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New Cardiovascular Risk Factors: 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 20 September 2025 | Viewed by 1707

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Guest Editor
Department of Clinical Medicine and Surgery, Federico II University of Naples Medical School, 80131 Naples, Italy
Interests: blood pressure; cardiovascular disease; metabolic syndrome; hypertension; atherosclerosis; cardiovascular epidemiology; metabolism; metabolic diseases; abdominal obesity; internal medicine
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Special Issue Information

Dear Colleagues,

Atherosclerosis is a common condition of vascular aging. However, several factors could influence this process, resulting in increased cardiovascular risk at a young age.

In addition to well-known factors (e.g., high blood pressure, dyslipidemia, diabetes, excess body weight), there are several emerging factors associated with atherosclerosis, such as inflammation, endothelial dysfunction, intestinal microbiota alteration, uric acid, vitamin D, or miRNA expression, that could potentially explain the residual cardiovascular risk.

This Special Issue focused on cardiovascular risk factors aims to report the most current scientific evidence available on this topic and reviews of the current literature on the role of emerging factors in the development of atherosclerosis, as demonstrated by both experimental and clinical studies, in order to gather a large body of data from which to start to highlight new potential objectives for reducing cardiovascular risk.

Dr. Antonio Barbato
Guest Editor

Manuscript Submission Information

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Keywords

  • atherosclerosis
  • cardiovascular risk
  • arterial stiffness
  • blood pressure
  • vitamin D
  • miRNA
  • inflammation

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Published Papers (1 paper)

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Review

17 pages, 1935 KiB  
Review
Non-Hypertensive Effects of Aldosterone
by Natalia Ekman, Ashley B. Grossman, Anna Nieckarz, Łukasz Jędrzejewski, Jacek Wolf and Dorota Dworakowska
Int. J. Mol. Sci. 2025, 26(2), 540; https://doi.org/10.3390/ijms26020540 - 10 Jan 2025
Cited by 1 | Viewed by 1485
Abstract
Aldosterone, the primary adrenal mineralocorticoid hormone, as an integral part of the renin–angiotensin–aldosterone system (RAAS), is crucial in blood pressure regulation and maintaining sodium and potassium levels. It interacts with the mineralocorticoid receptor (MR) expressed in the kidney and promotes sodium and water [...] Read more.
Aldosterone, the primary adrenal mineralocorticoid hormone, as an integral part of the renin–angiotensin–aldosterone system (RAAS), is crucial in blood pressure regulation and maintaining sodium and potassium levels. It interacts with the mineralocorticoid receptor (MR) expressed in the kidney and promotes sodium and water reabsorption, thereby increasing blood pressure. However, MRs are additionally expressed in other cells, such as cardiomyocytes, the endothelium, neurons, or brown adipose tissue cells. Therefore, aldosterone (especially aldosterone excess) may have other major impacts besides simply regulating blood pressure and circulating ion balance. Recent studies have reported a non-hypertensive impact on the cardiovascular, immune, and metabolic systems, a pro-oxidant effect, and a pro-fibrotic effect. In this review, we emphasise the non-hypertension-related effects of aldosterone, including advances in our understanding of the cellular mechanisms by which aldosterone mediates its cellular effects. We also summarise potential clinical complications related to both the hypertensive and non-hypertensive effects of aldosterone. Full article
(This article belongs to the Special Issue New Cardiovascular Risk Factors: 2nd Edition)
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