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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Nucleolus, Nucleolar Stress, and Ribosome Biogenesis in the Nervous System

edited by

Theologos Michaelidis

submission deadline 20 Nov 2025 | Viewed by 962 | Submission Open

Keywords: nucleolus; nucleolar stress; nucleolar homeostasis; polymerase I; rDNA transcription; ribosome biogenesis; translation; ribosomopathies; apoptosis; autophagy; senescence; neurodegeneration; tumorigenesis

(This special issue belongs to the Section Molecular Neurobiology)

Aquatic Organisms Models Dedicated to Disease

edited by

Malgorzata Kloc

and

Jacek Z. Kubiak

submission deadline 20 Nov 2025 | Viewed by 889 | Submission Open

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cancer Models: Development and Applications

edited by

Yong Teng

submission deadline 20 Nov 2025 | 1 articles | Viewed by 864 | Submission Open

Keywords: tumor organoids; animal models of cancer; drug screening models; highly clinically relevant cancer models; technologies related to cancer model development

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Precision Cancer Medicine: Molecular Insights, Biological Events and Clinical Perspectives

edited by

Dimitrios H. Roukos

submission deadline 20 Nov 2025 | Viewed by 747 | Submission Open

Keywords: multi-omics at bulk level; single-cell multi-omics; precision oncology; precision immune-oncology; tumor molecular profiling

(This special issue belongs to the Section Molecular Oncology)

Endothelial Dysfunction, Inflammation and Cognition

edited by Christelle Basset and Anne S. Prigent-Tessier

submission deadline 20 Nov 2025 | Viewed by 720 | Submission Open

Keywords: inflammation; endothelial dysfunction; cognition; nitric oxide (NO); BDNF; physical exercise

(This special issue belongs to the Section Molecular Biology)

Molecular Research on PRDM Genes

edited by

Erika Zazzo

Ciro Abbondanza

and

Monica Rienzo

submission deadline 20 Nov 2025 | Viewed by 684 | Submission Open

Keywords: PRDM; cancer; gene expression regulation; epigenetic modifications; proliferation; differentiation; gene expression regulation; apoptosis; cancer biomarkers; cancer diagnosis

(This special issue belongs to the Section Molecular Genetics and Genomics)

Antimicrobial Materials: Novel Studies and Related Applications

edited by

Iuliana Deleanu

submission deadline 20 Nov 2025 | 1 articles | Viewed by 668 | Submission Open

Keywords: antimicrobial materials; functional materials; composite materials; contamination; green materials; green technologies; metallic materials; drug resistance; environmental safety; biocompatibility; biodegradability

(This special issue belongs to the Section Materials Science)

Research on Artificial Intelligence in Plant Biology

edited by Haopeng Yu

submission deadline 20 Nov 2025 | Viewed by 649 | Submission Open

Keywords: artificial intelligence; plant biology; RNA regulation; DNA regulatory elements; plant development; plant biotechnology

(This special issue belongs to the Section Molecular Plant Sciences)

Diabetes: Genetics and Genomics, Hormone Regulation, and Metabolic Control

edited by Maria Stathopoulou

submission deadline 20 Nov 2025 | Viewed by 599 | Submission Open

Keywords: type 1 diabetes; type 2 diabetes; monogenic diabetes; polygenic risk factors; gestational diabetes (GDM); maturity-onset diabetes of the young (MODY); latent autoimmune diabetes in adults (LADAs); genome-wide association studies (GWASs); single nucleotide polymorphisms (SNPs); epigenetic modifications in diabetes; insulin production regulation; hormone action and metabolic control; β -cell dysfunction; gene-environment interactions in diabetes; precision medicine in diabetes treatment; genetics; genomics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Multifaceted Roles of Extracellular Vesicles in Cancer and Other Diseases

edited by

Eleni Myrto Trifylli

submission deadline 20 Nov 2025 | 1 articles | Viewed by 565 | Submission Open

Keywords: extracellular vesicles; exosomes; cancer diagnostics; non-invasive tests; liquid biopsy; cancer therapy; biomarker discovery; nanotechnology; EV engineering; drug delivery; neurodegenerative diseases; cardiovascular diseases; infectious diseases; autoimmune diseases; precision diagnostics

