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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Novel Statistical Methods in Gene Expression Analysis, Functional Genomics, Genetics, and Biochemistry
edited by Łukasz Huminiecki
submission deadline 20 Mar 2026 | 1 articles | Viewed by 1490 | Submission Open
Keywords: multi-omics; statistics; gene expression analysis
(This special issue belongs to the Section Molecular Informatics)
Green Chemical Pesticide Design, Synthesis and Evaluation
edited by Ranfeng Sun
submission deadline 20 Mar 2026 | 1 articles | Viewed by 1456 | Submission Open
Keywords: green pesticides; natural products; action mechanism of pesticides; synthesis
(This special issue belongs to the Section Biochemistry)
Cotton Molecular Genomics and Genetics (Third Edition)
edited by
submission deadline 20 Mar 2026 | 1 articles | Viewed by 1435 | Submission Open
Keywords: cotton; biotic or abiotic stress; disease resistance; fiber yield and quality; gene editing; gene identification and function validation; genome-wide association study; QTL identification
(This special issue belongs to the Section Molecular Plant Sciences)
Mechanism of Cellular Signaling, Dysfunction, and Drug Effects on Alzheimer's Disease
edited by
submission deadline 20 Mar 2026 | 1 articles | Viewed by 1360 | Submission Open
Keywords: AD; targeted therapy; Alzheimer's disease; neurodegenerative disease; tau protein
(This special issue belongs to the Section Molecular Neurobiology)
Nanostructures: From Synthesis, Modification to Biomedical Applications
edited by Kleoniki Giannousi and
submission deadline 20 Mar 2026 | 1 articles | Viewed by 1345 | Submission Open
Keywords: nanostructures; post-synthetic methods; multi-drug resistant bacteria; amyloidopathies; neurodegeneration; photocatalysis; biosensors
(This special issue belongs to the Section Molecular Nanoscience)
Solanaceae Biology: From Genetics to Metabolism
edited by
submission deadline 20 Mar 2026 | 1 articles | Viewed by 1295 | Submission Open
Keywords: Solanaceae; nightshade family; tomato; potato; tobacco; eggplant; genetics; metabolism; crop improvement; specialized metabolite
(This special issue belongs to the Section Molecular Plant Sciences)
Mechanistic Insights into Pharmacological and Non-Pharmacological Pain Therapies: From Cellular Responses to Therapy Outcomes
edited by
submission deadline 20 Mar 2026 | 1 articles | Viewed by 1291 | Submission Open
Keywords: neuromodulation; neural plasticity; glial activation; endogenous pain modulation; neuroinflammation; therapeutic mechanisms
(This special issue belongs to the Section Molecular Pharmacology)
Gene Function, Molecular Mechanisms, and Crop Breeding
edited by Hongwei Lu
submission deadline 20 Mar 2026 | 1 articles | Viewed by 1284 | Submission Open
Keywords: molecular biology; gene function; molecular mechanism; crop breeding; molecular biology; agronomic traits; gene discovery; genomics; bioinfomatics; gene regulation
(This special issue belongs to the Section Molecular Plant Sciences)
Inflammatory Bowel Disease: Molecular Insights—2nd Edition
edited by
submission deadline 20 Mar 2026 | 1 articles | Viewed by 1206 | Submission Open
Keywords: genomic sequencing; microbiome; dysbiosis; commensal flora; omics; immunobiology; colitis; Crohn’ s disease; ulcerative colitis; multiomics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Focus on the Tryptophan Pathway
edited by
submission deadline 20 Mar 2026 | 1 articles | Viewed by 1191 | Submission Open
Keywords: aging; indole-3-propionic acid; kynurenic acid; melatonin; serotonin; tryptophan
(This special issue belongs to the Section Molecular Biology)
Metabolic Regulators of Bone Health
edited by
submission deadline 20 Mar 2026 | 1 articles | Viewed by 1170 | Submission Open
Keywords: bone; osteoporosis; diabetes; obesity; glucose; insulin; lipids; estrogen; microRNA; osteoblasts
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Metabolism in Human Health and Disease
edited by
submission deadline 20 Mar 2026 | 2 articles | Viewed by 1159 | Submission Open
Keywords: molecular metabolism; metabolic pathways; insulin resistance; Warburg effect; chronic disease; metabolomics; precision medicine; metabolic dysfunction; cancer metabolism; personalized nutrition; enzyme-targeted therapy; systems biology; cellular energy; metabolic health; preventative healthcare
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Studies of Hematologic Malignancies
edited by
submission deadline 20 Mar 2026 | 1 articles | Viewed by 1100 | Submission Open
