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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms and Diagnostics in Hereditary Hemolytic Anemias
edited by Joan-Lluís Vives-Corrons
submission deadline 31 Jan 2027 | Viewed by 463 | Submission Open
Keywords: anemia; red blood cell erythropoiesis; membranopathies ; erythro enzymopathies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights into T Cell Exhaustion and Tumor Immune Evasion submission deadline 31 Jan 2027 | Viewed by 455 | Submission Open
Keywords: T cell exhaustion; immune evasion; tumor microenvironment; immune checkpoints; immunometabolism; epigenetics; cancer immunology; molecular immunotherapy; single-cell analysis; transcriptional regulation
(This special issue belongs to the Section Molecular Immunology)
Cryo-EM and Cryo-Tomography in Macromolecular Structure Analysis
edited by
submission deadline 31 Jan 2027 | Viewed by 451 | Submission Open
Keywords: macromolecular structure; precision nanomedicine; cryo-electron microscopy (cryo-EM); cryo-electron tomography (cryo-ET); viral capsids; AI/ML in structural analysis; time-resolved imaging; nanoparticle delivery; in-cell tomography; structural dynamics; molecular mechanisms; protein complexes; membrane proteins; macromolecular assemblies; conformational changes; integrative structural biology; cellular structural biology; drug delivery systems; therapeutic design
(This special issue belongs to the Section Macromolecules)
Relevant Molecules in the Process of Oxidative Stress submission deadline 31 Jan 2027 | Viewed by 448 | Submission Open
Keywords: oxidative stress; reactive oxygen species; reactive nitrogen species; antioxidant enzymes; non-enzymatic antioxidants; poly(ADPribosyl)ation; transcription factors
(This special issue belongs to the Section Biochemistry)
Progress in Molecular Breeding and Genetic Engineering for Fruit Crop Improvement
edited by
submission deadline 31 Jan 2027 | Viewed by 444 | Submission Open
Keywords: genetics; GWAS; genome; abiotic and biotic stress; transcriptomic analysis; fruit crop germplasm; breeding
(This special issue belongs to the Section Molecular Plant Sciences)
Biomedical Applications of Mesenchymal Stem Cells, 2nd Edition submission deadline 31 Jan 2027 | Viewed by 443 | Submission Open
Keywords: mesenchymal stem cells; cell differentiation; cell therapy; regenerative medicine; tissue homeostasis; disease; cartilage
(This special issue belongs to the Section Molecular Biology)
Biomaterials: From Design, Synthesis and Characterization to Application—2nd Edition
edited by and
submission deadline 31 Jan 2027 | Viewed by 441 | Submission Open
Keywords: biomaterials; synthesis; characterization; therapeutics; diagnosis
(This special issue belongs to the Section Materials Science)
Lysosomal Storage Disorders: Molecular Pathogenesis and Next-Generation Therapeutics
edited by and
submission deadline 31 Jan 2027 | Viewed by 430 | Submission Open
Keywords: lysosomal storage disorders; cellular mechanisms; multi-omics biomarkers; gene therapy; precision medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cellular Immunotherapy in Cancer: Current Trends and Future Directions
edited by
submission deadline 31 Jan 2027 | Viewed by 417 | Submission Open
Keywords: cellular immunotherapy; CAR-T cells; CAR-NK cells; CAR-macrophages; tumor-infiltrating lymphocytes (TILs); immune receptor signaling; tumor microenvironment; CRISPR/Cas9 genome editing; precision cancer immunotherapy; translational immuno-oncology
(This special issue belongs to the Section Molecular Immunology)
Microbial Bioconversion of Agri-Food Waste for the Production of Pharmacologically Active Compound
edited by Alicia Paz
submission deadline 31 Jan 2027 | Viewed by 413 | Submission Open
Keywords: microbial bioconversion; agri-food waste valorization; bioactive compounds; bioprocess optimization; pharmaceuticals; functional foods; cosmetic bioactives
(This special issue belongs to the Section Molecular Microbiology)
Micro/Nano-Structure Regulation of Two-Dimensional Materials
edited by
submission deadline 31 Jan 2027 | Viewed by 411 | Submission Open
Keywords: 2D materials; micro/nano-engineering; structure–property relationships
(This special issue belongs to the Section Materials Science)
Molecular and Metabolic Mechanisms Regulating Reproduction and Development in Animals
edited by Borhan Shokrollahi and Kimberly M. Davenport
submission deadline 31 Jan 2027 | Viewed by 408 | Submission Open
Keywords: molecular nutrition; metabolic signaling; reproductive physiology; epigenetic programming; placental biology; transcriptomics and metabolomics; mitochondrial function; oxidative stress pathways; developmental programming; ruminant health
(This special issue belongs to the Section Molecular Biology)
