Mechanisms and Treatments of Adenosine Signaling-Regulated Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 July 2026 | Viewed by 55
Special Issue Editor
Special Issue Information
Dear Colleagues,
Adenosine signaling has emerged as a central regulator of cellular homeostasis under both physiological and pathological conditions. Acting through its four G protein-coupled receptors (A1, A2A, A2B, and A3), adenosine modulates key biological processes including inflammation, immune regulation, metabolism, fibrosis, vascular tone, and tissue repair. Dysregulation of this pathway is increasingly recognized as a critical driver of a wide range of diseases, such as cancer, chronic inflammatory disorders, cardiovascular and metabolic diseases, and fibrotic pathologies.
This Special Issue aims to provide a comprehensive and up-to-date overview of the molecular mechanisms governing adenosine signaling and its therapeutic targeting. We invite original research articles and high-quality reviews exploring receptor-specific signaling pathways, downstream molecular networks, and the context-dependent effects of adenosine in disease. Particular emphasis is placed on translational studies bridging fundamental mechanistic insights with therapeutic strategies, including pharmacological modulation of adenosine receptors, enzyme targeting (e.g., CD39/CD73), and emerging combination therapies.
By bringing together contributions from diverse experimental models and clinical perspectives, this Special Issue seeks to advance our understanding of adenosine signaling as a unifying and druggable pathway, fostering the development of innovative treatments for adenosine signaling-regulated diseases.
Dr. Ángelo Torres
Guest Editor
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Keywords
- adenosine signaling
- adenosine signaling–regulated diseases
- adenosine receptors
- A1, A2A, A2B and A3 receptors
- purinergic signaling
- extracellular adenosine
- adenosine-mediated inflammation
- adenosine in cancer and fibrosis
- therapeutic targeting of adenosine pathways
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