Fibrosis: Molecular Mechanisms and Targeted Therapy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 31 January 2027 | Viewed by 41
Editor
Interests: matrix metalloproteinases; VEGF and VEGF receptors; MMPs inhibitors; angiogenesis; wound healing; cornea
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Fibrosis is a common consequence of chronic tissue injury and a major cause of organ dysfunction affecting the eye, lung, liver, kidney, heart, skin, and other tissues. Despite diverse causes, fibrotic diseases share common features, including persistent myofibroblast activation, excessive extracellular matrix deposition, chronic inflammation, and impaired tissue repair. As a result, fibrosis remains a significant unmet clinical challenge, with limited therapies capable of reversing established scar tissue.
Recent advances in single-cell and spatial transcriptomics, lineage tracing, multi-omics technologies, and high-resolution imaging have transformed our understanding of fibrosis. These approaches have revealed previously unrecognized cellular heterogeneity among fibroblasts, myofibroblasts, immune cells, and progenitor populations, while identifying signaling pathways that regulate fibrosis progression and resolution. Emerging evidence also highlights the critical roles of immune–stromal interactions, macrophage plasticity, extracellular matrix remodeling, and regenerative repair mechanisms in determining tissue outcomes following injury.
This Special Issue welcomes original research articles, reviews, and perspectives addressing fibrosis biology, tissue remodeling, and regenerative repair. Topics of interest include fibroblast and myofibroblast heterogeneity, lineage tracing, immune–stromal interactions, extracellular matrix remodeling, single-cell and spatial omics approaches, fibrosis resolution, novel anti-fibrotic therapies, tissue-specific fibrotic diseases, and translational applications.
By bringing together investigators from diverse disciplines, this Special Issue aims to advance our understanding of fibrotic disease mechanisms and accelerate the development of effective therapies to prevent, halt, or reverse pathological tissue scarring.
Dr. Kyu-Yeon Han
Guest Editor
Manuscript Submission Information
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Keywords
- fibrosis
- myofibroblasts
- tissue remodelling
- extracellular matrix
- wound healing
- anti-fibrotic therapy
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