The Relationship Between Cytokines and Autoimmune Diseases: New Insights submission deadline 31 Jan 2027 | Viewed by 402 | Submission Open
Keywords: cytokines; autoimmune diseases; biomarkers; therapeutic targets; etiology; pathophysiology
(This special issue belongs to the Section Molecular Immunology)
Advances in Photodynamic Therapy and Photodetection: Targeted Approaches and Immunological Perspectives submission deadline 31 Jan 2027 | 1 articles | Viewed by 397 | Submission Open
Keywords: photodynamic therapy (PDT); photodetection (PD); photosensitiser; nanoparticles; nanotechnology; targeted therapy; immunotherapy; vaccines
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Unraveling Bioactive Peptides: Structure, Function, and Applications
edited by
submission deadline 31 Jan 2027 | Viewed by 394 | Submission Open
Keywords: bioactive peptides; peptide structure–activity relationship; peptidomics; bioactivity assays; human health
(This special issue belongs to the Section Macromolecules)
Male Reproduction: Unveiling the Molecular Revolution
edited by
submission deadline 31 Jan 2027 | Viewed by 386 | Submission Open
Keywords: testosterone; spermatogenesis; capacitation; acrosome reaction; endocrine disruptors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Immuno-Oncology Approaches for Glioblastoma
edited by
submission deadline 31 Jan 2027 | Viewed by 377 | Submission Open
Keywords: GBM pathogenesis; GBM diagnostic; neuro-cancerogenesis; genetics; growth factors; immunotherapy; gene therapy; chemotherapy; radiotherapy; nanotechnology
(This special issue belongs to the Section Molecular Oncology)
Nano-Biomaterials for Biomedicine and Tissue Regeneration
edited by and
submission deadline 31 Jan 2027 | Viewed by 376 | Submission Open
Keywords: nanostructured biomaterials; cell-scaffold interactions; drug delivery systems; tissue engineering; regenerative medicine
(This special issue belongs to the Section Molecular Nanoscience)
Interplay of Nanoparticles with Plant Physiology and Molecular Biology: Effects, Mechanisms and Agricultural Applications
edited by
submission deadline 31 Jan 2027 | Viewed by 375 | Submission Open
Keywords: plant nano biology; abiotic stress tolerance; physiological and molecular mechanisms; nanotoxicology; detoxification strategies
(This special issue belongs to the Section Molecular Plant Sciences)
Natural Antioxidants in Human Health and Disease: Molecular Advances
edited by Aneta Kopeć
submission deadline 31 Jan 2027 | Viewed by 375 | Submission Open
Keywords: antioxidants; immune response; free radicals; mechanism of action
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Targeted Cancer Therapeutics: Molecular Pathways and Precision Strategies
edited by
submission deadline 31 Jan 2027 | Viewed by 371 | Submission Open
Keywords: targeted cancer therapy; small molecules; combination therapy; inhibitors; cancer cell death and proliferation
(This special issue belongs to the Section Molecular Oncology)
Design and Application of Biocatalysts: Emerging Advances and Innovations in Enzyme Immobilization and Technologies submission deadline 31 Jan 2027 | Viewed by 366 | Submission Open
Keywords: low-cost immobilization of enzymes; treatments post-immobilization; enzymatic synthesis of derivatives; polyesters depolymerization; hydroxy-acids polymerization; bioimprinting; post-immobilization treatments; composites
(This special issue belongs to the Section Biochemistry)
Phytochemicals in Cancer Therapy: From Preclinical Studies to Clinical Practice
edited by Mounir Tilaoui
submission deadline 31 Jan 2027 | Viewed by 365 | Submission Open
Keywords: phytochemicals; cancer therapy; molecular mechanisms; signaling pathways; programmed cell death; tumor microenvironment; drug resistance; preclinical models; clinical translation; adjuvant therapy
(This special issue belongs to the Section Molecular Oncology)
Signaling and Stress Adaptation in Plants: 2nd Edition
edited by
submission deadline 31 Jan 2027 | Viewed by 362 | Submission Open
Keywords: plants; environmental stress; stress signaling; reactive oxygen/nitrogen species; calcium; protein kinases; stress resistance; adaptive mechanisms
(This special issue belongs to the Section Molecular Plant Sciences)
Eosinophils: Function and Related Disorders
edited by Giulia Costanzo
submission deadline 31 Jan 2027 | Viewed by 360 | Submission Open
Keywords: eosinophils; polymorphonuclear cells; interleukin; cytotoxic proteins; host defense; tissue remodeling; dysregulation; eosinophilic disorders; therapeutics
(This special issue belongs to the Section Biochemistry)
Advancing Molecular Psychiatry: Biomarkers, Mechanisms, and Precision Therapeutics
edited by Masaru Tanaka
submission deadline 31 Jan 2027 | Viewed by 358 | Submission Open