(This special issue belongs to the Section Molecular Oncology)

New Insights into the Pathogenesis of Type 1 Diabetes

edited by

Alessandra Fierabracci

submission deadline 20 Nov 2025 | Viewed by 551 | Submission Open

Keywords: type 1 diabetes; insulin-dependent diabetes mellitus; human leukocyte antigen (HLA); pathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Adaptation Mechanisms of Plants to Environmental Stress

edited by

Michael Moustakas

submission deadline 20 Nov 2025 | Viewed by 547 | Submission Open

Keywords: signal perception; signal transduction; post-translational modifications; stress response genes; reactive oxygen species; osmoprotectant; antioxidants; plant hormones; stress-related proteins; climate change; biotic stress; abiotic stress

(This special issue belongs to the Section Molecular Plant Sciences)

Genetic Testing and Tailored Treatment for Thyroid Disorders: Molecular Basis and New Trends

edited by

Kyoung Sik Park

submission deadline 20 Nov 2025 | Viewed by 516 | Submission Open

Keywords: thyroid diseases; genetics; personalized medicine; novel therapies

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular, Translational and Clinical Research of Cancer Structural Biomarkers

edited by

Sabine Mai

submission deadline 20 Nov 2025 | Viewed by 508 | Submission Open

Keywords: structural biomarker; extracellular matrix; nuclear organization; discovery research; translational research; clinical research; cancer staging and prognosis; cancer therapy

(This special issue belongs to the Section Molecular Oncology)

Neuroinflammation: From Molecular Mechanisms to Therapy

edited by

Silvia Alboni

and Miriam Ciani

submission deadline 20 Nov 2025 | 1 articles | Viewed by 494 | Submission Open

Keywords: neuroinflammation; neurodegenerative diseases; psychiatric disorders; molecular and cellular targets

(This special issue belongs to the Section Molecular Neurobiology)

Insights into the Pathogenesis, Molecular Landscape and Therapeutics of Triple-Negative Breast Cancer

edited by Rebecca Chin

submission deadline 20 Nov 2025 | 1 articles | Viewed by 466 | Submission Open

Keywords: breast cancer; cancer stemness; therapeutic resistance; brain metastasis; epigenetic mechanisms; chromatin remodeling; multi-omics approaches; high-throughput screening; patient-derived organoids

(This special issue belongs to the Section Molecular Oncology)

Application of Nanomaterials and Molecular Detection in Human Diseases

edited by

Liangcan He

submission deadline 20 Nov 2025 | Viewed by 459 | Submission Open

Keywords: cancer; infectious diseases; neurological diseases; hematological disorders; cardiovascular diseases; nanoparticles; nanodrug delivery; nanoimaging

(This special issue belongs to the Section Materials Science)

Peptide Receptor Radionuclide Therapy (PRRT) and Targeted Alpha Therapy (TAT) in Cancer

edited by

Behrooz H. Yousefi

submission deadline 20 Nov 2025 | Viewed by 453 | Submission Open

Keywords: novel radiopharmaceutical synthesis; translational research; theranostic studies; manufacturing of radiopharmaceuticals; therapy efficacy; personalized dosimetry

(This special issue belongs to the Section Molecular Oncology)

Structure–Activity Relationships Within Pharmaceutical Interactions and the Discovery of Molecular Targets

edited by

Yoshihiro Uesawa

submission deadline 20 Nov 2025 | Viewed by 446 | Submission Open

Keywords: molecular dynamics; docking simulation; QSAR; moleular initiating event

