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Antibacterial Activity of Novel Antimicrobial Agents

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: 20 July 2026 | Viewed by 1080

Special Issue Editor


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Guest Editor
The Kielanowski Institute of Animal Physiology and Nutrition of the Polish Academy of Sciences, Jablonna, Poland
Interests: coumarin derivatives; oxidative stress; nanoparticles; antibiotic resistance

Special Issue Information

Dear Colleagues,

This Special Issue focuses on the urgent need for novel antimicrobial agents to combat the global rise of antibiotic resistance. We present cutting-edge research exploring various strategies, including the development of new chemical entities, repurposing existing drugs, and innovative approaches like phage therapy and antimicrobial peptides. The encompass in vitro and in vivo evaluations of antimicrobial efficacy against various bacterial pathogens, including Gram-positive and Gram-negative bacteria, as well as mechanisms of action. They highlight advancements in understanding bacterial resistance mechanisms and the design of agents that overcome these challenges. This collection aims to stimulate further research and accelerate the translation of promising candidates into effective clinical therapies to address the critical threat of antimicrobial resistance.

Dr. Paweł Kowalczyk
Guest Editor

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Keywords

  • novel antimicrobial agents
  • antibiotic resistance
  • chemical entities
  • phage therapy
  • bacterial pathogens
  • antimicrobial peptides
  • resistance mechanisms

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Published Papers (1 paper)

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Research

16 pages, 1215 KB  
Article
Copper(II) Complexes of Selected Acylhydrazones as Potential Biological Agents
by Izabela Czyżewska, Liliana Mazur, Robert Mroczka, Anna Biernasiuk, Anna Hordyjewska and Łukasz Popiołek
Int. J. Mol. Sci. 2025, 26(22), 10980; https://doi.org/10.3390/ijms262210980 - 13 Nov 2025
Cited by 1 | Viewed by 796
Abstract
In the current research a series of new copper(II) complexes with novel acylhydrazone ligands were synthesized and their antibacterial and anticancer activities were determined. The complexes were characterized by molecular spectroscopy (FT-IR and UV-Vis) and conductivity measurements. Additionally, their structure was confirmed by [...] Read more.
In the current research a series of new copper(II) complexes with novel acylhydrazone ligands were synthesized and their antibacterial and anticancer activities were determined. The complexes were characterized by molecular spectroscopy (FT-IR and UV-Vis) and conductivity measurements. Additionally, their structure was confirmed by single-crystal X-ray analysis. The crystallographic data revealed that all compounds are mononuclear Cu(II) species. The Cu(II) ion is four-coordinated by the ONO donor set from mono-deprotonated hydrazone ligand and one Cl¯ anion, forming distorted square-planar geometry. The biological studies revealed that the compounds exhibit high antimicrobial activity, especially against Gram-positive bacteria, in some cases greater than the reference substances, and better activity than free ligands. The tested complexes possessed the lowest MIC and MBC values towards Staphylococcus epidermidis ATCC 12228 and Micrococcus luteus ATCC 10240. Furthermore, they showed no toxicity towards normal cell lines. Full article
(This article belongs to the Special Issue Antibacterial Activity of Novel Antimicrobial Agents)
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