Article
Targeted Metabolomics of Tissue and Plasma Identifies Biomarkers in Mice with NOTCH1-Dependent T-Cell Acute Lymphoblastic Leukemia
by Valeria Tosello, Ludovica Di Martino and Erich Piovan
Int. J. Mol. Sci. 2024, 25(12), 6543; https://doi.org/10.3390/ijms25126543 - 13 Jun 2024
Viewed by 877
Abstract
While the genomics era has allowed remarkable advances in understanding the mechanisms driving the biology and pathogenesis of numerous blood cancers, including acute lymphoblastic leukemia (ALL), metabolic studies are still lagging, especially regarding how the metabolism differs between healthy and diseased individuals. T-cell [...] Read more.
While the genomics era has allowed remarkable advances in understanding the mechanisms driving the biology and pathogenesis of numerous blood cancers, including acute lymphoblastic leukemia (ALL), metabolic studies are still lagging, especially regarding how the metabolism differs between healthy and diseased individuals. T-cell ALL (T-ALL) is an aggressive hematological neoplasm deriving from the malignant transformation of T-cell progenitors characterized by frequent NOTCH1 pathway activation. The aim of our study was to characterize tumor and plasma metabolomes during T-ALL development using a NOTCH1-induced murine T-ALL model (ΔE-NOTCH1). In tissue, we found a significant metabolic shift with leukemia development, as metabolites linked to glycolysis (lactic acid) and Tricarboxylic acid cycle replenishment (succinic and malic acids) were elevated in NOTCH1 tumors, while metabolites associated with lipid oxidation (e.g., carnitine) as well as purine and pyrimidine metabolism were elevated in normal thymic tissue. Glycine, serine, and threonine metabolism, glutathione metabolism, as well as valine, leucine, and isoleucine biosynthesis were enriched pathways in tumor tissue. Phenylalanine and tyrosine metabolism was highly enriched in plasma from leukemia-bearing mice compared to healthy mice. Further, we identified a metabolic signature consisting of glycine, alanine, proline, 3-hydroxybutyrate, and glutamic acid as potential biomarkers for leukemia progression in plasma. Hopefully, the metabolic differences detected in our leukemia model will apply to humans and contribute to the development of metabolism-oriented therapeutic approaches. Full article
(This article belongs to the Special Issue Editorial Board Members’ Collection Series: Cancer Metabolism)
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