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms and Performances of Photocatalysis

edited by

Shaojun Yuan

submission deadline 20 Nov 2025 | Viewed by 426 | Submission Open

Keywords: photocatalytic materials; photocatalysis; energy conversion; environmental remediation; carbon dioxide reduction; organic synthesis

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Research on Potential New Antidepressant Drugs

edited by

Marta Jóźwiak-Bębenista

and

Anna Stasiak

submission deadline 20 Nov 2025 | Viewed by 424 | Submission Open

Keywords: antidepressant drug discovery; treatment-resistant depression; neuroinflammation; neuroplasticity; hallucinogens and psychedelics; CNS drug development; molecular targets for depression; neurotransmitter systems (serotonin; norepinephrine; dopamine); preclinical research (in vitro; in vivo; in silico); psychiatric disorders

(This special issue belongs to the Section Molecular Pharmacology)

Recent Advances in the Biological Function of Tyrosinase

edited by

Kazumasa Wakamatsu

submission deadline 20 Nov 2025 | Viewed by 416 | Submission Open

Keywords: tyrosinase-related proteins; tyrosinase; melanogenesis; copper; zinc; metal enzymes; tyrosinase inhibitor; pigmentation disorders

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanism of Hypertension-Induced Renal Injury

edited by

Ningjun Li

and Guangbi Li

submission deadline 20 Nov 2025 | Viewed by 399 | Submission Open

Keywords: hypertension; renal injury; molecular mechanisms; chronic kidney disease; pharmacological interventions; vascular biology; renoprotection; blood pressure regulation; toxicology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mesenteric Adipose Tissue: The New Player in Health and Disease

edited by Eva Pardina and Jose M. Balibrea

submission deadline 20 Nov 2025 | Viewed by 393 | Submission Open

Keywords: mesenteric adipose tissue; obesity; inflammatory bowel diseases; Chron’ s disease; MASLD; metabolic inflammation; metabolic syndrome; mesenteric resections

(This special issue belongs to the Section Molecular Biology)

Cardiomyopathy: From Molecular Pathology to Treatment

edited by

Andrea Sonaglioni

and

Gian Luigi Nicolosi

submission deadline 20 Nov 2025 | Viewed by 389 | Submission Open

Keywords: obesity; myocardial fibrosis; subclinical myocardial dysfunction; fibrotic remodeling; microRNAs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antibacterial Activity of Novel Antimicrobial Agents

edited by Paweł Kowalczyk

submission deadline 20 Nov 2025 | 1 articles | Viewed by 388 | Submission Open

Keywords: novel antimicrobial agents; antibiotic resistance; chemical entities; phage therapy; bacterial pathogens; antimicrobial peptides; resistance mechanisms

(This special issue belongs to the Section Molecular Pharmacology)

Nucleic Acid Aptamers in Molecular Medicine

edited by

Silvia Catuogno

submission deadline 20 Nov 2025 | Viewed by 386 | Submission Open

Keywords: aptamers; SELEX; targeted therapy; drug delivery; diagnosis; biomarker discovery

(This special issue belongs to the Section Molecular Biology)

Preparations and Applications of Aerogels and/or Cryogels: From a Molecular Perspective

edited by

Angelika Kmita

and

Dorota Lachowicz

submission deadline 20 Nov 2025 | Viewed by 384 | Submission Open

Keywords: inorganic and/or organic aerogels; hybrid materials; eco-friendly materials; diagnosis

(This special issue belongs to the Section Materials Science)

Deciphering the Multifaceted Mechanisms of Antimicrobial Peptides

edited by

Xiumin Wang

submission deadline 20 Nov 2025 | Viewed by 383 | Submission Open

Keywords: antimicrobial peptides; antimicrobial activity; mechanisms of action; membrane disruption; inhibition of cellular processes; immune modulation

(This special issue belongs to the Section Macromolecules)

The Importance of Inflammation as a Link Between Adipokines and Myokines in Obesity

edited by

Maria Greabu

submission deadline 20 Nov 2025 | Viewed by 377 | Submission Open

Keywords: inflammation; adipokines; myokines; obesity; adipose tissue; muscle

(This special issue belongs to the Section Molecular Immunology)