Keywords: hematologic malignancies; molecular mechanisms; genetic and epigenetic aberrations; molecular diagnosis; targeted therapy and biomarkers
(This special issue belongs to the Section Molecular Oncology)
Biological Barriers: Consciousness and Mental Illness
edited by
submission deadline 20 Mar 2026 | 1 articles | Viewed by 1095 | Submission Open
Keywords: cell membranes; transport protein regulation; blood– brain barrier; epithelial barriers; gut barrier; respiratory barriers; blood– saliva barrier; biological barriers and pathological changes; protection of biological barriers in diseases
(This special issue belongs to the Section Molecular Biology)
Vitamin D Signaling in Human Health and Diseases
edited by
submission deadline 20 Mar 2026 | 1 articles | Viewed by 1091 | Submission Open
Keywords: vitamin D receptor; vitamin D; prevention; therapeutic potential; mineral homeostasis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research on Microbial Natural Products
edited by Wenli Li
submission deadline 20 Mar 2026 | 1 articles | Viewed by 1082 | Submission Open
Keywords: microbial natural products; biosynthetic gene clusters; structural elucidation; metabolic engineering; synthetic biology; bioactivity profiling; sustainable biomanufacturing
(This special issue belongs to the Section Molecular Microbiology)
Bioactive Phenolics and Polyphenols 2025
edited by
submission deadline 20 Mar 2026 | 2 articles | Viewed by 1068 | Submission Open
Keywords: phenolic metabolism; biological activities; stability to food processing; elicitation; methods of analysis; dietary supplements; nutraceutical ingredients; non-thermal processing; extraction and purification
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Bioactive Molecules from Food Waste in Food Packaging Applications
edited by
submission deadline 20 Mar 2026 | 1 articles | Viewed by 1060 | Submission Open
Keywords: wastes upcycling; waste management; circular economy; green chemistry; bioactive molecules; agri-food wastes and by-products; food packaging; active packaging
(This special issue belongs to the Section Materials Science)
Molecular Mechanisms of Various Diseases and Drugs Involved in Vascular Tone Regulation in Cardiovascular Disease
edited by
submission deadline 20 Mar 2026 | 1 articles | Viewed by 1027 | Submission Open
Keywords: vasoconstriction; vasodilation; calcium; protein kinase C; Rho-kinase; hypertension; nitric oxide
(This special issue belongs to the Section Molecular Biology)
Molecular Research on Plant Breeding
edited by , Sandra Correia and
submission deadline 20 Mar 2026 | 1 articles | Viewed by 987 | Submission Open
Keywords: plant breeding; proteomics; metabolomics; epigenomics; gene editing
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Insights into the Obstetrics and Gynecology
edited by
submission deadline 20 Mar 2026 | Viewed by 950 | Submission Open
Keywords: ginecology; pelvic disorders; endometrial; cervical and ovarian cancers; covid and pregnancy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Genetics and Omics in Autoimmune Diseases submission deadline 20 Mar 2026 | 1 articles | Viewed by 948 | Submission Open
Keywords: autoimmune diseases; genetics; genomics; omics; single-nucleotide variants; copy number variants; variation; susceptibility; mRNAs; microRNAs; long non-coding RNAs; masive sequencing
(This special issue belongs to the Section Molecular Genetics and Genomics)
Genetic and Epigenetic Insights into Extracellular Vesicles submission deadline 20 Mar 2026 | Viewed by 935 | Submission Open
Keywords: exosomes; extracellular vesicles; cell– cell communication; endocrinology
(This special issue belongs to the Section Biochemistry)
Oxygen Variations, 3rd Edition submission deadline 20 Mar 2026 | Viewed by 886 | Submission Open
Keywords: hypoxia; hyperoxia; normoxia; biochemichal response; integrative approach; normo-hypo-hyperbaric; molecular research; gene expression; adaptive reactions; extreme environments
(This special issue belongs to the Section Molecular Biology)
Peptide and Protein Metalation submission deadline 20 Mar 2026 | 1 articles | Viewed by 861 | Submission Open
Keywords: metallodrugs; metal ions; metal complexes; metal– protein interaction; metal– peptide interaction
(This special issue belongs to the Section Biochemistry)
Advancements in Novel Drug Delivery Systems for Gene and Drug Delivery
edited by
submission deadline 20 Mar 2026 | 1 articles | Viewed by 796 | Submission Open
Keywords: drug and gene delivery; novel drug delivery systems; nanoparticle-based delivery systems