Keywords: brain organoids; induced pluripotent stem cells (iPSC); neural stem cells; CRISPER-CAS systems (CRISPR); neuropsychiatric disorders; neurodevelopmental disorders; synaptic transmission; neuroinflammation; drug discovery; animal disease models
(This special issue belongs to the Section Molecular Neurobiology)
Fibrosis: Molecular Mechanisms and Targeted Therapy
edited by
submission deadline 31 Jan 2027 | 1 articles | Viewed by 358 | Submission Open
Keywords: fibrosis; myofibroblasts; tissue remodelling; extracellular matrix; wound healing; anti-fibrotic therapy
(This special issue belongs to the Section Biochemistry)
Advanced Materials for Next-Generation Energy Storage: Molecular Design, Functional Properties, and Applications submission deadline 31 Jan 2027 | Viewed by 357 | Submission Open
Keywords: energy storage devices; molecular materials; smart functionalities; structure-property relationships; molecular design and engineering; advanced applications
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Emerging Technologies Driving New Insights into the Multi-Omic Understanding of Human Disease
edited by and
submission deadline 31 Jan 2027 | 1 articles | Viewed by 356 | Submission Open
Keywords: metabolomic, lipidomic, proteomic, transcriptomic, and genomic analysis; spatial omics; omic analysis applied to human disease; biocomputational approaches for the management of large omic datasets; integration of multi-omic datasets
(This special issue belongs to the Section Molecular Informatics)
Cancer Genomics and Immunotherapy: Mechanisms, Biomarkers, and Clinical Translation submission deadline 31 Jan 2027 | Viewed by 354 | Submission Open
Keywords: cancer genomics; cancer immunotherapy; tumor immune microenvironment; immunogenomics biomarkers; precision oncology
(This special issue belongs to the Section Molecular Oncology)
Molecular Insights into Porous Polymers
edited by Bolin Ji
submission deadline 31 Jan 2027 | Viewed by 347 | Submission Open
Keywords: porous organic polymer; covalent organic framework; adsorption and separation of gases; energy storage materials; water treatment; antimicrobial; fluorescence imaging; tumor treatment
(This special issue belongs to the Section Materials Science)
Nanobiotechnology: Breaking Barriers in Phytomedicine submission deadline 31 Jan 2027 | Viewed by 347 | Submission Open
Keywords: nanotechnology; nanobiotechnology; phytocompounds; phytochemistry; natural products
(This special issue belongs to the Section Molecular Nanoscience)
Immunity and Autoimmunity in Cardiovascular and Respiratory Diseases
edited by
submission deadline 31 Jan 2027 | Viewed by 344 | Submission Open
Keywords: cardiovascular diseases; respiratory diseases; autoimmune diseases; T cell; B cell; lipid mediators; autoantibodies; genetic variants; mucin
(This special issue belongs to the Section Molecular Immunology)
Organoid Models: Advancing the Study of Disease Mechanisms and Nutritional Regulations
edited by and Pinghuang Liu
submission deadline 31 Jan 2027 | Viewed by 344 | Submission Open
Keywords: organoids; disease mechanisms; nutritional regulation; disease modeling; stem cells
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanism of Xenobiotics on Respiratory Disorders submission deadline 31 Jan 2027 | Viewed by 342 | Submission Open
Keywords: xenobiotics; polycyclic aromatic hydrocarbons-PHAs; volatile organic compounds-VOCs; metals; respiratory disorders; asthma; chronic obstructive pulmonary disease (COPD); lung cancer; environmental pollutants; DNA methylation; non-coding RNA deregulation; oxidative damage
(This special issue belongs to the Section Molecular Biology)
Exploring the Chemistry of 2D Transition Metal Carbides and Nitrides (MXenes): Synthesis Methods and Surface Chemistry
edited by
submission deadline 31 Jan 2027 | Viewed by 340 | Submission Open
Keywords: synthesis optimization of non-Al MAX phase; wet chemical etching of non-Al MAX phase; molten salt etching of non-Al MAX phase; surface modification of MXenes; colloidal stability of MXenes; solution process of MXenes
(This special issue belongs to the Section Materials Science)
Angiogenesis: Mechanisms and Targets in a Wide Spectrum of Diseases
edited by Lei Phillip Wang
submission deadline 31 Jan 2027 | Viewed by 334 | Submission Open
Keywords: angiogenesis; immune–vascular interactions; cancer; autoimmune disease; neurodegenera-tion; blood–brain barrier; biomarkers; therapeutic targeting
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Role of Ion Channels in Heart Health and Diseases
edited by Ernesto Alejandro Aiello
submission deadline 31 Jan 2027 | Viewed by 334 | Submission Open
Keywords: ion channels; heart; channelopathies; hypertrophy; heart failure; ischemia; hypertension; inflammation
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Cancer Nanomedicine
edited by Hari Krishnareddy Rachamala and Sandeep Atla