Allosteric Modulation of Kinases in Cancer Therapeutic Strategies and Challenges

edited by

Nidhi Joshi

submission deadline 20 Nov 2025 | Viewed by 344 | Submission Open

Keywords: kinase signaling; allosteric modulators; cancer therapy; drug resistance; molecular mechanisms; protein– protein interactions; targeted therapy; conformational changes; ATP-competitive inhibitors; drug design

(This special issue belongs to the Section Molecular Biology)

Natural Product and Enzyme Inhibition for Disease Management

edited by

Viet Phong Nguyen

and

Le Ba Vinh

submission deadline 20 Nov 2025 | Viewed by 335 | Submission Open

Keywords: bioactive compounds; natural sources; enzyme inhibition; drug discovery; cancer; cardiovascular diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Pharmacological Advances in Gastrointestinal Health

edited by

Mirjana Stupnisek

submission deadline 20 Nov 2025 | Viewed by 333 | Submission Open

Keywords: gastrointestinal disorders; gastrointestinal healing; gut microbiota; inflammatory bowel disease; irritable bowel syndrome; gastrointestinal cancer; Crohn’ s disease; metabolic syndrome; cytoprotective agents; nonsteroidal anti-inflammatory drugs’ toxicity

(This special issue belongs to the Section Molecular Pharmacology)

Nanoformulations for the Treatment of Human Diseases

edited by Sergio Acin Martinez

submission deadline 20 Nov 2025 | Viewed by 331 | Submission Open

Keywords: nanomedicine; nanomaterials nanomedicine; liposomes; nanocrystal; polymeric nanoparticles

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Science of Anesthesia

edited by Jose Luis Guerrero Orriach and Maria Dolores Carmona-Luque

submission deadline 20 Nov 2025 | Viewed by 330 | Submission Open

Keywords: anesthesia; nervous system; signal; receptor

(This special issue belongs to the Section Molecular Biology)

Bitter Taste Receptors in Health and Disease: From Molecular Mechanisms to Translational Applications

edited by

Luigia Grazia Fresu

and

Maria Talmon

submission deadline 20 Nov 2025 | Viewed by 316 | Submission Open

Keywords: bitter taste receptors; TAS2Rs; immune disease; immunity response

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Yeast Engineering and Stress Responses

edited by

Joaquin Ariño

and

Pau Ferrer

submission deadline 20 Nov 2025 | Viewed by 315 | Submission Open

Keywords: stress tolerance; cellular adaptation; nutrient limitation; gene expression; metabolic engineering; synthetic biology; strain robustness; fermentation efficiency; bioprocess optimization

(This special issue belongs to the Section Molecular Microbiology)

Microbiome in Cancer: From Pathogenesis to Therapeutic Innovation

edited by

Francesca Benedetti

and

Davide Zella

submission deadline 20 Nov 2025 | Viewed by 312 | Submission Open

Keywords: microbiome; cancer; anticancer drugs; chemoresistance; immune modulation

(This special issue belongs to the Section Molecular Microbiology)

Molecular Insights into the Pathophysiology of Placenta Accreta Spectrum

edited by Jessian L. Munoz

submission deadline 20 Nov 2025 | Viewed by 309 | Submission Open

Keywords: placenta accreta; invasive placenta; trophoblasts; placenta; high-risk pregnancy; placenta previa; in vitro fertilization; biomarkers; multi-omics research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Metabolic Reprogramming in Health and Aging-Related Diseases

edited by

Hung-Yao Ho

submission deadline 20 Nov 2025 | Viewed by 309 | Submission Open

Keywords: aging; degenerative diseases; lifestyle intervention; metabolic reprogramming; metabolic syndromes; metabolome; metabolomics; neurodegenerative diseases; omics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Mechanism(s) of HFpEF and HFrEF

edited by

Suresh C. Tyagi

submission deadline 20 Nov 2025 | Viewed by 295 | Submission Open

Keywords: HFpEF; HFrEF; diabetes; hypertension; obesity; microbiota; epigenetics; probiotics; postbiotics