(This special issue belongs to the Section Molecular Biology)
Exploring Tolerance Mechanisms in Plants Under Stress
edited by
submission deadline 20 Mar 2026 | 1 articles | Viewed by 741 | Submission Open
Keywords: stress; tolerance; gene family; phytohormones; mechanisms
(This special issue belongs to the Section Molecular Plant Sciences)
Cutting Edge Advances in Antitumor Properties of Natural Products submission deadline 20 Mar 2026 | Viewed by 739 | Submission Open
Keywords: natural product; cancer; cell signaling; cell death and differentiation; oxidative stress
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Insights into Transplantation and Machine Perfusion submission deadline 20 Mar 2026 | 1 articles | Viewed by 685 | Submission Open
Keywords: transplantation (liver; kidney; and other organs); primary failure; ischemia-reperfusion injury; static graft preservation; HOPE; NMP; cell signaling; glycocalyx; metabolomics; mitochondria; sterile inflammation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Lung Diseases and Lung Transplantations: Molecular Pathogenesis and Advanced Therapies
edited by Christopher Lambers
submission deadline 20 Mar 2026 | Viewed by 676 | Submission Open
Keywords: lung disease; lung transplantation; ECMO; EVLP; LAS; antibody-mediated rejection (AMR); CLAD; RAS/BOS; immunosuppression; pathogenesis; cell-free DNA; IPF therapies; gene therapies; stem cell therapies; immunotherapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Drug Treatment in Alzheimer’s Disease
edited by and Diego Dolcetta
submission deadline 20 Mar 2026 | 1 articles | Viewed by 671 | Submission Open
Keywords: Alzheimer’ s disease (AD); glia; immune system; neurotoxicity; inflammation; beta-Amyloid (bA); neurofibrillary tangles (NFTs)
(This special issue belongs to the Section Molecular Neurobiology)
The Role of Selenium in Human Health and Disease
edited by
submission deadline 20 Mar 2026 | Viewed by 644 | Submission Open
Keywords: selenium; oxidative stress; immune modulation; cancer prevention and therapy
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Advances in Brain Plasticity submission deadline 20 Mar 2026 | 1 articles | Viewed by 617 | Submission Open
Keywords: neurophysiology; neurobiology; synapses; synaptic plasticity; microglia; astrocytes; dendritic spines; neurodevelopment; neurodevelopmental disease; learning and memory; neuropharmacology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Mechanisms of Protein–Ligand Interactions in Therapies for Lifestyle Diseases and Their Complications
edited by Agnieszka Szkudlarek
submission deadline 20 Mar 2026 | Viewed by 610 | Submission Open
Keywords: chronic diseases and their complications; protein– ligand interactions; protein modifications; therapeutic efficacy; binding affinity; serum proteins; pharmaceutical applications; biomedical research
(This special issue belongs to the Section Molecular Biology)
The Medicinal Mechanism and Application of Biologically Active Compounds in Melanoma
edited by Rosanna Avola and Adriana C. E. Graziano
submission deadline 20 Mar 2026 | Viewed by 591 | Submission Open
Keywords: biologically active compounds; medicinal mechanism; cancer; melanoma; chemoprevention; anticancer effect; immunomodulation; apoptosis
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Autophagy and Programmed Cell Death in Plants and Algae
edited by
submission deadline 20 Mar 2026 | Viewed by 587 | Submission Open
Keywords: algal autophagy and PCD; autophagy-related (Atg) genes and proteins; biotic and abiotic stresses; caspase-like proteases; crop plant improvement; macro-; micro-; and mega-autophagy; metacaspases; selective autophagy; signaling; vacuolar processing enzymes (VPEs)
(This special issue belongs to the Section Molecular Plant Sciences)
Functional Materials in Photocatalysis: From Design to Application submission deadline 20 Mar 2026 | Viewed by 565 | Submission Open
Keywords: nanostructured materials  ; photocatalysis  ; catalysis  ; green synthesis  ; material design  ; surface engineering
(This special issue belongs to the Section Materials Science)
Retinoids in Ageing and Age-Related Diseases
edited by
submission deadline 20 Mar 2026 | Viewed by 561 | Submission Open
Keywords: retinoids; retinoic acid; ageing; age-related diseases
(This special issue belongs to the Section Molecular Biology)
Relationship Between Plant Microbiome and Immunity
edited by
submission deadline 20 Mar 2026 | 1 articles | Viewed by 549 | Submission Open