submission deadline 31 Jan 2027 | Viewed by 329 | Submission Open
Keywords: cancer nanomedicine; lipid nanoparticles; polymeric nanoparticles; nano-immunotherapy; targeted drug delivery; personalized cancer vaccines; mRNA delivery; tumor microenvironment; theranostics; precision oncology
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms of Neuroinflammation in Neuropsychiatric Disorders
edited by Dmitrii A. Pavlov and
submission deadline 31 Jan 2027 | Viewed by 326 | Submission Open
Keywords: neuroinflammation; GSK-3β; neuropsychiatric disorders; depression; anxiety; brain circuits; microglia; astrocytes; gut–brain axis; synaptic plasticity
(This special issue belongs to the Section Molecular Neurobiology)
Calcium Signaling in Human Health and Diseases, 4th Edition
edited by
submission deadline 31 Jan 2027 | Viewed by 326 | Submission Open
Keywords: Ca2+ signalling; intracellular organelles; plasma membrane; inositol-1,4,5-receptors; ryanodine receptors; ionotropic receptors; metabotropic receptors; TRP channels; two-pore channels; STIM and Orai
(This special issue belongs to the Section Biochemistry)
Proteoglycans and Glycosaminoglycans in Cancer Biology and Therapy
edited by Masao Nakamura
submission deadline 31 Jan 2027 | Viewed by 317 | Submission Open
Keywords: proteoglycans; glycosaminoglycans; tumor microenvironment; chondroitin sulfate; heparan sulfate; sulfation patterns; extracellular matrix remodeling; metastasis and invasion; angiogenesis; immune evasion; antibody therapeutics and ADCs; drug resistance mechanisms
(This special issue belongs to the Section Molecular Oncology)
Advanced Molecular Mechanisms, Bioprocessing and Functional Evaluation of Edible Plants: From Bioactive-Ingredient Enhancement to Health-Promoting Applications
edited by Hongxun Tao, and
submission deadline 31 Jan 2027 | Viewed by 313 | Submission Open
Keywords: edible plants; plant foods; molecular mechanisms; advanced bioprocessing; bioactive ingredients; functional evaluation; health-promoting applications; structure–function relationship; signal transduction pathways; bioavailability and metabolism; gut microbiota modulation; omics technologies
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Mechanisms and Treatments of Adenosine Signaling-Regulated Diseases
edited by
submission deadline 31 Jan 2027 | Viewed by 310 | Submission Open
Keywords: adenosine signaling; adenosine signaling–regulated diseases; adenosine receptors; A1, A2A, A2B and A3 receptors; purinergic signaling; extracellular adenosine; adenosine-mediated inflammation; adenosine in cancer and fibrosis; therapeutic targeting of adenosine pathways
(This special issue belongs to the Section Molecular Biology)
Molecular Engineering in Insoluble Antibacterial Particle for Medical Devices
edited by Ole T. Jensen
submission deadline 31 Jan 2027 | Viewed by 309 | Submission Open
Keywords: antibacterial; quaternary ammonium silica particles; bactericidal mechanism; antibacterial particle; medical devices
(This special issue belongs to the Section Materials Science)
Genetics- and Genomics-Based Wheat Improvement and Breeding
edited by Jian Ma
submission deadline 31 Jan 2027 | Viewed by 305 | Submission Open
Keywords: wheat crop; germplasm; genetics; genomics; breeding
(This special issue belongs to the Section Molecular Plant Sciences)
Recent Advances in Electrochemical Properties
edited by
submission deadline 31 Jan 2027 | Viewed by 297 | Submission Open
Keywords: electrochemical properties; electrode materials; electrodeposition; electrocatalysis; corrosion protection; electrochemical sensors; energy storage and conversion; electrochemical impedance spectroscopy; thin films and coatings; nanostructured materials; computational electrochemistry; artificial intelligence; explainable AI; machine learning; structure–property relationships
(This special issue belongs to the Section Materials Science)
Advances in MaternalFetal/Neonatal Interactions: Implications for Infant Immunity and Long-Term Health submission deadline 31 Jan 2027 | Viewed by 296 | Submission Open
Keywords: immune development; microbiome; epigenetic mechanisms; autoimmune diseases; breastfeednig
(This special issue belongs to the Section Molecular Immunology)
Latest Research in Bioactive Compounds
edited by
submission deadline 31 Jan 2027 | Viewed by 291 | Submission Open
Keywords: peptides; nervous system; feeding regulation; glucose; lipid metabolism
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Gut Microbiota and Host Interactions: From Metabolites to Metabolic Diseases
edited by
submission deadline 31 Jan 2027 | Viewed by 290 | Submission Open
Keywords: gut microbiota; omics science; microbial metabolites; dysbiosis; gut–organ axis; cardiometabolic disease
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
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