(This special issue belongs to the Section Molecular Biology)

Application of Fluorescent Probes in Visualization and Intervention Processes in Pathology

edited by Kang-Nan Wang

submission deadline 20 Nov 2025 | Viewed by 281 | Submission Open

Keywords: fluorescent probes; targeted fluorescent molecules; pathological markers; reactive oxygen species (ROS); pH variations; DNA/RNA dynamics; enzyme activity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Unveiling the Complexity of TRPC Channels: From Molecular Mechanisms to Clinical Applications

edited by Oleksandra Tiapko

submission deadline 20 Nov 2025 | Viewed by 272 | Submission Open

Keywords: TRPC channels; TRPC– lipid interactions; TRPC– protein interactions; cellular homeostasis; TRPC-dependent disorders; (photo)pharmacology; TRPC in native tissue

(This special issue belongs to the Section Molecular Biology)

Innovations in Photodynamic Therapy: New Horizons in Breast Cancer Care

edited by Sandeep Surendra Panikar

submission deadline 20 Nov 2025 | Viewed by 269 | Submission Open

Keywords: noninvasive therapy; tumor targeting; breast cancer therapy; oncology; photosensitizers; theranostics; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Structural and Functional Insights into Chemokines and Chemokine Receptors in Immune Pathologies

edited by

Nidhi Joshi

submission deadline 20 Nov 2025 | Viewed by 269 | Submission Open

Keywords: chemokines; chemokine receptors; immune pathologies; signaling mechanisms; therapeutic targeting

(This special issue belongs to the Section Molecular Immunology)

Recent Developments in Obesity: Metabolism, Pathophysiology, and Treatment

edited by

Byungyong Ahn

submission deadline 20 Nov 2025 | Viewed by 267 | Submission Open

Keywords: obesity; pathophysiology; hormones (GLP-1; GIP; glucagon); inflammation; pharmacotherapy; incretin-based treatments; bariatric surgery; lifestyle interventions; personalized medicine; metabolic syndrome

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Cutting-Edge Research for Cancer Stem Cells

edited by

Suryavathi Viswanadhapalli

submission deadline 20 Nov 2025 | Viewed by 258 | Submission Open

Keywords: cancer stem cells; tumor initiation; metastasis; self-renewal; therapy resistance; single-cell sequencing; patient-derived organoids; CRISPR/Cas9; small molecules; monoclonal antibodies; CAR-T cell therapy; tumor microenvironment; combination therapies

(This special issue belongs to the Section Molecular Oncology)

Molecular Insights into Emerging Nanomaterials and Their Environmental Implications

edited by Gao Xiao

submission deadline 20 Nov 2025 | Viewed by 255 | Submission Open

Keywords: nanomaterials; molecular level; water purification; bioavailability; environmental effects; renewable energy solutions; ecotoxicology and sustainability; degradation pathways; toxicity

(This special issue belongs to the Section Materials Science)

Innovative Advances and Applications in Medical and Molecular Virology

edited by

Vincent T. K. Chow

and

Julian Tang

submission deadline 20 Nov 2025 | Viewed by 252 | Submission Open

Keywords: medical virology; molecular virology; molecular diagnostics; genomics; metagenomics; interactomics; integrative omics

(This special issue belongs to the Section Molecular Microbiology)

Emerging Topics in Polymer Crystallization

edited by Lei Zhang

submission deadline 20 Nov 2025 | Viewed by 250 | Submission Open

Keywords: polymer crystal; nucleation and growth; crystallization under extreme conditions; characterization of crystal structure

(This special issue belongs to the Section Macromolecules)

Displaying special issue 201-250 on page 5 of 69.

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