Keywords: microbiome; plant immune system; rhizosphere of plant roots; microbe-associated molecular patterns (MAMPs)
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Innate Immune Mechanism of Autoimmune Syndrome
edited by Diana Prieto-Peña
submission deadline 20 Mar 2026 | Viewed by 539 | Submission Open
Keywords: innate immunity; autoimmune syndrome; cell subsets; pathogenesis; translational; therapeutic modulation
(This special issue belongs to the Section Molecular Immunology)
Molecular Mechanism of VCP/p97 in Health and Diseases
edited by
submission deadline 20 Mar 2026 | Viewed by 497 | Submission Open
Keywords: AAA ATPase; VCP/p97/cdc48/TER ATPase; AAA ATPase; protein unfolding; protein degradation; protein quality control; ERAD; mitochondria-associated degradation; lysosome degradation; ribosome-associated degradation; membrane fusion and trafficking; ubiquitin; TDP43; inclusion body myopathy (IBM); paget disease (PD); frontotemporal dementia (FD); MSP1; amyotrophic lateral sclerosis (ALS); charcot-marie-tooth disease 2Y; Parkinson’ s disease; intellectual development disabilities (IDDs); lysosomal diseases; tauopathies
(This special issue belongs to the Section Molecular Biology)
Advances in Plant Biotechnology: From Pathogen Diagnostics to Disease Management submission deadline 20 Mar 2026 | 1 articles | Viewed by 496 | Submission Open
Keywords: plant pathogens; diagnostic; isothermal; biosensor; RNAi; CRISPRi; QTL mapping; GWAS; MAS or MABC
(This special issue belongs to the Section Molecular Plant Sciences)
The Impact of Environmental Factors on Male Reproductive Development and Disorders
edited by
submission deadline 20 Mar 2026 | Viewed by 456 | Submission Open
Keywords: spermatozoa; DNA; protamine; male reproductive health; pollution; endocrine disruption; heavy metals
(This special issue belongs to the Section Molecular Biology)
Influenza Pathogenesis and Vaccine Development
edited by
submission deadline 20 Mar 2026 | Viewed by 454 | Submission Open
Keywords: avian influenza; influenza virus; influenza surveillance; interspecies transmission; immune response; pandemic preparedness; pathogenesis; One Health; universal vaccines; vaccine development; viral adaptation; viral evolution; zoonotic infections
(This special issue belongs to the Section Molecular Microbiology)
The Medicinal Mechanism of Natural Products in Cancer Therapies
edited by
submission deadline 20 Mar 2026 | Viewed by 450 | Submission Open
Keywords: natural product; phytochemicals; protein– ligand interaction; mechanism of action; drug discovery; prevention; treatment
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Recent Progress in Synthesis, Properties, and Applications of Polyoxometalates and Their Nanocrystals
edited by and
submission deadline 20 Mar 2026 | Viewed by 440 | Submission Open
Keywords: polyoxometalates; POMs; metal cluster compound; inorganic chemistry; nanocrystals
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Molecular Insights into the Precision Medicine on Neoplastic Diseases: Challenges, Perspectives and Opportunities
edited by
submission deadline 20 Mar 2026 | Viewed by 431 | Submission Open
Keywords: cancer; molecular biology; precision medicine; targeted therapy
(This special issue belongs to the Section Molecular Oncology)
Genetic Mechanisms of Neurological Disorders
edited by and Sara Duarte-Silva
submission deadline 20 Mar 2026 | Viewed by 422 | Submission Open
Keywords: neurodevelopmental disorders; neurodegenerative disorders; neuropsychiatric disorders; genetics; molecular biology; cellular models; animal models; pathogenesis; biomarkers; therapeutic targets; drug discovery; therapy  
(This special issue belongs to the Section Molecular Genetics and Genomics)
Exploring Molecular-Scale and Nano-Scale Materials: Design, Characterization and Application
edited by Xiaogang Li
submission deadline 20 Mar 2026 | Viewed by 408 | Submission Open
Keywords: molecular scale; nano scale; material design and preparation; characterization; regulation; application
(This special issue belongs to the Section Molecular Nanoscience)
Microbial Mediators: The Bridge Between Soils, Plants, and Animal Infectious Diseases
edited by Wensheng Fang, and Bin Huang
submission deadline 20 Mar 2026 | Viewed by 399 | Submission Open
Keywords: micro-organisms; soil health; plant– microbe interactions; microbial regulation; agricultural ecosystems; animal infectious diseases; microbiome; microbiota
(This special issue belongs to the Section Molecular Microbiology)
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